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  1. Article ; Online: Fear of cancer recurrence in peritoneal malignancy patients following complete cytoreductive surgery (CCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)

    Sophia Stanford / Norman Carr / Kandiah Chandrakumaran / Rayan Taher / Nancy Vanderpuye

    BMJ Open, Vol 12, Iss

    an observational study protocol

    2022  Volume 2

    Keywords Medicine ; R
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Early sepsis identification following cytoreductive surgery for peritoneal malignancy.

    Wilson, Darius Cameron / Yershov, Danylo / Kandiah, Chandrakumaran / Cortes, Nicholas / Gordon, Kirsty / Saeed, Kordo

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 112

    MeSH term(s) Aged ; Cytoreduction Surgical Procedures/methods ; Cytoreduction Surgical Procedures/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Neoplasms/physiopathology ; Neoplasms/surgery ; Peritoneal Neoplasms/physiopathology ; Peritoneal Neoplasms/surgery ; Sepsis/diagnosis ; Sepsis/physiopathology
    Language English
    Publishing date 2020-03-23
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-2831-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The effect of intravesical instillations with Hyaluronic Acid on sexual dysfunction in women with recurrent urinary tract infections (RUTI).

    Nightingale, Gemma / Shehab, Qasem / Kandiah, Chandrakumaran / Rush, Lorraine / Rowe-Jones, Clare / Phillips, Christian H

    European journal of obstetrics, gynecology, and reproductive biology

    2017  Volume 221, Page(s) 105–108

    Abstract: Objective: To determine whether sexual dysfunction in women with recurrent urinary tract infections (RUTI) improved following treatment with intravesical Hyaluronic Acid (HA) instillations.: Study design: Ethical approval was obtained for a ... ...

    Abstract Objective: To determine whether sexual dysfunction in women with recurrent urinary tract infections (RUTI) improved following treatment with intravesical Hyaluronic Acid (HA) instillations.
    Study design: Ethical approval was obtained for a prospective study to be performed. Patients referred for bladder instillations to treat RUTI, and who were sexually active, were recruited to the study. A selection of validated questionnaires (ICIQ-UI, ICIQ-VS, FSDS-R, ICIQ-FLUTS, O'Leary/Sant and PGI-I) were completed at baseline, three, six and 12 months after initiation of treatment with bladder instillations. Treatment consisted of weekly bladder instillations with a preparation containing HA for four weeks then monthly for two further treatments. Results were populated in SPSS for statistical analysis and statistical significance was powered for 22 patients.
    Results: Thirty women were included in the study. FSDS-R was used to determine sexual dysfunction and showed that 57% patients with RUTI had significant sexual distress. There was a significant improvement in FSDS-R at three, six and 12 months when compared to baseline (Friedman two-way analysis p < 0.001). ICIQ FLUTS F and I scores, O'Leary/Sant, ICIQ VS and PGI-I also showed a statistically significant improvement throughout the period of follow up. A statistically significant, negative correlation was found between FSDS-R and PGI-I at 12 months (r = -0.468, p = 0.009).
    Conclusion: We have reinforced previous work showing the association between RUTI and sexual dysfunction, and an improvement in bladder symptoms following treatment with HA. To our knowledge, this is the first study to prove an improvement in sexual dysfunction following intravesical treatment with HA which is sustained for up to 12 months.
    MeSH term(s) Administration, Intravesical ; Adult ; Female ; Humans ; Hyaluronic Acid/therapeutic use ; Middle Aged ; Prospective Studies ; Recurrence ; Sexual Dysfunction, Physiological/drug therapy ; Sexual Dysfunction, Physiological/etiology ; Treatment Outcome ; Urinary Tract Infections/complications ; Urinary Tract Infections/drug therapy
    Chemical Substances Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2017-12-15
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2017.12.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 837: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: PCI is Not Predictive of Survival After Complete CRS/HIPEC in Peritoneal Dissemination from High-Grade Appendiceal Primaries.

    Votanopoulos, Konstantinos Ioannis / Bartlett, David / Moran, Brendan / Haroon, Choudry M / Russell, Greg / Pingpank, James F / Ramalingam, Lekshmi / Kandiah, Chandrakumaran / Chouliaras, Konstantinos / Shen, Perry / Levine, Edward A

    Annals of surgical oncology

    2017  Volume 25, Issue 3, Page(s) 674–678

    Abstract: Background: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is a treatment option in patients with carcinomatosis from high-grade appendiceal (HGA) primaries. It is unknown if there is a Peritoneal Carcinomatosis Index ( ... ...

    Abstract Background: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is a treatment option in patients with carcinomatosis from high-grade appendiceal (HGA) primaries. It is unknown if there is a Peritoneal Carcinomatosis Index (PCI) upper limit above which a complete CRS/HIPEC does not assure long-term survival.
    Methods: Retrospective analysis from three centers was performed. The PCI was used to grade volume of of disease. Survival in relation to PCI was studied on patients with complete cytoreduction.
    Results: Overall, 521 HGA patients underwent CRS/HIPEC from 1993 to 2015, with complete CRS being achieved in 50% (260/622). Mean PCI was 14.8 (standard deviation 8.7, range 0-36). Median survival for the complete CRS cohort was 6.1 years, while 5- and 10-year survival was 51.7% (standard error [SE] 4.6) and 36.1% (SE 6.3), respectively. Arbitrary cut-off PCI limits with 5-point splits (p = 0.63) were not predictive of a detrimental effect on survival as long as a complete CRS was achieved. A linear effect of the PCI on survival (p = 0.62) was not observed, and single-point PCI cohort splits within a PCI range of < 5 to > 10 were not predictive of survival for complete CRS patients. The PCI correlated with the ability to achieve a complete CRS, with a mean PCI of 14.7 (8.7) for completeness of cytoreduction (CC)0, 22.3 (7.8) for CC1 and 26.1 (9.5) for CC2/3 resections (p = 0.0001, hazard ratio 1.12, 95% confidence interval 1.09), with an HR of 1.15 for each 1-unit increase in the PCI score. Only 21% of the cohort achieved a complete CRS with a PCI ≥ 21.
    Conclusions: The PCI correlates with the ability to achieve a complete CRS in carcinomatosis from HGA. PCI is not associated with survival as long as a complete CRS can be achieved.
    MeSH term(s) Appendiceal Neoplasms/mortality ; Appendiceal Neoplasms/pathology ; Appendiceal Neoplasms/therapy ; Chemotherapy, Adjuvant ; Chemotherapy, Cancer, Regional Perfusion/mortality ; Combined Modality Therapy ; Cytoreduction Surgical Procedures/mortality ; Female ; Follow-Up Studies ; Humans ; Hyperthermia, Induced/mortality ; Male ; Middle Aged ; Peritoneal Neoplasms/mortality ; Peritoneal Neoplasms/pathology ; Peritoneal Neoplasms/therapy ; Prognosis ; Retrospective Studies ; Severity of Illness Index ; Survival Rate
    Language English
    Publishing date 2017-12-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-017-6315-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
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