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  1. Article ; Online: A Meta-Analysis of Bioelectric Data in Cancer, Embryogenesis, and Regeneration.

    Srivastava, Pranjal / Kane, Anna / Harrison, Christina / Levin, Michael

    Bioelectricity

    2021  Volume 3, Issue 1, Page(s) 42–67

    Abstract: Developmental bioelectricity is the study of the endogenous role of bioelectrical signaling in all cell types. Resting potentials and other aspects of ionic cell physiology are known to be important regulatory parameters in embryogenesis, regeneration, ... ...

    Abstract Developmental bioelectricity is the study of the endogenous role of bioelectrical signaling in all cell types. Resting potentials and other aspects of ionic cell physiology are known to be important regulatory parameters in embryogenesis, regeneration, and cancer. However, relevant quantitative measurement and genetic phenotyping data are distributed throughout wide-ranging literature, hampering experimental design and hypothesis generation. Here, we analyze published studies on bioelectrics and transcriptomic and genomic/phenotypic databases to provide a novel synthesis of what is known in three important aspects of bioelectrics research. First, we provide a comprehensive list of channelopathies-ion channel and pump gene mutations-in a range of important model systems with developmental patterning phenotypes, illustrating the breadth of channel types, tissues, and phyla (including man) in which bioelectric signaling is a critical endogenous aspect of embryogenesis. Second, we perform a novel bioinformatic analysis of transcriptomic data during regeneration in diverse taxa that reveals an electrogenic protein to be the one common factor specifically expressed in regeneration blastemas across Kingdoms. Finally, we analyze data on distinct V
    Language English
    Publishing date 2021-03-16
    Publishing country United States
    Document type Journal Article
    ISSN 2576-3113
    ISSN (online) 2576-3113
    DOI 10.1089/bioe.2019.0034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nirmatrelvir-ritonavir treatment of COVID-19 in a high-risk patient population: A retrospective observational study.

    Kane, Anna M / Keenan, Erica M / Lee, Kasheng / Hartkopf, Katherine J / Ludwig, Trisha A / Trapskin, Philip J / Vanderloo, Joshua P / Schulz, Lucas T

    Journal of the American College of Clinical Pharmacy : JACCP

    2022  Volume 6, Issue 1, Page(s) 29–33

    Abstract: Background: Coronavirus disease 2019 (COVID-19) is a highly contagious, airborne viral infection that can infect anyone. Those with certain underlying conditions may be at higher risk for infection to develop into a severe disease requiring ... ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) is a highly contagious, airborne viral infection that can infect anyone. Those with certain underlying conditions may be at higher risk for infection to develop into a severe disease requiring hospitalization. This report summarizes use of nirmatrelvir-ritonavir for the treatment of COVID-19 in high-risk patients at a single academic medical center through a pharmacist delegation protocol and demonstrates real-world efficacy and safety of treatment.
    Methods: This retrospective, single-center, observational study analyzed all patients who received nirmatrelvir-ritonavir ordered by a clinical pharmacist for treatment of COVID-19 infection. The primary outcomes were safety and efficacy of nirmatrelvir-ritonavir. Safety was evaluated by analyzing drug interaction management and adverse events. Efficacy was evaluated through hospitalization and death within 28 days of nirmatrelvir-ritonavir use.
    Results: Sixty patients were eligible for inclusion. No patients were hospitalized or died within 28 days after initiation of nirmatrelvir-ritonavir. Pharmacists identified 101 drug interactions with 60% considered clinically significant, requiring modification of home medications. Adverse outcomes associated with the use of nirmatrelvir-ritonavir were reported in 13 patients (21.7%).
    Conclusions: A comprehensive program to mitigate drug interactions and prescribe nirmatrelvir-ritonavir ensured timely access to COVID-19 therapy, which may be associated with the prevention of hospitalization and death.
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Journal Article
    ISSN 2574-9870
    ISSN (online) 2574-9870
    DOI 10.1002/jac5.1729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Write your way to a winning funding bid.

    O'Kane, Anna

    Nursing times

    2012  Volume 108, Issue 50, Page(s) 1 p following 36

    MeSH term(s) Competitive Bidding ; Efficiency, Organizational ; United Kingdom
    Language English
    Publishing date 2012-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 391202-4
    ISSN 0954-7762 ; 0029-6589
    ISSN 0954-7762 ; 0029-6589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 428: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 17: Show issues

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  4. Article: What can the NHS learn from the private sector?

    O'Kane, Anna

    Nursing times

    2012  Volume 108, Issue 37, Page(s) 37

    MeSH term(s) Private Sector/organization & administration ; State Medicine/organization & administration ; United Kingdom
    Language English
    Publishing date 2012-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 391202-4
    ISSN 0954-7762 ; 0029-6589
    ISSN 0954-7762 ; 0029-6589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 428: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 17: Show issues

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  5. Book ; Thesis: Die Gesetzgebungskompetenzen des Bundes im Umweltschutz

    Kane, Anna-Miriam

    (Bielefelder umweltrechtliche Studien ; 2)

    2013  

    Title variant Die Reichweite der Gesetzgebungskompetenzen des Bundes im Umweltschutz
    Author's details Anna-Miriam Kane
    Series title Bielefelder umweltrechtliche Studien ; 2
    Keywords Bundesstaat ; Gesetzgebungskompetenz ; Umweltschutz ; Deutschland ; Gesetzgebung ; Umweltrecht
    Language German
    Size 296 S.
    Edition 1. Aufl.
    Publisher Nomos
    Publishing place Baden-Baden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss. u.d.T.: Die Reichweite der Gesetzgebungskompetenzen des Bundes im Umweltschutz--Bielefeld, 2012
    ISBN 3848702096 ; 9783848702091
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Book ; Thesis: Die Gesetzgebungskompetenzen des Bundes im Umweltschutz

    Kane, Anna-Miriam

    (Bielefelder umweltrechtliche Studien ; 2)

    2013  

    Title variant Die Reichweite der Gesetzgebungskompetenzen des Bundes im Umweltschutz
    Author's details Anna-Miriam Kane
    Series title Bielefelder umweltrechtliche Studien ; 2
    Keywords Environmental law ; Federal government ; Legislation ; Bundesstaat ; Gesetzgebungskompetenz ; Umweltschutz ; Deutschland
    Language German
    Size 296 S.
    Edition 1. Aufl.
    Publisher Nomos
    Publishing place Baden-Baden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss. u.d.T.: Die Reichweite der Gesetzgebungskompetenzen des Bundes im Umweltschutz--Bielefeld, 2012
    ISBN 3848702096 ; 9783848702091
    Database Former special subject collection: coastal and deep sea fishing

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  7. Book ; Online ; Thesis: Die Gesetzgebungskompetenzen des Bundes im Umweltschutz

    Kane, Anna-Miriam

    (Bielefelder umweltrechtliche Studien ; 2)

    2013  

    Abstract: ... Reihe ... Bielefelder umweltrechtliche Studien - Band ... ...

    Author's details Anna-Miriam Kane
    Series title Bielefelder umweltrechtliche Studien ; 2
    Abstract Reihe Bielefelder umweltrechtliche Studien - Band 2
    Language German
    Size Online-Ressource
    Edition 1. Aufl.
    Publisher Nomos
    Publishing place Baden-Baden
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss. u. d. T: Kane, Anna-Miriam: Die Reichweite der Gesetzgebungskompetenzen des Bundes im Umweltschutz--Bielefeld, 2012
    Note Description based upon print version of record
    ISBN 9783845246239 ; 9783848702091 ; 3845246235 ; 3848702096
    DOI 10.5771/9783845246239
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book ; Online ; Thesis: Die Gesetzgebungskompetenzen des Bundes im Umweltschutz

    Kane, Anna-Miriam [Verfasser]

    2013  

    Author's details Anna-Miriam Kane
    Keywords Recht ; Law
    Subject code sg340
    Language German
    Publisher Nomos Verlagsgesellschaft mbH & Co. KG
    Publishing place Baden-Baden
    Document type Book ; Online ; Thesis
    ISBN 978-3-8452-4623-9 ; 3-8452-4623-5
    Database Digital theses on the web

    Full text online

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  9. Article ; Online: Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult

    Murugan, Nirosha J / Vigran, Hannah J / Miller, Kelsie A / Golding, Annie / Pham, Quang L / Sperry, Megan M / Rasmussen-Ivey, Cody / Kane, Anna W / Kaplan, David L / Levin, Michael

    Science advances

    2022  Volume 8, Issue 4, Page(s) eabj2164

    Abstract: Limb regeneration is a frontier in biomedical science. Identifying triggers of innate morphogenetic responses in vivo to induce the growth of healthy patterned tissue would address the needs of millions of patients, from diabetics to victims of trauma. ... ...

    Abstract Limb regeneration is a frontier in biomedical science. Identifying triggers of innate morphogenetic responses in vivo to induce the growth of healthy patterned tissue would address the needs of millions of patients, from diabetics to victims of trauma. Organisms such as
    MeSH term(s) Adult ; Animals ; Bioreactors ; Hindlimb/physiology ; Humans ; Morphogenesis ; Wearable Electronic Devices ; Xenopus laevis/metabolism
    Language English
    Publishing date 2022-01-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abj2164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mechanosensation Mediates Long-Range Spatial Decision-Making in an Aneural Organism.

    Murugan, Nirosha J / Kaltman, Daniel H / Jin, Paul H / Chien, Melanie / Martinez, Ramses / Nguyen, Cuong Q / Kane, Anna / Novak, Richard / Ingber, Donald E / Levin, Michael

    Advanced materials (Deerfield Beach, Fla.)

    2021  Volume 33, Issue 34, Page(s) e2008161

    Abstract: The unicellular protist Physarum polycephalum is an important emerging model for understanding how aneural organisms process information toward adaptive behavior. Here, it is revealed that Physarum can use mechanosensation to reliably make decisions ... ...

    Abstract The unicellular protist Physarum polycephalum is an important emerging model for understanding how aneural organisms process information toward adaptive behavior. Here, it is revealed that Physarum can use mechanosensation to reliably make decisions about distant objects in its environment, preferentially growing in the direction of heavier, substrate-deforming, but chemically inert masses. This long-range sensing is abolished by gentle rhythmic mechanical disruption, changing substrate stiffness, or the addition of an inhibitor of mechanosensitive transient receptor potential channels. Additionally, it is demonstrated that Physarum does not respond to the absolute magnitude of strain. Computational modeling reveales that Physarum may perform this calculation by sensing the fraction of its perimeter that is distorted above a threshold substrate strain-a fundamentally novel method of mechanosensation. Using its body as both a distributed sensor array and computational substrate, this aneural organism leverages its unique morphology to make long-range decisions. Together, these data identify a surprising behavioral preference relying on biomechanical features and quantitatively characterize how the Physarum exploits physics to adaptively regulate its growth and shape.
    MeSH term(s) Agar/chemistry ; Animals ; Biomechanical Phenomena ; Chemotaxis ; Computer Simulation ; Feedback, Physiological ; Gravity Sensing/physiology ; In Vitro Techniques ; Movement/physiology ; Photic Stimulation ; Physarum polycephalum/growth & development ; Sensation/physiology ; Spatial Navigation/physiology ; Stress, Mechanical
    Chemical Substances Agar (9002-18-0)
    Language English
    Publishing date 2021-07-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202008161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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