Article ; Online: Regulation of Tim-3 function by binding to phosphatidylserine.
2021 Volume 478, Issue 22, Page(s) 3999–4004
Abstract: Tim-3 is a transmembrane protein that is highly expressed on subsets of chronically stimulated CD4+ helper and CD8+ cytotoxic T cells, with more transient expression during acute activation and infection. Tim-3 is also constitutively expressed by ... ...
Abstract | Tim-3 is a transmembrane protein that is highly expressed on subsets of chronically stimulated CD4+ helper and CD8+ cytotoxic T cells, with more transient expression during acute activation and infection. Tim-3 is also constitutively expressed by multiple types of myeloid cells. Like other TIM family members, Tim-3 can bind to phosphatidylserine displayed by apoptotic cells, and this interaction has been shown to mediate uptake of such cells by dendritic cells and cross-presentation of antigens to CD8+ T cells. In contrast, how the recognition of PS by Tim-3 might regulate the function of Tim-3+ T cells is not known. In their recent paper, Lemmon and colleagues demonstrate for the first time that recognition of PS by Tim-3 leads to enhanced T cell activation. |
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MeSH term(s) | Hepatitis A Virus Cellular Receptor 2/genetics ; Lymphocyte Activation ; Membrane Proteins/genetics ; Phagocytosis ; Phosphatidylserines |
Chemical Substances | Hepatitis A Virus Cellular Receptor 2 ; Membrane Proteins ; Phosphatidylserines |
Language | English |
Publishing date | 2021-12-21 |
Publishing country | England |
Document type | Journal Article ; Comment |
ZDB-ID | 2969-5 |
ISSN | 1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021 |
ISSN (online) | 1470-8728 |
ISSN | 0006-2936 ; 0306-3275 ; 0264-6021 |
DOI | 10.1042/BCJ20210652 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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