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Article ; Online: Prognostic model for relapsed/refractory transplant-ineligible diffuse large B-cell lymphoma utilizing the lymphocyte-to-monocyte ratio.

Ide, Daisuke / Fujino, Takahiro / Kobayashi, Tsutomu / Egashira, Aya / Miyashita, Akihiro / Mizuhara, Kentaro / Isa, Reiko / Tsukamoto, Taku / Mizutani, Shinsuke / Uchiyama, Hitoji / Kaneko, Hiroto / Uoshima, Nobuhiko / Kawata, Eri / Taniwaki, Masafumi / Shimura, Yuji / Kuroda, Junya

International journal of hematology

2024

Abstract: We conducted a multi-institutional retrospective study in 100 transplant-ineligible (TI) patients with diffuse large B-cell lymphoma (DLBCL) that relapsed or progressed after first-line R-CHOP (or -like) therapy to develop a robust predictive model for ... ...

Abstract	We conducted a multi-institutional retrospective study in 100 transplant-ineligible (TI) patients with diffuse large B-cell lymphoma (DLBCL) that relapsed or progressed after first-line R-CHOP (or -like) therapy to develop a robust predictive model for TI relapsed/refractory (r/r) DLBCL, which has a heterogeneous but poor prognosis by currently available treatment modalities other than chimeric antigen receptor T-cell (CAR-T) therapy or bispecific antibodies. The median age at relapse or progression was 76 years. The median progression-free survival (PFS) and overall survival (OS) from the first progression were 11.5 months and 21.9 months, respectively. Multivariate analysis identified low lymphocyte-to-monocyte ratio (LMR), elevated high lactate dehydrogenase, and elevated C-reactive protein at progression as independent predictors of OS. A predictive model based on these three factors, here designated as the Kyoto Prognostic Index for r/r DLBCL (KPI-R), successfully stratified their OS and PFS with statistical significance. In addition, event-free survival less than 24 months for R-CHOP and low LMR were identified as significant predictive factors for non-response in any sequence of salvage therapy. We concluded that LMR is a bonafide predictor of treatment response and prognosis in patients with TI r/r DLBCL, and may be helpful in treatment decision-making.
Language	English
Publishing date	2024-03-16
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-024-03750-y
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Article: Serum Albumin Levels Strongly Predict Survival Outcome of Elderly Patients with Diffuse Large B-Cell Lymphoma Treated with Rituximab-Combined Chemotherapy.

Kaneko, Hiroto / Shimura, Kazuho / Yoshida, Mihoko / Matsumoto, Yosuke / Kobayashi, Tsutomu / Uchiyama, Hitoji / Kuroda, Junya / Taniwaki, Masafumi

International journal of hematology-oncology and stem cell research

2022 Volume 16, Issue 1, Page(s) 1–8

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-08-11
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2652853-8
ISSN	2008-2207 ; 2008-3009
ISSN (online)	2008-2207
ISSN	2008-3009
DOI	10.18502/ijhoscr.v16i1.8433
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Article ; Online: Genomic adaptation of giant viruses in polar oceans.

Meng, Lingjie / Delmont, Tom O / Gaïa, Morgan / Pelletier, Eric / Fernàndez-Guerra, Antonio / Chaffron, Samuel / Neches, Russell Y / Wu, Junyi / Kaneko, Hiroto / Endo, Hisashi / Ogata, Hiroyuki

Nature communications

2023 Volume 14, Issue 1, Page(s) 6233

Abstract: Despite being perennially frigid, polar oceans form an ecosystem hosting high and unique biodiversity. Various organisms show different adaptive strategies in this habitat, but how viruses adapt to this environment is largely unknown. Viruses of phyla ... ...

Abstract	Despite being perennially frigid, polar oceans form an ecosystem hosting high and unique biodiversity. Various organisms show different adaptive strategies in this habitat, but how viruses adapt to this environment is largely unknown. Viruses of phyla Nucleocytoviricota and Mirusviricota are groups of eukaryote-infecting large and giant DNA viruses with genomes encoding a variety of functions. Here, by leveraging the Global Ocean Eukaryotic Viral database, we investigate the biogeography and functional repertoire of these viruses at a global scale. We first confirm the existence of an ecological barrier that clearly separates polar and nonpolar viral communities, and then demonstrate that temperature drives dramatic changes in the virus-host network at the polar-nonpolar boundary. Ancestral niche reconstruction suggests that adaptation of these viruses to polar conditions has occurred repeatedly over the course of evolution, with polar-adapted viruses in the modern ocean being scattered across their phylogeny. Numerous viral genes are specifically associated with polar adaptation, although most of their homologues are not identified as polar-adaptive genes in eukaryotes. These results suggest that giant viruses adapt to cold environments by changing their functional repertoire, and this viral evolutionary strategy is distinct from the polar adaptation strategy of their hosts.
MeSH term(s)	Giant Viruses/genetics ; Genome, Viral/genetics ; Ecosystem ; Oceans and Seas ; Phylogeny ; DNA Viruses/genetics ; Genomics ; Viruses/genetics ; Eukaryota/genetics
Language	English
Publishing date	2023-10-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-41910-6
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Article ; Online: Quantitative Assessment of Nucleocytoplasmic Large DNA Virus and Host Interactions Predicted by Co-occurrence Analyses.

Meng, Lingjie / Endo, Hisashi / Blanc-Mathieu, Romain / Chaffron, Samuel / Hernández-Velázquez, Rodrigo / Kaneko, Hiroto / Ogata, Hiroyuki

mSphere

2021 Volume 6, Issue 2

Abstract: Nucleocytoplasmic large DNA viruses (NCLDVs) are highly diverse and abundant in marine environments. However, the knowledge of their hosts is limited because only a few NCLDVs have been isolated so far. Taking advantage of the recent large-scale marine ... ...

Abstract	Nucleocytoplasmic large DNA viruses (NCLDVs) are highly diverse and abundant in marine environments. However, the knowledge of their hosts is limited because only a few NCLDVs have been isolated so far. Taking advantage of the recent large-scale marine metagenomics census,
MeSH term(s)	DNA Viruses/classification ; DNA Viruses/genetics ; Genome, Viral ; Host Microbial Interactions/genetics ; Host Microbial Interactions/physiology ; Humans ; Metagenomics/statistics & numerical data ; Phylogeny
Language	English
Publishing date	2021-04-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-5042
ISSN (online)	2379-5042
DOI	10.1128/mSphere.01298-20
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Article ; Online: Endoscopic findings in a patient with idiopathic/immune thrombocytopenic purpura: Gastrointestinal bleeding caused by Dieulafoy's lesion.

Yoshida, Mihoko / Matsumoto, Yosuke / Horie, Hideki / Nishimura, Satoshi / Shimura, Kazuho / Kaneko, Hiroto / Taniwaki, Masafumi

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

2019 Volume 39, Issue 1, Page(s) 102–103

MeSH term(s)	Endoscopy ; Gastrointestinal Hemorrhage/etiology ; Humans ; Purpura, Thrombocytopenic, Idiopathic/complications ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Purpura, Thrombocytopenic, Idiopathic/pathology
Language	English
Publishing date	2019-12-05
Publishing country	India
Document type	Case Reports ; Journal Article
ZDB-ID	632595-6
ISSN	0975-0711 ; 0254-8860
ISSN (online)	0975-0711
ISSN	0254-8860
DOI	10.1007/s12664-019-01001-1
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Article: Detection of hepatitis B virus DNA and HBsAg from postmortem blood and bloodstains

Hara, Junpei / Tanaka, Yuka / Kaneko, Hiroto / Itoh, Yoshito / Ikegaya, Hiroshi

Archives of virology. 2018 Mar., v. 163, no. 3

2018

Abstract: A large number of accidental virus infections occur in medical and non-medical workers exposed to infectious individuals and materials. We evaluated whether postmortem blood and bloodstains containing hepatitis B virus (HBV) are infectious. HBV-infected ... ...

Abstract	A large number of accidental virus infections occur in medical and non-medical workers exposed to infectious individuals and materials. We evaluated whether postmortem blood and bloodstains containing hepatitis B virus (HBV) are infectious. HBV-infected blood and bloodstains were stored for up to 60 days at room temperature and subsequently screened for hepatitis B surface antigen (HBsAg) and HBV DNA. In addition, HBV-positive postmortem blood was added to a cell line and the production of HBV virions was examined over a period of 7 days. HBsAg and HBV DNA were detected in all samples stored for 60 days at room temperature. HBV-positive postmortem blood successfully infected the cell line and progeny viruses were produced for up to 6 days. Thus, it is crucial that due care is taken when handling not only living material infected with HBV, as well as other harmful viruses, but also blood or body fluids from cadavers or medical waste.
Keywords	DNA ; Hepatitis B virus ; ambient temperature ; blood ; cell lines ; hepatitis B antigens ; progeny ; virion ; viruses ; wastes ; covid19
Language	English
Dates of publication	2018-03
Size	p. 633-637.
Publishing place	Springer Vienna
Document type	Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-017-3665-x
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Article: Impact of Treatment with Anti-CD20 Monoclonal Antibody on the Production of Neutralizing Antibody Against Anti-SARS-CoV-2 Vaccination in Mature B-Cell Neoplasms.

Onishi, Akio / Matsumura-Kimoto, Yayoi / Mizutani, Shinsuke / Tsukamoto, Taku / Fujino, Takahiro / Miyashita, Akihiro / Nishiyama, Daichi / Shimura, Kazuho / Kaneko, Hiroto / Kawata, Eri / Takahashi, Ryoichi / Kobayashi, Tsutomu / Uchiyama, Hitoji / Uoshima, Nobuhiko / Nukui, Yoko / Shimura, Yuji / Inaba, Tohru / Kuroda, Junya

Infection and drug resistance

2023 Volume 16, Page(s) 509–519

Abstract: Background and purpose: Anti-CD20 monoclonal antibodies (MoAbs), rituximab (RIT), and obinutuzumab (OBZ) are the central components of immunochemotherapy for B-cell lymphoma (BCL). However, these agents potentially cause B-cell depletion, resulting in ... ...

Abstract	Background and purpose: Anti-CD20 monoclonal antibodies (MoAbs), rituximab (RIT), and obinutuzumab (OBZ) are the central components of immunochemotherapy for B-cell lymphoma (BCL). However, these agents potentially cause B-cell depletion, resulting in the impairment of antibody (Ab) production. During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, the optimal prediction of Ab response against anti-SARS-CoV-2 vaccination is critically important in patients with BCL treated by B-cell depletion therapeutics to prevent coronavirus disease 2019 (COVID-19). Patients and methods: We investigated the effect of using RIT and/or OBZ on the Ab response in 131 patients with various types of BCL who received the second SARS-CoV-2 mRNA vaccine either after, during, or before immunochemotherapy containing B-cell-depleting moiety between June and November 2021 at seven institutes belonging to the Kyoto Clinical Hematology Study Group. The SARS-Cov-2 neutralizing Ab (nAb) was measured from 14 to 207 days after the second vaccination dose using the iFlash3000 automatic analyzer and the iFlash-2019-nCoV Nab kit. Results: Among 86 patients who received the vaccine within 12 months after B-cell depletion therapy, 8 (9.3%) were seropositive. In 30 patients who received the vaccine after 12 months from B-cell depletion therapy, 22 (73%) were seropositive. In 15 patients who were subjected to B-cell depletion therapy after vaccination, 2 (13%) were seropositive. The multivariate analysis indicated that an interval of 12 months between B-cell depletion therapy and the subsequent vaccination was significantly associated with effective Ab production. Receiver operating characteristic curve analysis identified the optimal threshold period after anti-CD20 MoAb treatment, which determines the seropositivity against SARS-CoV-2, to be 342 days. Conclusion: The use of anti-CD20 MoAb within 12 months before vaccination is a critical risk for poor Ab response against anti-SARS-CoV-2 vaccination in patients with BCL.
Language	English
Publishing date	2023-01-25
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S396271
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Article ; Online: Predicting global distributions of eukaryotic plankton communities from satellite data.

Kaneko, Hiroto / Endo, Hisashi / Henry, Nicolas / Berney, Cédric / Mahé, Frédéric / Poulain, Julie / Labadie, Karine / Beluche, Odette / El Hourany, Roy / Chaffron, Samuel / Wincker, Patrick / Nakamura, Ryosuke / Karp-Boss, Lee / Boss, Emmanuel / Bowler, Chris / de Vargas, Colomban / Tomii, Kentaro / Ogata, Hiroyuki

ISME communications

2023 Volume 3, Issue 1, Page(s) 101

Abstract: Satellite remote sensing is a powerful tool to monitor the global dynamics of marine plankton. Previous research has focused on developing models to predict the size or taxonomic groups of phytoplankton. Here, we present an approach to identify community ...

Abstract	Satellite remote sensing is a powerful tool to monitor the global dynamics of marine plankton. Previous research has focused on developing models to predict the size or taxonomic groups of phytoplankton. Here, we present an approach to identify community types from a global plankton network that includes phytoplankton and heterotrophic protists and to predict their biogeography using global satellite observations. Six plankton community types were identified from a co-occurrence network inferred using a novel rDNA 18 S V4 planetary-scale eukaryotic metabarcoding dataset. Machine learning techniques were then applied to construct a model that predicted these community types from satellite data. The model showed an overall 67% accuracy in the prediction of the community types. The prediction using 17 satellite-derived parameters showed better performance than that using only temperature and/or the concentration of chlorophyll a. The constructed model predicted the global spatiotemporal distribution of community types over 19 years. The predicted distributions exhibited strong seasonal changes in community types in the subarctic-subtropical boundary regions, which were consistent with previous field observations. The model also identified the long-term trends in the distribution of community types, which suggested responses to ocean warming.
Language	English
Publishing date	2023-09-22
Publishing country	England
Document type	Journal Article
ISSN	2730-6151
ISSN (online)	2730-6151
DOI	10.1038/s43705-023-00308-7
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Article ; Online: Clinical impacts of severe thrombocytopenia in the first cycle of azacitidine monotherapy and cytogenetics in patients with myelodysplastic syndrome: The Kyoto Conditional Survival Scoring System.

Inoue, Yu / Okamoto, Haruya / Miyashita, Akihiro / Kawaji-Kanayama, Yuka / Chinen, Shotaro / Fujino, Takahiro / Tsukamoto, Taku / Shimura, Yuji / Mizutani, Shinsuke / Kaneko, Hiroto / Kuwahara-Ota, Saeko / Fuchida, Shin-Ichi / Nishiyama, Daichi / Hirakawa, Koichi / Uchiyama, Hitoji / Uoshima, Nobuhiko / Kawata, Eri / Kuroda, Junya

Oncology letters

2023 Volume 27, Issue 2, Page(s) 62

Abstract: Azacitidine (AZA) has been one of the standard treatments for transplantation-ineligible patients with myelodysplastic syndrome (MDS); however, hematological toxicities frequently cause treatment interruption in the early phase of the therapy. The ... ...

Abstract	Azacitidine (AZA) has been one of the standard treatments for transplantation-ineligible patients with myelodysplastic syndrome (MDS); however, hematological toxicities frequently cause treatment interruption in the early phase of the therapy. The present study conducted a multicenter retrospective study to investigate the prognostic impacts of various factors, including factors included in the Revised International Prognostic Scoring System (IPSS-R) and severe cytopenia in the early phase of AZA monotherapy in 212 patients with MDS. Severe cytopenia was evaluated after the initiation of therapy by absolute neutrophil counts on the 29th day after AZA (ANC29) initiation, and red cell concentrates (RCC) and platelet concentrate (PC) transfusion units required within 28 days from the start of AZA, designated in the present study as RCC28 and PC28, respectively. The survival period was determined from the 29th day of AZA treatment to death from any cause as the conditional survival period after the first cycle of AZA (CS-AZA1). Multivariate analysis demonstrated that severe thrombocytopenia defined by >30 units of PC28 and very poor risk cytogenetics according to IPSS-R were independent prognostic factors for CS-AZA1. The Kyoto Conditional Survival Scoring System was subsequently developed by incorporating severe thrombocytopenia defined by PC28 and very poor risk cytogenetics, which successfully stratified the risks of the patients in CS-AZA1. In conclusion, extreme PC transfusion dependency during the first cycle of AZA and very poor risk cytogenetics are important prognostic factors in AZA monotherapy for MDS.
Language	English
Publishing date	2023-12-18
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2023.14193
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Article ; Online: Detection of hepatitis B virus DNA and HBsAg from postmortem blood and bloodstains.

Hara, Junpei / Tanaka, Yuka / Kaneko, Hiroto / Itoh, Yoshito / Ikegaya, Hiroshi

Archives of virology

2017 Volume 163, Issue 3, Page(s) 633–637

Abstract	A large number of accidental virus infections occur in medical and non-medical workers exposed to infectious individuals and materials. We evaluated whether postmortem blood and bloodstains containing hepatitis B virus (HBV) are infectious. HBV-infected blood and bloodstains were stored for up to 60 days at room temperature and subsequently screened for hepatitis B surface antigen (HBsAg) and HBV DNA. In addition, HBV-positive postmortem blood was added to a cell line and the production of HBV virions was examined over a period of 7 days. HBsAg and HBV DNA were detected in all samples stored for 60 days at room temperature. HBV-positive postmortem blood successfully infected the cell line and progeny viruses were produced for up to 6 days. Thus, it is crucial that due care is taken when handling not only living material infected with HBV, as well as other harmful viruses, but also blood or body fluids from cadavers or medical waste.
MeSH term(s)	Autopsy ; Blood Preservation ; DNA, Viral/blood ; Female ; Hep G2 Cells ; Hepatitis B/blood ; Hepatitis B/prevention & control ; Hepatitis B/transmission ; Hepatitis B/virology ; Hepatitis B Antibodies/blood ; Hepatitis B Surface Antigens/blood ; Hepatitis B virus/genetics ; Hepatitis B virus/immunology ; Hepatitis B virus/isolation & purification ; Humans ; Male ; Middle Aged
Chemical Substances	DNA, Viral ; Hepatitis B Antibodies ; Hepatitis B Surface Antigens
Keywords	covid19
Language	English
Publishing date	2017-12-02
Publishing country	Austria
Document type	Case Reports ; Journal Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-017-3665-x
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