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  1. Article ; Online: Genome Editing of Rat.

    Kaneko, Takehito

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2637, Page(s) 223–231

    Abstract: Many genetically engineered rat strains have been produced by the development of genome editing technology, although it used to be technical difficulty and low production efficiency. Knockout and knock-in strains can be simple and quick produced using ... ...

    Abstract Many genetically engineered rat strains have been produced by the development of genome editing technology, although it used to be technical difficulty and low production efficiency. Knockout and knock-in strains can be simple and quick produced using zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), or clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9. Presently, genome edited strains have been produced by microinjection and a new electroporation method named technique for animal knockout system by electroporation (TAKE). This chapter presents the latest protocols for producing genome edited rats.
    MeSH term(s) Rats ; Animals ; Gene Editing/methods ; CRISPR-Cas Systems ; Genetic Engineering/methods ; Transcription Activator-Like Effector Nucleases/genetics ; Transcription Activator-Like Effector Nucleases/metabolism ; Zinc Finger Nucleases/genetics ; Zinc Finger Nucleases/metabolism
    Chemical Substances Transcription Activator-Like Effector Nucleases (EC 3.1.-) ; Zinc Finger Nucleases (EC 3.1.-)
    Language English
    Publishing date 2023-02-11
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3016-7_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Genome Editing in Mouse and Rat by Electroporation.

    Kaneko, Takehito

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2637, Page(s) 125–134

    Abstract: Many genome-edited mouse and rat strains have been produced using engineered endonucleases, including zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), or clustered regularly interspaced short palindromic repeats (CRISPR) ...

    Abstract Many genome-edited mouse and rat strains have been produced using engineered endonucleases, including zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), or clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9. Especially, CRISPR-Cas9 is powerful tool that can be easy, rapid, and high-efficiency-produced new genome-edited strains. Furthermore, new technique, Technique for Animal Knockout system by Electroporation (TAKE), efficiently accelerate production of new strains by direct nuclease introduction into intact embryos using electroporation. This chapter presents a latest technical information in the production of genome-edited mouse and rat by TAKE method.
    MeSH term(s) Rats ; Mice ; Animals ; Gene Editing/methods ; CRISPR-Cas Systems ; Mice, Knockout ; Electroporation/methods ; Electroporation Therapies ; Endonucleases/genetics ; Endonucleases/metabolism ; Craniocerebral Trauma
    Chemical Substances Endonucleases (EC 3.1.-)
    Language English
    Publishing date 2023-02-11
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3016-7_10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: MIMO-NeRF

    Kaneko, Takuhiro

    Fast Neural Rendering with Multi-input Multi-output Neural Radiance Fields

    2023  

    Abstract: Neural radiance fields (NeRFs) have shown impressive results for novel view synthesis. However, they depend on the repetitive use of a single-input single-output multilayer perceptron (SISO MLP) that maps 3D coordinates and view direction to the color ... ...

    Abstract Neural radiance fields (NeRFs) have shown impressive results for novel view synthesis. However, they depend on the repetitive use of a single-input single-output multilayer perceptron (SISO MLP) that maps 3D coordinates and view direction to the color and volume density in a sample-wise manner, which slows the rendering. We propose a multi-input multi-output NeRF (MIMO-NeRF) that reduces the number of MLPs running by replacing the SISO MLP with a MIMO MLP and conducting mappings in a group-wise manner. One notable challenge with this approach is that the color and volume density of each point can differ according to a choice of input coordinates in a group, which can lead to some notable ambiguity. We also propose a self-supervised learning method that regularizes the MIMO MLP with multiple fast reformulated MLPs to alleviate this ambiguity without using pretrained models. The results of a comprehensive experimental evaluation including comparative and ablation studies are presented to show that MIMO-NeRF obtains a good trade-off between speed and quality with a reasonable training time. We then demonstrate that MIMO-NeRF is compatible with and complementary to previous advancements in NeRFs by applying it to two representative fast NeRFs, i.e., a NeRF with sample reduction (DONeRF) and a NeRF with alternative representations (TensoRF).

    Comment: Accepted to ICCV 2023. Project page: https://www.kecl.ntt.co.jp/people/kaneko.takuhiro/projects/mimo-nerf/
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Artificial Intelligence ; Computer Science - Graphics ; Computer Science - Machine Learning ; Electrical Engineering and Systems Science - Image and Video Processing
    Subject code 006
    Publishing date 2023-10-03
    Publishing country us
    Document type Book ; Online
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  4. Article ; Online: Improvement of survivability and developmental ability in vitrified rat oocytes.

    Nakagawa, Yuki / Kaneko, Takehito

    Cryobiology

    2024  Volume 115, Page(s) 104882

    Abstract: Oocyte cryopreservation is useful for human fertility treatment and strain preservation in both experimental and domestic animals. However, the embryonic development of vitrified rat oocytes was lower than that of vitrified embryos. To increase the ... ...

    Abstract Oocyte cryopreservation is useful for human fertility treatment and strain preservation in both experimental and domestic animals. However, the embryonic development of vitrified rat oocytes was lower than that of vitrified embryos. To increase the viability of vitrified oocytes, intracellular ice formation during cooling and warming must be prevented. Rapid warming is important to prevent ice formation. Furthermore, suppressing the spontaneous activation of oocytes is also important because vitrification promotes the spontaneous activation of rat oocytes, and thus compromise developmental competence of the gametes. MG132, a proteasome inhibitor, suppresses the spontaneous activation of rat oocytes. Here, we examined the effects of rapid warming and MG132 treatment on the survival and embryonic development of vitrified rat oocytes. The warming rate was adjusted by changing the vitrification solution volume and warming solution temperature. The survival rate of oocytes vitrified in 10 μL solution and warmed at 50 °C (94%) was significantly higher than that of oocytes vitrified in 100 μL and 10 μL solution and warmed at 37 °C (49% and 81%, respectively). Furthermore, the rate of embryonic development of vitrified oocytes treated with MG132 during vitrification, warming, and intracytoplasmic sperm injection (ICSI) (44%) was significantly higher than that of untreated gametes (10%). Offspring were obtained after transferring embryos derived from MG132-treated vitrified oocytes (14%). Altogether, the survivability of vitrified rat oocytes increased by rapid warming, and MG132 improved embryonic development after ICSI.
    Language English
    Publishing date 2024-03-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80098-3
    ISSN 1090-2392 ; 0011-2240
    ISSN (online) 1090-2392
    ISSN 0011-2240
    DOI 10.1016/j.cryobiol.2024.104882
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 528: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Much Ado About Nothing? CABG or PCI for Left Main Coronary Artery Disease.

    Giri, Jay / Kaneko, Tsuyoshi

    Circulation

    2024  Volume 149, Issue 17, Page(s) 1339–1340

    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.124.069354
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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.60: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Flow in the Aortic Sinus After Valve-in-Valve TAVR: Disruption of God's Creation?

    Kaneko, Tsuyoshi

    JACC. Cardiovascular interventions

    2021  Volume 14, Issue 24, Page(s) 2667–2669

    MeSH term(s) Bioprosthesis ; Heart Valve Prosthesis ; Humans ; Sinus of Valsalva ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2021-11-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2021.10.016
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6669: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  7. Book ; Online: AR-NeRF

    Kaneko, Takuhiro

    Unsupervised Learning of Depth and Defocus Effects from Natural Images with Aperture Rendering Neural Radiance Fields

    2022  

    Abstract: Fully unsupervised 3D representation learning has gained attention owing to its advantages in data collection. A successful approach involves a viewpoint-aware approach that learns an image distribution based on generative models (e.g., generative ... ...

    Abstract Fully unsupervised 3D representation learning has gained attention owing to its advantages in data collection. A successful approach involves a viewpoint-aware approach that learns an image distribution based on generative models (e.g., generative adversarial networks (GANs)) while generating various view images based on 3D-aware models (e.g., neural radiance fields (NeRFs)). However, they require images with various views for training, and consequently, their application to datasets with few or limited viewpoints remains a challenge. As a complementary approach, an aperture rendering GAN (AR-GAN) that employs a defocus cue was proposed. However, an AR-GAN is a CNN-based model and represents a defocus independently from a viewpoint change despite its high correlation, which is one of the reasons for its performance. As an alternative to an AR-GAN, we propose an aperture rendering NeRF (AR-NeRF), which can utilize viewpoint and defocus cues in a unified manner by representing both factors in a common ray-tracing framework. Moreover, to learn defocus-aware and defocus-independent representations in a disentangled manner, we propose aperture randomized training, for which we learn to generate images while randomizing the aperture size and latent codes independently. During our experiments, we applied AR-NeRF to various natural image datasets, including flower, bird, and face images, the results of which demonstrate the utility of AR-NeRF for unsupervised learning of the depth and defocus effects.

    Comment: Accepted to CVPR 2022. Project page: https://www.kecl.ntt.co.jp/people/kaneko.takuhiro/projects/ar-nerf/
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Artificial Intelligence ; Computer Science - Graphics ; Computer Science - Machine Learning ; Electrical Engineering and Systems Science - Image and Video Processing
    Subject code 006
    Publishing date 2022-06-13
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The Longest Reported Outcomes of the Ross Procedure.

    Kaneko, Tsuyoshi / Ouzounian, Maral

    JAMA cardiology

    2023  Volume 9, Issue 1, Page(s) 14–15

    MeSH term(s) Humans ; Heart Valve Diseases/surgery ; Aortic Valve/surgery ; Patient Reported Outcome Measures
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2023.4100
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  9. Article: Ultra-tough artificial woods of polyphenol-derived biodegradable Co-polymer with Poly(butylene succinate).

    Singh, Maninder / Kaneko, Tatsuo

    Heliyon

    2023  Volume 9, Issue 6, Page(s) e16567

    Abstract: Large productions of plastics worldwide are greater concern to the environment because of their non degradability and thus, damaging the ecosystem. Recent advancements in biobased plastics are growing exponentially because of their promise of a ... ...

    Abstract Large productions of plastics worldwide are greater concern to the environment because of their non degradability and thus, damaging the ecosystem. Recent advancements in biobased plastics are growing exponentially because of their promise of a sustainable environment. Biobased polycoumarates plastics have a wood-like appearance with liquid crystalline grains, light brown color, and cinnamon-like aroma, but have very low toughness. The polycoumarates were hybridized via main-chain transesterification with poly (butylene succinate) (PBS). PBS itself being a biobased material has added more value to the final product due to biodegradability. The mechanical flexibility and toughness of the bio-based copolymers were controlled by varying the PBS content. As a result, well-processable and in-soil degradable artificial woods with a high strain energy density of approximately 76 MJ/m
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e16567
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  10. Article ; Online: Research Collaborations in the Post-COVID Era.

    Kaneko, Takahiro / Saeki, Soichiro

    JMA journal

    2023  Volume 6, Issue 3, Page(s) 358–359

    Language English
    Publishing date 2023-05-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 3053329-6
    ISSN 2433-3298 ; 2433-328X
    ISSN (online) 2433-3298
    ISSN 2433-328X
    DOI 10.31662/jmaj.2023-0034
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