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Article ; Online: High-speed performance evaluation of ultra-flexible polymer waveguides supporting meter-scale optical interconnects.

Shi, Ying / Ma, Lin / Kaneta, Motoya / Xu, Bingxin / Fan, Xinyu / Zhuang, Yudi / He, Zuyuan

2022 Volume 30, Issue 15, Page(s) 27236–27248

Abstract: We demonstrate bandwidth measurement and high-speed data transmission of meter-scale connectorized ultra-flexible multimode waveguide links with a maximum length of 180 cm. The pulses propagating through the waveguides broadened linearly with the ... ...

Abstract	We demonstrate bandwidth measurement and high-speed data transmission of meter-scale connectorized ultra-flexible multimode waveguide links with a maximum length of 180 cm. The pulses propagating through the waveguides broadened linearly with the increase of the length from 20 cm to 240 cm and the estimated mode delay from the pulse broadening was 0.093 ps/cm. The corresponding waveguide bandwidth decreased inversely with the increase of waveguide length, leading to a bandwidth-length product of 42 GHz·m. Degradation in bandwidth due to the introduction of bending or twisting was small when the samples were bent with a bending radius as small as 1 mm for 3 turns or twisted for 4 full turns, respectively. Error-free transmission of 30 Gb/s non-return-to-zero (NRZ) signal was achieved with a record link length up to 140 cm to the best of our knowledge. Our results show that the demonstrated flexible waveguides have both excellent optical and mechanical properties and are ideal for high-speed optical interconnects application especially those have a strict requirement on flexibility.
Language	English
Publishing date	2022-10-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.460783
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A case of multisystem inflammatory syndrome in children in a Japanese boy: with discussion of cytokine profile.

Fukuda, Sayaka / Kaneta, Mio / Miyake, Mayuko / Ohya, Takashi / Miyakawa, Kei / Iwamoto, Mari / Ito, Shuichi

Modern rheumatology case reports

2021 Volume 5, Issue 2, Page(s) 442–447

Abstract: The new disease concept of multisystem inflammatory syndrome in children (MIS-C), which is a systemic inflammatory syndrome with multiple organ involvement after SARS-CoV2 infection, was established in 2020. MIS-C is common in Hispanic and black children ...

Abstract	The new disease concept of multisystem inflammatory syndrome in children (MIS-C), which is a systemic inflammatory syndrome with multiple organ involvement after SARS-CoV2 infection, was established in 2020. MIS-C is common in Hispanic and black children in Europe and North America, with few reports in East Asians. A significant portion of patients with MIS-C develop Kawasaki disease (KD)-like symptoms. Therefore, differential diagnosis is challenging, especially in East Asia, where KD is most prevalent. No Japanese cases have been reported in the literatures so far. We report a case of MIS-C in Japan with KD-like symptoms. A 9-year-old Japanese boy, who was infected with SARS-CoV2 1 month previously along with his family, was admitted to our hospital owing to fever for 6 d and erythema mainly in the groyne and pubic area. He also had conjunctivitis, strawberry tongue and diarrhoea. His laboratory findings were as follows: WBC, 12,840/µL (lymphocytes, 4%); CRP, 22.6 mg/dL, pro-calcitonin, 1.8 ng/mL (normal, <0.50 ng/mL); NT pro-BNP, 7627 pg/mL (<125 pg/mL); and troponin T, 0.14 ng/mL (<0.01 ng/mL). His cardiac function was normal. We initially diagnosed him with KD. His fever rapidly resolved with intravenous immunoglobulin (IVIG) and there were no coronary artery lesions. Desquamation of the fingers was observed later. Finally, a history of SARS-COV2 infection, his age, atypical skin rash, elevation of markers of inflammation and heart failure and lymphopenia suggested the diagnosis of MIS-C rather than KD. Differentiation between KD and MIS-C is necessary even in Japan, especially in patients with atypical features of KD.
MeSH term(s)	COVID-19/complications ; COVID-19/diagnosis ; Child ; Cytokines/blood ; Diagnosis, Differential ; Humans ; Japan ; Male ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/diagnosis
Chemical Substances	Cytokines
Language	English
Publishing date	2021-07-21
Publishing country	England
Document type	Case Reports
ISSN	2472-5625
ISSN (online)	2472-5625
DOI	10.1080/24725625.2021.1920140
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Article: [Fine structure of the juxtaglomerular cells, with special reference to its relation to the submandibular gland and gonad].

Kaneta, M

Nihon Jinzo Gakkai shi

1982 Volume 24, Issue 8, Page(s) 855–868

MeSH term(s)	Animals ; Castration ; Female ; Juxtaglomerular Apparatus/ultrastructure ; Male ; Mice ; Mice, Inbred Strains ; Submandibular Gland/physiology ; Submandibular Gland/surgery
Language	Japanese
Publishing date	1982-08
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	1195538-7
ISSN	0385-2385
ISSN	0385-2385
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Article: [Effect of gonadectomy on juxtaglomerular cells in mice: qualitative and quantitative electron microscopy (author's transl)].

Kaneta, M

Hokkaido igaku zasshi] The Hokkaido journal of medical science

1981 Volume 56, Issue 3, Page(s) 259–265

Abstract: Effect of gonadectomy on juxtaglomerular cells of the kidney was examined by qualitative and quantitative electron microscopy. Mice were gondectomized at 25 or 60 days of age and examined at 110 days of age. For quantitative analysis, the volume ratios ... ...

Abstract	Effect of gonadectomy on juxtaglomerular cells of the kidney was examined by qualitative and quantitative electron microscopy. Mice were gondectomized at 25 or 60 days of age and examined at 110 days of age. For quantitative analysis, the volume ratios of nucleus, specific granules, Golgi apparatus, rough endoplasmic reticulum and mitochondria to cell were obtained stereologically. In normal mice, the juxtaglomerular cells contained numerous specific granules. The Golgi apparatus was not well developed and the rough endoplasmic reticulum was generally flat and short in profile. In males castrated at 25 days, the specific granules were significantly increased in amount. In male castrated at 60 days, the specific granules were increased in amount, and the Golgi apparatus and rough endoplasmic reticulum were well developed. Crystalline granules were frequently seen around the Golgi area. In females, ovariectomy caused no significant change in juxtaglomerular cells.
MeSH term(s)	Animals ; Body Weight ; Castration ; Female ; Juxtaglomerular Apparatus/cytology ; Juxtaglomerular Apparatus/ultrastructure ; Kidney/anatomy & histology ; Male ; Mice ; Microscopy, Electron ; Organ Size
Language	Japanese
Publishing date	1981-05
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	603130-4
ISSN	0367-6102
ISSN	0367-6102
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Article: [Juxtaglomerular cells after removal of the submandibular glands in male mice: quantitative electron microscopy (author's transl)].

Kaneta, M

Hokkaido igaku zasshi] The Hokkaido journal of medical science

1981 Volume 56, Issue 1, Page(s) 27–33

Abstract: The juxtaglomerular cells in the kidney were studied qualitatively and quantitatively on the 7th and 49th day after removal of the bilateral submandibular glands at 60 days of age in male mice. In normal mice, the juxtaglomerular cells contained numerous ...

Abstract	The juxtaglomerular cells in the kidney were studied qualitatively and quantitatively on the 7th and 49th day after removal of the bilateral submandibular glands at 60 days of age in male mice. In normal mice, the juxtaglomerular cells contained numerous specific granules. The Golgi apparatus was not well developed and the rough endoplasmic reticulum was generally flat and short in profile. At 7 days after extirpation of the submandibular glands, the specific granules were sparsely distributed, the Golgi apparatus was relatively prominent, and the rough endoplasmic reticulum was dilated and increased in amount. At 49 days after operation, the specific granules were increased in number, and the Golgi apparatus and rough endoplasmic reticulum were as prominent as at 7 days. The volume ratios of the nucleus, specific granules, Golgi apparatus, rough endoplasmic reticulum and mitochondria were examined by quantitative electron microscopy. After operation, the volume ratio of specific granules was significantly decreased at 7 days, but was increased at 49 days. The volume ratios of Golgi apparatus and rough endoplasmic reticulum were significantly increased at both 7 and 49 days after operation. The volume ratios of nucleus and mitochondria showed no significant difference from those in normal and sham-operated mice. The volumes of adrenal cortex and medulla at 49 days after operation were also examined by quantitative microscopy. They were not significantly different from those in normal mice.
MeSH term(s)	Animals ; Endoplasmic Reticulum/ultrastructure ; Golgi Apparatus/ultrastructure ; Juxtaglomerular Apparatus/ultrastructure ; Male ; Mice ; Microscopy, Electron ; Submandibular Gland/physiology
Language	Japanese
Publishing date	1981-01
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	603130-4
ISSN	0367-6102
ISSN	0367-6102
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Article ; Online: Mechanism for Increased Expression of UGT2B in the Liver of Mice with Neuropathic Pain.

Kaneta, Mitsumasa / Ochiai, Wataru / Nagae, Marina / Suto, Wataru / Hanagata, Mika / Suzuki, Haruka / Kitaoka, Satoshi / Hatogai, Jo / Ikarashi, Nobutomo / Sugiyama, Kiyoshi

Biological & pharmaceutical bulletin

2016 Volume 39, Issue 11, Page(s) 1809–1814

Abstract: Approximately 30% of patients with cancer pain experience concurrent neuropathic pain. Since these patients are not sufficiently responsive to morphine, the development of an effective method of pain relief is urgently needed. Decreased function of the μ ...

Abstract	Approximately 30% of patients with cancer pain experience concurrent neuropathic pain. Since these patients are not sufficiently responsive to morphine, the development of an effective method of pain relief is urgently needed. Decreased function of the μ opioid receptor, which binds to the active metabolite of morphine M-6-G in the brain, has been proposed as a mechanism for morphine resistance. Previously, we pharmacokinetically examined morphine resistance in mice with neuropathic pain, and demonstrated that the brain morphine concentration was decreased, expression level of P-glycoprotein (P-gp) in the small intestine was increased, and expression level and activity of uridine diphosphate glucuronosyltransferase (UGT)2B in the liver were increased. In order to clarify the mechanism of the increased expression of UGT2B, we examined the phase of neuropathic pain during which UGT2B expression in the liver begins to increase, and whether this increased expression is nuclear receptor-mediated. The results of this study revealed that the increased expression of UGT2B in the liver occurred during the maintenance phase of neuropathic pain, suggesting that it may be caused by transcriptional regulation which was not accompanied by increased nuclear import of pregnane X receptor (PXR).
MeSH term(s)	Animals ; Cytochrome P-450 CYP3A/genetics ; Glucuronosyltransferase/genetics ; Hot Temperature ; Liver/metabolism ; Male ; Membrane Proteins/genetics ; Mice, Inbred ICR ; Neuralgia/genetics ; RNA, Messenger/metabolism ; Receptors, Cytoplasmic and Nuclear/genetics ; Receptors, Steroid/genetics ; Sciatic Nerve/injuries
Chemical Substances	Membrane Proteins ; RNA, Messenger ; Receptors, Cytoplasmic and Nuclear ; Receptors, Steroid ; constitutive androstane receptor ; pregnane X receptor ; Cyp3a11 protein, mouse (EC 1.14.14.1) ; Cyp3a25 protein, mouse (EC 1.14.14.1) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Glucuronosyltransferase (EC 2.4.1.17)
Language	English
Publishing date	2016
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b16-00341
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Zs.A 1474: Show issues

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Article: Migration of virus-infected neuronal cells in cerebral slice cultures of developing mouse brains after in vitro infection with murine cytomegalovirus.

Shinmura, Y / Kosugi, I / Kaneta, M / Tsutsui, Y

Acta neuropathologica

1999 Volume 98, Issue 6, Page(s) 590–596

Abstract: To investigate the effect of murine cytomegalovirus (MCMV) infection on the developing mouse brain in vitro, we developed an infection system using cerebral slice cultures. Using a micromanipulator, the cerebral slices from mouse embryos on day 18.5 of ... ...

Abstract	To investigate the effect of murine cytomegalovirus (MCMV) infection on the developing mouse brain in vitro, we developed an infection system using cerebral slice cultures. Using a micromanipulator, the cerebral slices from mouse embryos on day 18.5 of gestation were injected in the subventricular zone with recombinant MCMV in which the lacZ gene was inserted into a late gene, and were cultured for 7 days. Viral infection, detected by beta-galactosidase reaction, was developed at the injection sites of the slices. The virus-infected spots in the slices were enhanced by adding tumor necrosis factor-alpha to the medium and inhibited by adding phosphonoacetic acid or ganciclovir. Sections from paraffin-embedded slices were subjected to immunohistochemical analyses. Neuronal cells, labeled with 5-bromo-2-deoxyuridine 24 h before cutting the slices, migrated to the cerebral cortex in the slices. Virus-infected neuronal cells expressing only the early viral antigen migrated to the cortex, whereas glial cells expressing the immediate early and late antigens tended to remain at the injected sites. The neuronal migration of infected cells was not observed in the cerebral slices from 7-day-old mice and viral infection was not detected after injection in the cerebral slices from 14- and 21-day-old mice. These results from these cerebral slices may reflect the infectious dynamics in vivo, and this system may provide a useful model for analysis of disorders of brain development caused by CMV.
MeSH term(s)	Animals ; Antiviral Agents/pharmacology ; Cell Movement/physiology ; Cerebral Cortex/embryology ; Cerebral Cortex/pathology ; Cerebral Cortex/virology ; Cytomegalovirus Infections/genetics ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/physiopathology ; Ganciclovir/pharmacology ; Mice ; Mice, Inbred ICR ; Muromegalovirus/genetics ; Muromegalovirus/immunology ; Nervous System Malformations/etiology ; Nervous System Malformations/physiopathology ; Nervous System Malformations/virology ; Neurons/pathology ; Neurons/virology ; Organ Culture Techniques ; Tumor Necrosis Factor-alpha/pharmacology
Chemical Substances	Antiviral Agents ; Tumor Necrosis Factor-alpha ; Ganciclovir (P9G3CKZ4P5)
Language	English
Publishing date	1999-12
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1079-0
ISSN	1432-0533 ; 0001-6322
ISSN (online)	1432-0533
ISSN	0001-6322
DOI	10.1007/s004010051123
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Article: The third zinc finger of TFIIIA stabilizes a hairpin structure of the non-coding strand in the internal control region of 5S RNA gene.

Miura, T / Okada, A / Kaneta, M / Urayama, Y / Takeuchi, H

Journal of inorganic biochemistry

2000 Volume 82, Issue 1-4, Page(s) 207–213

Abstract: The structures of non-coding and coding strands in box C of the internal control region (ICR) of Xenopus laevis somatic 5S RNA gene have been examined by circular dichroism (CD) and Raman spectroscopy in the absence and presence of the third zinc finger ... ...

Abstract	The structures of non-coding and coding strands in box C of the internal control region (ICR) of Xenopus laevis somatic 5S RNA gene have been examined by circular dichroism (CD) and Raman spectroscopy in the absence and presence of the third zinc finger of transcription factor IIIA (TFIIIA), which binds to the ICR. The non-coding strand exhibits CD signals assignable to a hairpin and an unfolded structure. The presence of the hairpin structure is supported by Raman spectra, gel electrophoresis, and nucleotide deletion experiments. Binding of the zinc finger to the non-coding strand increases the CD signal of hairpin structure, indicating stabilization of the hairpin structure by the zinc finger. In contrast, the corresponding coding strand remains unfolded even in the presence of the zinc finger. The TFIIIA-ICR complex is not only required for initiation of transcription but also lasts during many rounds of transcription of the 5S RNA gene including the ICR (Bogenhagen et al., Cell 28 (1982) 413). TFIIIA may play a role in promoting the transcription by maintaining the unwound non-coding strand in the hairpin structure and leaving the coding strand available for transcription by RNA polymerase.
MeSH term(s)	Animals ; Circular Dichroism ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; Genes, rRNA ; Nucleic Acid Conformation ; Oligonucleotides/chemistry ; RNA, Ribosomal, 5S/genetics ; Regulatory Sequences, Nucleic Acid/genetics ; Spectrum Analysis, Raman ; Transcription Factor TFIIIA ; Transcription Factors/chemistry ; Transcription Factors/genetics ; Xenopus laevis/genetics ; Zinc Fingers/genetics ; Zinc Fingers/physiology
Chemical Substances	DNA-Binding Proteins ; Oligonucleotides ; RNA, Ribosomal, 5S ; Transcription Factor TFIIIA ; Transcription Factors
Language	English
Publishing date	2000-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/s0162-0134(00)00150-1
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Article: [On Meckel's cartilage].

KANETA, M

Kaibogaku zasshi. Journal of anatomy

1961 Volume 36, Page(s) 529–543

MeSH term(s)	Branchial Region/embryology ; Cartilage
Language	Japanese
Publishing date	1961-12-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	603897-9
ISSN	0022-7722
ISSN	0022-7722
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Article: Occurrence of Wall Slip in Elastohydrodynamic Lubrication Contacts

Guo, F / Wong, P. L / Geng, M / Kaneta, M

Tribology letters. 2009 May, v. 34, no. 2

2009

Abstract: Preliminary experimental work has been carried out to identify some of the boundary slip phenomena of highly pressurised polybutenes in an elastohydrodynamic lubrication (EHL) conjunction. The movement of the oil is signified using an entrapment that can ...

Abstract	Preliminary experimental work has been carried out to identify some of the boundary slip phenomena of highly pressurised polybutenes in an elastohydrodynamic lubrication (EHL) conjunction. The movement of the oil is signified using an entrapment that can be readily formed by the impact of a steel ball against a layer of oil on a glass block in an optical EHL test apparatus. The post-impact lateral movement of the entrapment was investigated under the conditions: (i) pure rolling, (ii) pure glass block sliding (steel ball stationary) and (iii) pure ball sliding (glass block stationary). It was observed that under pure rolling the entrapped oil travels within the contact region at the entrainment speed, which is correlated with EHL theory. Under pure glass block sliding conditions, the speed of the entrapped oil core is less than the entrainment speed, and in the extreme cases, this core can be nearly stationary. Under pure ball sliding conditions, the oil core moves at a speed greater than the entrainment speed. The observation indicates that the oil/steel ball interface can sustain higher shear stress than the oil/glass (chromium coated) interface and there is a boundary slip in terms of relative sliding at the latter interface under the experimental conditions. Furthermore, the amount of slip increases with an increase in the pressure. These experiments provide evidence of the existence of wall slippage, which leads to the abnormal EHL film profile characterised with an inlet dimple as reported earlier.
Language	English
Dates of publication	2009-05
Size	p. 103-111.
Publisher	Springer US
Publishing place	Boston
Document type	Article
ZDB-ID	2015908-0
ISSN	1573-2711 ; 1023-8883
ISSN (online)	1573-2711
ISSN	1023-8883
DOI	10.1007/s11249-009-9414-x
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