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  1. Article ; Online: BZ Junctions and Its Application as Probe (2AP) to Detect Z-DNA Formation and Its Effector.

    Kang, MinSoung / Kim, Doyoun

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2651, Page(s) 105–113

    Abstract: The left-handed Z-DNA is surrounded by right-handed canonical B-DNA, and thus the junction between B- and Z-DNA has been occurred during temporal Z-DNA formation in the genome. The base extrusion structure of the BZ junction may help detect Z-DNA ... ...

    Abstract The left-handed Z-DNA is surrounded by right-handed canonical B-DNA, and thus the junction between B- and Z-DNA has been occurred during temporal Z-DNA formation in the genome. The base extrusion structure of the BZ junction may help detect Z-DNA formation in DNAs. Here we describe the BZ junction structural detection by using 2-aminopurine (2AP) fluorescent probe. BZ junction formation can be measured in solution by this method.
    MeSH term(s) DNA, Z-Form ; DNA/genetics ; DNA, B-Form ; 2-Aminopurine/chemistry ; DNA Replication ; Nucleic Acid Conformation
    Chemical Substances DNA, Z-Form ; DNA (9007-49-2) ; DNA, B-Form ; 2-Aminopurine (452-06-2)
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3084-6_7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Crystallization of Z-DNA in Complex with Chemical and Z-DNA Binding Z-Alpha Protein.

    Kang, MinSoung / Kim, Doyoun

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2651, Page(s) 59–67

    Abstract: The molecular basis of Z-DNA recognition and stabilization is mostly discovered via X-ray crystallography. The sequences composed with alteration of purine and pyrimidine are known to adopt Z-DNA conformation. Due to the energy penalty for forming Z-DNA, ...

    Abstract The molecular basis of Z-DNA recognition and stabilization is mostly discovered via X-ray crystallography. The sequences composed with alteration of purine and pyrimidine are known to adopt Z-DNA conformation. Due to the energy penalty for forming Z-DNA, the small molecular stabilizer or Z-DNA-specific binding protein is required for DNA to adopt Z conformation prior to crystallizing Z-DNA. Here we described the methods ranging from preparation of DNA and Z-alpha protein to crystallization of Z-DNA in detail.
    MeSH term(s) DNA, Z-Form ; Crystallization ; Models, Molecular ; Base Sequence ; DNA/chemistry ; Nucleic Acid Conformation ; Crystallography, X-Ray
    Chemical Substances DNA, Z-Form ; DNA (9007-49-2)
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3084-6_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Electrochemical Transparency of Graphene.

    Jeong, Du Won / Kim, Kyuhyoung / Lee, Geonhee / Kang, Minsoung / Chang, Hyunju / Jang, A-Rang / Lee, Jeong-O

    ACS nano

    2022  Volume 16, Issue 6, Page(s) 9278–9286

    Abstract: In the present study, we used the electrochemical transparency of graphene to show that the direct intercalation of alkali-metal cations is not a prerequisite for the redox reaction of Prussian blue (PB). PB thin films passivated with monolayer graphene ... ...

    Abstract In the present study, we used the electrochemical transparency of graphene to show that the direct intercalation of alkali-metal cations is not a prerequisite for the redox reaction of Prussian blue (PB). PB thin films passivated with monolayer graphene still underwent electrochemical redox reactions in the presence of alkali-metal ions (K
    Language English
    Publishing date 2022-06-14
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.2c01786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits.

    Cho, Heejin / Yoo, Taesun / Moon, Heera / Kang, Hyojin / Yang, Yeji / Kang, MinSoung / Yang, Esther / Lee, Dowoon / Hwang, Daehee / Kim, Hyun / Kim, Doyoun / Kim, Jin Young / Kim, Eunjoon

    Molecular psychiatry

    2023  Volume 28, Issue 8, Page(s) 3548–3562

    Abstract: ADNP syndrome, involving the ADNP transcription factor of the SWI/SNF chromatin-remodeling complex, is characterized by developmental delay, intellectual disability, and autism spectrum disorders (ASD). Although Adnp-haploinsufficient (Adnp-HT) mice ... ...

    Abstract ADNP syndrome, involving the ADNP transcription factor of the SWI/SNF chromatin-remodeling complex, is characterized by developmental delay, intellectual disability, and autism spectrum disorders (ASD). Although Adnp-haploinsufficient (Adnp-HT) mice display various phenotypic deficits, whether these mice display abnormal synaptic functions remain poorly understood. Here, we report synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIα hyperactivity in Adnp-HT mice. These mice show impaired and inflexible contextual learning and memory, additional to social deficits, long after the juvenile-stage decrease of ADNP protein levels to ~10% of the newborn level. The adult Adnp-HT hippocampus shows hyperphosphorylated CaMKIIα and its substrates, including SynGAP1, and excessive long-term potentiation that is normalized by CaMKIIα inhibition. Therefore, Adnp haploinsufficiency in mice leads to cognitive inflexibility involving CaMKIIα hyperphosphorylation and excessive LTP in adults long after its marked expressional decrease in juveniles.
    MeSH term(s) Mice ; Animals ; Nerve Tissue Proteins/metabolism ; Neuronal Plasticity/genetics ; Long-Term Potentiation/genetics ; Autistic Disorder/metabolism ; Intellectual Disability ; Cognition ; Homeodomain Proteins/metabolism
    Chemical Substances Nerve Tissue Proteins ; Adnp protein, mouse ; Homeodomain Proteins
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-023-02129-5
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    Zs.A 4812: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Correction: Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits.

    Cho, Heejin / Yoo, Taesun / Moon, Heera / Kang, Hyojin / Yang, Yeji / Kang, MinSoung / Yang, Esther / Lee, Dowoon / Hwang, Daehee / Kim, Hyun / Kim, Doyoun / Kim, Jin Young / Kim, Eunjoon

    Molecular psychiatry

    2023  Volume 28, Issue 8, Page(s) 3563

    Language English
    Publishing date 2023-07-21
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-023-02192-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4812: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Multifunctional-high resolution imaging plate based on hydrophilic graphene for digital pathology.

    Lee, Geonhee / Oh, Yuna / Nam, Jung Tae / Ji, Seulgi / Jang, A-Rang / Jeong, Du Won / Kang, MinSoung / Lee, Sun Sook / Chae, Soosang / Cho, Donghwi / Hwang, Jun Yeon / Lee, Kyungeun / Lee, Jeong-O

    Nanotechnology

    2022  Volume 33, Issue 50

    Abstract: In the present study, we showed that hydrophilic graphene can serve as an ideal imaging plate for biological specimens. Graphene being a single-atom-thick semi-metal with low secondary electron emission, array tomography analysis of serial sections of ... ...

    Abstract In the present study, we showed that hydrophilic graphene can serve as an ideal imaging plate for biological specimens. Graphene being a single-atom-thick semi-metal with low secondary electron emission, array tomography analysis of serial sections of biological specimens on a graphene substrate showed excellent image quality with improved
    MeSH term(s) Dimethylpolysiloxanes ; Graphite ; Microscopy, Electron, Scanning ; Optical Imaging ; Oxygen
    Chemical Substances Dimethylpolysiloxanes ; Graphite (7782-42-5) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-10-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ac9143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Structural evidence for visual arrestin priming via complexation of phosphoinositols.

    Sander, Christopher L / Luu, Jennings / Kim, Kyumhyuk / Furkert, David / Jang, Kiyoung / Reichenwallner, Joerg / Kang, MinSoung / Lee, Ho-Jun / Eger, Bryan T / Choe, Hui-Woog / Fiedler, Dorothea / Ernst, Oliver P / Kim, Yong Ju / Palczewski, Krzysztof / Kiser, Philip D

    Structure (London, England : 1993)

    2021  Volume 30, Issue 2, Page(s) 263–277.e5

    Abstract: Visual arrestin (Arr1) terminates rhodopsin signaling by blocking its interaction with transducin. To do this, Arr1 translocates from the inner to the outer segment of photoreceptors upon light stimulation. Mounting evidence indicates that inositol ... ...

    Abstract Visual arrestin (Arr1) terminates rhodopsin signaling by blocking its interaction with transducin. To do this, Arr1 translocates from the inner to the outer segment of photoreceptors upon light stimulation. Mounting evidence indicates that inositol phosphates (InsPs) affect Arr1 activity, but the Arr1-InsP molecular interaction remains poorly defined. We report the structure of bovine Arr1 in a ligand-free state featuring a near-complete model of the previously unresolved C-tail, which plays a crucial role in regulating Arr1 activity. InsPs bind to the N-domain basic patch thus displacing the C-tail, suggesting that they prime Arr1 for interaction with rhodopsin and help direct Arr1 translocation. These structures exhibit intact polar cores, suggesting that C-tail removal by InsP binding is insufficient to activate Arr1. These results show how Arr1 activity can be controlled by endogenous InsPs in molecular detail.
    MeSH term(s) Animals ; Arrestin/chemistry ; Arrestin/metabolism ; Cattle ; Crystallography, X-Ray ; Inositol Phosphates/metabolism ; Mice ; Models, Molecular ; Protein Conformation ; Protein Domains ; Rhodopsin/metabolism ; Sequence Analysis, RNA ; Single-Cell Analysis
    Chemical Substances Arrestin ; Inositol Phosphates ; Rhodopsin (9009-81-8)
    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1213087-4
    ISSN 1878-4186 ; 0969-2126
    ISSN (online) 1878-4186
    ISSN 0969-2126
    DOI 10.1016/j.str.2021.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4141: Show issues Location:
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