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  1. Article ; Online: Model-free robust motion control for biological optical microscopy using time-delay estimation with an adaptive RBFNN compensator.

    Yu, Shengdong / Wu, Hongyuan / Kang, Shengzheng / Ma, Jinyu / Xie, Mingyang / Dai, Luru

    ISA transactions

    2024  

    Abstract: The field of large numerical aperture microscopy has witnessed significant advancements in spatial and temporal resolution, as well as improvements in optical microscope imaging quality. However, these advancements have concurrently raised the demand for ...

    Abstract The field of large numerical aperture microscopy has witnessed significant advancements in spatial and temporal resolution, as well as improvements in optical microscope imaging quality. However, these advancements have concurrently raised the demand for enhanced precision, extended range, and increased load-bearing capacity in objective motion carrier (OMC). To address this challenge, this study introduces an innovative OMC that employs a ball screw mechanism as its primary driving component. Furthermore, a robust nonlinear motion control strategy has been developed, which integrates fast nonsingular terminal sliding mode, experimental estimation techniques, and adaptive radial basis neural network, to mitigate the impact of nonlinear friction within the ball screw mechanism on motion precision. The stability of the closed-loop control system has been rigorously demonstrated through Lyapunov theory. Compared with other enhanced sliding mode control strategies, the maximum error and root mean square error of this controller are improved by 33% and 34% respectively. The implementation of the novel OMC has enabled the establishment of a high-resolution bio-optical microscope, which has proven its effectiveness in the microscopic imaging of retinal organoids.
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2012746-7
    ISSN 1879-2022 ; 0019-0578
    ISSN (online) 1879-2022
    ISSN 0019-0578
    DOI 10.1016/j.isatra.2024.04.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Rate-Dependent Cell Microinjection Model Based on Membrane Theory.

    Kang, Shengzheng / Song, Zhicheng / Yang, Xiaolong / Li, Yao / Wu, Hongtao / Li, Tao

    Journal of biomechanical engineering

    2023  Volume 145, Issue 9

    Abstract: As an effective method to deliver external materials into biological cells, microinjection has been widely applied in the biomedical field. However, the knowledge of cell mechanical property is still inadequate, which greatly limits the efficiency and ... ...

    Abstract As an effective method to deliver external materials into biological cells, microinjection has been widely applied in the biomedical field. However, the knowledge of cell mechanical property is still inadequate, which greatly limits the efficiency and success rate of injection. Thus, a new rate-dependent mechanical model based on membrane theory is proposed for the first time. In this model, an analytical equilibrium equation between the injection force and cell deformation is established by considering the speed effect of microinjection. Different from the traditional membrane-theory-based model, the elastic coefficient of the constitutive material in the proposed model is modified as a function of the injection velocity and acceleration, effectively simulating the influence of speeds on the mechanical responses and providing a more generalized and practical model. Using this model, other mechanical responses at different speeds can be also accurately predicted, including the distribution of membrane tension and stress and the deformed shape. To verify the validity of the model, numerical simulations and experiments were carried out. The results show that the proposed model can match the real mechanical responses well at different injection speeds up to 2 mm/s. The model presented in this paper will be promising in the application of automatic batch cell microinjection with high efficiency.
    MeSH term(s) Microinjections/methods ; Models, Biological ; Mechanical Phenomena
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 243094-0
    ISSN 1528-8951 ; 0148-0731
    ISSN (online) 1528-8951
    ISSN 0148-0731
    DOI 10.1115/1.4062422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Cell Biomechanical Modeling Based on Membrane Theory with Considering Speed Effect of Microinjection

    Kang, Shengzheng / Song, Zhicheng / Yang, Xiaolong / Li, Yao / Wu, Hongtao / Li, Tao

    2022  

    Abstract: As an effective method to deliver external materials into biological cells, microinjection has been widely applied in the biomedical field. However, the cognition of cell mechanical property is still inadequate, which greatly limits the efficiency and ... ...

    Abstract As an effective method to deliver external materials into biological cells, microinjection has been widely applied in the biomedical field. However, the cognition of cell mechanical property is still inadequate, which greatly limits the efficiency and success rate of injection. Thus, a new rate-dependent mechanical model based on membrane theory is proposed for the first time. In this model, an analytical equilibrium equation between the injection force and cell deformation is established by considering the speed effect of microinjection. Different from the traditional membrane-theory-based model, the elastic coefficient of the constitutive material in the proposed model is modified as a function of the injection velocity and acceleration, effectively simulating the influence of speeds on the mechanical responses and providing a more generalized and practical model. Using this model, other mechanical responses at different speeds can be also accurately predicted, including the distribution of membrane tension and stress and the deformed shape. To verify the validity of the model, numerical simulations and experiments are carried out. The results show that the proposed model can match the real mechanical responses well at different injection speeds.

    Comment: 10 pages, 12 figures, submitted to IEEE TMech;
    Keywords Computer Science - Robotics
    Subject code 612
    Publishing date 2022-11-28
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Online: A Fractional-Order Normalized Bouc-Wen Model for Piezoelectric Hysteresis Nonlinearity

    Kang, Shengzheng / Wu, Hongtao / Li, Yao / Yang, Xiaolong / Yao, Jiafeng

    2020  

    Abstract: This paper presents a new fractional-order normalized Bouc-Wen (BW) (FONBW) model to describe the asymmetric and rate-dependent hysteresis nonlinearity of piezoelectric actuators (PEAs). In view of the fact that the classical BW (CBW) model is only ... ...

    Abstract This paper presents a new fractional-order normalized Bouc-Wen (BW) (FONBW) model to describe the asymmetric and rate-dependent hysteresis nonlinearity of piezoelectric actuators (PEAs). In view of the fact that the classical BW (CBW) model is only efficient for the symmetric and rate-independent hysteresis description, the FONBW model is devoted to characterizing the asymmetric and rate-dependent behaviors of the hysteresis in PEAs by adopting an Nth-order polynomial input function and two fractional operators, respectively. Different from the traditional modified BW models, the proposed FONBW model also eliminates the redundancy of parameters in the CBW model via the normalization processing. By this way, the developed FONBW model has a relatively simple mathematic expression with fewer parameters to simultaneously characterize the asymmetric and rate-dependent hysteresis behaviors of PEAs. Model parameters are identified by the self-adaptive differential evolution algorithm. To validate the effectiveness of the proposed model, a series of model verification and inverse-multiplicative-structure-based feedforward control experiments are carried out on a PEA system. Results show that the proposed model is superior to the CBW model and traditional modified BW model in modeling accuracy and hysteresis compensation.

    Comment: 9 pages, 10 figures, submitted to TMech; 10 pages, 11 figures, add two subsections in Section IV; modify Tables I and III, and Figures 9 and 10
    Keywords Computer Science - Robotics ; Electrical Engineering and Systems Science - Signal Processing
    Subject code 510
    Publishing date 2020-03-10
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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