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Article ; Online: An Unusual Etiology of Severe Right Heart Failure Deserving of Wider Recognition.

Kang, Woosun / Zong, Yu / Patel, Dhruvil Ashishkumar / Mishra, Tushar / Afonso, Luis

JACC. Case reports

2024 Volume 29, Issue 5, Page(s) 102222

Abstract: A previously healthy 31-year-old man presented with worsening shortness of breath and a petechial rash. Echocardiography showed severe right-sided heart failure with midsystolic notching of the antegrade right ventricular outflow Doppler envelope ... ...

Abstract	A previously healthy 31-year-old man presented with worsening shortness of breath and a petechial rash. Echocardiography showed severe right-sided heart failure with midsystolic notching of the antegrade right ventricular outflow Doppler envelope suggesting pulmonary hypertension. An extensive work-up revealed scurvy, with a dramatic resolution of symptoms shortly after vitamin C supplementation.
Language	English
Publishing date	2024-01-31
Publishing country	Netherlands
Document type	Case Reports
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2024.102222
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Subaortic Membrane Mimicking Hypertrophic Cardiomyopathy in the Setting of Mitral Valve Infective Endocarditis.

Polina, Aws / Kang, Woosun / Shah, Rajendra P / Alraies, M Chadi

Cureus

2023 Volume 15, Issue 6, Page(s) e41129

Abstract: Infective endocarditis (IE) can present in a wide spectrum of systemic signs and symptoms. Here we report a case of a patient who presented with a headache. Upon further investigation, the patient was found to have mitral valve IE. This likely led to a ... ...

Abstract	Infective endocarditis (IE) can present in a wide spectrum of systemic signs and symptoms. Here we report a case of a patient who presented with a headache. Upon further investigation, the patient was found to have mitral valve IE. This likely led to a subarachnoid hemorrhage secondary to a ruptured mycotic aneurysm. In this case report, we emphasize the importance of noticing early neurological signs of IE even when initial imaging is negative for aneurysmal formation. Further, this patient had a subaortic membrane (SAoM) mimicking the sonographic appearance of hypertrophic obstructive cardiomyopathy. Remarkably, SAoM is usually associated with aortic valvular pathology; however, this patient unusually presented with mitral valve involvement.
Language	English
Publishing date	2023-06-29
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.41129
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Methotrexate Toxicity: A Simple Solution to a Complex Problem.

Asghar, Muhammad / Shoaib, Hasan / Kang, Woosun / Tariq, Irfa / Chatterjee, Tulika

Cureus

2021 Volume 13, Issue 4, Page(s) e14364

Abstract: Methotrexate is a highly effective medication that is the mainstay of treatment for numerous complex dermatological and rheumatological disorders. However, its use requires close monitoring as it has serious side effects that could be fatal if not ... ...

Abstract	Methotrexate is a highly effective medication that is the mainstay of treatment for numerous complex dermatological and rheumatological disorders. However, its use requires close monitoring as it has serious side effects that could be fatal if not recognized promptly. Herein, we present an interesting case of methotrexate toxicity leading to a prolonged hospital stay with resultant increase in health care cost and patient dissatisfaction. It remains of pivotal importance for primary care physicians and hospitalists to be aware of its side effect profile. As such, early recognition of methotrexate toxicity can result in earlier initiation of goal-directed therapies, leading to improved outcomes and shorter hospital stay. Patient education and effective communication between health care providers and the patient are of utmost importance in ensuring patient safety.
Language	English
Publishing date	2021-04-08
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.14364
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Article: Pseudoaneurysm Leading to Aortic Dissection: An Interesting Case Presentation.

Ge, Liang D / Kang, Woosun / Patel, Puja / Patel, Raj / Kizhakekuttu, Tinoy

Cureus

2020 Volume 12, Issue 6, Page(s) e8545

Abstract: This is an interesting case of ascending penetrating aortic ulcer (PAU) leading to pseudoaneurysm and eventually type A aortic dissection and peri-aortic hematoma. PAUs are common clinical manifestations, however, uncommonly lead to pseudoaneurysms that ... ...

Abstract	This is an interesting case of ascending penetrating aortic ulcer (PAU) leading to pseudoaneurysm and eventually type A aortic dissection and peri-aortic hematoma. PAUs are common clinical manifestations, however, uncommonly lead to pseudoaneurysms that cause aortic dissection.
Language	English
Publishing date	2020-06-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.8545
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Article: Rare and Fascinating Case of ST-Elevation Myocardial Infarction Diagnosis From an Underlying Ventricular Paced Rhythm.

Kang, Woosun / Ge, Liang D / Patel, Puja / Patel, Raj / Kizhakekuttu, Tinoy

Cureus

2020 Volume 12, Issue 5, Page(s) e8274

Abstract: This is a case of a patient diagnosed with anterior ST-elevation myocardial infarction (STEMI) with a ventricular paced rhythm after the patient underwent a femoral-femoral bypass surgery for severe peripheral vascular disease. The case highlights the ... ...

Abstract	This is a case of a patient diagnosed with anterior ST-elevation myocardial infarction (STEMI) with a ventricular paced rhythm after the patient underwent a femoral-femoral bypass surgery for severe peripheral vascular disease. The case highlights the diagnosis of STEMI in the setting of paced rhythm in the appropriate clinical setting.
Language	English
Publishing date	2020-05-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.8274
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Article ; Online: Association of Pretransplant Skin Cancer With Posttransplant Malignancy, Graft Failure and Death in Kidney Transplant Recipients.

Kang, Woosun / Sampaio, Marcelo Santos / Huang, Edmund / Bunnapradist, Suphamai

Transplantation

2017 Volume 101, Issue 6, Page(s) 1303–1309

Abstract: Background: Posttransplant malignancy (PTM) is one of the leading causes of late death in kidney recipients. Those with a cancer history may be more prone to develop a recurrent or a new cancer. We studied the association between pretransplant skin ... ...

Abstract	Background: Posttransplant malignancy (PTM) is one of the leading causes of late death in kidney recipients. Those with a cancer history may be more prone to develop a recurrent or a new cancer. We studied the association between pretransplant skin cancer, PTM, death, and graft failure. Methods: Primary adult kidney recipients transplanted between 2005 and 2013 were included. Malignancy information was obtained from Organ Procurement Kidney Transplant Network/United Network for Organ Sharing registration and follow-up forms. Posttransplant malignancy was classified into skin cancer, solid tumor, and posttransplant lymphoproliferative disorder (PTLD). Competing risk and survival analysis with adjustment for confounders were used to calculate risk for PTM, death and graft failure in recipients with pretransplant skin cancer compared with those without cancer. Risk was reported in hazard ratios (HR) with 95% confidence interval (CI). Results: The cohort included 1671 recipients with and 102 961 without pretransplant skin malignancy. The 5-year cumulative incidence of PTM in patients with and without a pretransplant skin cancer history was 31.6% and 7.4%, respectively (P < 0.001). Recipients with pretransplant skin cancer had increased risk of PTM (sub-HR [SHR], 2.60; 95% CI, 2.27-2.98), and posttransplant skin cancer (SHR, 2.92; 95% CI, 2.52-3.39), PTLD (SHR, 1.93; 95% CI, 1.01-3.66), solid tumor (SHR, 1.44; 95% CI, 1.04-1.99), death (HR, 1.20; 95% CI, 1.07-1.34), and graft failure (HR, 1.17; 95% CI, 1.05-1.30) when compared with those without pretransplant malignancy. Conclusions: Pretransplant skin cancer was associated with an increased risk of posttransplant skin cancer, PTLD, solid organ cancer, death and graft failure.
MeSH term(s)	Adolescent ; Adult ; Female ; Graft Survival ; Humans ; Incidence ; Kaplan-Meier Estimate ; Kidney Transplantation/adverse effects ; Kidney Transplantation/mortality ; Lymphoproliferative Disorders/diagnosis ; Lymphoproliferative Disorders/epidemiology ; Lymphoproliferative Disorders/mortality ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/mortality ; Proportional Hazards Models ; Registries ; Risk Assessment ; Risk Factors ; Skin Neoplasms/diagnosis ; Skin Neoplasms/epidemiology ; Skin Neoplasms/mortality ; Time Factors ; Tissue and Organ Procurement ; Treatment Outcome ; United States/epidemiology ; Young Adult
Language	English
Publishing date	2017-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000001286
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Pretransplant malignancy as a risk factor for posttransplant malignancy after heart transplantation.

Yoosabai, Anake / Mehta, Anurag / Kang, Woosun / Chaiwatcharayut, Wikrom / Sampaio, Marcelo / Huang, Edmund / Bunnapradist, Suphamai

Transplantation

2015 Volume 99, Issue 2, Page(s) 345–350

Abstract: Background: Posttransplant malignancy is a major cause of death in orthotopic heart transplant recipients. Our study objective is to identify whether pretransplant malignancy increases the risk for posttransplant malignancy.: Methods: Using the Organ ...

Abstract	Background: Posttransplant malignancy is a major cause of death in orthotopic heart transplant recipients. Our study objective is to identify whether pretransplant malignancy increases the risk for posttransplant malignancy. Methods: Using the Organ Procurement and Transplantation Network/United Network for Organ Sharing database, adult (≥18 years old) recipients of a primary orthotopic heart transplant performed between 2000 and 2012 were included. The cohort was stratified according to the presence and type of pretransplant malignancy. Outcomes were posttransplant overall, skin, solid malignancies, and posttransplant lymphoproliferative disorder. Incidence of and time to first posttransplant malignancy, accounting for death as a competing event, were calculated. Fine and Gray competing risks regression was performed to examine risk factors associated with posttransplant malignancy. Results: Of 23,171 recipients, overall posttransplant malignancy was diagnosed in 2673 recipients (11.5%).The median time to overall, skin, solid posttransplant malignancies, and posttransplant lymphoproliferative disorder were 3.2 (1.6-5.7), 3.2 (1.7-5.6), 3.5 (1.7-5.9), and 2.5 years(0.8-5.2), respectively. Pretransplant malignancy increased the risk of posttransplant overall (subhazard ratio [SHR], 1.51; 95% confidence interval [95% CI], 1.27-1.81), skin (SHR, 1.55, 95% CI, 1.23-1.93), and solid organ malignancies (SHR, 1.54; 95% CI, 1.13-2.11). Pretransplant skin malignancy increased the risk of posttransplant skin malignancy (SHR, 2.79; 95% CI, 1.82-4.28). Pretransplant solid malignancy also increased the risk of posttransplant skin malignancy (SHR, 1.55; 95% CI, 1.07-2.25) but not of posttransplant solid tumors (SHR, 1.23; 95% CI, 0.69-2.19). Older, male, and white were also risk factors for posttransplant malignancy. Conclusions: A history of any pretransplant malignancy was associated with increased risks of skin and solid malignancies after transplantation. The specific type of posttransplant malignancy risk differed according to the type of pretransplant malignancy.
MeSH term(s)	Adult ; Age Factors ; Aged ; Databases, Factual ; European Continental Ancestry Group ; Female ; Heart Diseases/complications ; Heart Diseases/diagnosis ; Heart Diseases/mortality ; Heart Diseases/surgery ; Heart Transplantation/adverse effects ; Heart Transplantation/mortality ; Humans ; Incidence ; Male ; Middle Aged ; Neoplasms/complications ; Neoplasms/etiology ; Neoplasms/mortality ; Neoplasms/pathology ; Risk Factors ; Sex Factors ; Time Factors ; Tissue and Organ Procurement ; Treatment Outcome ; United States/epidemiology
Language	English
Publishing date	2015-02
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000000563
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19): a systematic review of

Theranostics

2021 Volume 11, Issue 3, Page(s) 1207–1231

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Animals ; Antiviral Agents/therapeutic use ; COVID-19/mortality ; COVID-19/therapy ; Carbamates/therapeutic use ; Coronavirus Infections/mortality ; Coronavirus Infections/therapy ; Disease Models, Animal ; Drug Combinations ; Drug Evaluation, Preclinical ; Drug Therapy, Combination/methods ; Humans ; Imidazoles/therapeutic use ; Immunization, Passive/methods ; Pyrrolidines/therapeutic use ; Randomized Controlled Trials as Topic ; Severe Acute Respiratory Syndrome/mortality ; Severe Acute Respiratory Syndrome/therapy ; Sofosbuvir/therapeutic use ; Treatment Outcome ; Valine/analogs & derivatives ; Valine/therapeutic use ; COVID-19 Serotherapy
Chemical Substances	Antiviral Agents ; Carbamates ; Drug Combinations ; Imidazoles ; Pyrrolidines ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Valine (HG18B9YRS7) ; daclatasvir (LI2427F9CI) ; Alanine (OF5P57N2ZX) ; Sofosbuvir (WJ6CA3ZU8B)
Language	English
Publishing date	2021-01-01
Publishing country	Australia
Document type	Journal Article ; Systematic Review
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.48342
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Article ; Online: Treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19)

a systematic review of in vitro, in vivo, and clinical trials

2020

Keywords	covid19
Language	English
Publishing date	2020-10-22
Publisher	Ivyspring International Publisher
Publishing country	uk
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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