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Article: [Disorders of oblique muscles in horizontal strabismus].

Kang, X L / Chen, Y Y

Zhonghua yan ke za zhi] Chinese journal of ophthalmology

2020 Volume 56, Issue 3, Page(s) 171–175

Abstract: Horizontal strabismus, the most common type of strabismus, can be complicated by the disorder of inferior oblique muscle or superior oblique muscle. It may cause problems such as compensatory head posture, vertical diplopia, torsional diplopia, and ... ...

Abstract	Horizontal strabismus, the most common type of strabismus, can be complicated by the disorder of inferior oblique muscle or superior oblique muscle. It may cause problems such as compensatory head posture, vertical diplopia, torsional diplopia, and abnormal binocular fusion. In horizontal strabismus cases, the disorder of oblique muscles should be recognized, and appropriate surgical methods should be chosen, so that the best postoperative ortho and binocular vision could be obtained.
MeSH term(s)	Diplopia ; Humans ; Muscular Diseases/physiopathology ; Oculomotor Muscles/physiopathology ; Ophthalmologic Surgical Procedures ; Retrospective Studies ; Strabismus/physiopathology ; Vision, Binocular
Language	Chinese
Publishing date	2020-03-18
Publishing country	China
Document type	Journal Article
ZDB-ID	604574-1
ISSN	0412-4081
ISSN	0412-4081
DOI	10.3760/cma.j.issn.0412-4081.2020.03.003
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Article: [Pay attention to the clinical classification and individualized treatment of superior oblique palsy].

Kang, X L / Wei, Y

Zhonghua yan ke za zhi] Chinese journal of ophthalmology

2018 Volume 53, Issue 12, Page(s) 881–884

Abstract: Superior oblique palsy (SOP) has many anatomic variations, and the accompanied paralysis generalization could stimulate the secondary changes of other extra-ocular muscles. Therefore, the clinical manifestations of SOP can be various, and the surgical ... ...

Abstract	Superior oblique palsy (SOP) has many anatomic variations, and the accompanied paralysis generalization could stimulate the secondary changes of other extra-ocular muscles. Therefore, the clinical manifestations of SOP can be various, and the surgical design is complicated and changeable. It is necessary to understand the clinical development, stages and types of SOP correctly, and to take into account the developmental characteristics of the superior oblique muscle and select the individualized treatment plan. In this article, the SOP manifestations, imaging features, clinical examination and personalized treatment options are discussed, in order to provide some reasonable treatment options for SOP surgery.
MeSH term(s)	Humans ; Oculomotor Muscles ; Ophthalmoplegia ; Strabismus ; Trochlear Nerve Diseases/complications ; Trochlear Nerve Diseases/diagnosis ; Trochlear Nerve Diseases/surgery
Language	Chinese
Publishing date	2018-01-11
Publishing country	China
Document type	Journal Article
ZDB-ID	604574-1
ISSN	0412-4081
ISSN	0412-4081
DOI	10.3760/cma.j.issn.0412-4081.2017.12.001
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Article ; Online: Serum CXCL13 and PECAM-1 can be used as diagnostic and prognostic markers in elderly patients with gastric cancer.

Li, Y / Guo, X B / Wei, Y H / Kang, X L

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2020 Volume 23, Issue 1, Page(s) 130–138

Abstract: Purpose: To investigate the application value of serum CXC Chemokine-13 (CXCL-13) and platelet endothelial cell adhesion molecule-1 (PECAM-1) in elderly patients with gastric cancer (GC).: Methods: Ninety-eight elderly GC patients admitted to the ... ...

Abstract	Purpose: To investigate the application value of serum CXC Chemokine-13 (CXCL-13) and platelet endothelial cell adhesion molecule-1 (PECAM-1) in elderly patients with gastric cancer (GC). Methods: Ninety-eight elderly GC patients admitted to the Affiliated Hexian Memorial Hospital of Southern Medical University were selected as a research group, and 60 healthy subjects of the same age and in relatively good health who underwent physical examination at the same period were selected as a control group. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of CXCL13 and PECAM-1 in serum. The clinical diagnosis and prognostic value of serum CXCL13 and PECAM-1 in elderly GC patients were analyzed. Results: The levels of CXCL13 and PECAM-1 in serum of the research group were significantly higher than those of the control group (P < 0.001). The AUC value of combined diagnosis of elderly GC patients by serum CXCL13 and PECAM-1 was 0.950, and that of combined evaluation of prognosis of patients was 0.849. Serum CXCL13 and PECAM-1 were significantly related to TNM staging, differentiation degree and tumor diameter in elderly GC patients (P < 0.05). High levels of CXCL13 and PECAM-1 were significantly associated with lower 5-year OS (P < 0.05). Conclusion: Elderly GC patients with higher TNM staging, longer tumor diameters, high levels of CXCL13 and PECAM-1 had an increased risk of poor prognosis. Serum CXCL13 and PECAM-1 can be used as effective indicators for diagnosis and prognosis of elderly patients with GC, and can predict the 5-year OS in patients.
MeSH term(s)	Aged ; Biomarkers, Tumor/blood ; Case-Control Studies ; Chemokine CXCL13/blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Platelet Endothelial Cell Adhesion Molecule-1/blood ; Prognosis ; Stomach Neoplasms/blood ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/mortality ; Survival Rate
Chemical Substances	Biomarkers, Tumor ; CXCL13 protein, human ; Chemokine CXCL13 ; Platelet Endothelial Cell Adhesion Molecule-1
Language	English
Publishing date	2020-06-04
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-020-02403-w
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Article: [Craniosynostosis and strabismus].

Wang, A K / Kang, X L

Zhonghua yan ke za zhi] Chinese journal of ophthalmology

2016 Volume 52, Issue 8, Page(s) 626–630

Abstract: Craniosynostosis(CS), the premature fusion of cranial sutures leading to an abnormal shape and precocious maturity of skull, is classified into Non-syndromic Craniosynostosis (NSC) and Syndromic Craniosynostoses(SC).NCS only has different abnormality of ... ...

Abstract	Craniosynostosis(CS), the premature fusion of cranial sutures leading to an abnormal shape and precocious maturity of skull, is classified into Non-syndromic Craniosynostosis (NSC) and Syndromic Craniosynostoses(SC).NCS only has different abnormality of skull according to which cranial suture is involved while extra malformation of midface and limbs present in SCS. Common SCS contains Crouzon Syndrome, Apert Syndrome, Pfeiffer Sydrome, and etc. The clinical manifestation of CS includes malformation of skull, intracranial hypertension, brain hernia, developmental disorder of cerebral function, strabismus, and etc, while SCS has more complex manifestation. Along with the improvement of multidisciplinary cooperation, the ophthalmic complication of CS, like strabismus, is recognised by oculists gradually. This review is summarizing the clinical manifestation, complicated strabismus, pathogenesis and multidisciplinary cure of CS. (Chin J Ophthalmol, 2016, 52: 626-630).
MeSH term(s)	Craniosynostoses/diagnosis ; Craniosynostoses/physiopathology ; Craniosynostoses/surgery ; Humans ; Strabismus
Language	Chinese
Publishing date	2016-08
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	604574-1
ISSN	0412-4081
ISSN	0412-4081
DOI	10.3760/cma.j.issn.0412-4081.2016.08.018
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Article ; Online: Leptin promotes proliferation and inhibits apoptosis of prostate cancer cells by regulating ERK1/2 signaling pathway.

Xu, C-J / Dong, L-L / Kang, X-L / Li, Z-M / Zhang, H-Y

European review for medical and pharmacological sciences

2020 Volume 24, Issue 16, Page(s) 8341–8348

Abstract: Objective: The aim of this study was to investigate the effect of leptin (Lep) on the proliferation, invasion and apoptosis of prostate cancer cells through the extracellular regulated protein kinase 1/2 (ERK1/2) signaling pathway.: Materials and ... ...

Abstract	Objective: The aim of this study was to investigate the effect of leptin (Lep) on the proliferation, invasion and apoptosis of prostate cancer cells through the extracellular regulated protein kinase 1/2 (ERK1/2) signaling pathway. Materials and methods: Prostate cancer DU145 cells in the logarithmic growth phase were randomly divided into Lep (10, 20, 40, 80, 160 and 320 ng/mL) groups and blank control (Con) group. After culture, the cells were treated for 6 h, 12 h and 24 h, respectively. The effects of Lep on the proliferation and invasion of DU145 cells were detected via methyl thiazolyl tetrazolium (MTT) assay and transwell chamber assay, respectively. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was carried out to examine the messenger ribonucleic acid (mRNA) expressions of ERK1/2, b-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax) in DU145 cells after Lep treatment for 24 h. Thereafter, immunofluorescence assay was performed to detect the localization of ERK1/2 protein in prostate cancer DU145 cells. In addition, the expressions of phosphorylated (p)-ERK, ERK1/2 and apoptosis-related proteins, Bcl-2, Bax and cleaved cysteinyl aspartate specific proteinase (c-Caspase 3) in prostate cancer DU145 cells after treatment with different concentrations of Lep for 24 h were examined by Western blotting. Results: MTT assay results showed that the proliferation rate of DU145 cells increased significantly at 6 h, 12 h and 24 h after 5-320 ng/mL of Lep treatment (p<0.05). Transwell assay manifested that the number of invasive cells was significantly raised after Lep treatment for 24 h (p<0.05). Meanwhile, the invasion ability of cells increased gradually with the elevation of Lep concentration. Subsequent qRT-PCR results demonstrated that after treatment with different concentrations of Lep, the mRNA expressions of ERK1/2 and Bcl-2 rose markedly (p<0.05). However, the mRNA expression of Bax was remarkably down-regulated (p<0.05) with the increase of Lep concentration in a concentration-dependent manner. According to the detection using a laser scanning confocal microscope, ERK1/2 red fluorescence showed punctiform aggregation, which was gradually raised with the increase of Lep concentration for 24 h. Moreover, Western blotting results denoted that with the increase of Lep concentration, the protein expressions of p-ERK, ERK1/2 and Bcl-2 were notably elevated (p<0.05), while those of Bax and c-Caspase 3 were distinctly reduced (p<0.05). Conclusions: Lep activation induces the proliferation, promotes the invasion and inhibits the apoptosis of prostate cancer cells through the ERK1/2 signaling pathway.
MeSH term(s)	Apoptosis ; Cell Proliferation ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Leptin/metabolism ; Male ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Signal Transduction ; Tumor Cells, Cultured
Chemical Substances	LEP protein, human ; Leptin ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24)
Language	English
Publishing date	2020-09-06
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202008_22630
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Article: [Comprehensive analysis of the effect of null zone shifting surgery treatment on patients with infantile nystagmus syndrome].

Chen, J J / Tian, L L / Zhang, L H / Wang, J L / Kang, X L

Zhonghua yan ke za zhi] Chinese journal of ophthalmology

2019 Volume 55, Issue 1, Page(s) 13–19

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Child ; China ; Eye Movements ; Female ; Humans ; Male ; Nystagmus, Pathologic/surgery ; Oculomotor Muscles ; Retrospective Studies
Language	Chinese
Publishing date	2019-01-12
Publishing country	China
Document type	Journal Article
ZDB-ID	604574-1
ISSN	0412-4081
ISSN	0412-4081
DOI	10.3760/cma.j.issn.0412-4081.2019.01.004
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Article: [Longterm surgery outcome of Möbius syndrome].

Cen, J / Kang, X L / Yu, J / Dong, L Y / Wei, Y / Zhao, K X

Zhonghua yan ke za zhi] Chinese journal of ophthalmology

2018 Volume 53, Issue 12, Page(s) 897–902

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Child ; Esotropia/surgery ; Humans ; Mobius Syndrome/surgery ; Oculomotor Muscles ; Ophthalmologic Surgical Procedures ; Retrospective Studies ; Strabismus/surgery ; Treatment Outcome ; Vision, Binocular
Language	Chinese
Publishing date	2018-01-11
Publishing country	China
Document type	Journal Article
ZDB-ID	604574-1
ISSN	0412-4081
ISSN	0412-4081
DOI	10.3760/cma.j.issn.0412-4081.2017.12.004
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Article ; Online: Bibliometric network analysis of glaucoma.

Dong, L-Y / Yin, M / Kang, X-L

Genetics and molecular research : GMR

2014 Volume 13, Issue 2, Page(s) 3577–3585

Abstract: Elevated intraocular pressure is recognized as the principal risk factor for development of optic nerve head (ONH) injury. Lamina cribrosa (LC) cells and astrocytes are two types of cells in the ONH. We attempted to identify more target genes and predict ...

Abstract	Elevated intraocular pressure is recognized as the principal risk factor for development of optic nerve head (ONH) injury. Lamina cribrosa (LC) cells and astrocytes are two types of cells in the ONH. We attempted to identify more target genes and predict their underlying molecular mechanisms. In this study, we performed meta-analysis of the data from two microarray sets containing samples from LC cells and astrocytes each. Our analysis indicated that 47 differentially expressed genes (DEGs) had been identified, and 24 of them were used to construct a bibliometric network with other related genes, including GSTT1 ENO2, CPE, PTN, PTGDS, IL6, MMP1, and EGFR. Further, our results predicted these genes might be involved in glaucoma development through Toll-like receptor signaling pathway, ErbB signaling pathway, and glioma and other cancer-related pathways. Therefore our study provides potential target genes and pathways for future therapeutic studies of glaucoma.
MeSH term(s)	Astrocytes/metabolism ; Astrocytes/pathology ; Bibliometrics ; Gene Expression Regulation ; Gene Regulatory Networks ; Glaucoma/genetics ; Glaucoma/pathology ; Humans ; Optic Disk/metabolism ; Optic Disk/pathology ; Optic Nerve Injuries/genetics ; Optic Nerve Injuries/pathology ; Proteomics
Language	English
Publishing date	2014-05-09
Publishing country	Brazil
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	2114039-X
ISSN	1676-5680 ; 1676-5680
ISSN (online)	1676-5680
ISSN	1676-5680
DOI	10.4238/2014.May.9.1
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Article: Inactivation of the RAD1 excision-repair gene does not affect correction of mismatches on heteroduplex plasmid DNA in yeast.

Kang, X L / Kunz, B A

Current genetics

1992 Volume 21, Issue 3, Page(s) 261–263

Abstract: The efficiency and direction of mismatch correction in the Saccharomyces cerevisiae SUP4-o gene were not altered by an excision-repair defect (rad1). Although excision-repair functions remove methylated adenine from yeast, adenine methylation at a GAC ... ...

Abstract	The efficiency and direction of mismatch correction in the Saccharomyces cerevisiae SUP4-o gene were not altered by an excision-repair defect (rad1). Although excision-repair functions remove methylated adenine from yeast, adenine methylation at a GAC sequence in SUP4-o did not direct the correction of mismatches via excision repair.
MeSH term(s)	Adenine/metabolism ; Base Composition ; DNA Repair/genetics ; DNA, Fungal/genetics ; Genes, Fungal/physiology ; Genes, Suppressor/genetics ; Genetic Vectors ; Methylation ; Mutation ; Nucleic Acid Heteroduplexes/genetics ; RNA, Transfer/genetics ; Saccharomyces cerevisiae/genetics ; Transformation, Genetic
Chemical Substances	DNA, Fungal ; Nucleic Acid Heteroduplexes ; RNA, Transfer (9014-25-9) ; Adenine (JAC85A2161)
Language	English
Publishing date	1992-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	282876-5
ISSN	1432-0983 ; 0172-8083
ISSN (online)	1432-0983
ISSN	0172-8083
DOI	10.1007/bf00336851
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Article: The yeast rad18 mutator specifically increases G.C----T.A transversions without reducing correction of G-A or C-T mismatches to G.C pairs.

Kunz, B A / Kang, X L / Kohalmi, L

Molecular and cellular biology

1991 Volume 11, Issue 1, Page(s) 218–225

Abstract: Inactivation of the Saccharomyces cerevisiae RAD18 gene confers a mutator phenotype. To determine the specificity of this effect, a collection of 212 spontaneous SUP4-o mutants arising in a rad18 strain was characterized by DNA sequencing. Comparison of ... ...

Abstract	Inactivation of the Saccharomyces cerevisiae RAD18 gene confers a mutator phenotype. To determine the specificity of this effect, a collection of 212 spontaneous SUP4-o mutants arising in a rad18 strain was characterized by DNA sequencing. Comparison of the resulting mutational spectrum with that for an isogenic wild-type (RAD18) strain revealed that the rad18 mutator specifically enhanced the frequency of single base pair substitutions. Further analysis indicated that an increase in the frequency of G.C----T.A transversions accounted for the elevated SUP4-o mutation frequency. Thus, rad18 is the first eucaryotic mutator found to generate only a particular base pair substitution. The majority of G.C pairs that were not mutated in the rad18 background were at sites where G.C----T.A events can be detected in SUP4-o, suggesting that DNA sequence context influences the rad18 mutator effect. Transformation of heteroduplex plasmid DNAs into the two strains demonstrated that the rad18 mutator did not reduce the efficiency of correcting G-A or C-T mismatches to G.C pairs or preferentially correct the mismatches to A.T pairs. We propose that the RAD18 gene product might contribute to the fidelity of DNA replication in S. cerevisiae by involvement in a process that serves to limit the formation of G-A and C-T mismatches at template guanine and cytosine sites during DNA synthesis.
MeSH term(s)	Base Sequence ; Canavanine/pharmacology ; DNA Repair ; DNA, Fungal/genetics ; Genes, Fungal ; Genes, Suppressor ; Molecular Sequence Data ; Mutagenesis ; Saccharomyces cerevisiae/genetics
Chemical Substances	DNA, Fungal ; Canavanine (3HZV514J4B)
Language	English
Publishing date	1991-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	779397-2
ISSN	1098-5549 ; 0270-7306
ISSN (online)	1098-5549
ISSN	0270-7306
DOI	10.1128/mcb.11.1.218-225.1991
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