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Article ; Online: QuantiFERON-Cytomegalovirus Assay for Prediction of Cytomegalovirus Viremia in Kidney Transplant Recipients: Study From High Cytomegalovirus Seroprevalence Country.

Pongsakornkullachart, Kritsada / Chayakulkeeree, Methee / Vongwiwatana, Attapong / Kantakamalakul, Wannee / Skulratanasak, Peenida / Phoompoung, Pakpoom

Frontiers in cellular and infection microbiology

2022 Volume 12, Page(s) 893232

Abstract: Background: Early studies showed the utility of pretransplant QuantiFERON-Cytomegalovirus (QF-CMV) assays for CMV-disease prediction post kidney transplant (KT). However, recent data are conflicting.: Methods: This prospective cohort study enrolled ... ...

Abstract	Background: Early studies showed the utility of pretransplant QuantiFERON-Cytomegalovirus (QF-CMV) assays for CMV-disease prediction post kidney transplant (KT). However, recent data are conflicting. Methods: This prospective cohort study enrolled adult patients undergoing KT between July 2017 and May 2019. Patients with antithymocyte globulin therapy or negative pretransplant CMV IgG were excluded. QF-CMV assays were performed on transplantation day and one month thereafter, and CMV viral loads were obtained 1, 3, and 6 months posttransplantation. The primary outcome was CMV viremia within 6 months. The QF-CMV assay-posttransplant CMV viremia association was analyzed. Results: Fifty-five patients were enrolled (male, 58.2%; mean (SD) age, 46.5 (10.2) years). Fifty-two (94.5%) received CMV-seropositive donor kidneys. Over 6 months, 29 patients developed CMV viremia (52.7%), with 14 (25.5%) having significant viremia requiring antiviral therapy. The CMV-viremia incidence of patients with nonreactive and reactive baseline QF-CMV assays did not differ significantly (55.3% and 47.1%; Conclusions: Our study could not support the use of single-timepoint pretransplant or 1-month posttransplant QF-CMV assays as a predictor for posttransplant CMV viremia in CMV seropositive KT recipients. Investigation of the association between dynamic QF-CMV-status changes and CMV-viremia incidence are needed.
MeSH term(s)	Adult ; Cytomegalovirus ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/epidemiology ; Humans ; Kidney Transplantation ; Male ; Middle Aged ; Prospective Studies ; Seroepidemiologic Studies ; Viremia/diagnosis ; Viremia/epidemiology
Language	English
Publishing date	2022-05-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2022.893232
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Prevalence and clinical correlation of hepatitis E virus antibody in the patients’ serum samples from a tertiary care hospital in Thailand during 2015–2018

Boonyai, Atiporn / Thongput, Anchalee / Sisaeng, Thidarat / Phumchan, Parisut / Horthongkham, Navin / Kantakamalakul, Wannee / Chaimayo, Chutikarn

Virology journal. 2021 Dec., v. 18, no. 1

2021

Abstract: BACKGROUND: Prevalence and incidence of hepatitis caused by HEV infection are usually higher in developing countries. This study demonstrated the HEV seroprevalence and incidence of HEV infection in patients with clinical hepatitis in a tertiary hospital ...

Abstract	BACKGROUND: Prevalence and incidence of hepatitis caused by HEV infection are usually higher in developing countries. This study demonstrated the HEV seroprevalence and incidence of HEV infection in patients with clinical hepatitis in a tertiary hospital in Thailand. METHODS: A laboratory-based cross-sectional study was conducted using 1106 serum samples from patients suspected of HEV infection sent to the Serology laboratory, Siriraj Hospital, for detecting HEV antibodies during 2015–2018. Prevalence of anti-HEV IgG and IgM antibodies in general patients, including organ transplant recipients and pregnant women in a hospital setting, were determined using indirect enzyme-linked immunosorbent assay (ELISA) kits. Comparison of laboratory data between groups with different HEV serological statuses was performed. RESULTS: HEV IgG antibodies were detected in 40.82% of 904 serum samples, while HEV IgM antibodies were detected in 11.75% of 1081 serum samples. Similar IgG and IgM antibody detection rates were found in pregnant women. Interestingly, anti-HEV IgM antibodies were detected in 38.5% of patients who underwent organ transplantation. Patients who tested positive for anti-HEV IgM antibodies had higher alanine aminotransferase levels than those who had not. In contrast, patients who tested positive for anti-HEV IgG had more elevated levels of total bilirubin than those who tested negative. CONCLUSIONS: HEV seroprevalence and incidence in patients with clinical hepatitis were relatively high in the Thai population, including the pregnancy and organ transplant subgroups. The results potentially benefit the clinicians in decision-making to investigate HEV antibodies and facilitating proper management for patients.
Keywords	Orthohepevirus A ; alanine transaminase ; antibodies ; antibody detection ; bilirubin ; blood serum ; cross-sectional studies ; decision making ; enzyme-linked immunosorbent assay ; hepatitis ; hospitals ; organ transplantation ; pregnancy ; serology ; seroprevalence ; virology ; Thailand
Language	English
Dates of publication	2021-12
Size	p. 145.
Publishing place	BioMed Central
Document type	Article
ZDB-ID	2160640-7
ISSN	1743-422X
ISSN	1743-422X
DOI	10.1186/s12985-021-01616-x
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Prevalence and clinical correlation of hepatitis E virus antibody in the patients' serum samples from a tertiary care hospital in Thailand during 2015-2018.

Boonyai, Atiporn / Thongput, Anchalee / Sisaeng, Thidarat / Phumchan, Parisut / Horthongkham, Navin / Kantakamalakul, Wannee / Chaimayo, Chutikarn

Virology journal

2021 Volume 18, Issue 1, Page(s) 145

Abstract: Background: Prevalence and incidence of hepatitis caused by HEV infection are usually higher in developing countries. This study demonstrated the HEV seroprevalence and incidence of HEV infection in patients with clinical hepatitis in a tertiary ... ...

Abstract	Background: Prevalence and incidence of hepatitis caused by HEV infection are usually higher in developing countries. This study demonstrated the HEV seroprevalence and incidence of HEV infection in patients with clinical hepatitis in a tertiary hospital in Thailand. Methods: A laboratory-based cross-sectional study was conducted using 1106 serum samples from patients suspected of HEV infection sent to the Serology laboratory, Siriraj Hospital, for detecting HEV antibodies during 2015-2018. Prevalence of anti-HEV IgG and IgM antibodies in general patients, including organ transplant recipients and pregnant women in a hospital setting, were determined using indirect enzyme-linked immunosorbent assay (ELISA) kits. Comparison of laboratory data between groups with different HEV serological statuses was performed. Results: HEV IgG antibodies were detected in 40.82% of 904 serum samples, while HEV IgM antibodies were detected in 11.75% of 1081 serum samples. Similar IgG and IgM antibody detection rates were found in pregnant women. Interestingly, anti-HEV IgM antibodies were detected in 38.5% of patients who underwent organ transplantation. Patients who tested positive for anti-HEV IgM antibodies had higher alanine aminotransferase levels than those who had not. In contrast, patients who tested positive for anti-HEV IgG had more elevated levels of total bilirubin than those who tested negative. Conclusions: HEV seroprevalence and incidence in patients with clinical hepatitis were relatively high in the Thai population, including the pregnancy and organ transplant subgroups. The results potentially benefit the clinicians in decision-making to investigate HEV antibodies and facilitating proper management for patients.
MeSH term(s)	Cross-Sectional Studies ; Female ; Hepatitis Antibodies/blood ; Hepatitis E/epidemiology ; Hepatitis E virus/immunology ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Pregnancy ; Prevalence ; Seroepidemiologic Studies ; Tertiary Care Centers ; Thailand/epidemiology ; Transplant Recipients
Chemical Substances	Hepatitis Antibodies ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2021-07-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2160640-7
ISSN	1743-422X ; 1743-422X
ISSN (online)	1743-422X
ISSN	1743-422X
DOI	10.1186/s12985-021-01616-x
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Article ; Online: Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients.

Chuaychoo, Benjamas / Ngamwongwan, Sopita / Kaewnaphan, Bualan / Athipanyasilp, Niracha / Horthongkham, Navin / Kantakamalakul, Wannee / Muangman, Nisa

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2019 Volume 117, Page(s) 103–108

Abstract: Background: Respiratory syncytial virus (RSV) is an important virus found in adult hospitalized patients.: Objectives: To study the clinical outcomes of hospitalized patients aged ≥ 15 years and diagnosed with RSV infection.: Study design: Both ... ...

Abstract	Background: Respiratory syncytial virus (RSV) is an important virus found in adult hospitalized patients. Objectives: To study the clinical outcomes of hospitalized patients aged ≥ 15 years and diagnosed with RSV infection. Study design: Both retrospective and prospective cohort studies were conducted at a university hospital between May 2014 and December 2015. Results: RSV was detected in 86 of 1562(5.5%) adult hospitalized patients suspected of respiratory viral infection. Sixty-nine patients were included in the study. RSV was detected by RT-PCR (82.6%), IFA (10.1%), and both RT-PCR and IFA (7.3%). Most patients (87.0%) were aged ≥ 50 years. Cardiovascular diseases, pulmonary diseases, immunocompromised hosts, and diabetes were the major comorbidities. The common manifestations were cough (92.8%), dyspnea (91.3%), sputum production (87.0%), tachypnea (75.4%), wheezing (73.9%), and fever (71.0%). Fifty- five patients (79.7%) were diagnosed with pneumonia. Hypoxemia (SpO2 ≤ 92%) was found in 53.6% patients. Twenty-five of 69(36.2%) patients developed respiratory failure and required ventilatory support. Cardiovascular complications were found in 24.6% of patients. Congestive heart failure, acute myocardial infarction (MI), new atrial fibrillation, and supraventricular tachycardia were found in 9(13.0%), 7(10.1%), 4(5.8%), and 3(4.3%) of 69 patients, respectively. Overall mortality was 15.9%. Pneumonia (81.8%) and acute MI (18.2%) were the major causes of death. Conclusions: Most adult hospitalized patients with RSV infection were of advanced age and had comorbidities. Cardiopulmonary complications were the major causes of death. Management and prevention of RSV infection in these vulnerable groups are necessary.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Comorbidity ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Molecular Diagnostic Techniques ; Mortality ; Prospective Studies ; Respiratory Insufficiency/epidemiology ; Respiratory Insufficiency/etiology ; Respiratory Syncytial Virus Infections/complications ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus, Human/genetics ; Respiratory Syncytial Virus, Human/isolation & purification ; Retrospective Studies ; Thailand/epidemiology ; Young Adult
Keywords	covid19
Language	English
Publishing date	2019-07-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2019.07.001
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Article: Lymphocyte subsets and natural killer cell cytotoxicity in intravenous drug users with HIV-1 infection among Thai population.

Kantakamalakul, Wannee / Jangkhum, Suwalee / Ampol, Silawun / Burupharat, Porurtai / Chuachoowong, Rutt / Sutthent, Ruengpung / Pattanapanyasat, Kovit

Asian Pacific journal of allergy and immunology

2018 Volume 37, Issue 1, Page(s) 51–56

Abstract: Backgound: Intravenous drug users (IVDUs) are among the high-risk groups who are most vulnerable to HIV infection. Several illicit drugs alter host immune function with increased incidence of infections including that of HIV. Many studies of the immune ... ...

Abstract	Backgound: Intravenous drug users (IVDUs) are among the high-risk groups who are most vulnerable to HIV infection. Several illicit drugs alter host immune function with increased incidence of infections including that of HIV. Many studies of the immune response of NK cells in HIV-1 seronegative IVDUs and HIV-1 seropositive IVDUs have been published from the Western countries and yet no data is available from Thailand. Objective: To determine natural killer cell cytotoxicity and lymphocyte subsets in Thai HIV-1 infected intravenous drug users. Methods: The NK cell cytotoxic function was determined using our well-established EGFP-K562 flow cytometric assay in 30 IVDUs with HIV-1 infection (IVH) comparing with those from the same number of non-infected IVDUs (IVX), HIV-1 seropositive individuals (HIV-1+ve) and healthy controls. The percentage and the absolute number of NK cells, helper CD4+ T cells and cytotoxic CD8+ T cells were also investigated. Results: Among the study groups, IVH showed not only the lowest percentage of lytic activity by NK cells, but also a decline in the percentage and absolute count of NK cells. A decline in helper CD4+ T cells and an increase of cytotoxic CD8+ T cells of IVH group when compared to those of other 3 groups were also demonstrated. Conclusions: The failure of innate immune NK cell function and their number in IVH may support the involvement of additional components of the immune system in the control of HIV-1 disease.
MeSH term(s)	Adult ; CD4 Lymphocyte Count ; CD4-CD8 Ratio ; Cell Line ; Cytotoxicity, Immunologic ; Drug Users/statistics & numerical data ; Female ; HIV Infections/epidemiology ; HIV Infections/immunology ; HIV Infections/transmission ; HIV Infections/virology ; HIV-1/immunology ; Humans ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Lymphocyte Subsets/immunology ; Lymphocyte Subsets/metabolism ; Male ; Middle Aged ; Population Surveillance ; Seroepidemiologic Studies ; Thailand/epidemiology ; Young Adult
Language	English
Publishing date	2018-03-15
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	605782-2
ISSN	2228-8694 ; 0125-877X
ISSN (online)	2228-8694
ISSN	0125-877X
DOI	10.12932/AP-201017-0183
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Article: Common antibody dependent cell mediated cytotoxicity (ADCC) antibody epitopes of HIV-1 CRF01_AE Env and Gag in early HIV-1 infected individuals.

Sangjan, Soraya / Ampol, Silawun / Tabprasit, Sutchana / Horthongkham, Navin / Chuenchitra, Thippawan / Ekpo, Pattama / Kantakamalakul, Wannee

Asian Pacific journal of allergy and immunology

2018 Volume 37, Issue 1, Page(s) 43–50

Abstract: Background: There have been a few studies aimed at identifying epitopes of ADCC-inducing antibodies when compared to those of neutralizing antibodies and cytotoxic T lymphocytes against a variety of HIV-1 clades.: Objective: To map the common ADCC ... ...

Abstract	Background: There have been a few studies aimed at identifying epitopes of ADCC-inducing antibodies when compared to those of neutralizing antibodies and cytotoxic T lymphocytes against a variety of HIV-1 clades. Objective: To map the common ADCC epitopes of HIV-1 CRF01_AE. Methods: We screened 65 sera of confirmed early HIV-1 CRF01_AE infected individuals for ADCC antibody against gp120 utilizing an EGFP-CEM-NKr flow cytometric assay. Sera with high ADCC antibody were then examined against ADCC epitopes using the complete HIV-1 CRF01_AE gp160- and subtype A Gag-overlapping peptide sets which were divided into 7 pools:E1-E7 and 5 pools:G1-G5, respectively. Each positive peptide pool was further investigated for fine ADCC epitope mapping using matrix formats. Results: Twenty, 25 and 20 sera demonstrated the high-, medium- and low-ADCC antibody activities against gp120, respectively. Interestingly, 11 Env- and 6 Gag-peptides of pools E3, E4, E7 and pools G1, G2, G4 with high ADCC responses were also responded by at least 20%, 12% and 5%, 10% of medium- and low-ADCC antibody sera, respectively. These eleven common Env ADCC epitopes were localized at C2-V3-C3-V4 regions of gp120 and cytoplasmic tail of gp41 while six common Gag ADCC epitopes were localized at p17-p24-p2 regions. Conclusions: Although the degree of ADCC antibody responses to the gp120 protein varied from high to low, there were certain consensus Env and Gag peptides that could induce the ADCC antibody responses of 21.54-58.46% and 23.08-41.54%, respectively of the early infected individuals. This epitope information should be useful as the new antibody-based vaccine immunogens.
MeSH term(s)	Amino Acid Sequence ; Antibodies, Neutralizing/immunology ; Antibody-Dependent Cell Cytotoxicity/immunology ; Epitopes/chemistry ; Epitopes/immunology ; HIV Envelope Protein gp120/immunology ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/genetics ; HIV-1/immunology ; Humans ; Immune Sera/immunology ; Peptides/chemistry ; Peptides/immunology ; env Gene Products, Human Immunodeficiency Virus/immunology ; gag Gene Products, Human Immunodeficiency Virus/immunology
Chemical Substances	Antibodies, Neutralizing ; Epitopes ; HIV Envelope Protein gp120 ; Immune Sera ; Peptides ; env Gene Products, Human Immunodeficiency Virus ; gag Gene Products, Human Immunodeficiency Virus
Language	English
Publishing date	2018-03-30
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	605782-2
ISSN	2228-8694 ; 0125-877X
ISSN (online)	2228-8694
ISSN	0125-877X
DOI	10.12932/AP-101017-0177
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Article ; Online: Prevalence of HIV-1 Subtypes and Antiretroviral Drug Resistance Mutations in Nepal.

Bhusal, Nirajan / Sutthent, Ruengpung / Horthongkham, Navin / Athipanyasilp, Niracha / Kantakamalakul, Wannee

Current HIV research

2016 Volume 14, Issue 6, Page(s) 517–524

Abstract: Background: There have been very few reports of HIV-1 subtypes and drug resistance mutations (DRMs) from Nepal which is geographically located between two high-prevalence HIV-1 infection countries, China and India.: Objective: The aim of this study ... ...

Abstract	Background: There have been very few reports of HIV-1 subtypes and drug resistance mutations (DRMs) from Nepal which is geographically located between two high-prevalence HIV-1 infection countries, China and India. Objective: The aim of this study was to determine prevalence of acquired and transmitted DRMs and HIV-1 subtypes in Nepal. Methods: Thirty-five HIV-1 seropositive samples from central region of Nepal were collected in 2011. The subjects were divided into two groups, antiretroviral (ARV) drug naïve group (n=15) and antiretroviral treatment (ART) group (n=20), 90% (18/20) of them received zidovudine, lamivudine and nevirapine (AZT/3TC/NVP) regimen. HIV pol (protease and reverse transcriptase regions) nucleotide sequences were analyzed by Viroseq HIV-1 Genotyping System. Nearly full-length genomic (NFLG) sequences of 10 samples were performed. Results: NFLG genotyping revealed that 80% of samples were infected with subtype C and 20% with recombinants (C/D/H and C/A). Phylogenetic analysis of 35 pol sequences from Nepal were subtype C. The prevalence of acquired DRMs to NNRTIs and NRTIs was 15% (3/20). DRMs to NVP, K103N and V179D, and to NRTIs were observed at 11.1% (2/18) and 5% (1/20), respectively. The prevalence of DRMs to rilpivirine for E138A/G was 5.7%. The minor protease inhibitors (PI) associated mutations (A71T/V and T74S) were observed in 5/35 (14.3%) subjects. Conclusion: This is the first report of NFLG HIV-1 genomic sequences and DRMs from Nepal. National surveillance of HIV DRMs to ARVs and molecular epidemiology study should be done annually for better prevention and treatment of HIV infection in Nepal.
MeSH term(s)	Adult ; Anti-Retroviral Agents/therapeutic use ; Child ; Drug Resistance, Viral ; Female ; Genotype ; HIV Infections/drug therapy ; HIV Infections/virology ; HIV-1/classification ; HIV-1/drug effects ; HIV-1/genetics ; HIV-1/isolation & purification ; Humans ; Male ; Middle Aged ; Mutation ; Nepal ; Prevalence ; Sequence Analysis, DNA ; Young Adult ; pol Gene Products, Human Immunodeficiency Virus/genetics
Chemical Substances	Anti-Retroviral Agents ; pol Gene Products, Human Immunodeficiency Virus
Language	English
Publishing date	2016-10-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2192348-6
ISSN	1873-4251 ; 1570-162X
ISSN (online)	1873-4251
ISSN	1570-162X
DOI	10.2174/1570162x14666161003141950
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Article: Duration of neutralizing antibody persisting in Thai individuals after childhood vaccination against smallpox.

Kwanchum, Kannikar / Ampol, Silawun / Thongput, Anchalee / Horthongkham, Navin / Udomphunthurak, Suthiphol / Siritantikorn, Sontana / Kantakamalakul, Wannee

Asian Pacific journal of allergy and immunology

2017 Volume 35, Issue 4, Page(s) 239–243

Abstract: Background: Although smallpox was completely eliminated by 1980, it remains possible that variola virus could be intentionally released in an act of bioterrorism. Thus, several studies have been performed to detect antibody levels after smallpox ... ...

Abstract	Background: Although smallpox was completely eliminated by 1980, it remains possible that variola virus could be intentionally released in an act of bioterrorism. Thus, several studies have been performed to detect antibody levels after smallpox vaccination of the current population in various countries to indicate the duration of maintenance of immunological memory. Our study endeavored to investigate the level of neutralizing (Nt) antibody responses of Thai individuals who had been immunized with smallpox vaccine during childhood. Methods: The plaque reduction neutralization test (PRNT) was used to study vaccinia Nt antibody responses in sera of individuals ranging in age from 35-4, 45-54, 55-64, 65-74, 75-84 and > 84 years old, referred to as groups 1-6, respectively. Each group included 200 sera: 100 male sera and 100 female sera. Results: An incubation time of 15 hours for sera and vaccinia virus was confirmed to be the optimal incubation period for PRNT. Positive Nt antibody titers (≥32) were detected in 135 (11.25%) of 1,200 sera: 81 (6.75%) male sera and 54 (4.5%) female sera. There were 4 (2%), 11 (5.5%), 19 (9.5%), 16 (8%), 33 (16.5%), and 52 (26%) positive sera in groups 1-6, respectively. Interestingly, the oldest individual with positive Nt antibody was a 98-year-old female. Two males aged 96 and 91 years old had the highest Nt antibody titers. Conclusions: Our data suggests that the vaccinia-specific Nt antibody response in the current Thai population could be maintained for more than 90 years after vaccination. However, the majority of the Thai population aged ≥35-74 years old is still highly susceptible to infection.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; Bioterrorism ; Female ; Humans ; Immunologic Memory ; Male ; Middle Aged ; Neutralization Tests ; Smallpox/immunology ; Smallpox Vaccine/immunology ; Thailand ; Vaccination ; Variola virus/physiology
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Smallpox Vaccine
Language	English
Publishing date	2017-06-02
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	605782-2
ISSN	2228-8694 ; 0125-877X
ISSN (online)	2228-8694
ISSN	0125-877X
DOI	10.12932/AP0857
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Article ; Online: Epidemiology, clinical characteristics, and treatment outcomes of patients with COVID-19 at Thailand's university-based referral hospital.

Sirijatuphat, Rujipas / Suputtamongkol, Yupin / Angkasekwinai, Nasikarn / Horthongkham, Navin / Chayakulkeeree, Methee / Rattanaumpawan, Pinyo / Koomanachai, Pornpan / Assanasen, Susan / Rongrungruang, Yong / Chierakul, Nitipatana / Ratanarat, Ranistha / Jitmuang, Anupop / Wangchinda, Walaiporn / Kantakamalakul, Wannee

BMC infectious diseases

2021 Volume 21, Issue 1, Page(s) 382

Abstract: Background: The epidemiology and outcomes of COVID-19 patients in Thailand are scarce.: Methods: This retrospective cohort study included adult hospitalized patients who were diagnosed with COVID-19 at Siriraj Hospital during February 2020 to April ... ...

Abstract	Background: The epidemiology and outcomes of COVID-19 patients in Thailand are scarce. Methods: This retrospective cohort study included adult hospitalized patients who were diagnosed with COVID-19 at Siriraj Hospital during February 2020 to April 2020. Results: The prevalence of COVID-19 was 7.5% (107 COVID-19 patients) among 1409 patients who underwent RT-PCR for SARS-CoV-2 detection at our hospital during the outbreak period. Patients with COVID-19 presented with symptoms in 94.4%. Among the 104 patients who were treated with antiviral medications, 78 (75%) received 2-drug regimen (lopinavir/ritonavir or darunavir/ritonavir plus chloroquine or hydroxychloroquine), and 26 (25%) received a 3-drug regimen with favipiravir added to the 2-drug regimen. Disease progression was observed in 18 patients (16.8%). All patients with COVID-19 were discharged alive. Conclusions: The prevalence of COVID-19 was 7.5% among patients who underwent RT-PCR testing, and 10% among those having risk factors for COVID-19 acquisition. Combination antiviral therapies for COVID-19 patients were well-tolerated and produced a favorable outcome.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Amides/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/epidemiology ; Chloroquine/therapeutic use ; Darunavir/therapeutic use ; Disease Progression ; Drug Combinations ; Female ; Hospitals ; Hospitals, University ; Humans ; Hydroxychloroquine/therapeutic use ; Lopinavir/therapeutic use ; Male ; Middle Aged ; Pyrazines/therapeutic use ; Referral and Consultation ; Retrospective Studies ; Ritonavir/therapeutic use ; Thailand/epidemiology ; Treatment Outcome ; Young Adult
Chemical Substances	Amides ; Antiviral Agents ; Drug Combinations ; Pyrazines ; lopinavir-ritonavir drug combination ; Lopinavir (2494G1JF75) ; Hydroxychloroquine (4QWG6N8QKH) ; Chloroquine (886U3H6UFF) ; favipiravir (EW5GL2X7E0) ; Ritonavir (O3J8G9O825) ; Darunavir (YO603Y8113)
Language	English
Publishing date	2021-04-26
Publishing country	England
Document type	Journal Article
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/s12879-021-06081-z
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Article ; Online: The efficacy of peer teaching for medical microbiology lectures.

Ngamskulrungroj, Popchai / Kiratisin, Pattarachai / Dangprapai, Yodying / Thaipisuttikul, Iyarit / Leelaporn, Amornrut / Luisirirojanakul, Suda / Kantakamalakul, Wannee / Horthongkam, Navin

MedEdPublish (2016)

2018 Volume 6, Page(s) 132

Abstract: This article was migrated. The article was marked as recommended. ...

Abstract	This article was migrated. The article was marked as recommended.
Language	English
Publishing date	2018-11-15
Publishing country	Scotland
Document type	Journal Article
ISSN	2312-7996
ISSN (online)	2312-7996
DOI	10.15694/mep.2017.000132.2
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