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  1. Article: Captopril is more effective than Perindopril against aluminium chloride induced amyloidogenesis and AD like pathology.

    Mohapatra, Debashish / Kanungo, Srikant / Pradhan, Sweta Priyadarshini / Jena, Susmita / Prusty, Shakti Ketan / Sahu, Pratap Kumar

    Heliyon

    2022  Volume 8, Issue 2, Page(s) e08935

    Abstract: Alzheimer's disease (AD) is a common neurodegenerative disorder. Aluminium chloride induces AD like pathology in rats. Renin angiotensin system plays a significant role in the pathogenesis and occurrence of Alzheimer's disease. In the present study we ... ...

    Abstract Alzheimer's disease (AD) is a common neurodegenerative disorder. Aluminium chloride induces AD like pathology in rats. Renin angiotensin system plays a significant role in the pathogenesis and occurrence of Alzheimer's disease. In the present study we evaluated and compared the effect of Captopril and Perindopril against aluminium chloride induced amyloidogenesis and cognitive dysfunction in rats. Wistar rats of both sex were divided randomly into four groups i.e. Group I was served as normal control and treated with normal saline, Group II was administered with AlCl
    Language English
    Publishing date 2022-02-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e08935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Captopril is more effective than Perindopril against aluminium chloride induced amyloidogenesis and AD like pathology

    Mohapatra, Debashish / Kanungo, Srikant / Pradhan, Sweta Priyadarshini / Jena, Susmita / Prusty, Shakti Ketan / Sahu, P. K.

    Heliyon. 2022 Feb., v. 8, no. 2 p.e08935-

    2022  

    Abstract: Alzheimer's disease (AD) is a common neurodegenerative disorder. Aluminium chloride induces AD like pathology in rats. Renin angiotensin system plays a significant role in the pathogenesis and occurrence of Alzheimer's disease. In the present study we ... ...

    Abstract Alzheimer's disease (AD) is a common neurodegenerative disorder. Aluminium chloride induces AD like pathology in rats. Renin angiotensin system plays a significant role in the pathogenesis and occurrence of Alzheimer's disease. In the present study we evaluated and compared the effect of Captopril and Perindopril against aluminium chloride induced amyloidogenesis and cognitive dysfunction in rats. Wistar rats of both sex were divided randomly into four groups i.e. Group I was served as normal control and treated with normal saline, Group II was administered with AlCl₃ (100 mg/kg, p. o.) and Group III and IV received Captopril (30 mg/kg, p. o.) and Perindopril (5 mg/kg, p. o.) respectively 1hr prior to administration of AlCl₃. All the doses were given once daily for 42 days. The evaluation of memory function was carried out in Y-maze (spontaneous alternation), radial arm maze (number of correct responses) and elevated plus maze (transfer latency). After behavioral studies, estimation of antioxidant status (brain and serum), amyloid-β content (brain) and histopathology of brain hippocampus region was done. Administration of AlCl₃ for 42 days impaired cognitive dysfunction. Captopril and Perindopril prevented AlCl₃ induced cognitive dysfunction by improving spontaneous alternation behavior, number of correct responses and reducing transfer latency. They also increase the antioxidant status, reduce the Aβ42 content in the brain and reverse the histopathological changes caused by AlCl₃ in hippocampal region. Both Captopril and Perindopril protects against aluminium chloride induced amyloidogenesis and AD like pathology. Captopril is found to be more effective than Perindopril.
    Keywords Alzheimer disease ; aluminum chloride ; antioxidants ; blood serum ; cognitive disorders ; hippocampus ; histopathology ; memory ; neurodegenerative diseases ; pathogenesis ; renin ; Amyloid-β ; Oxidative stress ; ACE ; Rennin angiotensin system
    Language English
    Dates of publication 2022-02
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e08935
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Sequence analysis of Indian SARS-CoV-2 isolates shows a stronger interaction of mutated receptor binding domain with ACE2 receptor

    Dash, Pujarini / Turuk, Jyotirmayee / Behera, Santosh Ku. / Palo, Subrata Ku. / Raghav, Sunil K. / Ghosh, Arup / Sabat, Jyotsnamayee / Rath, Sonalika / Subhadra, Subhra / Bhattacharya, Debadutta / Kanungo, Srikant / Kshatri, Jayasingh / Mishra, Bijaya kumar / Dash, Saroj / Mahapatra, Namita / Parida, Ajay / Pati, Sanghamitra

    bioRxiv

    Abstract: SARS-CoV-2 is a RNA Coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). It has affected the whole world including Odisha, a state in eastern India. Many people migrated in the state from different countries as ... ...

    Abstract SARS-CoV-2 is a RNA Coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). It has affected the whole world including Odisha, a state in eastern India. Many people migrated in the state from different countries as well as states during this SARS-CoV-2 pandemic. As per the protocol laid by ICMR and Health & Family welfare of India, all the suspected cases were tested for SARS-CoV-2 infection. The aim of this study was to analyze the RNA binding domain (RBD) sequence of spike protein from the isolates collected from the throat swab samples of COVID-19 positive cases and further to assess the RBD affinity with ACE2 of different species including human. Whole genome sequencing for 35 clinical SARS-CoV-2 isolates from COVID-19 positive patients was performed using ARTIC amplicon based sequencing. Sequence analysis and phylogenetic analysis was carried out for the Spike and RBD region of all isolates. The interaction between the RBD and ACE2 receptor of five different species was also analysed. Except three isolates, spike region of 32 isolates showed one/multiple alterations in nucleotide bases in comparison to the Wuhan reference strain. One of the identified mutation at 1204 (Ref A, RMRC 22 C) in the RBD of spike protein was identified which depicted a stronger binding affinity with human ACE2 receptor compared to the wild type RBD. Furthermore, RBDs of all the Indian isolates are capable of binding to ACE2 of human, bat, hamster and pangolin. As mutated RBD showed stronger interaction with human ACE2, it could potentially result in higher infectivity. The study shows that RBDs of all the studied isolates have binding affinity for all the five species, which suggests that the virus can infect a wide variety of animals which could also act as natural reservoir for SARS-CoV-2.
    Keywords covid19
    Language English
    Publishing date 2020-08-28
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2020.08.28.271601
    Database COVID19

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  4. Article ; Online: Sequence analysis of Indian SARS-CoV-2 isolates shows a stronger interaction of mutated receptor binding domain with ACE2 receptor

    Dash, Pujarini / Turuk, Jyotirmayee / Behera, Santosh Ku. / Palo, Subrata Ku. / Raghav, Sunil K. / Ghosh, Arup / Sabat, Jyotsnamayee / Rath, Sonalika / Subhadra, Subhra / Bhattacharya, Debadutta / Kanungo, Srikant / Kshatri, Jayasingh / Mishra, Bijaya kumar / Dash, Saroj / Mahapatra, Namita / Parida, Ajay / Pati, Sanghamitra

    bioRxiv

    Abstract: SARS-CoV-2 is a RNA Coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). It has affected the whole world including Odisha, a state in eastern India. Many people migrated in the state from different countries as ... ...

    Abstract SARS-CoV-2 is a RNA Coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). It has affected the whole world including Odisha, a state in eastern India. Many people migrated in the state from different countries as well as states during this SARS-CoV-2 pandemic. As per the protocol laid by ICMR and Health & Family welfare of India, all the suspected cases were tested for SARS-CoV-2 infection. The aim of this study was to analyze the RNA binding domain (RBD) sequence of spike protein from the isolates collected from the throat swab samples of COVID-19 positive cases and further to assess the RBD affinity with ACE2 of different species including human. Whole genome sequencing for 35 clinical SARS-CoV-2 isolates from COVID-19 positive patients was performed using ARTIC amplicon based sequencing. Sequence analysis and phylogenetic analysis was carried out for the Spike and RBD region of all isolates. The interaction between the RBD and ACE2 receptor of five different species was also analysed. Except three isolates, spike region of 32 isolates showed one/multiple alterations in nucleotide bases in comparison to the Wuhan reference strain. One of the identified mutation at 1204 (Ref A, RMRC 22 C) in the RBD of spike protein was identified which depicted a stronger binding affinity with human ACE2 receptor compared to the wild type RBD. Furthermore, RBDs of all the Indian isolates are capable of binding to ACE2 of human, bat, hamster and pangolin. As mutated RBD showed stronger interaction with human ACE2, it could potentially result in higher infectivity. The study shows that RBDs of all the studied isolates have binding affinity for all the five species, which suggests that the virus can infect a wide variety of animals which could also act as natural reservoir for SARS-CoV-2.
    Keywords covid19
    Publisher BioRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.08.28.271601
    Database COVID19

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  5. Article ; Online: Resolvin D1 and D2 reduce SARS-Cov-2-induced inflammation in cystic fibrosis macrophages

    Dash, Pujarini / Turuk, Jyotirmayee / Behera, Santosh Ku. / Palo, Subrata Ku. / Raghav, Sunil / Ghosh, Arup / Sabat, Jyotsnamayee / Rath, Sonalika / Subhadra, Subhra / Bhattacharya, Debadutta / Kanungo, Srikant / Kshatri, Jayasingh / Mishra, Bijaya kumar / Dash, Saroj / Mahapatra, Namita / Parida, Ajay / Pati, Sanghamitra

    Abstract: Resolvins (Rv) are endogenous lipid autacoids that mediate resolution of inflammation and bacterial infections. Their roles in SARS-CoV-2 and COVID-19 are of considerable interest in the context of cystic fibrosis (CF) given the paucity of data regarding ...

    Abstract Resolvins (Rv) are endogenous lipid autacoids that mediate resolution of inflammation and bacterial infections. Their roles in SARS-CoV-2 and COVID-19 are of considerable interest in the context of cystic fibrosis (CF) given the paucity of data regarding the effect of this virus on immune cells from individuals with CF. Here, we provide evidence for Rv biosynthesis and regulatory actions on CF macrophage inflammatory responses.
    Keywords covid19
    Publisher WHO
    Document type Article ; Online
    Note WHO #Covidence: #255463
    DOI 10.1101/2020.08.28.255463
    Database COVID19

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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