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Article ; Online: Mandibular Endochondral Growth Is Specifically Augmented by Nutritional Supplementation with Myo-Inositol Even in Rabbits.

Shimoyama, Miho / Kanzaki, Hiroyuki / Tohyama, Syunnosuke / Ida, Tomomi / Ishikawa, Misao / Katsumata, Yuta / Arai, Chihiro / Wada, Satoshi / Manase, Shugo / Tomonari, Hiroshi

Dentistry journal

2024 Volume 12, Issue 3

Abstract: Mandibular retrognathism occurs by insufficient mandibular growth and causes several issues, such as respiratory difficulty and diminished masticatory function. At present, functional orthodontic appliances are used for stimulating mandibular growth in ... ...

Abstract	Mandibular retrognathism occurs by insufficient mandibular growth and causes several issues, such as respiratory difficulty and diminished masticatory function. At present, functional orthodontic appliances are used for stimulating mandibular growth in pediatric cases. However, the effectiveness of functional appliances is not always stable in daily practices. A more effective, reliable, and safer therapeutic method for mandibular growth promotion would be helpful for growing mandibular retrognathism patients. As we previously discovered that nutritional supplementation of myo-inositol in growing mice specifically increases mandibular endochondral growth, we performed preclinical animal experiments in rabbits in this study. Briefly, six-week-old male Japanese white rabbits were fed with or without myo-inositol supplementation in laboratory chow until 25 weeks old, and 3D image analysis using micro CT data and histological examinations was done. Myo-inositol had no systemic effect, such as femur length, though myo-inositol specifically augmented the mandibular growth. Myo-inositol increased the thickness of mandibular condylar cartilage. We discovered that the nutritional supplementation of myo-inositol during the growth period specifically augmented mandibular growth without any systemic influence, even in rabbits. Our results suggest the possibility of clinical use of myo-inositol for augmentation of the mandibular growth in growing mandibular retrognathism patients in the future.
Language	English
Publishing date	2024-02-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681351-8
ISSN	2304-6767 ; 2304-6767
ISSN (online)	2304-6767
ISSN	2304-6767
DOI	10.3390/dj12030049
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: In vivo delivery of an exogenous molecule into murine T lymphocytes using a lymphatic drug delivery system combined with sonoporation

Kato, Shigeki / Shirai, Yuko / Motozono, Chihiro / Kanzaki, Hiroyuki / Mori, Shiro / Kodama, Tetsuya

Biochemical and biophysical research communications. 2020 May 14, v. 525, no. 4

2020

Abstract: Physical delivery of exogenous molecules into lymphocytes is extremely challenging because conventional methods have notable limitations. Here, we evaluated the potential use of acoustic liposomes (ALs) and sonoporation to deliver exogenous molecules ... ...

Abstract	Physical delivery of exogenous molecules into lymphocytes is extremely challenging because conventional methods have notable limitations. Here, we evaluated the potential use of acoustic liposomes (ALs) and sonoporation to deliver exogenous molecules into lymphocytes within a lymph node (LN). MXH10/Mo-lpr/lpr (MXH10/Mo/lpr) mice, which show systemic LN swelling, were used as the model system. After direct injection into the subiliac LN, a solution containing both ALs and TOTO-3 fluorophores (molecular weight: 1355) was able to reach the downstream proper axillary LN (PALN) via the lymphatic vessels (LVs). This led to the accumulation of a high concentration of TOTO-3 fluorophores and ALs in the lymphatic sinuses of the PALN, where a large number of lymphocytes were densely packed. Exposure of the PALN to >1.93 W/cm² of 970-kHz ultrasound allowed the solution to extravasate into the parenchyma and reach the large number of lymphocytes in the sinuses. Flow cytometric analysis showed that TOTO-3 molecules were delivered into 0.49 ± 0.23% of CD8⁺7AAD⁻ cytotoxic T lymphocytes. Furthermore, there was no evidence of tissue damage. Thus, direct administration of drugs into LVs combined with sonoporation can improve the delivery of exogenous molecules into primary lymphocytes. This technique could become a novel approach to immunotherapy.
Keywords	acoustics ; cytotoxicity ; drug delivery systems ; flow cytometry ; fluorescent dyes ; immunotherapy ; lymph nodes ; mice ; molecular weight ; research ; ultrasonics
Language	English
Dates of publication	2020-0514
Size	p. 1025-1031.
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2020.02.174
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Article ; Online: Orthodontic treatment of acquired open bite accompanied with extreme mesially inclined mandibular molars.

Miyamoto, Yutaka / Kanzaki, Hiroyuki / Nakamura, Yoshiki

International orthodontics

2018 Volume 16, Issue 4, Page(s) 744–760

Abstract: Acquired open bite mainly occurs after adolescence and is caused by a pathological or biological process. We herein report the case of an 18-year and 10-month-old Japanese woman. Her chief complaint was difficulty with mastication. Only distal cusps of ... ...

Abstract	Acquired open bite mainly occurs after adolescence and is caused by a pathological or biological process. We herein report the case of an 18-year and 10-month-old Japanese woman. Her chief complaint was difficulty with mastication. Only distal cusps of first molars and second molars had contact. An angle class II molar relationship and extreme mesially inclined mandibular first molars were observed. The degree of overjet was +6.1mm and overbite was -2.0mm. There were no symptoms or abnormal findings in temporomandibular joints by radiography and magnetic resonance imaging. A skeletal class II jaw relationship was indicated. Therefore, the patient was diagnosed with a skeletal class II acquired open bite malocclusion accompanied with extreme mesial inclination of mandibular first molars. Orthodontic treatment with extraction of maxillary first premolars was performed. After stabilizing the maxillary dental arch, mandibular molars were uprighted and intruded by class III elastics. After treatment, overjet was +3.0mm and overbite was +2.3mm. Occlusal cusp-fossa relationships were established and canine relationships were class I. The lower occlusal plane and mandible were rotated counterclockwise, which helped to achieve proper overbite. After 2 years of retention, occlusion was well maintained.
MeSH term(s)	Adolescent ; Cephalometry ; Female ; Humans ; Magnetic Resonance Imaging ; Malocclusion, Angle Class II/therapy ; Mandible ; Mastication ; Molar ; Open Bite/diagnostic imaging ; Open Bite/therapy ; Orthodontic Anchorage Procedures ; Orthodontics, Corrective/methods ; Radiography ; Radiography, Panoramic ; Tooth Extraction ; Tooth Movement Techniques/methods
Language	English
Publishing date	2018-10-17
Publishing country	France
Document type	Case Reports ; Journal Article
ISSN	1879-680X
ISSN (online)	1879-680X
DOI	10.1016/j.ortho.2018.09.027
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Article ; Online: [No title information]

Miyamoto, Yutaka / Kanzaki, Hiroyuki / Nakamura, Yoshiki

International orthodontics

2018 Volume 16, Issue 4, Page(s) 744–760

Title translation	Traitement orthodontique de la béance acquise associée à une mésioversion très prononcée des molaires mandibulaires.
Language	French
Publishing date	2018-10-17
Publishing country	France
Document type	Journal Article
ISSN	1879-680X
ISSN (online)	1879-680X
DOI	10.1016/j.ortho.2018.09.028
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Article ; Online: In vivo delivery of an exogenous molecule into murine T lymphocytes using a lymphatic drug delivery system combined with sonoporation.

Kato, Shigeki / Shirai, Yuko / Motozono, Chihiro / Kanzaki, Hiroyuki / Mori, Shiro / Kodama, Tetsuya

Biochemical and biophysical research communications

2020 Volume 525, Issue 4, Page(s) 1025–1031

Abstract	Physical delivery of exogenous molecules into lymphocytes is extremely challenging because conventional methods have notable limitations. Here, we evaluated the potential use of acoustic liposomes (ALs) and sonoporation to deliver exogenous molecules into lymphocytes within a lymph node (LN). MXH10/Mo-lpr/lpr (MXH10/Mo/lpr) mice, which show systemic LN swelling, were used as the model system. After direct injection into the subiliac LN, a solution containing both ALs and TOTO-3 fluorophores (molecular weight: 1355) was able to reach the downstream proper axillary LN (PALN) via the lymphatic vessels (LVs). This led to the accumulation of a high concentration of TOTO-3 fluorophores and ALs in the lymphatic sinuses of the PALN, where a large number of lymphocytes were densely packed. Exposure of the PALN to >1.93 W/cm
MeSH term(s)	Animals ; Drug Carriers/chemistry ; Drug Delivery Systems/methods ; Female ; Flow Cytometry ; Fluorescent Antibody Technique ; Fluorescent Dyes/chemistry ; Liposomes/chemistry ; Lymph Nodes/cytology ; Lymph Nodes/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Quinolines/chemistry ; Quinolines/metabolism ; T-Lymphocytes/drug effects ; T-Lymphocytes/metabolism ; Thiazoles/chemistry ; Thiazoles/metabolism ; Ultrasonic Waves
Chemical Substances	Drug Carriers ; Fluorescent Dyes ; Liposomes ; Quinolines ; TOTO-3 compound ; Thiazoles
Language	English
Publishing date	2020-03-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2020.02.174
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Article: Novel device for application of continuous mechanical tensile strain to mammalian cells.

Wada, Satoshi / Kanzaki, Hiroyuki / Narimiya, Tsuyoshi / Nakamura, Yoshiki

Biology open

2017 Volume 6, Issue 4, Page(s) 518–524

Abstract: During orthodontic tooth movement, the periodontal ligament (PDL) is exposed to continuous mechanical strain. However, many researchers have applied cyclic tensile strain, not continuous tensile strain, to PDL ... ...

Abstract	During orthodontic tooth movement, the periodontal ligament (PDL) is exposed to continuous mechanical strain. However, many researchers have applied cyclic tensile strain, not continuous tensile strain, to PDL cells
Language	English
Publishing date	2017-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2632264-X
ISSN	2046-6390
ISSN	2046-6390
DOI	10.1242/bio.023671
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Article ; Online: Early diagnosis of aortic calcification through dental X-ray examination for dental pulp stones.

Ishikawa, Misao / Kanzaki, Hiroyuki / Kodera, Ryo / Sekimizu, Takehiro / Wada, Satoshi / Tohyama, Syunnosuke / Ida, Tomomi / Shimoyama, Miho / Manase, Shugo / Tomonari, Hiroshi / Kuroda, Noriyuki

Scientific reports

2023 Volume 13, Issue 1, Page(s) 18576

Abstract: Vascular calcification, an ectopic calcification exacerbated by aging and renal dysfunction, is closely associated with cardiovascular disease. However, early detection indicators are limited. This study focused on dental pulp stones, ectopic ... ...

Abstract	Vascular calcification, an ectopic calcification exacerbated by aging and renal dysfunction, is closely associated with cardiovascular disease. However, early detection indicators are limited. This study focused on dental pulp stones, ectopic calcifications found in oral tissues that are easily identifiable on dental radiographs. Our investigation explored the frequency and timing of these calcifications in different locations and their relationship to aortic calcification. In cadavers, we examined the association between the frequency of dental pulp stones and aortic calcification, revealing a significant association. Notably, dental pulp stones appeared prior to aortic calcification. Using a rat model of hyperphosphatemia, we confirmed that dental pulp stones formed earlier than calcification in the aortic arch. Interestingly, there were very few instances of aortic calcification without dental pulp stones. Additionally, we conducted cell culture experiments with vascular smooth muscle cells (SMCs) and dental pulp cells (DPCs) to explore the regulatory mechanism underlying high phosphate-mediated calcification. We found that DPCs produced calcification deposits more rapidly and exhibited a stronger augmentation of osteoblast differentiation markers compared with SMCs. In conclusion, the observation of dental pulp stones through X-ray examination during dental checkups could be a valuable method for early diagnosis of aortic calcification risk.
MeSH term(s)	Rats ; Animals ; X-Rays ; Dental Pulp Calcification/diagnostic imaging ; Radiography ; Vascular Calcification/diagnostic imaging ; Early Diagnosis ; Dental Pulp/diagnostic imaging
Language	English
Publishing date	2023-10-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45902-w
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Article ; Online: Soluble Sema4D cleaved from osteoclast precursors by TACE suppresses osteoblastogenesis.

Ishii, Takenobu / Ruiz-Torruella, Montserrat / Kim, Jae Young / Kanzaki, Hiroyuki / Albassam, Abdullah / Wisitrasameewong, Wichaya / Shindo, Satoru / Pierrelus, Roodelyne / Heidari, Alireza / Kandalam, Umadevi / Nakamura, Shin / Movila, Alexandru / Minond, Dmitriy / Kawai, Toshihisa

Journal of cellular and molecular medicine

2023 Volume 27, Issue 12, Page(s) 1750–1756

Abstract: Bone remodelling is mediated by orchestrated communication between osteoclasts and osteoblasts which, in part, is regulated by coupling and anti-coupling factors. Amongst formally known anti-coupling factors, Semaphorin 4D (Sema4D), produced by ... ...

Abstract	Bone remodelling is mediated by orchestrated communication between osteoclasts and osteoblasts which, in part, is regulated by coupling and anti-coupling factors. Amongst formally known anti-coupling factors, Semaphorin 4D (Sema4D), produced by osteoclasts, plays a key role in downmodulating osteoblastogenesis. Sema4D is produced in both membrane-bound and soluble forms; however, the mechanism responsible for producing sSema4D from osteoclasts is unknown. Sema4D, TACE and MT1-MMP are all expressed on the surface of RANKL-primed osteoclast precursors. However, only Sema4D and TACE were colocalized, not Sema4D and MT1-MMP. When TACE and MT1-MMP were either chemically inhibited or suppressed by siRNA, TACE was found to be more engaged in shedding Sema4D. Anti-TACE-mAb inhibited sSema4D release from osteoclast precursors by ~90%. Supernatant collected from osteoclast precursors (OC-sup) suppressed osteoblastogenesis from MC3T3-E1 cells, as measured by alkaline phosphatase activity, but OC-sup harvested from the osteoclast precursors treated with anti-TACE-mAb restored osteoblastogenesis activity in a manner that compensates for diminished sSema4D. Finally, systemic administration of anti-TACE-mAb downregulated the generation of sSema4D in the mouse model of critical-sized bone defect, whereas local injection of recombinant sSema4D to anti-TACE-mAb-treated defect upregulated local osteoblastogenesis. Therefore, a novel pathway is proposed whereby TACE-mediated shedding of Sema4D expressed on the osteoclast precursors generates functionally active sSema4D to suppress osteoblastogenesis.
MeSH term(s)	Animals ; Mice ; Disease Models, Animal ; Matrix Metalloproteinase 14/metabolism ; Osteoblasts/metabolism ; Osteoclasts/metabolism ; Semaphorins/genetics ; Semaphorins/metabolism
Chemical Substances	Matrix Metalloproteinase 14 (EC 3.4.24.80) ; Sema4d protein, mouse ; Semaphorins ; Adam17 protein, mouse (EC 3.4.24.86)
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.17416
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Article ; Online: Author's response.

Fukaya, Sari / Kanzaki, Hiroyuki / Miyamoto, Yutaka / Yamaguchi, Yuki / Nakamura, Yoshiki

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics

2018 Volume 154, Issue 4, Page(s) 461–462

MeSH term(s)	Animals ; Injections ; Insulin-Like Growth Factor I ; Mandible ; Mandibular Condyle ; Mice
Chemical Substances	Insulin-Like Growth Factor I (67763-96-6)
Language	English
Publishing date	2018-09-29
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	356699-7
ISSN	1097-6752 ; 0889-5406 ; 0002-9416
ISSN (online)	1097-6752
ISSN	0889-5406 ; 0002-9416
DOI	10.1016/j.ajodo.2018.07.003
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Article: Nrf2 activation in osteoblasts suppresses osteoclastogenesis via inhibiting IL-6 expression.

Narimiya, Tsuyoshi / Kanzaki, Hiroyuki / Yamaguchi, Yuki / Wada, Satoshi / Katsumata, Yuta / Tanaka, Ken / Tomonari, Hiroshi

Bone reports

2019 Volume 11, Page(s) 100228

Abstract: Bone destructive diseases such as periodontitis and rheumatoid arthritis are caused by excessive activation of osteoclasts. Osteoclastogenesis is regulated by Receptor activator of nuclear factor kappa-β ligand (RANKL) produced by osteoclastogenesis ... ...

Abstract	Bone destructive diseases such as periodontitis and rheumatoid arthritis are caused by excessive activation of osteoclasts. Osteoclastogenesis is regulated by Receptor activator of nuclear factor kappa-β ligand (RANKL) produced by osteoclastogenesis supporting cells such as osteoblast and osteocyte. Previously, we reported that NF-E2-related factor-2 (Nrf2) activation in osteoclast precursors inhibited osteoclastogenesis and bone destruction via induction of anti-oxidation and thereby attenuated intracellular ROS signaling. However, it still remains unknown whether Nrf2 activation in cells other than osteoclasts give any negative influence on supporting property for osteoclastogenesis. Here we discovered that Nrf2 activation in osteoblasts suppresses indirectly osteoclastogenesis via inhibiting the expression of interleukin-6 (IL-6) which promotes osteoclastogenesis. In this study, 5-aminolevulinic acid hydrochloride (ALA) and sodium ferrous citrate (SFC) was used as the Nrf2 activator.
Language	English
Publishing date	2019-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2821774-3
ISSN	2352-1872
ISSN	2352-1872
DOI	10.1016/j.bonr.2019.100228
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