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Article ; Online: Medicinal Herbs and Their Derived Ingredients Protect against Cognitive Decline in In Vivo Models of Alzheimer's Disease.

Tsai, Yueh-Ting / Kao, Shung-Te / Cheng, Chin-Yi

International journal of molecular sciences

2022 Volume 23, Issue 19

Abstract: Alzheimer's disease (AD) has pathological hallmarks including amyloid beta (Aβ) plaque formation. Currently approved single-target drugs cannot effectively ameliorate AD. Medicinal herbs and their derived ingredients (MHDIs) have multitarget and ... ...

Abstract	Alzheimer's disease (AD) has pathological hallmarks including amyloid beta (Aβ) plaque formation. Currently approved single-target drugs cannot effectively ameliorate AD. Medicinal herbs and their derived ingredients (MHDIs) have multitarget and multichannel properties, engendering exceptional AD treatment outcomes. This review delineates how in in vivo models MHDIs suppress Aβ deposition by downregulating β- and γ-secretase activities; inhibit oxidative stress by enhancing the antioxidant activities and reducing lipid peroxidation; prevent tau hyperphosphorylation by upregulating protein phosphatase 2A expression and downregulating glycogen synthase kinase-3β expression; reduce inflammatory mediators partly by upregulating brain-derived neurotrophic factor/extracellular signal-regulated protein kinase 1/2-mediated signaling and downregulating p38 mitogen-activated protein kinase (p38 MAPK)/c-Jun N-terminal kinase (JNK)-mediated signaling; attenuate synaptic dysfunction by increasing presynaptic protein, postsynaptic protein, and acetylcholine levels and preventing acetylcholinesterase activity; and protect against neuronal apoptosis mainly by upregulating Akt/cyclic AMP response element-binding protein/B-cell lymphoma 2 (Bcl-2)-mediated anti-apoptotic signaling and downregulating p38 MAPK/JNK/Bcl-2-associated x protein (Bax)/caspase-3-, Bax/apoptosis-inducing factor-, C/EBP homologous protein/glucose-regulated protein 78-, and autophagy-mediated apoptotic signaling. Therefore, MHDIs listed in this review protect against Aβ-induced cognitive decline by inhibiting Aβ accumulation, oxidative stress, tau hyperphosphorylation, inflammation, synaptic damage, and neuronal apoptosis in the cortex and hippocampus during the early and late AD phases.
MeSH term(s)	Acetylcholine ; Acetylcholinesterase/metabolism ; Alzheimer Disease/metabolism ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Peptides/metabolism ; Antioxidants/therapeutic use ; Apoptosis Inducing Factor/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Caspase 3/metabolism ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/etiology ; Cyclic AMP Response Element-Binding Protein/metabolism ; Glucose/adverse effects ; Glycogen Synthase Kinases ; Humans ; Inflammation Mediators/therapeutic use ; JNK Mitogen-Activated Protein Kinases/metabolism ; Plants, Medicinal/metabolism ; Protein Phosphatase 2/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; bcl-2-Associated X Protein/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Amyloid beta-Peptides ; Antioxidants ; Apoptosis Inducing Factor ; Brain-Derived Neurotrophic Factor ; Cyclic AMP Response Element-Binding Protein ; Inflammation Mediators ; bcl-2-Associated X Protein ; Glycogen Synthase Kinases (EC 2.7.11.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Acetylcholinesterase (EC 3.1.1.7) ; Protein Phosphatase 2 (EC 3.1.3.16) ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; Caspase 3 (EC 3.4.22.-) ; Glucose (IY9XDZ35W2) ; Acetylcholine (N9YNS0M02X)
Language	English
Publishing date	2022-09-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231911311
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Article ; Online: Acorus tatarinowii Schott extract reduces cerebral edema caused by ischemia-reperfusion injury in rats: involvement in regulation of astrocytic NKCC1/AQP4 and JNK/iNOS-mediated signaling.

Lee, Yu-Chen / Kao, Shung-Te / Cheng, Chin-Yi

BMC complementary medicine and therapies

2020 Volume 20, Issue 1, Page(s) 374

Abstract: Background: This study aimed to evaluate the effects of the Acorus tatarinowii Schott [Shi Chang Pu (SCP)] extract administered at the start of 2 h of middle cerebral artery occlusion (MCAo), followed by 3 d of reperfusion, and to determine mechanisms ... ...

Abstract	Background: This study aimed to evaluate the effects of the Acorus tatarinowii Schott [Shi Chang Pu (SCP)] extract administered at the start of 2 h of middle cerebral artery occlusion (MCAo), followed by 3 d of reperfusion, and to determine mechanisms involved in anti-edema effects in the penumbra of the cerebral cortex. Method: Rats were intraperitoneally administered the SCP extract at a dose of 0.25 g/kg (SCP-0.25 g), 0.5 g/kg (SCP-0.5 g), or 1 g/kg (SCP-1 g) at the start of MCAo. Result: SCP-0.5 g and SCP-1 g treatments effectively reduced the cerebral infarct size, ameliorated cerebral edema, reduced blood-brain barrier permeability, and restored neurological function. SCP-0.5 g and SCP-1 g treatments markedly downregulated the levels of glial fibrillary acidic protein, Na Conclusions: SCP-0.5 g and SCP-1 g treatments exert neuroprotective effects against cerebral infarction and cerebral edema partially by mitigating astrocytic swelling and blood-brain barrier disruption. Moreover, the anti-cerebral edema effects of SCP extract treatments are possibly associated with the downregulation of astrocytic NKCC1/AQP4 and JNK/iNOS-mediated ICAM-1/MMP-9 signaling in the penumbra of the cerebral cortex 3 d after reperfusion.
MeSH term(s)	Acorus ; Animals ; Aquaporin 4/metabolism ; Brain Edema/drug therapy ; MAP Kinase Kinase 4/metabolism ; Male ; Medicine, Chinese Traditional/methods ; Nitric Oxide Synthase/metabolism ; Plant Extracts/pharmacology ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/drug therapy ; Signal Transduction ; Solute Carrier Family 12, Member 2/metabolism
Chemical Substances	Aqp4 protein, rat ; Aquaporin 4 ; Plant Extracts ; Slc12a2 protein, rat ; Solute Carrier Family 12, Member 2 ; Nitric Oxide Synthase (EC 1.14.13.39) ; MAP Kinase Kinase 4 (EC 2.7.12.2)
Language	English
Publishing date	2020-12-09
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-020-03168-z
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Article ; Online: Angelica sinensis extract protects against ischemia-reperfusion injury in the hippocampus by activating p38 MAPK-mediated p90RSK/p-Bad and p90RSK/CREB/BDNF signaling after transient global cerebral ischemia in rats.

Cheng, Chin-Yi / Kao, Shung-Te / Lee, Yu-Chen

Journal of ethnopharmacology

2020 Volume 252, Page(s) 112612

Abstract: Ethnopharmacological relevance: Angelica sinensis (Oliv.) Diels, commonly known as Dang Gui (DG), is one of the most popular traditional Chinese herbal medicines for the treatment of stroke. However, the effects of DG on transient global cerebral ... ...

Abstract	Ethnopharmacological relevance: Angelica sinensis (Oliv.) Diels, commonly known as Dang Gui (DG), is one of the most popular traditional Chinese herbal medicines for the treatment of stroke. However, the effects of DG on transient global cerebral ischemia (GCI) and its precise mechanisms remain unclear. Aim of the study: This study aimed to investigate the effects of the DG extract on ischemia-reperfusion (I/R) injury in the hippocampus 7 d after transient GCI and to identify the potential mitogen-activated protein kinase (MAPK)-related signaling pathway in the hippocampus involved in the effects. Materials and methods: Rats were intragastrically administered DG at doses of 0.25 g/kg (DG-0.25g), 0.5 g/kg (DG-0.5g), or 1 g/kg (DG-1g) 1, 3, and 5 d after GCI. Results: DG-0.5g and DG-1g treatments effectively promoted hippocampal cornu ammonis 1 (CA1) neuronal survival. DG-0.5g and DG-1g treatments markedly increased phospho-p38 MAPK (p-p38 MAPK), phospho-90-kDa ribosomal S6 kinase (p-p90RSK), cytosolic and mitochondrial phospho-Bad (p-Bad), phospho-cAMP response element-binding protein (p-CREB), brain-derived neurotrophic factor (BDNF), and p-CREB/BDNF expression; decreased 4-hydroxy-2-nonenal, cytochrome c (Cytc), and cleaved caspase-3 expression, and inhibited apoptosis in the hippocampal CA1 region. Pretreatment with a specific inhibitor of p38 MAPK, SB203580, completely blocked the effects of DG-1g on the expression of the aforementioned proteins. Conclusions: DG-0.5g and DG-1g treatments exerted neuroprotective effects on I/R injury by activating p38 MAPK-mediated p90RSK/p-Bad-induced anti-apoptotic-Cytc/caspase-3-related and p90RSK/CREB/BDNF survival signaling in the hippocampus 7 d after transient GCI.
MeSH term(s)	Angelica sinensis ; Animals ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; CREB-Binding Protein/metabolism ; Hippocampus/drug effects ; Hippocampus/metabolism ; Male ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Rats, Sprague-Dawley ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Ribosomal Protein S6 Kinases, 90-kDa/metabolism ; Signal Transduction/drug effects ; bcl-Associated Death Protein/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Bad protein, rat ; Bdnf protein, rat ; Brain-Derived Neurotrophic Factor ; Plant Extracts ; bcl-Associated Death Protein ; CREB-Binding Protein (EC 2.3.1.48) ; Crebbp protein, rat (EC 2.3.1.48) ; Ribosomal Protein S6 Kinases, 90-kDa (EC 2.7.11.1) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2020-01-24
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.112612
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Article: Alpinia oxyphylla Miq extract reduces cerebral infarction by downregulating JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling in the acute phase of transient focal cerebral ischemia in rats.

Cheng, Chin-Yi / Chiang, Su-Yin / Kao, Shung-Te / Huang, Shang-Chih

Chinese medicine

2021 Volume 16, Issue 1, Page(s) 82

Abstract: Background: Post-ischemic inflammation is a crucial component in stroke pathology in the early phase of cerebral ischemia-reperfusion (I/R) injury. Inflammation caused by microglia, astrocytes, and necrotic cells, produces pro-inflammatory mediators and ...

Abstract	Background: Post-ischemic inflammation is a crucial component in stroke pathology in the early phase of cerebral ischemia-reperfusion (I/R) injury. Inflammation caused by microglia, astrocytes, and necrotic cells, produces pro-inflammatory mediators and exacerbates cerebral I/R injury. This study evaluated the effects of the Alpinia oxyphylla Miq [Yi Zhi Ren (YZR)] extract on cerebral infarction at 1 day after 90 min of transient middle cerebral artery occlusion (MCAo) and investigated the molecular mechanisms underlying the regulation of c-Jun N-terminal kinase (JNK)-mediated inflammatory cascades in the penumbral cortex. Rats were intraperitoneally injected with the YZR extract at the doses of 0.2 g/kg (YZR-0.2 g), 0.4 g/kg (YZR-0.4 g), or 0.8 g/kg (YZR-0.8 g) at MCAo onset. Results: YZR-0.4 g and YZR-0.8 g treatments markedly reduced cerebral infarction, attenuated neurological deficits, and significantly downregulated the expression of phospho-apoptosis signal-regulating kinase 1 (p-ASK1)/ASK1, tumor necrosis factor receptor-associated factor 3 (TRAF3), TRAF3-interacting JNK-activating modulator (T3JAM), ionized calcium-binding adapter molecule 1 (Iba1), p-JNK/JNK, inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-α, toll-like receptor 4 (TLR4), glial fibrillary acidic protein (GFAP), nuclear factor-kappa B (NF-κB), and interleukin-6 in the penumbral cortex at 1 day after reperfusion. SP600125 (SP), a selective JNK inhibitor, had the same effects. Furthermore, Iba1- and GFAP-positive cells were colocalized with TLR4, and colocalization of GFAP-positive cells was found with NF-κB in the nuclei. Conclusion: YZR-0.4 g and YZR-0.8 g treatments exerted beneficial effects on cerebral ischemic injury by downregulating JNK-mediated signaling in the peri-infarct cortex. Moreover, the anti-infarction effects of YZR extract treatments were partially attributed to the downregulation of JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling pathways in the penumbral cortex at 1 day after reperfusion.
Language	English
Publishing date	2021-08-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-021-00495-2
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Article ; Online: Angelica sinensis extract promotes neuronal survival by enhancing p38 MAPK-mediated hippocampal neurogenesis and dendritic growth in the chronic phase of transient global cerebral ischemia in rats.

Cheng, Chin-Yi / Huang, Hui-Chi / Kao, Shung-Te / Lee, Yu-Chen

Journal of ethnopharmacology

2021 Volume 278, Page(s) 114301

Abstract: Ethnopharmacological relevance: Angelica sinensis (Oliv.) Diels (ASD), commonly known as Dang Gui, is a popular Chinese herb that has long been used to treat ischemic stroke. However, the effects of ASD in chronic cerebral ischemia and its underlying ... ...

Abstract	Ethnopharmacological relevance: Angelica sinensis (Oliv.) Diels (ASD), commonly known as Dang Gui, is a popular Chinese herb that has long been used to treat ischemic stroke. However, the effects of ASD in chronic cerebral ischemia and its underlying mechanisms still remain unclear. Aim of the study: This study aimed to determine the effects of the ASD extract on hippocampal neuronal survival at 28 d after transient global cerebral ischemia (GCI) and to investigate the precise mechanisms underlying the p38 mitogen-activated protein kinase (MAPK)-related signaling pathway's involvement in hippocampal neurogenesis. Materials and methods: Rats underwent 25 min of four-vessel occlusion. The ASD extract was intragastrically administered at doses of 0.25 g/kg (ASD-0.25 g), 0.5 g/kg (ASD-0.5 g), 1 g/kg (ASD-1 g), 1 g/kg after dimethyl sulfoxide administration (D + ASD-1 g), or 1 g/kg after SB203580 (a p38 MAPK inhibitor) administration (SB + ASD-1 g) at 1, 3, 7, 10, 14, 17, 21, and 24 d after transient GCI. Results: ASD-0.5 g, ASD-1 g, and D + ASD-1 g treatments had the following effects: upregulation of bromodeoxyuridine (BrdU) and Ki67 expression, and BrdU/neuronal nuclei (NeuN) and Ki67/nestin co-expression in the hippocampal dentate gyrus (DG); upregulation of microtubule-associated protein 2/NeuN co-expression, and NeuN and glial fibrillary acidic protein (GFAP) expression, and downregulation of tumor necrosis factor-α/GFAP co-expression in the hippocampal CA1 region; upregulation of phospho-p38 MAPK (p-p38 MAPK), phospho-cAMP response element-binding protein (p-CREB), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and vascular endothelial growth factor A (VEGF-A) expression in the hippocampus. SB + ASD-1 g treatment abrogated the effects of ASD-1 g on the expression of these proteins. Conclusions: ASD-0.5 g and ASD-1 g treatments promotes neuronal survival by enhancing hippocampal neurogenesis. The effects of the ASD extract on astrocyte-associated hippocampal neurogenesis and dendritic growth are caused by the activation of p38 MAPK-mediated CREB/BDNF, GDNF, and VEGF-A signaling pathways in the hippocampus at 28 d after transient GCI.
MeSH term(s)	Angelica sinensis/chemistry ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Brain Ischemia ; Cell Survival/drug effects ; Dimethyl Sulfoxide/pharmacology ; Gene Expression Regulation, Enzymologic/drug effects ; Hippocampus/cytology ; Imidazoles/pharmacology ; Neurogenesis/drug effects ; Neurons/drug effects ; Neurons/physiology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Pyridines/pharmacology ; Rats ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Imidazoles ; Plant Extracts ; Pyridines ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; SB 203580 (OU13V1EYWQ) ; Dimethyl Sulfoxide (YOW8V9698H)
Language	English
Publishing date	2021-06-04
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114301
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Article ; Online: Neuroprotective Effects of

Tsai, Yueh-Ting / Huang, Hui-Chi / Kao, Shung-Te / Chang, Tung-Ti / Cheng, Chin-Yi

The American journal of Chinese medicine

2022 Volume 50, Issue 8, Page(s) 2057–2083

Abstract: Apoptosis in the penumbra region is the major cell death mechanism occurring during ischemia-reperfusion injury's early phase. Here, we evaluated how ... ...

Abstract	Apoptosis in the penumbra region is the major cell death mechanism occurring during ischemia-reperfusion injury's early phase. Here, we evaluated how the
MeSH term(s)	Rats ; Animals ; Neuroprotective Agents/pharmacology ; Caspase 3/metabolism ; Alpinia ; Cathepsin B/metabolism ; Cathepsin B/pharmacology ; Cathepsin B/therapeutic use ; bcl-2-Associated X Protein/metabolism ; Actins/metabolism ; Tumor Suppressor Protein p53 ; Apoptosis ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism ; Apoptosis Regulatory Proteins/metabolism ; Reperfusion ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Infarction
Chemical Substances	Neuroprotective Agents ; Caspase 3 (EC 3.4.22.-) ; Cathepsin B (EC 3.4.22.1) ; bcl-2-Associated X Protein ; Actins ; Tumor Suppressor Protein p53 ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Apoptosis Regulatory Proteins ; Plant Extracts
Language	English
Publishing date	2022-10-20
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193085-0
ISSN	1793-6853 ; 0090-2942 ; 0192-415X
ISSN (online)	1793-6853
ISSN	0090-2942 ; 0192-415X
DOI	10.1142/S0192415X22500884
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Article ; Online: Preserving residual renal function: Is interdialytic acupuncture an add-on option? A case series report.

Jung, Hsuan-Kuang / Lai, Tzu-Hsuan / Lai, Jung-Nien / Lin, Jaung-Geng / Kao, Shung-Te

Explore (New York, N.Y.)

2022 Volume 18, Issue 6, Page(s) 710–713

Abstract: Background: Whether acupuncture therapy contributes to preserving residual renal function (RRF) remains largely unknown. This case series demonstrated the potential beneficial effects of acupuncture for preserving RRF in five patients with end-stage ... ...

Abstract	Background: Whether acupuncture therapy contributes to preserving residual renal function (RRF) remains largely unknown. This case series demonstrated the potential beneficial effects of acupuncture for preserving RRF in five patients with end-stage renal disease undergoing hemodialysis (HD) treatment. Participants: HD patients received eight sessions of weekly 30 min interdialytic acupuncture (Inter-A) at ten selected acupoints, namely Yintang (GV29), Yingxiang (LI20), Shuijin (Tung's Acupuncture), Lianquan (CV23), Shangqu (KI17), Tianshu (ST25), Siman (KI14), Hegu (LI4), Zusanli (ST36) and Sanyingjao (SP6). Residual urine volume (rUV) and residual glomerular filtration rate (rGFR) were recorded once every two weeks Outcomes: Changes in rUV and rGFR were calculated using 24 h urine collection data to assess RRF. Variations in hemoglobin, urea Kt/V and serum albumin levels were measured monthly to evaluate HD adequacy. Results: After eight Inter-A sessions, the mean[standard deviation] rUV and rGFR increased from 612[184] ml/day and 1.48[0.94] ml/min/1.73 m Conclusions: Acupuncture might be an optional add-on treatment for HD population with poor control of water; however, further well-designed controlled trials are warranted.
MeSH term(s)	Humans ; Kidney Failure, Chronic/therapy ; Glomerular Filtration Rate ; Renal Dialysis ; Acupuncture Therapy ; Kidney/physiology
Language	English
Publishing date	2022-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2183945-1
ISSN	1878-7541 ; 1550-8307
ISSN (online)	1878-7541
ISSN	1550-8307
DOI	10.1016/j.explore.2022.01.001
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Article ; Online: Ferulic Acid Exerts Anti-apoptotic Effects against Ischemic Injury by Activating HSP70/Bcl-2- and HSP70/Autophagy-Mediated Signaling after Permanent Focal Cerebral Ischemia in Rats.

Cheng, Chin-Yi / Kao, Shung-Te / Lee, Yu-Chen

The American journal of Chinese medicine

2019 Volume 47, Issue 1, Page(s) 39–61

Abstract: This study assessed the anti-apoptotic effects of the administration of ferulic acid (FrA) in rats ... ...

Abstract	This study assessed the anti-apoptotic effects of the administration of ferulic acid (FrA) in rats 30
MeSH term(s)	Angelica sinensis/chemistry ; Animals ; Apoptosis/drug effects ; Autophagy/drug effects ; Autophagy/genetics ; Brain Ischemia/genetics ; Brain Ischemia/metabolism ; Brain Ischemia/physiopathology ; Brain Ischemia/prevention & control ; Cerebral Cortex/metabolism ; Coumaric Acids/administration & dosage ; Coumaric Acids/isolation & purification ; Coumaric Acids/pharmacology ; Gene Expression/drug effects ; HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/metabolism ; Male ; Phytotherapy ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Up-Regulation/drug effects
Chemical Substances	Coumaric Acids ; HSP70 Heat-Shock Proteins ; Proto-Oncogene Proteins c-bcl-2 ; ferulic acid (AVM951ZWST)
Language	English
Publishing date	2019-01-07
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193085-0
ISSN	1793-6853 ; 0090-2942 ; 0192-415X
ISSN (online)	1793-6853
ISSN	0090-2942 ; 0192-415X
DOI	10.1142/S0192415X19500034
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Article: Angelica sinensis extract promotes neuronal survival by enhancing p38 MAPK–mediated hippocampal neurogenesis and dendritic growth in the chronic phase of transient global cerebral ischemia in rats

Cheng, Chin-Yi / Huang, Hui-Chi / Kao, Shung-Te / Lee, Yu-Chen

Journal of ethnopharmacology. 2021 Oct. 05, v. 278

2021

Abstract: Angelica sinensis (Oliv.) Diels (ASD), commonly known as Dang Gui, is a popular Chinese herb that has long been used to treat ischemic stroke. However, the effects of ASD in chronic cerebral ischemia and its underlying mechanisms still remain unclear ... ...

Abstract	Angelica sinensis (Oliv.) Diels (ASD), commonly known as Dang Gui, is a popular Chinese herb that has long been used to treat ischemic stroke. However, the effects of ASD in chronic cerebral ischemia and its underlying mechanisms still remain unclear.This study aimed to determine the effects of the ASD extract on hippocampal neuronal survival at 28 d after transient global cerebral ischemia (GCI) and to investigate the precise mechanisms underlying the p38 mitogen-activated protein kinase (MAPK)-related signaling pathway's involvement in hippocampal neurogenesis.Rats underwent 25 min of four-vessel occlusion. The ASD extract was intragastrically administered at doses of 0.25 g/kg (ASD-0.25 g), 0.5 g/kg (ASD-0.5 g), 1 g/kg (ASD-1 g), 1 g/kg after dimethyl sulfoxide administration (D + ASD-1 g), or 1 g/kg after SB203580 (a p38 MAPK inhibitor) administration (SB + ASD-1 g) at 1, 3, 7, 10, 14, 17, 21, and 24 d after transient GCI.ASD-0.5 g, ASD-1 g, and D + ASD-1 g treatments had the following effects: upregulation of bromodeoxyuridine (BrdU) and Ki67 expression, and BrdU/neuronal nuclei (NeuN) and Ki67/nestin co-expression in the hippocampal dentate gyrus (DG); upregulation of microtubule-associated protein 2/NeuN co-expression, and NeuN and glial fibrillary acidic protein (GFAP) expression, and downregulation of tumor necrosis factor-α/GFAP co-expression in the hippocampal CA1 region; upregulation of phospho-p38 MAPK (p-p38 MAPK), phospho-cAMP response element-binding protein (p-CREB), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and vascular endothelial growth factor A (VEGF-A) expression in the hippocampus. SB + ASD-1 g treatment abrogated the effects of ASD-1 g on the expression of these proteins.ASD-0.5 g and ASD-1 g treatments promotes neuronal survival by enhancing hippocampal neurogenesis. The effects of the ASD extract on astrocyte–associated hippocampal neurogenesis and dendritic growth are caused by the activation of p38 MAPK–mediated CREB/BDNF, GDNF, and VEGF-A signaling pathways in the hippocampus at 28 d after transient GCI.
Keywords	Angelica sinensis ; dimethyl sulfoxide ; hippocampus ; ischemia ; mitogen-activated protein kinase ; necrosis ; neoplasms ; neurogenesis ; neuroglia ; neurons ; stroke ; traditional medicine ; vascular endothelial growth factor A
Language	English
Dates of publication	2021-1005
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114301
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of

Hsu, Wei-Hsiang / Lin, Li-Jen / Lu, Chung-Kuang / Kao, Shung-Te / Lin, Yun-Lian

Biomolecules

2021 Volume 11, Issue 6

Abstract: Chinese herbal remedies have long been used for enhancing immunity and treating asthma. However, the evidence-based efficacy remains to be supported. This study aimed to explore the potential bio-signatures in allergic asthma and the effect ... ...

Abstract	Chinese herbal remedies have long been used for enhancing immunity and treating asthma. However, the evidence-based efficacy remains to be supported. This study aimed to explore the potential bio-signatures in allergic asthma and the effect of
MeSH term(s)	Animals ; Asthma/chemically induced ; Asthma/drug therapy ; Asthma/metabolism ; Asthma/microbiology ; Dermatophagoides pteronyssinus ; Drugs, Chinese Herbal/pharmacology ; Dysbiosis/drug therapy ; Dysbiosis/metabolism ; Dysbiosis/microbiology ; Gastrointestinal Microbiome/drug effects ; Male ; Metabolic Diseases/chemically induced ; Metabolic Diseases/drug therapy ; Metabolic Diseases/metabolism ; Metabolic Diseases/microbiology ; Mice ; Mice, Inbred BALB C
Chemical Substances	Drugs, Chinese Herbal ; you-gui-wan
Language	English
Publishing date	2021-05-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom11060812
Database	MEDical Literature Analysis and Retrieval System OnLINE

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