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  1. AU="Kaori Yamamoto"
  2. AU="Cernei C."
  3. AU="Faiz Alfaiz"
  4. AU="Fallon, Anne"
  5. AU="Ramos, Davi L."
  6. AU="Mancini, Valentina"
  7. AU="Lamothe, Valérie"
  8. AU=Powell-Jackson P R AU=Powell-Jackson P R
  9. AU="Neeltje A Kootstra"
  10. AU=Gloria e Silva Filipe AU=Gloria e Silva Filipe
  11. AU="Shuaijia Hao"
  12. AU=Heinrichs Stefan
  13. AU="Khosravan, Shahla"
  14. AU=Garcia-Carracedo Dario
  15. AU="Lannon, Margaret C"
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  17. AU="Choza, Juliana"
  18. AU=Tronin Andrey Y.
  19. AU="Singh, Jyoti"
  20. AU=Charlier Philippe
  21. AU="Thiermann, Horst"
  22. AU="Gullo, Paride"
  23. AU="Lewis, Gayle"
  24. AU=Jain Harshwardhan AU=Jain Harshwardhan
  25. AU="Gaur, Aman"
  26. AU=Huynh Thu P.
  27. AU=Giebel Clarissa
  28. AU=Laskin Daniel M

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  1. Artikel ; Online: Healing rate of macular edema secondary to branch retinal vein occlusion in two years after initiation of intravitreal ranibizumab later combined with other treatment as needed and characteristics of refractory cases.

    Setsuko Kawakami / Yoshihiro Wakabayashi / Yoko Watanabe / Kazuhiko Umazume / Kaori Yamamoto / Hiroshi Goto

    PLoS ONE, Vol 18, Iss 1, p e

    2023  Band 0278968

    Abstract: Purpose To investigate the 2-year healing rate of macular edema (ME) secondary to branch retinal vein occlusion (BRVO) treated initially with intravitreal ranibizumab (IVR) and later combined with other treatment as needed, and the characteristics of ... ...

    Abstract Purpose To investigate the 2-year healing rate of macular edema (ME) secondary to branch retinal vein occlusion (BRVO) treated initially with intravitreal ranibizumab (IVR) and later combined with other treatment as needed, and the characteristics of refractory cases. Methods 130 patients (130 eyes) with BRVO-ME who received IVR initially were studied. Anti-vascular endothelial growth factor drug was additionally administered when ME relapsed or persisted. Photocoagulation was performed when the non-perfusion area (NPA) was ≥5 disc diameter (DD), and/or when ME relapsed due to microaneurysm. Patients were classified into a healed group [ME resolved in <2 years or mild ME remained without best-corrected visual acuity (BCVA) loss for ≥6 months] or refractory group (ME persisted for ≥2 years). Results 110 eyes were classified into the healed group, and 20 eyes into the refractory group. The healed group and refractory group had, respectively, mean follow-up periods of 21.2 and 37.4 months, and frequencies of NPA ≥5 DD of 55.5 and 25.0% (p = 0.015). In the healed group, mean BCVA (logMAR) improved significantly compared to baseline in all the periods until 24 months after treatment initiation and at the last visit (p<0.001). In the refractory group, mean BCVA improved significantly compared to baseline until 12 months after treatment initiation (p<0.05 for all periods), but was not significantly different at 18 or 24 months or at the last visit. Conclusion In patients with BRVO-ME treated initially with IVR and later given additional treatments as needed, the healing rate was 84.6%. In eyes that healed within 2 years, BCVA improved relative to baseline throughout 24 months and at the last visit. In refractory eyes, BCVA improved only until 12 months, and thereafter deteriorated to baseline level at the last examination.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel: Staphylococcal food poisoning caused by Staphylococcus argenteus harboring staphylococcal enterotoxin genes

    Wakabayashi, Yuki / Hiromi Nakamura / Kaori Yamamoto / Kaoru Umeda / Kentaro Kawatsu / Shinya Yonogi / Yuko Kumeda

    International journal of food microbiology. 2018 Jan. 16, v. 265

    2018  

    Abstract: Staphylococcal food poisoning (SFP) is caused by staphylococcal enterotoxins (SEs) preformed in food materials. SE genes are encoded on mobile genetic elements and are widely found across Staphylococcus species including S. argenteus, although most SFP ... ...

    Abstract Staphylococcal food poisoning (SFP) is caused by staphylococcal enterotoxins (SEs) preformed in food materials. SE genes are encoded on mobile genetic elements and are widely found across Staphylococcus species including S. argenteus, although most SFP cases are caused by S. aureus. S. argenteus, recently discriminated from S. aureus as a novel species, are non-pigmented staphylococci phenotypically related to S. aureus. In 2014 and 2015, two independent food poisoning cases occurred in Osaka, Japan, in which non-pigmented staphylococci were predominantly isolated. Several enterotoxin genes (seb, seg, sei, sem, sen, seo, and selu2) were found in their genome and the production of SEB was confirmed by reverse passive agglutination tests. The non-pigmented isolates from patients, food handlers, food, and cooking utensils all produced the same pulsed-field gel electrophoresis pattern. These non-pigmented isolates were coagulase-positive and biochemically identical to S. aureus. We performed further genetic analysis using nucA sequencing and multi-locus sequence typing, and identified these isolates as S. argenteus. We also found that seb was encoded on the Staphylococcus aureus pathogenicity island, while seg, sei, sem, sen, seo, and selu2 were encoded on the enterotoxin gene cluster. From these results, we concluded that the two food poisoning outbreaks were SFP cases caused by S. argenteus harboring SE genes.
    Schlagwörter agglutination tests ; cooking utensils ; enterotoxins ; food handling ; genetic analysis ; interspersed repetitive sequences ; multigene family ; multilocus sequence typing ; pathogenicity islands ; patients ; poisoning ; pulsed-field gel electrophoresis ; staphylococcal intoxication ; Staphylococcus aureus ; Japan
    Sprache Englisch
    Erscheinungsverlauf 2018-0116
    Umfang p. 23-29.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 87122-9
    ISSN 1879-3460 ; 0168-1605
    ISSN (online) 1879-3460
    ISSN 0168-1605
    DOI 10.1016/j.ijfoodmicro.2017.10.022
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel ; Online: Clonality and micro-diversity of a nationwide spreading genotype of Mycobacterium tuberculosis in Japan.

    Takayuki Wada / Tomotada Iwamoto / Aki Tamaru / Junji Seto / Tadayuki Ahiko / Kaori Yamamoto / Atushi Hase / Shinji Maeda / Taro Yamamoto

    PLoS ONE, Vol 10, Iss 3, p e

    2015  Band 0118495

    Abstract: Mycobacterium tuberculosis transmission routes can be estimated from genotypic analysis of clinical isolates from patients. In Japan, still a middle-incidence country of TB, a unique genotype strain designated as 'M-strain' has been isolated nationwide ... ...

    Abstract Mycobacterium tuberculosis transmission routes can be estimated from genotypic analysis of clinical isolates from patients. In Japan, still a middle-incidence country of TB, a unique genotype strain designated as 'M-strain' has been isolated nationwide recently. To ascertain the history of the wide spread of the strain, 10 clinical isolates from different areas were subjected to genome-wide analysis based on deep sequencers. Results show that all isolates possessed common mutations to those of referential strains. The greatest number of accumulated single nucleotide variants (SNVs) from the oldest coalescence was 13 nucleotides, indicating high clonality of these isolates. When an SNV common to the isolates was used as a surrogate marker of the clone, authentic clonal isolates with variation in a reliable subset of variable number of tandem repeat (VNTR) genotyping method can be selected successfully from clinical isolates populations of M. tuberculosis. When the authentic clones can also be assigned to sub-clonal groups by SNVs derived from the genomic comparison, they are classifiable into three sub-clonal groups with a bias of geographical origins. Feedback from genomic analysis of clinical isolates of M. tuberculosis to genotypic markers will be an efficient strategy for the big data in various settings for public health actions against TB.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2015-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Molecular and epidemiological characterization of staphylococcal foodborne outbreak of Staphylococcus aureus harboring seg, sei, sem, sen, seo, and selu genes without production of classical enterotoxins

    Umeda, Kaoru / Atsushi Hase / Hiromi Nakamura / Jun Ogasawara / Kaori Yamamoto / Kaoru Goto / Kiyoshi Yasufuku / Nobuko Nishina / Teruo Hirayama / Yuki Hirai

    International journal of food microbiology. 2017 Sept. 01, v. 256

    2017  

    Abstract: Staphylococcal food poisoning is the result of consumption of food contaminated with staphylococcal enterotoxins (SEs) produced by Staphylococcus aureus. To date, 23 SEs and SE-like enterotoxins (SEls) have been described in the literature. They are ... ...

    Abstract Staphylococcal food poisoning is the result of consumption of food contaminated with staphylococcal enterotoxins (SEs) produced by Staphylococcus aureus. To date, 23 SEs and SE-like enterotoxins (SEls) have been described in the literature. They are divided into classical SEs (SEA-SEE) and new SE/SEls (SEG-SElX). Some have proved to be foodborne-inducible, but others remain unidentified. In May 2016, at an elderly group home in Osaka city, Japan, an outbreak from foodborne pathogens occurred among lunch party participants. Within 2h 30min to 4h 40min, 15 of 53 participants presented gastrointestinal symptoms of vomiting, diarrhea, and nausea. A subsequent laboratory investigation detected S. aureus from most stool samples from patients, several left-over food items, a kitchen swab, and hand swabs from two food handlers. Classical SEs was not detected from S. aureus isolates or left-over food items. From examination for the presence of SE/SEl genes of 20 kinds by PCR, seg, sei, sem, sen, seo, and selu genes were detected in almost all isolates. These isolates exhibited identical or closely related types by coagulase type (type VII), Sma I digested pulsed-field gel electrophoresis analysis and multi-locus sequence typing (MLST-CC45 lineage). These results suggest that the foodborne outbreak was caused by S. aureus harboring seg, sei, sem, sen, seo, and selu genes without production of classical SEs. Additionally, some S. aureus isolates from human nasal swabs and healthy human feces harboring seg, sei, sem, sen, seo, and selu genes without production of classical SEs were classified into CC45 lineage using MLST. These findings suggest new SE/SEls as a potential cause of foodborne outbreaks.
    Schlagwörter diarrhea ; elderly ; enterotoxins ; feces ; food handling ; food pathogens ; gastrointestinal system ; genes ; humans ; lunch ; multilocus sequence typing ; nausea ; nose ; patients ; polymerase chain reaction ; pulsed-field gel electrophoresis ; staphylococcal intoxication ; Staphylococcus aureus ; vomiting ; Japan
    Sprache Englisch
    Erscheinungsverlauf 2017-0901
    Umfang p. 30-35.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 87122-9
    ISSN 1879-3460 ; 0168-1605
    ISSN (online) 1879-3460
    ISSN 0168-1605
    DOI 10.1016/j.ijfoodmicro.2017.05.023
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  5. Artikel ; Online: Rapid On-Site Evaluation by Endosonographers during Endoscopic Ultrasonography-Guided Fine-Needle Aspiration for Diagnosis of Gastrointestinal Stromal Tumors

    Takashi Tamura / Yasunobu Yamashita / Kazuki Ueda / Yuki Kawaji / Masahiro Itonaga / Shin-ichi Murata / Kaori Yamamoto / Takeichi Yoshida / Hiroki Maeda / Takao Maekita / Mikitaka Iguchi / Hideyuki Tamai / Masao Ichinose / Jun Kato

    Clinical Endoscopy, Vol 50, Iss 4, Pp 372-

    2017  Band 378

    Abstract: Background/Aims Endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) has been used to diagnose gastrointestinal submucosal tumors (SMTs). Although rapid on-site evaluation (ROSE) has been reported to improve the diagnostic accuracy of EUS- ... ...

    Abstract Background/Aims Endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) has been used to diagnose gastrointestinal submucosal tumors (SMTs). Although rapid on-site evaluation (ROSE) has been reported to improve the diagnostic accuracy of EUS-FNA for pancreatic lesions, on-site cytopathologists are not routinely available. Given this background, the usefulness of ROSE by endosonographers themselves for pancreatic tumors has also been reported. However, ROSE by endosonographers for diagnosis of SMT has not been reported. The aim of this study was to evaluate the diagnostic accuracy of EUS-FNA with ROSE by endosonographers for SMT, focusing on diagnosis of gastrointestinal stromal tumor (GIST), compared with that of EUS-FNA alone. Methods Twenty-two consecutive patients who underwent EUS-FNA with ROSE by endosonographers for SMT followed by surgical resection were identified. Ten historical control subjects who underwent EUS-FNA without ROSE were used for comparison. Results The overall diagnostic accuracy for SMT was significantly higher in cases with than without ROSE (100% vs. 80%, p=0.03). The number of needle passes by FNA with ROSE by endosonographers tended to be fewer, although accuracy was increased (3.3±1.3 vs. 5.9±3.8, p=0.06). Conclusions ROSE by endosonographers during EUS-FNA for SMT is useful for definitive diagnosis, particularly for GIST.
    Schlagwörter Endoscopic ultrasound-guided fine needle aspiration ; Gastrointestinal stromal tumor ; Endosonographer ; On-site cytology ; Internal medicine ; RC31-1245 ; Diseases of the digestive system. Gastroenterology ; RC799-869
    Sprache Englisch
    Erscheinungsdatum 2017-07-01T00:00:00Z
    Verlag Hoon Jai Chun
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel: Phylogenetic assignment of Mycobacterium tuberculosis Beijing clinical isolates in Japan by maximum a posteriori estimation

    Seto, Junji / Takayuki Wada / Tomotada Iwamoto / Aki Tamaru / Shinji Maeda / Kaori Yamamoto / Atsushi Hase / Koichi Murakami / Eriko Maeda / Akira Oishi / Yuji Migita / Taro Yamamoto / Tadayuki Ahiko

    Infection, Genetics and Evolution. 2015 Oct., v. 35

    2015  

    Abstract: Intra-species phylogeny of Mycobacterium tuberculosis has been regarded as a clue to estimate its potential risk to develop drug-resistance and various epidemiological tendencies. Genotypic characterization of variable number of tandem repeats (VNTR), a ... ...

    Abstract Intra-species phylogeny of Mycobacterium tuberculosis has been regarded as a clue to estimate its potential risk to develop drug-resistance and various epidemiological tendencies. Genotypic characterization of variable number of tandem repeats (VNTR), a standard tool to ascertain transmission routes, has been improving as a public health effort, but determining phylogenetic information from those efforts alone is difficult. We present a platform based on maximum a posteriori (MAP) estimation to estimate phylogenetic information for M. tuberculosis clinical isolates from individual profiles of VNTR types. This study used 1245 M. tuberculosis clinical isolates obtained throughout Japan for construction of an MAP estimation formula. Two MAP estimation formulae, classification of Beijing family and other lineages, and classification of five Beijing sublineages (ST11/26, STK, ST3, and ST25/19 belonging to the ancient Beijing subfamily and modern Beijing subfamily), were created based on 24 loci VNTR (24Beijing-VNTR) profiles and phylogenetic information of the isolates. Recursive estimation based on the formulae showed high concordance with their authentic phylogeny by multi-locus sequence typing (MLST) of the isolates. The formulae might further support phylogenetic estimation of the Beijing lineage M. tuberculosis from the VNTR genotype with various geographic backgrounds. These results suggest that MAP estimation can function as a reliable probabilistic process to append phylogenetic information to VNTR genotypes of M. tuberculosis independently, which might improve the usage of genotyping data for control, understanding, prevention, and treatment of TB.
    Schlagwörter Mycobacterium tuberculosis ; drug resistance ; genotype ; minisatellite repeats ; multilocus sequence typing ; phylogeny ; risk ; Japan
    Sprache Englisch
    Erscheinungsverlauf 2015-10
    Umfang p. 82-88.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 2037068-4
    ISSN 1567-1348
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2015.07.029
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  7. Artikel: Structural Snapshots of Actively Translating Human Ribosomes

    Behrmann, Elmar / Justus Loerke / Tatyana V. Budkevich / Kaori Yamamoto / Andrea Schmidt / Pawel A. Penczek / Matthijn R. Vos / Jörg Bürger / Thorsten Mielke / Patrick Scheerer / Christian M.T. Spahn

    Cell. 2015 May 07, v. 161

    2015  

    Abstract: Macromolecular machines, such as the ribosome, undergo large-scale conformational changes during their functional cycles. Although their mode of action is often compared to that of mechanical machines, a crucial difference is that, at the molecular ... ...

    Abstract Macromolecular machines, such as the ribosome, undergo large-scale conformational changes during their functional cycles. Although their mode of action is often compared to that of mechanical machines, a crucial difference is that, at the molecular dimension, thermodynamic effects dominate functional cycles, with proteins fluctuating stochastically between functional states defined by energetic minima on an energy landscape. Here, we have used cryo-electron microscopy to image ex-vivo-derived human polysomes as a source of actively translating ribosomes. Multiparticle refinement and 3D variability analysis allowed us to visualize a variety of native translation intermediates. Significantly populated states include not only elongation cycle intermediates in pre- and post-translocational states, but also eEF1A-containing decoding and termination/recycling complexes. Focusing on the post-translocational state, we extended this assessment to the single-residue level, uncovering striking details of ribosome-ligand interactions and identifying both static and functionally important dynamic elements.
    Schlagwörter cryo-electron microscopy ; equipment ; humans ; image analysis ; mechanism of action ; polyribosomes ; proteins ; thermodynamics
    Sprache Englisch
    Erscheinungsverlauf 2015-0507
    Umfang p. 845-857.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2015.03.052
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