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Article: Silver nitrate stick helps manage aphthous ulcers.

Kaplan, A S

2001 Volume 64, Issue 5, Page(s) 737

MeSH term(s)	Humans ; Pain/etiology ; Silver Nitrate/adverse effects ; Silver Nitrate/therapeutic use ; Stomatitis, Aphthous/complications ; Stomatitis, Aphthous/therapy
Chemical Substances	Silver Nitrate (95IT3W8JZE)
Language	English
Publishing date	2001-09-01
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	412694-4
ISSN	0002-838X ; 0572-3612
ISSN	0002-838X ; 0572-3612
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Article: History and examination of the orofacial pain patient.

Kaplan, A S

Texas dental journal

2000 Volume 117, Issue 7, Page(s) 42–49

Abstract: Taking a history and performing an examination on an orofacial pain patient differs significantly from that in the general dental patient. Orofacial pain dentists must be familiar with the disorders that cause chronic head and neck pain. In addition, ... ...

Abstract	Taking a history and performing an examination on an orofacial pain patient differs significantly from that in the general dental patient. Orofacial pain dentists must be familiar with the disorders that cause chronic head and neck pain. In addition, they must know the pertinent aspects of history taking with regard to the chief complaint, history of the present illness, the relevance of the past medical and dental history and how the social history can act as an important etiologic and prognostic factor. The clinician must also be versed in the elements of the orofacial pain examination which include evaluation of the TMJ and cervical spine; head, neck and dental examination; and, often, neurological and otolaryngological screening. The clinician should also have a familiarity with blood testing, urinalysis and know the uses and limitations of diagnostic imaging.
MeSH term(s)	Anesthetics, Local ; Chronic Disease ; Dental Occlusion ; Diagnostic Imaging ; Facial Pain/blood ; Facial Pain/diagnosis ; Facial Pain/urine ; Headache/diagnosis ; Humans ; Masticatory Muscles/physiopathology ; Medical History Taking ; Neck Pain/diagnosis ; Neurologic Examination ; Otorhinolaryngologic Diseases/diagnosis ; Pain Measurement ; Physical Examination ; Prognosis ; Social Adjustment ; Temporomandibular Joint Disorders/diagnosis
Chemical Substances	Anesthetics, Local
Language	English
Publishing date	2000-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	412554-x
ISSN	0040-4284
ISSN	0040-4284
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Article ; Online: The role of depression and childhood trauma on cortisol suppression in women with bulimia nervosa: a pilot study.

Yilmaz, Z / Kaplan, A S / Levitan, R D

Eating and weight disorders : EWD

2012 Volume 17, Issue 1, Page(s) e17–21

Abstract: Objective: Although some studies have shown cortisol nonsuppression following dexamethasone suppression test (DST) in current bulimia nervosa (BN), no study has looked at HPA axis abnormalities in behaviorally recovered BN patients. The purpose of this ... ...

Abstract	Objective: Although some studies have shown cortisol nonsuppression following dexamethasone suppression test (DST) in current bulimia nervosa (BN), no study has looked at HPA axis abnormalities in behaviorally recovered BN patients. The purpose of this pilot study is to explore the role of current vs behaviorally recovered BN, as well as depression and childhood trauma in cortisol suppression in BN. Methods: A 0.5 mg DST was performed on 21 patients with behaviorally recovered BN, 9 women with current BN and 14 controls. BN group also completed the Hamilton Depression Rating Scale and Childhood Trauma Questionnaire. Results: There were no differences between the three groups in cortisol suppression, and BMI was not associated with cortisol levels following DST. Within the BN group, depression was significantly associated with afternoon cortisol nonsuppression (p=0.005). Discussion: As researchers look for more accurate ways to identify biological phenotypes of BN, presence of comorbid depression may help explain differences in cortisol suppression.
MeSH term(s)	Adolescent ; Adult ; Adult Survivors of Child Abuse/psychology ; Body Mass Index ; Bulimia Nervosa/metabolism ; Bulimia Nervosa/psychology ; Case-Control Studies ; Depression/metabolism ; Dexamethasone/pharmacology ; Female ; Glucocorticoids/pharmacology ; Humans ; Hydrocortisone/analysis ; Hydrocortisone/metabolism ; Hypothalamo-Hypophyseal System/drug effects ; Hypothalamo-Hypophyseal System/metabolism ; Pilot Projects ; Pituitary-Adrenal System/drug effects ; Pituitary-Adrenal System/metabolism ; Saliva/chemistry
Chemical Substances	Glucocorticoids ; Dexamethasone (7S5I7G3JQL) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2012-07-03
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2038625-4
ISSN	1590-1262 ; 1124-4909
ISSN (online)	1590-1262
ISSN	1124-4909
DOI	10.1007/BF03325324
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Article: History and examination of the orofacial pain patient.

Kaplan, A S

Dental clinics of North America

1997 Volume 41, Issue 2, Page(s) 155–166

Abstract: The clinician should recognize the importance of screening examinations for all patients seen in the dental office. The elements of a brief screening history and examination have been reviewed. In addition, the indications and elements of a comprehensive ...

Abstract	The clinician should recognize the importance of screening examinations for all patients seen in the dental office. The elements of a brief screening history and examination have been reviewed. In addition, the indications and elements of a comprehensive history and examination have been described. A discussion of current opinion on available diagnostic testing was also presented.
MeSH term(s)	Anesthetics, Local ; Arthrography ; Diagnosis, Oral ; Facial Pain/diagnosis ; Facial Pain/etiology ; Humans ; Malocclusion/diagnosis ; Medical History Taking ; Neurologic Examination ; Physical Examination ; Psychological Tests ; Temporomandibular Joint Disorders/complications ; Temporomandibular Joint Disorders/diagnosis
Chemical Substances	Anesthetics, Local
Language	English
Publishing date	1997-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	392075-6
ISSN	1558-0512 ; 0011-8532
ISSN (online)	1558-0512
ISSN	0011-8532
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Article: New perspectives on the eating disorders.

Kaplan, A S

Journal of psychiatry & neuroscience : JPN

1996 Volume 21, Issue 1, Page(s) 7–8

MeSH term(s)	Anorexia Nervosa/diagnosis ; Anorexia Nervosa/psychology ; Bulimia/diagnosis ; Bulimia/psychology ; Cognition Disorders ; Humans ; Obsessive-Compulsive Disorder/diagnosis ; Obsessive-Compulsive Disorder/psychology ; Psychometrics ; Serotonin/physiology
Chemical Substances	Serotonin (333DO1RDJY)
Language	English
Publishing date	1996-01
Publishing country	Canada
Document type	Editorial
ZDB-ID	1077443-9
ISSN	1180-4882
ISSN	1180-4882
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Article: Dual antibody response to coxsackie and poliomyelitis viruses in patients with paralytic poliomyelitis.

MELNICK, J L / KAPLAN, A S

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

2004 Volume 74, Issue 4, Page(s) 812–815

MeSH term(s)	Antibody Formation ; Enterovirus ; Poliomyelitis ; Poliovirus
Language	English
Publishing date	2004-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.3181/00379727-74-18057
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Article: Oral administration of Coxsackie viruses to newborn and adult mice.

KAPLAN, A S / MELNICK, J L

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

2004 Volume 76, Issue 2, Page(s) 312–315

MeSH term(s)	Administration, Oral ; Animals ; Enterovirus ; Mice
Language	English
Publishing date	2004-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.3181/00379727-76-18475
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Article: KINETICS OF SYNTHESIS OF VARIOUS TYPES OF ANTIGENIC PROTEINS IN CELLS INFECTED WITH PSEUDORABIES VIRUS.

HAMADA, C / KAPLAN, A S

Journal of bacteriology

2003 Volume 89, Page(s) 1328–1334

Abstract: Hamada, Chuya (Albert Einstein Medical Center, Philadelphia, Pa.), and Albert S. Kaplan. Kinetics of synthesis of various types of antigenic proteins in cells infected with pseudorabies virus. J. Bacteriol. 89:1328-1334. 1965.-By means of an indirect ... ...

Abstract	Hamada, Chuya (Albert Einstein Medical Center, Philadelphia, Pa.), and Albert S. Kaplan. Kinetics of synthesis of various types of antigenic proteins in cells infected with pseudorabies virus. J. Bacteriol. 89:1328-1334. 1965.-By means of an indirect precipitation test, a determination was made of the rates of synthesis of various types of serologically specific proteins in rabbit kidney cells infected with pseudorabies virus. The rate of synthesis of cell-specific protein decreased after infection. During the early stages of the infective process, proteins which bear no precursor relationship to the viral particles (nonstructural viral proteins) and which cannot be detected in noninfected cells were formed. Almost concurrently with these nonstructural proteins, synthesis of virus precursor proteins began. The synthesis of these proteins preceded the formation of mature virus and continued until the end of the virus growth cycle.
MeSH term(s)	Animals ; Antigens ; Carbon Isotopes ; DNA ; DNA, Viral ; Herpesviridae ; Herpesvirus 1, Suid ; Kinetics ; Precipitin Tests ; Proteins/metabolism ; Pseudorabies ; Rabbits ; Research ; Thymidine ; Tissue Culture Techniques ; Viral Proteins ; Virus Cultivation ; gamma-Globulins
Chemical Substances	Antigens ; Carbon Isotopes ; DNA, Viral ; Proteins ; Viral Proteins ; gamma-Globulins ; DNA (9007-49-2) ; Thymidine (VC2W18DGKR)
Language	English
Publishing date	2003-08-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2968-3
ISSN	1098-5530 ; 0021-9193
ISSN (online)	1098-5530
ISSN	0021-9193
DOI	10.1128/jb.89.5.1328-1334.1965
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Article: Quantitative studies of the virus-host relationship in chimpanzees after inapparent infection with Coxsackie viruses. I. The virus carrier state and the development of neutralizing antibodies.

MELNICK, J L / KAPLAN, A S

The Journal of experimental medicine

2003 Volume 97, Issue 3, Page(s) 367–400

Abstract: Following oral administration of Coxsackie viruses (C viruses) to susceptible chimpanzees, these agents can be isolated from the throat for a period of approximately a week, from the blood for a few days, and from the stools for 2 to 3 weeks or even ... ...

Abstract	Following oral administration of Coxsackie viruses (C viruses) to susceptible chimpanzees, these agents can be isolated from the throat for a period of approximately a week, from the blood for a few days, and from the stools for 2 to 3 weeks or even longer. Animals so infected respond with the formation of specific neutralizing antibodies which are maintained for at least 1 to 2 years. Such chimpanzees are immune when challenged orally with homologous strains of virus. They then excrete virus in the stools for 3 or 4 days (passive transfer); no virus can be recovered from the throats and blood of these animals, and neutralizing antibody levels remain unchanged. Animals immune to one antigenic type of C virus can be infected by feeding a different antigenic type. Following such a heterotypic challenge, virus can again be isolated from the throat, blood, and stools; neutralizing antibodies develop to the new strain. Antibodies to the Texas-1 type of C virus were already present in four chimpanzees upon their arrival in the laboratory from Africa. It was possible to set up intestinal carriage of the Texas-1 virus in these animals and to demonstrate a 10- to 100-fold increase in titer of neutralizing, as well as complement-fixing, antibody. Quantitative titrations of the amount of virus present in the stools and throat were performed. Immediately after the first feeding of virus relatively large amounts can be detected in the stools; the titer drops, but may be maintained for as long as 25 days at 10(-2) to 10(-3), furnishing evidence that virus multiplication has taken place. Virus in the throat reached the same order of magnitude at first as in the stools but there was a rapid decline to zero in a few days. The Ohio-1 virus differed from the others in that it persisted in the throat as long as in the stools, and in several instances reached a higher titer in the throat. Following homotypic challenge with all types, virus could be detected in the stools for only a relatively short period of time and at low concentration. Virus-neutralizing substances could not be detected in the stools or throat swabs of convalescent animals, at a time when their serum-neutralizing antibody titers were high. Under the limited conditions of the present experiments, C viruses had no effect on the infection of chimpanzees with three different antigenic types of poliomyelitis virus. Both poliomyelitis and C viruses set up independent infections without apparent interaction between them. No enhancement of the poliomyelitis infection took place, as was plain from the fact that none of the infected chimpanzees became paralyzed. a titration of Texas-1 C virus in four chimpanzees revealed that a suspension of infected tissue diluted to 10(6.0) could cause the development of the carrier state; accidental infection of control animals with other Coxsackie types indicated also that very little virus may be necessary to initiate infection. Seven distinct antigenic types of C virus were inoculated subcutaneously and intramuscularly at the same time into four chimpanzees. The response was the same as that following feeding; virus could be recovered from the throat, blood, and stools, and the animals developed neutralizing antibodies to all seven types of C virus. There was no detectable interference among the viruses. Cortisone did not bring about the reappearance of the virus excretion in chimpanzees previously infected and shown to be intestinal carriers of poliomyelitis and Coxsackie viruses.
MeSH term(s)	Animals ; Antibodies ; Antibodies, Neutralizing ; Carrier State ; Enterovirus ; Infection ; Pan troglodytes ; Poliomyelitis
Chemical Substances	Antibodies ; Antibodies, Neutralizing
Language	English
Publishing date	2003-07-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.97.3.367
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Article: The intracellular localization of poliomyelitis virus.

KAPLAN, A S / MELNICK, J L

The Journal of experimental medicine

2003 Volume 97, Issue 1, Page(s) 91–116

Abstract: A study was made of the intracellular localization of Type 2 poliomyelitis virus, using the technique of Mirsky and Pollister (23) for cellular fractionation. After isotonic saline homogenization of central nervous system tissue from infected mice, and ... ...

Abstract	A study was made of the intracellular localization of Type 2 poliomyelitis virus, using the technique of Mirsky and Pollister (23) for cellular fractionation. After isotonic saline homogenization of central nervous system tissue from infected mice, and subsequent centrifugation of the suspension, the virus present in the supernatant fluid was held to be of cytoplasmic origin. Upon serial washings of the sediment with physiological saline, the resulting supernates contained progressively less virus until by the seventh washing, virtually none was present. At this point extraction of the washed sediment with molar NaCl, which lyses the nuclei, yielded substantial amounts of virus, and this was assumed to be from nuclear sources. The possibility has not been excluded however that the "nuclear" sediment was contaminated by cytoplasmic particles too large to remain in the supernate. Experiments on the increase of virus during the incubation and acute stages of infection have revealed that it was first detectable in the "cytoplasmic" fraction and subsequently in the "nuclear" fraction. Virus in the "nuclear" fraction from paralyzed mice sometimes reached titers almost as high as those found in the "cytoplasm." Adsorption experiments indicated that the "nuclear" fraction of CNS tissue from normal, uninoculated mice did not adsorb added Type 2 poliomyelitis virus, nor did such fractions adsorb virus procured from the "cytoplasm" or "nuclei" of infected cells. Although individual mice varied in their response after virus injection, the "cytoplasmic" fraction of paralytic mice was found to contain virus regularly, whereas little more than half of the non-paralytic mice yielded it. When virus was present in the "cytoplasm," it could be found in the "nuclear" fraction of paralytic mice with much greater regularity than in that of non-paralytic mice. A comparison between the lines of the MEF1 strain of poliomyelitis virus, "adapted" and "non-adapted" to newborn mice, and the Lansing strain, revealed no differences in their intracellular increase. In both infant and adult mice, the chief difference in the findings with non-paralyzed and paralyzed mice lay in the greater concentration of virus in the "nuclear" fractions of the latter group.
MeSH term(s)	Animals ; Cell Nucleus ; Central Nervous System ; Cytoplasm ; Mice ; Mice, Inbred Strains ; Poliomyelitis ; Poliovirus
Language	English
Publishing date	2003-07-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.97.1.91
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