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  1. Book: Clinical Cases in Uveitis

    Sandhu, Harpal / Kaplan, Henry J

    Differential Diagnosis and Management

    2021  

    Keywords MHMC100
    Language English
    Size 400 p.
    Publisher Elsevier Science
    Document type Book
    Note PDA Manuell_10
    Format 151 x 228 x 15
    ISBN 9780323695411 ; 0323695418
    Database PDA

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  2. Book ; Online ; E-Book: Cystoid macular edema

    Schaal, Shlomit / Kaplan, Henry J.

    medical and surgical management

    2017  

    Author's details Shlomit Schaal, Henry J. Kaplan, editors
    Keywords Macular Edema / surgery
    Language English
    Size 1 Online-Ressource (xiii, 239 Seiten), Illustrationen, 25 cm
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019472751
    ISBN 978-3-319-39766-5 ; 9783319397641 ; 3-319-39766-4 ; 3319397648
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  3. Article ; Online: Innovations in retinitis pigmentosa - Metabolic rescue of cones, gene therapy, retinal transplantation.

    Kaplan, Henry J

    Taiwan journal of ophthalmology

    2021  Volume 11, Issue 4, Page(s) 329–330

    Language English
    Publishing date 2021-12-09
    Publishing country India
    Document type Editorial
    ZDB-ID 2652841-1
    ISSN 2211-5072 ; 2211-5072
    ISSN (online) 2211-5072
    ISSN 2211-5072
    DOI 10.4103/tjo.tjo_50_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Role of Complement in the Onset of Age-Related Macular Degeneration.

    Piri, Niloofar / Kaplan, Henry J

    Biomolecules

    2023  Volume 13, Issue 5

    Abstract: Age-related macular degeneration (AMD) is a progressive degenerative disease of the central retina and the leading cause of severe loss of central vision in people over age 50. Patients gradually lose central visual acuity, compromising their ability to ... ...

    Abstract Age-related macular degeneration (AMD) is a progressive degenerative disease of the central retina and the leading cause of severe loss of central vision in people over age 50. Patients gradually lose central visual acuity, compromising their ability to read, write, drive, and recognize faces, all of which greatly impact daily life activities. Quality of life is significantly affected in these patients, and there are worse levels of depression as a result. AMD is a complex, multifactorial disease in which age and genetics, as well as environmental factors, all play a role in its development and progression. The mechanism by which these risk factors interact and converge towards AMD are not fully understood, and therefore, drug discovery is challenging, with no successful therapeutic attempt to prevent the development of this disease. In this review, we describe the pathophysiology of AMD and review the role of complement, which is a major risk factor in the development of AMD.
    MeSH term(s) Humans ; Middle Aged ; Quality of Life ; Macular Degeneration/drug therapy ; Retina ; Complement System Proteins ; Risk Factors
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2023-05-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13050832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Role of Adenosine in γδ T-Cell Regulation of Th17 Responses in Experimental Autoimmune Uveitis.

    Shao, Hui / Kaplan, Henry J / Sun, Deming

    Biomolecules

    2023  Volume 13, Issue 10

    Abstract: Autoimmune diseases caused by T cells can arise from either T-helper 1 (Th1) or T-helper 17 (Th17)-type pathogenic T cells. However, it is unclear whether these two T-cell subsets are influenced by distinct pathogenic factors and whether treatments that ... ...

    Abstract Autoimmune diseases caused by T cells can arise from either T-helper 1 (Th1) or T-helper 17 (Th17)-type pathogenic T cells. However, it is unclear whether these two T-cell subsets are influenced by distinct pathogenic factors and whether treatments that are effective for Th1 responses also work for Th17 responses. To compare these two pathogenic responses, we conducted a systematic analysis in a mouse model of experimental autoimmune uveitis (EAU) to identify the factors that promote or inhibit each response and to determine their responses to various treatments. Our study found that the two types of pathogenic responses differ significantly in their pathological progressions and susceptibility to treatments. Specifically, we observed that extracellular adenosine is a crucial pathogenic molecule involved in the pathogenicity of inflammation and T-cell reactivity and that reciprocal interaction between adenosine and gamma delta (γδ) T cells plays a significant role in amplifying Th17 responses in the development of autoimmune diseases. The potential effect of targeting adenosine or adenosine receptors is analyzed regarding whether such targeting constitutes an effective approach to modulating both γδ T-cell responses and the pathogenic Th17 responses in autoimmune diseases.
    MeSH term(s) Animals ; Mice ; Adenosine ; Receptors, Antigen, T-Cell, gamma-delta ; Autoimmune Diseases ; T-Lymphocyte Subsets ; Uveitis/pathology ; Mice, Inbred C57BL
    Chemical Substances Adenosine (K72T3FS567) ; Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2023-09-22
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13101432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Retinal Hydration Assessment With Optical Coherence Tomography: Unraveling Its Significance in Retinal Fluid Dynamics, Macular Edema and Cell Viability.

    Inam, Onur / Kaplan, Henry J / Tezel, Tongalp H

    Translational vision science & technology

    2023  Volume 12, Issue 8, Page(s) 4

    Abstract: Purpose: The purpose of this study was to quantify retinal hydration (RH) levels with optical coherence tomography (OCT) and determine the extent of cellular damage resulting from intraretinal fluid alterations.: Methods: We took 6.0 mm sections of ... ...

    Abstract Purpose: The purpose of this study was to quantify retinal hydration (RH) levels with optical coherence tomography (OCT) and determine the extent of cellular damage resulting from intraretinal fluid alterations.
    Methods: We took 6.0 mm sections of the human sensory retina that were excised from 18 fresh (<24 hours) donor eyes. They were either exposed to various osmotic stresses between 90 and 305 mOsm or dehydrated under a laminar flow hood. Change in tissue weight was used to calculate the retinal water content (RWC). Image analyses were conducted on OCT between 0 and 180 minutes to assess retinal thickness (RT) and "optically empty areas" (OEAs) representing intraretinal fluid. Correlations were sought among RWC, OEA, RWC, and RT. The effect of RH on retinal cell viability (RCV) was assessed with the Live-Dead Assay.
    Results: RH demonstrated a stronger correlation with the OEA than plain RT measurements (r = 0.99, P < 0.001). RH-RCV interaction fits well to a bell-shaped curve. A significant proportion of retinal cells (>80%) remained viable despite the change in RH ranging between 0.87 and 1.42 times. This "safe zone" was found to be associated with a 22% increase in OEA (r = 0.99, P < 0.01).
    Conclusions: OCT has been demonstrated as a valuable tool for assessing RH and can be used for intraretinal fluid content analysis. RH is a better indicator of RCV compared with RT. Computing RH may improve the determination of functional outcome of intravitreal pharmacotherapeutics used for diabetic macular edema and exudative age-related macular degeneration.
    Translational relevance: We link basic research and clinical care by assessing retinal hydration's impact on retinal fluid dynamics, macular edema, and cell viability.
    MeSH term(s) Humans ; Macular Edema/diagnostic imaging ; Tomography, Optical Coherence/methods ; Diabetic Retinopathy/diagnostic imaging ; Cell Survival ; Hydrodynamics ; Retina/diagnostic imaging
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2674602-5
    ISSN 2164-2591 ; 2164-2591
    ISSN (online) 2164-2591
    ISSN 2164-2591
    DOI 10.1167/tvst.12.8.4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Bidirectional Effect of IFN-γ on Th17 Responses in Experimental Autoimmune Uveitis.

    Shao, Hui / Kaplan, Henry J / Sun, Deming

    Frontiers in ophthalmology

    2022  Volume 2

    Abstract: Pro- and ant-inflammatory effects of IFN-γ have been repeatedly found in various immune responses, including cancer and autoimmune diseases. In a previous study we showed that the timing of treatment determines the effect of adenosine-based immunotherapy. ...

    Abstract Pro- and ant-inflammatory effects of IFN-γ have been repeatedly found in various immune responses, including cancer and autoimmune diseases. In a previous study we showed that the timing of treatment determines the effect of adenosine-based immunotherapy. In this study we examined the role of IFN-γ in pathogenic Th17 responses in experimental autoimmune uveitis (EAU). We observed that IFN-γ has a bidirectional effect on Th17 responses, when tested both
    Language English
    Publishing date 2022-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 3123828-2
    ISSN 2674-0826 ; 2674-0826
    ISSN (online) 2674-0826
    ISSN 2674-0826
    DOI 10.3389/fopht.2022.831084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Gene therapy for retinitis pigmentosa.

    Piri, Niloofar / Grodsky, Jacob D / Kaplan, Henry J

    Taiwan journal of ophthalmology

    2021  Volume 11, Issue 4, Page(s) 348–351

    Abstract: Rhodopsin-mediated autosomal dominant retinitis pigmentosa (RP) is the most common cause of RP in North America. There is no proven cure for the disease, and multiple approaches are being studied. Gene therapy is an evolving field in medicine and ... ...

    Abstract Rhodopsin-mediated autosomal dominant retinitis pigmentosa (RP) is the most common cause of RP in North America. There is no proven cure for the disease, and multiple approaches are being studied. Gene therapy is an evolving field in medicine and ophthalmology. In this review, we will go over the basic concept of gene therapy and the different types of gene therapy that are currently being studied to treat this disease.
    Language English
    Publishing date 2021-11-19
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2652841-1
    ISSN 2211-5072 ; 2211-5072
    ISSN (online) 2211-5072
    ISSN 2211-5072
    DOI 10.4103/tjo.tjo_47_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Damage-associated Molecular Patterns in Clinical and Animal Models of Uveitis.

    Kaplan, Henry J / Sun, Deming / Shao, Hui

    Ocular immunology and inflammation

    2021  Volume 30, Issue 3, Page(s) 734–740

    MeSH term(s) Animals ; Autoimmune Diseases ; Disease Models, Animal ; Models, Animal ; Uveitis/diagnosis
    Language English
    Publishing date 2021-09-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2021.1954203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Book: Cystoid macular edema

    Schaal, Shlomit / Kaplan, Henry J

    medical and surgical management

    2017  

    Author's details Shlomit Schaal, Henry J. Kaplan, editors
    MeSH term(s) Macular Edema/surgery
    Language English
    Size xiii, 239 pages :, illustrations (partly color) ;, 25 cm
    Document type Book
    ISBN 9783319397641 ; 3319397648 ; 9783319397665 ; 3319397664
    Database Catalogue of the US National Library of Medicine (NLM)

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