Article ; Online: It is not NOD2 - genetic and clinical risk factors for postoperative complications following ileocolic resection in Crohn's disease.
International journal of colorectal disease
2022 Volume 37, Issue 8, Page(s) 1901–1908
Abstract: Purpose: To evaluate the role of the nucleotide oligomerization domain 2 (NOD2) mutation status and other risk factors for the incidence of postoperative complications after ileocolic resection for Crohn's disease (CD).: Methods: Data of 138 patients ...
| Abstract | Purpose: To evaluate the role of the nucleotide oligomerization domain 2 (NOD2) mutation status and other risk factors for the incidence of postoperative complications after ileocolic resection for Crohn's disease (CD). Methods: Data of 138 patients consecutively undergoing ileocolic resection for CD at a tertiary academic referral center were retrospectively analyzed including single nucleotide polymorphism (SNP) data of the NOD2 gene. Uni- and multivariate regression analysis was performed to identify factors associated with increased risk of severe postoperative complications. Results: From 114 patients (83%), the NOD2 mutation status was available. Of these, 60 (53%) had a NOD2 wildtype, whereas eleven (10%) were homozygous for the high risk p.Leu1007fsX1008 (rs2066847) variant. Major postoperative complications occurred in 28 patients (20%). Twenty-seven of these (96%) were intraabdominal septic complications such as anastomotic leakage or abscess. Male gender (P = 0.029; OR 3.052, the duration of CD (time [months] from initial diagnosis of CD to surgery; P = 0.001; OR 1.009), previous abdominal surgery for CD (P = 0.017; OR 3.49), and the presence of enteric fistulas (P = 0.023; OR 3.21) were identified as independent risk factors for major postoperative complications. Homozygosity for the NOD2 high-risk variant p.Leu1007fsX1008 did not show increased postoperative morbidity in the short and long-term outcome. Conclusions: We could detect independent risk factors for major postoperative complications after ileocolic resection for Crohn's disease. However, patients with the high-risk variant p.Leu1007fsX1008 of the NOD2 gene did not show increased postoperative morbidity. |
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| MeSH term(s) | Crohn Disease/complications ; Crohn Disease/genetics ; Crohn Disease/surgery ; Humans ; Male ; Nod2 Signaling Adaptor Protein/genetics ; Nucleotides ; Postoperative Complications/genetics ; Retrospective Studies ; Risk Factors | |||||
| Chemical Substances | Nod2 Signaling Adaptor Protein ; Nucleotides | |||||
| Language | English | |||||
| Publishing date | 2022-08-01 | |||||
| Publishing country | Germany | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 84975-3 | |||||
| ISSN | 1432-1262 ; 0179-1958 | |||||
| ISSN (online) | 1432-1262 | |||||
| ISSN | 0179-1958 | |||||
| DOI | 10.1007/s00384-022-04223-6 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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