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  1. Article: Circulating Tumour DNA and Its Prognostic Role in Management of Muscle Invasive Bladder Cancer: A Narrative Review of the Literature.

    Kapriniotis, Konstantinos / Tzelves, Lazaros / Lazarou, Lazaros / Mitsogianni, Maria / Mitsogiannis, Iraklis

    Biomedicines

    2024  Volume 12, Issue 4

    Abstract: Current management of non-metastatic muscle invasive bladder cancer (MIBC) includes radical cystectomy and cisplatin-based neoadjuvant chemotherapy (NAC), offers a 5-year survival rate of approximately 50% and is associated with significant toxicities. A ...

    Abstract Current management of non-metastatic muscle invasive bladder cancer (MIBC) includes radical cystectomy and cisplatin-based neoadjuvant chemotherapy (NAC), offers a 5-year survival rate of approximately 50% and is associated with significant toxicities. A growing body of evidence supports the role of liquid biopsies including circulating tumour DNA (ctDNA) as a prognostic and predictive marker that could stratify patients according to individualised risk of progression/recurrence. Detectable ctDNA levels prior to radical cystectomy have been shown to be correlated with higher risk of recurrence and worse overall prognosis after cystectomy. In addition, ctDNA status after NAC/neoadjuvant immunotherapy is predictive of the pathological response to these treatments, with persistently detectable ctDNA being associated with residual bladder tumour at cystectomy. Finally, detectable ctDNA levels post-cystectomy have been associated with disease relapse and worse disease-free (DFS) and overall survival (OS) and might identify a population with survival benefit from adjuvant immunotherapy.
    Language English
    Publishing date 2024-04-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12040921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The utility of Martius fat pad in the repair of urogenital fistulae: review of current evidence.

    Kapriniotis, Konstantinos / Loufopoulos, Ioannis / Gresty, Helena C M / Greenwell, Tamsin J / Ockrim, Jeremy L

    BJU international

    2024  

    Abstract: Objective: To present the contemporary evidence on transvaginal urogenital fistulae (UGF) repair with Martius fat pad (MFP), compared to direct graftless fistula repair.: Methods: We reviewed all available studies reporting lower UGF repair via the ... ...

    Abstract Objective: To present the contemporary evidence on transvaginal urogenital fistulae (UGF) repair with Martius fat pad (MFP), compared to direct graftless fistula repair.
    Methods: We reviewed all available studies reporting lower UGF repair via the transvaginal approach in MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL). The primary outcome of interest was the fistula closure rates. When available, patients' baseline characteristics, indications for surgery, and early and late postoperative complications with focus on MFP-related complications are reported.
    Results and discussion: In obstetric fistulae, tissue interposition has been almost completely abandoned, with contemporary large series reporting closure rates of >90% with graftless repair, even for complex fistulae. Similarly, most simple, non-irradiated iatrogenic fistulae can be closed safely without or with tissue interposition with success rates ranging between 86% and 100%. However, MFP is valuable in fistulae with difficulty achieving tension-free and layered closure, with significant tissue loss, urethral involvement and with poorly vascularised tissues after radiotherapy, with reported success rates between 80% and 97% in those challenging situations.
    Conclusion: A UGF repair should be individualised after considering the specific characteristics and complexity of the procedure. MFP interposition is probably unnecessary for the majority of low (obstetric) fistulae within otherwise healthy tissues. However, MFP may still have a place to maximise outcomes in low-income settings, in select cases with higher (iatrogenic) fistulae, and in most cases with radiotherapy.
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.16350
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  3. Article ; Online: Early investigational agents for the treatment of benign prostatic hyperplasia'.

    Katsimperis, Stamatios / Kapriniotis, Konstantinos / Manolitsis, Ioannis / Bellos, Themistoklis / Angelopoulos, Panagiotis / Juliebø-Jones, Patrick / Somani, Bhaskar / Skolarikos, Andreas / Tzelves, Lazaros

    Expert opinion on investigational drugs

    2024  Volume 33, Issue 4, Page(s) 359–370

    Abstract: Introduction: Benign prostatic hyperplasia (BPH), as a clinical entity that affects many people, has always been in the forefront of interest among researchers, pharmaceutical companies, and physicians. Patients with BPH exhibit a diverse range of ... ...

    Abstract Introduction: Benign prostatic hyperplasia (BPH), as a clinical entity that affects many people, has always been in the forefront of interest among researchers, pharmaceutical companies, and physicians. Patients with BPH exhibit a diverse range of symptoms, while current treatment options can occasionally cause adverse events. All the aforementioned have led to an increased demand for more effective treatment options.
    Areas covered: This review summarizes the outcomes of new medications used in a pre-clinical and clinical setting for the management of male lower urinary tract symptoms (LUTS)/BPH and provides information about ongoing trials and future directions in the management of this condition. More specifically, sheds light upon drug categories, such as reductase‑adrenoceptor antagonists, drugs interfering with the nitric oxide (NO)/cyclic guanosine monophosphate (GMP) signaling pathway, onabotulinumtoxinA, vitamin D3 (calcitriol) analogues, selective cannabinoid (CB) receptor agonists, talaporfin sodium, inhibitor of transforming growth factor beta 1 (TGF-β1), drugs targeting the hormonal control of the prostate, phytotherapy, and many more.
    Expert opinion: Clinical trials are being conducted on a number of new medications that may emerge as effective therapeutic alternatives in the coming years.
    MeSH term(s) Humans ; Male ; Prostatic Hyperplasia/drug therapy ; Prostatic Hyperplasia/complications ; Lower Urinary Tract Symptoms/drug therapy ; Treatment Outcome
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2024.2326023
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    Zs.A 3739: Show issues Location:
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  4. Article ; Online: Facilitating robotic thymectomy in patients with pectus excavatum deformity.

    Kapriniotis, Konstantinos / Geropoulos, Georgios / Vianna, Thabbta / Mitsos, Sofoklis / Panagiotopoulos, Nikolaos

    General thoracic and cardiovascular surgery

    2020  Volume 69, Issue 3, Page(s) 618–620

    Abstract: Robotic procedures in the anterior mediastinum can be challenging in the existence of pectus excavatum deformity due to the limited intrathoracic working space caused by sternal depression. We propose that the temporary application of a vacuum bell ... ...

    Abstract Robotic procedures in the anterior mediastinum can be challenging in the existence of pectus excavatum deformity due to the limited intrathoracic working space caused by sternal depression. We propose that the temporary application of a vacuum bell device during the procedure can correct the deformity and thus, facilitate robotic approach similarly to the standard procedure.
    MeSH term(s) Funnel Chest/diagnostic imaging ; Funnel Chest/surgery ; Humans ; Robotic Surgical Procedures ; Sternum ; Thymectomy ; Vacuum
    Keywords covid19
    Language English
    Publishing date 2020-10-22
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2376888-5
    ISSN 1863-6713 ; 1863-6705
    ISSN (online) 1863-6713
    ISSN 1863-6705
    DOI 10.1007/s11748-020-01515-y
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    Zs.A 1173: Show issues Location:
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  5. Article: Robotic-assisted thoracoscopic resection of an anterior mediastinal vascular malformation.

    Geropoulos, Georgios / Kapriniotis, Konstantinos / Mitsos, Sofoklis / Joslin, Emily / Klimatsidas, Michael / Panagiotopoulos, Nikolaos

    Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery

    2021  Volume 17, Issue 4, Page(s) 210–211

    Language English
    Publishing date 2021-01-15
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2237053-5
    ISSN 1897-4252 ; 1731-5530
    ISSN (online) 1897-4252
    ISSN 1731-5530
    DOI 10.5114/kitp.2020.102338
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  6. Article: Urethral self-insertion of a USB cable as sexual experimentation: A case report.

    Loufopoulos, Ioannis / Kapriniotis, Konstantinos / Kennedy, Clio / Huq, Sabareen / Reid, Thomas / Sridhar, Ashwin

    Urology case reports

    2021  Volume 39, Page(s) 101850

    Abstract: The insertion of a foreign body into the urethra is a delicate matter that may prevent patients from presenting promptly. It can have serious long-term implications. Sexual experimentation and gratification, as well as underlying mental disorders, are ... ...

    Abstract The insertion of a foreign body into the urethra is a delicate matter that may prevent patients from presenting promptly. It can have serious long-term implications. Sexual experimentation and gratification, as well as underlying mental disorders, are considered the main causes of retained foreign bodies in the urethra and bladder. Management varies depending on the shape and size of the object, and the mechanism of insertion. Here we describe the case of a 15-year-old boy who self-inserted a USB wire into his proximal urethra. Manual and endoscopic attempts at removal were unsuccessful. A peno-scrotal urethrostomy was performed.
    Language English
    Publishing date 2021-09-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2021.101850
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  7. Article ; Online: Heart and Lung Transplantation in the Era of COVID-19: Early Recommendations and Outcomes.

    Kapriniotis, Konstantinos / Giannis, Dimitrios / Geropoulos, Georgios / Evangeliou, Alexandros P / Ziogas, Ioannis A / Panagiotopoulos, Nikolaos

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2021  Volume 19, Issue 11, Page(s) 1117–1123

    Abstract: The severe acute respiratory syndrome coronavirus 2 pandemic has dramatically changed medical practices worldwide. These changes have been aimed both to reallocate resources toward fighting the novel coronavirus and to prevent its transmission during ... ...

    Abstract The severe acute respiratory syndrome coronavirus 2 pandemic has dramatically changed medical practices worldwide. These changes have been aimed both to reallocate resources toward fighting the novel coronavirus and to prevent its transmission during nonurgent medical and surgical interventions. Heart and lung transplantation could not be an exception, as most transplant centers have either restricted their activity to only urgent, lifesaving procedures or stopped these surgical procedures for various periods of time depending on the local virus epidemiology. The effect of this infection on the immunosuppressed heart and lung transplant recipient is still questionable; however, there are limited reports suggesting that there is no increased risk of transmission or more severe disease course compared with that shown in the general population. Transplant organizations have disseminated early recommendations as a guidance in a yet evolving situation. Finally, data suggest that lung transplant could potentially serve as an ultimate, lifesaving procedure for COVID-19-related end-stage respiratory failure in carefully selected patients.
    MeSH term(s) COVID-19/immunology ; COVID-19/mortality ; COVID-19/surgery ; COVID-19/transmission ; Delivery of Health Care, Integrated ; Health Services Needs and Demand ; Heart Transplantation/adverse effects ; Heart Transplantation/mortality ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/adverse effects ; Lung Transplantation/adverse effects ; Lung Transplantation/mortality ; Needs Assessment ; Patient Safety ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2021-02-01
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.2020.0289
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    Zs.A 6632: Show issues Location:
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  8. Article ; Online: Does response to percutaneous tibial nerve stimulation predict similar outcome to sacral nerve stimulation?

    Kapriniotis, Konstantinos / Jenks, Julie / Toia, Bogdan / Pakzad, Mahreen / Gresty, Helena / Stephens, Ross / Malde, Sachin / Sahai, Arun / Greenwell, Tamsin / Ockrim, Jeremy

    Neurourology and urodynamics

    2022  Volume 41, Issue 5, Page(s) 1172–1176

    Abstract: Aims: Percutaneous tibial nerve stimulation (PTNS) is a simple neuromodulation technique to treat an overactive bladder. It is unclear whether the response to PTNS would suggest a similar response to sacral nerve stimulation (SNS), and whether PTNS ... ...

    Abstract Aims: Percutaneous tibial nerve stimulation (PTNS) is a simple neuromodulation technique to treat an overactive bladder. It is unclear whether the response to PTNS would suggest a similar response to sacral nerve stimulation (SNS), and whether PTNS could be utilized as an alternative test phase for an SNS implant. This study assessed whether PTNS response was a reliable indicator for subsequent SNS trials.
    Methods: We performed a retrospective review of the hospital databases to collect all patients who had PTNS and who subsequently had an SNS trial in two tertiary hospitals from 2014 to 2020. Response to both interventions was assessed. A 50% reduction in overactive symptoms (frequency-volume charts) was considered a positive response. McNemar's tests using exact binomial probability calculations were used. The statistical significance level was set to 0.05.
    Results: Twenty-three patients who had PTNS subsequently went on to a trial of SNS. All patients except one had previously poor response to PTNS treatment. Eight of them also failed the SNS trial. However, 15 patients (including the PTNS responder) had a successful SNS trial and proceeded with the second-stage battery implantation. The difference in response rates between the PTNS and SNS trial was statistically significant (p < 0.001).
    Conclusions: Poor response to PTNS does not seem to predict the likelihood of patients responding to SNS. A negative PTNS trial should not preclude a trial of a sacral nerve implant. The predictive factors for good and poor responses will be the subject of a larger study.
    MeSH term(s) Fecal Incontinence/therapy ; Humans ; Spinal Nerves ; Tibial Nerve/physiology ; Transcutaneous Electric Nerve Stimulation/methods ; Treatment Outcome ; Urinary Bladder, Overactive/therapy
    Language English
    Publishing date 2022-04-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604904-7
    ISSN 1520-6777 ; 0733-2467
    ISSN (online) 1520-6777
    ISSN 0733-2467
    DOI 10.1002/nau.24944
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  9. Article: Total hip arthroplasty in sickle cell disease: a systematic review.

    Kenanidis, Eustathios / Kapriniotis, Konstantinos / Anagnostis, Panagiotis / Potoupnis, Michael / Christofilopoulos, Panayiotis / Tsiridis, Eleftherios

    EFORT open reviews

    2020  Volume 5, Issue 3, Page(s) 180–188

    Abstract: Total hip arthroplasty (THA) in sickle cell disease (SCD) patients can be a challenging procedure.This systematic review evaluated the revision rate, functional outcomes and complications of THA in sicklers.A systematic search was conducted according to ... ...

    Abstract Total hip arthroplasty (THA) in sickle cell disease (SCD) patients can be a challenging procedure.This systematic review evaluated the revision rate, functional outcomes and complications of THA in sicklers.A systematic search was conducted according to the PRISMA guidelines, using four search engines from inception to May 2019.Fifteen studies with 971 THAs were included. There were 437 cemented and 520 uncemented THAs.There were 164 revision THAs (16.8%); 52 uncemented and 105 cemented THAs.Forty-two infections were recorded; 16 infections for cemented and 23 for uncemented THAs.Fifty-seven cups, 26 stems, eight cup/stem with aseptic loosening that were more frequently cemented were reported. The 28 unspecified aseptic loosening cases were more frequently uncemented THAs.All studies demonstrated the functional improvement of patients.There were 109 medical complications (14.3%). Sickle cell crises (SCC) and transfusion reactions were most usually recorded.Forty-six intraoperative complications (4.7%) were reported; 18 femoral fractures, four acetabular and 18 femoral perforations. Seventeen femoral fractures occurred during uncemented THA.THA in SCD is still related to a high risk of complications. The outcomes in properly selected sicklers have been improved. Perioperative adequate hydration, warming, oxygen supply and transfusion protocols are mandated to prevent SCC and transfusion reactions. The surgeon must be prepared to deal with a high rate of intraoperative fractures and have different implant options readily available. No definite conclusion can be made regarding the best fixation mode. Cemented implants demonstrated a higher revision rate and uncemented implants a higher risk for intraoperative complications. Cite this article:
    Language English
    Publishing date 2020-03-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2844421-8
    ISSN 2058-5241 ; 2058-5241 ; 2396-7544
    ISSN (online) 2058-5241
    ISSN 2058-5241 ; 2396-7544
    DOI 10.1302/2058-5241.5.190038
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  10. Article: Metastatic mandibular ameloblastoma of the lung ten years after primary resection: A rare case report.

    Kapriniotis, Konstantinos / Bania, Angelina / Lampridis, Savvas / Geropoulos, Georgios / Mitsos, Sofoklis / Monk, Fleur / Moore, David A / Panagiotopoulos, Nikolaos

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

    2021  Volume 91, Issue 2

    Abstract: Ameloblastoma is a rare odontogenic neoplasm of the jaw. It usually behaves as a benign, slow growing tumour of the oral cavity with a high recurrence rate, especially when it is inadequately resected. A small proportion of ameloblastomas metastasize to ... ...

    Abstract Ameloblastoma is a rare odontogenic neoplasm of the jaw. It usually behaves as a benign, slow growing tumour of the oral cavity with a high recurrence rate, especially when it is inadequately resected. A small proportion of ameloblastomas metastasize to distant organs, with lungs representing the most common site of metastatic spread. In this report, we present the case of a middle-aged man with two pulmonary nodules and a history of mandibular ameloblastoma excised 10 years prior to this radiological finding. Following resection and histopathological analysis of the lung lesion, a diagnosis of metastatic ameloblastoma was confirmed. No local recurrence of the primary tumour was identified. At 1-year follow-up, the patient had no evidence of local or metastatic disease.
    MeSH term(s) Ameloblastoma/diagnostic imaging ; Ameloblastoma/surgery ; Humans ; Lung ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/surgery ; Male ; Mandibular Neoplasms/diagnostic imaging ; Mandibular Neoplasms/surgery ; Middle Aged ; Multiple Pulmonary Nodules
    Language English
    Publishing date 2021-04-09
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 1160940-0
    ISSN 1122-0643 ; 1120-0391
    ISSN 1122-0643 ; 1120-0391
    DOI 10.4081/monaldi.2021.1643
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