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  1. Article ; Online: The Effect of Immunoglobulin G on the Humoral Immunity in Patients with Tuberculosis/HIV Coinfection.

    Matsegora, Nina A / Kaprosh, Antonina V / Vasylyeva, Tetyana I / Antonenko, Petro B / Antonenko, Kateryna

    AIDS research and human retroviruses

    2024  Volume 40, Issue 4, Page(s) 246–252

    Abstract: Previously, an increase in clinical effectiveness of the antituberculosis treatment (ATT) and antiretroviral therapy (ART) in case of additional immunoglobulin G (IgG) administration in patients with multidrug-resistant tuberculosis (MDR-TB)/HIV ... ...

    Abstract Previously, an increase in clinical effectiveness of the antituberculosis treatment (ATT) and antiretroviral therapy (ART) in case of additional immunoglobulin G (IgG) administration in patients with multidrug-resistant tuberculosis (MDR-TB)/HIV coinfection was reported. The aim of this study was to investigate the impact of IgG administration in addition to the standard second-line ATT and ART on the humoral immunity status in patients with MDR-TB/HIV coinfection immune deficiency. The study involved 52 patients living with HIV with MDR-TB coinfection and CD4+ lymphocyte cell count below 50 cells/μCL. Patients in the control group and intervention group received the second-line ATT and ART; in addition, patients in the intervention group received IgG intravenously. The humoral immunity status was evaluated by measurement of IgA, IgE, IgG, and IgM in plasma. The standard ATT and ART resulted in a two-step change in humoral immunity: IgM, IgG, IgA, and IgE levels gradually increased to a maximal level at the 5-month mark and started to gradually decrease after the 8-month mark. Addition of IgG to the standard therapy resulted in a steeper decrease in the immunoglobulin level in serum, especially IgG, compared with standard therapy alone, allowing for an earlier initiation of ART in patients in the intervention group.
    MeSH term(s) Humans ; HIV Infections/complications ; HIV Infections/drug therapy ; Antitubercular Agents/therapeutic use ; Antitubercular Agents/adverse effects ; Immunoglobulin G ; Immunity, Humoral ; Tuberculosis/complications ; Tuberculosis/drug therapy ; Tuberculosis, Multidrug-Resistant/drug therapy ; Coinfection/drug therapy ; Immunoglobulin A ; Immunoglobulin E/therapeutic use ; Immunoglobulin M/therapeutic use
    Chemical Substances Antitubercular Agents ; Immunoglobulin G ; Immunoglobulin A ; Immunoglobulin E (37341-29-0) ; Immunoglobulin M
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/AID.2023.0074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Biochemical value dynamics in patients with multidrug-resistant tuberculosis/hiv with CD4+ lymphocyte cells below 50 cells/μCL and its variability in the application of adjuvant immunoglobulin therapy.

    Matsegora, Nina A / Kaprosh, Antonina V / Antonenko, Petro B

    International journal of mycobacteriology

    2019  Volume 8, Issue 4, Page(s) 374–380

    Abstract: Context: Treatment of the patients with multidrug-resistant tuberculosis (MDR-TB)/HIV coinfection in a state of severely suppressed immune system remains under efficient.: Aims: The aim of this study was to assess the effectiveness of adjuvant ... ...

    Abstract Context: Treatment of the patients with multidrug-resistant tuberculosis (MDR-TB)/HIV coinfection in a state of severely suppressed immune system remains under efficient.
    Aims: The aim of this study was to assess the effectiveness of adjuvant immunoglobulin therapy in TB/HIV patients.
    Settings and design: The relationship between biochemical indexes in the patients with MDR-TB/HIV co-infection and adjuvant immunoglobulin therapy.
    Materials and methods: The study involved 52 HIV-positive patients with MDR-TB and CD4+ lymphocyte cells below 50 cells/μCL. Patients in control group (Group 1) and in basic group (Group 2) received standard treatment with second-line antituberculosis agents and antiretroviral agents. In addition patients in basic group were treated by immunoglobulin G intravenously. The evaluation of biochemical parameters such as bilirubin level, thymol test, the activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) was carried out on automatic analyzer HumaStar 300 at the beginning and after 0.5-8 months of treatment. Statistical analysis was performed using the Statistica 10.0 software (Stat. Soft Inc., USA). Kruskal-Wallis, ANOVA, and Chi-square tests were used in this study.
    Results: After 8 months of treatment, studied biochemical indexes were lower in Group 2 than in patients from Group 1. For example, the number of patients in Group 2 with increased bilirubin level was 1.7 times more than in Group 1 (p < 0.05), with increased ALT, AST, or GGT activity in 2.5 times (p < 0.01), 2.7 times (p < 0.01), or 2.4 times (p < 0.05) correspondently, comparatively with Group 1.
    Conclusion: The usage of immunoglobulins intravenously in the group of patients with MDR-TB associated with HIV infection, with CD4+ level <50 cells/μCL, is appropriate and essential because it improves treatment outcome.
    MeSH term(s) Administration, Intravenous ; Adult ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/immunology ; Coinfection/immunology ; Coinfection/therapy ; HIV Infections/immunology ; HIV Infections/therapy ; Humans ; Immunization, Passive ; Immunoglobulin G/therapeutic use ; Middle Aged ; Tuberculosis, Multidrug-Resistant/immunology ; Tuberculosis, Multidrug-Resistant/therapy ; Young Adult
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2019-12-03
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2212-554X
    ISSN (online) 2212-554X
    DOI 10.4103/ijmy.ijmy_122_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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