Article ; Online: The impact of sentinel lymph node mapping with hybrid single photon emission computed tomography/computed tomography in patients with melanoma. Comparison to planar radioisotopic lymphoscintigraphy.
2023 Volume 33, Issue 3, Page(s) 239–246
Abstract: We studied the diagnostic value of 16 slices of single photon emission computed tomography (SPECT)/computed tomography (CT) in the anatomical localization, image interpretation and extra-sentinel lymph nodes (SLNs) detection compared to dynamic and ... ...
Abstract | We studied the diagnostic value of 16 slices of single photon emission computed tomography (SPECT)/computed tomography (CT) in the anatomical localization, image interpretation and extra-sentinel lymph nodes (SLNs) detection compared to dynamic and static planar radioisotopic lymphoscintigraphy (PLS) in patients with melanoma. Eighty-two patients with melanoma underwent dynamic PLS, static PLS and SPECT/CT. Data were obtained using a dual head SPECT/CT 16 slices γ-camera. We evaluated the number and localization of SLNs detected with each imaging method. SPECT/CT demonstrated 48 additional SLNs in comparison with PLS in 29 patients. In five truncal and seven head-neck lesions, dynamic and static PLS failed to detect the SLNs found on SPECT/CT (false negative). In one case of truncal and one case of lower limb melanoma, the foci of increased activity interpreted on PLS as possible SLNs were confirmed to be non-nodal sites of uptake on SPECT/CT (false positive). PLS underestimated the number of SLNs detected, whereas SPECT/CT revealed higher agreement compared to the respective number from histological reports. SPECT/CT showed a better prediction of the number of SLNs and higher diagnostic parameters in comparison to planar imaging. SPECT/CT is an important complementary diagnostic modality to PLS, that improves detection, preoperative evaluation, anatomical landmarks of SLNs and surgical management of patients with melanoma. |
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MeSH term(s) | Humans ; Melanoma/pathology ; Sentinel Lymph Node/diagnostic imaging ; Sentinel Lymph Node/pathology ; Lymphoscintigraphy/methods ; Skin Neoplasms/pathology ; Sentinel Lymph Node Biopsy/methods ; Single Photon Emission Computed Tomography Computed Tomography/methods ; Tomography, Emission-Computed, Single-Photon/methods ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology |
Language | English |
Publishing date | 2023-04-12 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 1095779-0 |
ISSN | 1473-5636 ; 0960-8931 |
ISSN (online) | 1473-5636 |
ISSN | 0960-8931 |
DOI | 10.1097/CMR.0000000000000893 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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