LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article ; Online: Sex-specific neuropsychological correlates of apathy and depression across neurodegenerative disorders.

    Kapustin, Daniel / Tumati, Shankar / Wong, Melissa / Herrmann, Nathan / Dixon, Roger A / Seitz, Dallas / Rapoport, Mark J / Lanctôt, Krista L

    International journal of geriatric psychiatry

    2024  Volume 39, Issue 3, Page(s) e6080

    Abstract: Background: Apathy and depression are common neuropsychiatric symptoms across neurodegenerative disorders and are associated with impairment in several cognitive domains, yet little is known about the influence of sex on these relationships.: ... ...

    Abstract Background: Apathy and depression are common neuropsychiatric symptoms across neurodegenerative disorders and are associated with impairment in several cognitive domains, yet little is known about the influence of sex on these relationships.
    Objectives: We examined the relationship between these symptoms with neuropsychological performance across a combined cohort with mild or major neurodegenerative disorders, then evaluated the impact of sex.
    Design, setting and participants: We conducted a cohort analysis of participants in the COMPASS-ND study with mild cognitive impairment (MCI), vascular MCI, Alzheimer's disease, mixed dementia, Parkinson's disease, frontotemporal dementia, and cognitively unimpaired (CU) controls.
    Measurements: Participants with neurodegenerative disease and CU controls were stratified by the presence (severity ≥1 on Neuropsychiatric Inventory Questionnaire) of either depressive symptoms alone, apathy symptoms alone, both symptoms, or neither. A neuropsychological battery evaluated executive function, verbal fluency, verbal learning, working memory, and visuospatial reasoning. Analysis of covariance was used to assess group differences with age, sex, and education as covariates.
    Results: Groups included depressive symptoms only (n = 70), apathy symptoms only (n = 52), both (n = 68), or neither (n = 262). The apathy and depression + apathy groups performed worse than the neither group on tests of working memory (t
    Conclusions: This study demonstrated that in neurodegenerative diseases, apathy with or without depression in males was associated with broad cognitive impairments. In females, depression was associated with deficits in executive function and verbal learning. These findings highlight the importance of effectively treating apathy and depression across the spectrum of neurodegenerative disorders with the goal of optimizing neuropsychological outcomes.
    MeSH term(s) Female ; Male ; Humans ; Neurodegenerative Diseases ; Apathy ; Depression ; Alzheimer Disease ; Frontotemporal Dementia
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 806736-3
    ISSN 1099-1166 ; 0885-6230
    ISSN (online) 1099-1166
    ISSN 0885-6230
    DOI 10.1002/gps.6080
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Hydroxycarbamide treatment in children with Sickle Cell Anaemia is associated with more intact white matter integrity: a quantitative MRI study.

    Kapustin, Daniel / Leung, Jackie / Odame, Isaac / Williams, Suzan / Shroff, Manohar / Kassner, Andrea

    British journal of haematology

    2019  Volume 187, Issue 2, Page(s) 238–245

    Abstract: Sickle cell anaemia (SCA) is a devastating genetic blood disorder leading to chronic anaemia, impaired cerebrovascular dilatory capacity and cerebral infarctions. Our aim was to assess the relationship between microstructural properties of the white ... ...

    Abstract Sickle cell anaemia (SCA) is a devastating genetic blood disorder leading to chronic anaemia, impaired cerebrovascular dilatory capacity and cerebral infarctions. Our aim was to assess the relationship between microstructural properties of the white matter (WM) and both cerebrovascular reactivity (CVR) and cerebral blood flow, as well as the effects of hydroxycarbamide on these relationships. Our results demonstrate that mean CVR was increased in hydroxycarbamide-treated patients compared to untreated patients. Moreover, untreated SCA patients had increased skew and kurtosis of mean diffusivity histograms in the WM compared to hydroxycarbamide-treated patients and healthy age-matched controls, indicating disruption of WM integrity. Regression analysis of CVR and WM mean diffusivity (MD) revealed a significant linear relationship between CVR and MD histogram skew and kurtosis in healthy controls, but not in either of the two SCA groups. These findings suggest that patients treated with hydroxycarbamide possess white matter MD histogram parameters which more closely resemble those of healthy controls.
    MeSH term(s) Adolescent ; Anemia, Sickle Cell/diagnostic imaging ; Anemia, Sickle Cell/drug therapy ; Child ; Female ; Humans ; Hydroxyurea/administration & dosage ; Hydroxyurea/adverse effects ; Male ; White Matter/diagnostic imaging
    Chemical Substances Hydroxyurea (X6Q56QN5QC)
    Language English
    Publishing date 2019-06-18
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16063
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.182: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Evaluating the impact of cannabinoids on sleep health and pain in patients with chronic neuropathic pain: a systematic review and meta-analysis of randomized controlled trials.

    McParland, Aidan Leonard / Bhatia, Anuj / Matelski, John / Tian, Chenchen / Diep, Calvin / Clarke, Hance / Kapustin, Daniel / Triveda, Aditya / Brull, Richard / Singh, Mandeep

    Regional anesthesia and pain medicine

    2022  Volume 48, Issue 4, Page(s) 180–190

    Abstract: Background: Chronic neuropathic pain is often debilitating and can have a significant impact on sleep health and quality of life. There is limited information on the impact of cannabinoids on sleep health when treating neuropathic pain.: Objective: ... ...

    Abstract Background: Chronic neuropathic pain is often debilitating and can have a significant impact on sleep health and quality of life. There is limited information on the impact of cannabinoids on sleep health when treating neuropathic pain.
    Objective: The objectives of this systematic review and meta-analysis were to determine the effect of cannabinoids on sleep quality, pain intensity, and patient impression of treatment efficacy in patients with neuropathic pain.
    Evidence review: Nine available medical literature databases were searched for randomized controlled trials comparing synthetic and natural cannabinoids to placebo in patients with neuropathic pain syndromes. Data on validated tools for sleep quality, pain intensity, patients' global impression of change (PGIC), and incidence of adverse effects of cannabinoids were extracted and synthesized.
    Findings: Of the 3491 studies screened, eight randomized controlled trials satisfied the inclusion criteria for this review. Analyses were performed using R -4.1.2. using the
    Conclusions: Cannabinoids have a role in treating chronic neuropathic pain as evidenced by significant improvements in sleep quality, pain intensity, and PGIC. More research is needed to comprehensively evaluate the impact of cannabinoids on sleep health and analgesic efficacy.
    Prospero registration number: CRD42017074255.
    MeSH term(s) Humans ; Cannabinoids/adverse effects ; Chronic Pain/drug therapy ; Quality of Life ; Randomized Controlled Trials as Topic ; Neuralgia/drug therapy ; Analgesics ; Sleep
    Chemical Substances Cannabinoids ; Analgesics
    Language English
    Publishing date 2022-12-05
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 1425299-5
    ISSN 1532-8651 ; 1098-7339 ; 0146-521X
    ISSN (online) 1532-8651
    ISSN 1098-7339 ; 0146-521X
    DOI 10.1136/rapm-2021-103431
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2399: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Evaluating the impact of gabapentinoids on sleep health in patients with chronic neuropathic pain: a systematic review and meta-analysis.

    Kapustin, Daniel / Bhatia, Anuj / McParland, Aidan / Trivedi, Aditya / Davidson, Alexandra / Brull, Richard / Singh, Mandeep

    Pain

    2019  Volume 161, Issue 3, Page(s) 476–490

    Abstract: Chronic neuropathic pain (NP) is debilitating and impacts sleep health and quality of life. Treatment with gabapentinoids (GBs) has been shown to reduce pain, but its effects on sleep health have not been systematically evaluated. The objective of this ... ...

    Abstract Chronic neuropathic pain (NP) is debilitating and impacts sleep health and quality of life. Treatment with gabapentinoids (GBs) has been shown to reduce pain, but its effects on sleep health have not been systematically evaluated. The objective of this systematic review and meta-analysis was to assess the relationship between GB therapy dose and duration on sleep quality, daytime somnolence, and intensity of pain in patients with NP. Subgroup comparisons were planned for high- vs low-dose GBs, where 300 mg per day or more of pregabalin was used to classify high-dose therapy. Trial data were segregated by duration less than 6 weeks and 6 weeks or greater. Twenty randomized controlled trials were included. Primary outcome measures included pain-related sleep interference and incidence of daytime somnolence. Secondary outcomes included daily pain scores (numerical rating scale 0-10) and patient global impression of change. Significant improvement in sleep quality was observed after 6 weeks of GB treatment when compared with placebo (standardized mean difference 0.39, 95% confidence interval 0.32-0.46 P < 0.001). Increased daytime somnolence was observed among all GB-treated groups when compared with placebo. Treated patients were also more likely to report improvement of patient global impression of change scores. Pain scores decreased significantly in patients both after 6 weeks of treatment (P < 0.001) and in trials less than 6 weeks (P = 0.017) when compared with placebo. Our data demonstrate that GBs have a positive impact on sleep health, quality of life, and pain in patients with NP syndromes. However, these benefits come at the expense of daytime somnolence.
    MeSH term(s) Analgesics/pharmacology ; Analgesics/therapeutic use ; Chronic Pain/drug therapy ; Chronic Pain/epidemiology ; Chronic Pain/psychology ; Clinical Trials as Topic/methods ; Gabapentin/analogs & derivatives ; Gabapentin/pharmacology ; Gabapentin/therapeutic use ; Humans ; Neuralgia/drug therapy ; Neuralgia/epidemiology ; Neuralgia/psychology ; Pain Measurement ; Quality of Life/psychology ; Sleep/drug effects ; Sleep/physiology ; Sleep Wake Disorders/drug therapy ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/psychology ; Treatment Outcome
    Chemical Substances Analgesics ; Gabapentin (6CW7F3G59X)
    Language English
    Publishing date 2019-11-06
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 193153-2
    ISSN 1872-6623 ; 0304-3959
    ISSN (online) 1872-6623
    ISSN 0304-3959
    DOI 10.1097/j.pain.0000000000001743
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1158: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Early Impedance-Guided Intervention Improves Long-Term Outcome in Patients With Heart Failure.

    Kleiner Shochat, Michael / Fudim, Marat / Kapustin, Daniel / Kazatsker, Mark / Kleiner, Ilia / Weinstein, Jean Marc / Panjrath, Gurusher / Rozen, Guy / Roguin, Ariel / Meisel, Simcha R

    Journal of the American College of Cardiology

    2021  Volume 78, Issue 17, Page(s) 1751–1752

    MeSH term(s) Diuretics/pharmacology ; Electric Impedance ; Furosemide/pharmacology ; Heart Failure/drug therapy ; Heart Failure/physiopathology ; Humans ; Lung/physiopathology ; Lung Diseases/drug therapy ; Lung Diseases/physiopathology ; Outpatients ; Single-Blind Method ; Stroke Volume ; Treatment Outcome
    Chemical Substances Diuretics ; Furosemide (7LXU5N7ZO5)
    Language English
    Publishing date 2021-11-08
    Publishing country United States
    Document type Letter ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2021.08.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1846: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 196: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: The Degree of the Predischarge Pulmonary Congestion in Patients Hospitalized for Worsening Heart Failure Predicts Readmission and Mortality.

    Kleiner-Shochat, Michael / Kapustin, Daniel / Fudim, Marat / Ambrosy, Andrew P / Glantz, Juliya / Kazatsker, Mark / Kleiner, Ilia / Weinstein, Jean Marc / Panjrath, Gurusher / Roguin, Ariel / Meisel, Simcha R

    Cardiology

    2020  Volume 146, Issue 1, Page(s) 49–59

    Abstract: Background: Prediction of readmission and death after hospitalization for heart failure (HF) is an unmet need.: Aim: We evaluated the ability of clinical parameters, NT-proBNP level and noninvasive lung impedance (LI), to predict time to readmission ( ...

    Abstract Background: Prediction of readmission and death after hospitalization for heart failure (HF) is an unmet need.
    Aim: We evaluated the ability of clinical parameters, NT-proBNP level and noninvasive lung impedance (LI), to predict time to readmission (TTR) and time to death (TTD).
    Methods and results: The present study is a post hoc analysis of the IMPEDANCE-HF extended trial comprising 290 patients with LVEF ≤45% and New York Heart Association functional class II-IV, randomized 1:1 to LI-guided or conventional therapy. Of all patients, 206 were admitted 766 times for HF during a follow-up of 57 ± 39 months. The normal LI (NLI), representing the "dry" lung status, was calculated for each patient at study entry. The current degree of pulmonary congestion (PC) compared with its dry status was represented by ΔLIR = ([measured LI/NLI] - 1) × 100%. Twenty-six parameters recorded during HF admission were used to predict TTR and TTD. To determine the parameter which mainly impacted TTR and TTD, variables were standardized, and effect size (ES) was calculated. Multivariate analysis by the Andersen-Gill model demonstrated that ΔLIRadmission (ES = 0.72), ΔLIRdischarge (ES = -3.14), group assignment (ES = 0.2), maximal troponin during HF admission (ES = 0.19), LVEF related to admission (ES = -0.22) and arterial hypertension (ES = 0.12) are independent predictors of TTR (p < 0.01, χ2 = 1,206). Analysis of ES showed that residual PC assessed by ∆LIRdischarge was the most prominent predictor of TTR. One percent improvement in predischarge PC, assessed by ∆LIRdischarge, was associated with a likelihood of TTR increase by 14% (hazard ratio [HR] 1.14, 95% confidence interval [CI] 1.13-1.15, p < 0.01) and TTD increase by 8% (HR 1.08, 95% CI 1.07-1.09, p < 0.01).
    Conclusion: The degree of predischarge PC assessed by ∆LIR is the most dominant predictor of TTR and TTD.
    MeSH term(s) Follow-Up Studies ; Heart Failure ; Hospitalization ; Humans ; Lung ; Natriuretic Peptide, Brain ; Patient Readmission ; Peptide Fragments ; Prognosis
    Chemical Substances Peptide Fragments ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2020-10-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 80092-2
    ISSN 1421-9751 ; 0008-6312
    ISSN (online) 1421-9751
    ISSN 0008-6312
    DOI 10.1159/000510073
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.31: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function.

    Kapustin, Daniel / Zarei, Shadi / Wang, Wei / Binns, Malcolm A / McLaughlin, Paula M / Abrahao, Agessandro / Black, Sandra E / Borrie, Michael / Breen, David / Casaubon, Leanna / Dowlatshahi, Dar / Finger, Elizabeth / Fischer, Corinne E / Frank, Andrew / Freedman, Morris / Grimes, David / Hassan, Ayman / Jog, Mandar / Kwan, Donna /
    Lang, Anthony / Levine, Brian / Mandzia, Jennifer / Marras, Connie / Masellis, Mario / Orange, Joseph B / Pasternak, Stephen / Peltsch, Alicia / Pollock, Bruce G / Rajji, Tarek K / Roberts, Angela / Sahlas, Demetrios / Saposnik, Gustavo / Seitz, Dallas / Shoesmith, Christen / Southwell, Alisia / Steeves, Thomas D L / Sunderland, Kelly / Swartz, Richard H / Tan, Brian / Tang-Wai, David F / Tartaglia, Maria Carmela / Troyer, Angela / Turnbull, John / Zinman, Lorne / Kumar, Sanjeev

    Canadian journal of psychiatry. Revue canadienne de psychiatrie

    2023  Volume 68, Issue 5, Page(s) 347–358

    Abstract: Objective: Neuropsychiatric symptoms (NPS) are prevalent in neurodegenerative disorders, however, their frequency and impact on function across different disorders is not well understood. We compared the frequency and severity of NPS across Alzheimer's ... ...

    Abstract Objective: Neuropsychiatric symptoms (NPS) are prevalent in neurodegenerative disorders, however, their frequency and impact on function across different disorders is not well understood. We compared the frequency and severity of NPS across Alzheimer's disease (AD) (either with mild cognitive impairment or dementia), Cerebrovascular disease (CVD), Parkinson's disease (PD), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS), and explored the association between NPS burden and function.
    Methods: We obtained data from Ontario Neurodegenerative Disease Research Initiative (ONDRI) that included following cohorts: AD (
    Results: Frequency of NPS varied across cohorts (χ
    Conclusions: NPS frequency and severity are markedly greater in FTD as compared to other neurodegenerative diseases. Further, NPS burden appears to be associated differently with function across neurodegenerative disorders, highlighting the need for individualized clinical interventions.
    MeSH term(s) Humans ; Neurodegenerative Diseases/epidemiology ; Frontotemporal Dementia/epidemiology ; Frontotemporal Dementia/psychology ; Amyotrophic Lateral Sclerosis ; Alzheimer Disease/epidemiology ; Cardiovascular Diseases
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304227-3
    ISSN 1497-0015 ; 0008-4824 ; 0706-7437
    ISSN (online) 1497-0015
    ISSN 0008-4824 ; 0706-7437
    DOI 10.1177/07067437221147443
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 110: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top