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  1. Article ; Online: Redemption for self-reactive antibodies.

    Kara, Ervin E / Nussenzweig, Michel C

    Science (New York, N.Y.)

    2018  Volume 360, Issue 6385, Page(s) 152–153

    MeSH term(s) Autoantibodies ; Humans
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2018--13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aat5758
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  2. Article ; Online: Correction: Germinal center-dependent and -independent memory B cells produced throughout the immune response.

    Viant, Charlotte / Wirthmiller, Tobias / ElTanbouly, Mohamed A / Chen, Spencer T / Kara, Ervin E / Cipolla, Melissa / Ramos, Victor / Oliveira, Thiago Y / Stamatatos, Leonidas / Nussenzweig, Michel C

    The Journal of experimental medicine

    2024  Volume 221, Issue 5

    Language English
    Publishing date 2024-04-29
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.2020248904162024c
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  3. Article ; Online: T

    Bastow, Cameron R / Kara, Ervin E / Tyllis, Timona S / Vinuesa, Carola G / McColl, Shaun R / Comerford, Iain

    Frontiers in immunology

    2022  Volume 13, Page(s) 873586

    Abstract: Follicular T cells including T follicular helper ( ... ...

    Abstract Follicular T cells including T follicular helper (T
    MeSH term(s) Animals ; Germinal Center ; Immunity, Humoral ; Mice ; Receptors, CCR6/genetics ; Receptors, CCR6/metabolism ; Receptors, CXCR5/genetics ; Receptors, CXCR5/metabolism ; Spleen ; T Follicular Helper Cells ; T-Lymphocytes, Regulatory
    Chemical Substances CCR6 protein, mouse ; Receptors, CCR6 ; Receptors, CXCR5
    Language English
    Publishing date 2022-06-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.873586
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  4. Article ; Online: Continuous germinal center invasion contributes to the diversity of the immune response.

    Hägglöf, Thomas / Cipolla, Melissa / Loewe, Maximilian / Chen, Spencer T / Kara, Ervin E / Mesin, Luka / Hartweger, Harald / ElTanbouly, Mohamed A / Cho, Alice / Gazumyan, Anna / Ramos, Victor / Stamatatos, Leonidas / Oliveira, Thiago Y / Nussenzweig, Michel C / Viant, Charlotte

    Cell

    2024  

    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2024.04.004
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  5. Article ; Online: Protein Amounts of the MYC Transcription Factor Determine Germinal Center B Cell Division Capacity.

    Finkin, Shlomo / Hartweger, Harald / Oliveira, Thiago Y / Kara, Ervin E / Nussenzweig, Michel C

    Immunity

    2019  Volume 51, Issue 2, Page(s) 324–336.e5

    Abstract: High-affinity B cell selection in the germinal center (GC) is governed by signals delivered by follicular helper T (Tfh) cells to B cells. Selected B cells undergo clonal expansion and affinity maturation in the GC dark zone in direct proportion to the ... ...

    Abstract High-affinity B cell selection in the germinal center (GC) is governed by signals delivered by follicular helper T (Tfh) cells to B cells. Selected B cells undergo clonal expansion and affinity maturation in the GC dark zone in direct proportion to the amount of antigen they capture and present to Tfh cells in the light zone. Here, we examined the mechanisms whereby Tfh cells program the number of GC B cell divisions. Gene expression analysis revealed that Tfh cells induce Myc expression in light-zone B cells in direct proportion to antigen capture. Conditional Myc haplo-insufficiency or overexpression combined with cell division tracking showed that MYC expression produces a metabolic reservoir in selected light-zone B cells that is proportional to the number of cell divisions in the dark zone. Thus, MYC constitutes the GC B cell division timer that when deregulated leads to emergence of B cell lymphoma.
    MeSH term(s) Animals ; Antibody Affinity ; B-Lymphocytes/immunology ; Cell Differentiation ; Cell Division ; Cell Proliferation ; Clonal Selection, Antigen-Mediated ; Gene Expression Regulation ; Genes, myc/genetics ; Germinal Center/immunology ; Humans ; Lymphoma, B-Cell/genetics ; Mice ; T-Lymphocytes, Helper-Inducer/immunology
    Language English
    Publishing date 2019-07-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2019.06.013
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    Zs.MG 69: Show issues

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  6. Article ; Online: CXCR5

    Tyllis, Timona S / Fenix, Kevin A / Norton, Todd S / Kara, Ervin E / McKenzie, Duncan R / David, Shannon C / Alsharifi, Mohammed / Yu, Di / McColl, Shaun R / Comerford, Iain

    Frontiers in immunology

    2021  Volume 12, Page(s) 626199

    Abstract: Crosstalk between T and B cells is crucial for generating high-affinity, class-switched antibody responses. The roles of ... ...

    Abstract Crosstalk between T and B cells is crucial for generating high-affinity, class-switched antibody responses. The roles of CD4
    MeSH term(s) Animals ; Antibody Formation ; B-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Humans ; Immunization ; Influenza A virus/physiology ; Influenza, Human/immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Orthomyxoviridae Infections/immunology ; Ovalbumin/immunology ; Receptors, CXCR5/genetics ; Receptors, CXCR5/metabolism
    Chemical Substances CXCR5 protein, mouse ; Receptors, CXCR5 ; Ovalbumin (9006-59-1)
    Language English
    Publishing date 2021-07-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.626199
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  7. Article ; Online: Germinal center-dependent and -independent memory B cells produced throughout the immune response.

    Viant, Charlotte / Wirthmiller, Tobias / ElTanbouly, Mohamed A / Chen, Spencer T / Kara, Ervin E / Cipolla, Melissa / Ramos, Victor / Oliveira, Thiago Y / Stamatatos, Leonidas / Nussenzweig, Michel C

    The Journal of experimental medicine

    2021  Volume 218, Issue 8

    Abstract: Memory B cells comprise a heterogenous group of cells that differ in origin and phenotype. During the early phases of the immune response, activated B cells can differentiate into IgM-expressing memory cells, short-lived plasma cells, or seed germinal ... ...

    Abstract Memory B cells comprise a heterogenous group of cells that differ in origin and phenotype. During the early phases of the immune response, activated B cells can differentiate into IgM-expressing memory cells, short-lived plasma cells, or seed germinal centers (GCs). The memory compartment is subsequently enriched by B cells that have been through several rounds of division and selection in the GC. Here, we report on the use of an unbiased lineage-tracking approach to explore the origins and properties of memory B cell subsets in mice with an intact immune system. We find that activated B cells continue to differentiate into memory B cells throughout the immune response. When defined on the basis of their origins, the memory B cells originating from activated B cells or GCs differ in isotype and overall gene expression, somatic hypermutation, and their affinity for antigen.
    MeSH term(s) Animals ; Antibody Affinity/immunology ; B-Lymphocytes/immunology ; Cell Differentiation/immunology ; Clone Cells ; Gene Expression Profiling ; Germinal Center/immunology ; Immunity ; Immunoglobulin Class Switching/genetics ; Immunologic Memory ; Lymphocyte Activation/immunology ; Mice, Inbred C57BL ; Mutation/genetics ; Recombination, Genetic/genetics ; Mice
    Language English
    Publishing date 2021-06-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20202489
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  8. Article ; Online: The basophil: resolved questions and new avenues of investigation.

    Kara, Ervin E / McColl, Shaun R / Comerford, Iain

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2013  Volume 35, Issue 8, Page(s) 670

    MeSH term(s) Animals ; Basophils/immunology ; Helminthiasis/pathology ; Host-Parasite Interactions ; Humans ; Hypersensitivity/pathology
    Language English
    Publishing date 2013-08
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.201300044
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  9. Article ; Online: Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration.

    Bastow, Cameron R / Bunting, Mark D / Kara, Ervin E / McKenzie, Duncan R / Caon, Adriana / Devi, Sapna / Tolley, Lynn / Mueller, Scott N / Frazer, Ian H / Harvey, Natasha / Condina, Mark R / Young, Clifford / Hoffmann, Peter / McColl, Shaun R / Comerford, Iain

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 17

    Abstract: Leukocyte homing driven by the chemokine CCL21 is pivotal for adaptive immunity because it controls dendritic cell (DC) and T cell migration through CCR7. ACKR4 scavenges CCL21 and has been shown to play an essential role in DC trafficking at the steady ... ...

    Abstract Leukocyte homing driven by the chemokine CCL21 is pivotal for adaptive immunity because it controls dendritic cell (DC) and T cell migration through CCR7. ACKR4 scavenges CCL21 and has been shown to play an essential role in DC trafficking at the steady state and during immune responses to tumors and cutaneous inflammation. However, the mechanism by which ACKR4 regulates peripheral DC migration is unknown, and the extent to which it regulates CCL21 in steady-state skin and lymph nodes (LNs) is contested. Specifically, our previous findings that CCL21 levels are increased in LNs of ACKR4-deficient mice [I. Comerford et al.,
    MeSH term(s) Animals ; Cell Movement ; Chemokine CCL21/metabolism ; Dendritic Cells/physiology ; Lymph Nodes/metabolism ; Mice, Inbred C57BL ; Receptors, CCR/metabolism ; Mice
    Chemical Substances Ackr4 protein, mouse ; Chemokine CCL21 ; Receptors, CCR
    Language English
    Publishing date 2021-04-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2025763118
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  10. Article ; Online: CCR6 supports migration and differentiation of a subset of DN1 early thymocyte progenitors but is not required for thymic nTreg development.

    Bunting, Mark D / Comerford, Iain / Kara, Ervin E / Korner, Heinrich / McColl, Shaun R

    Immunology and cell biology

    2014  Volume 92, Issue 6, Page(s) 489–498

    Abstract: T-cell selection and development occurs as precursor cells journey through the thymus and interact with stromal cells residing in distinct microenvironments. Although the chemokines CCL19, CCL21, CCL25 and CXCL12 are known to have major roles in ... ...

    Abstract T-cell selection and development occurs as precursor cells journey through the thymus and interact with stromal cells residing in distinct microenvironments. Although the chemokines CCL19, CCL21, CCL25 and CXCL12 are known to have major roles in intrathymic migration of thymocytes and thymocyte precursors, the significance of other chemokines such as CCL20, which is also expressed in the thymus, is unknown. This is of particular interest given that the thymus is the location of development of the natural regulatory T-cell (nTreg) population and that the CCL20 receptor CCR6 has an important role in peripheral tolerance via control of Treg cell migration. However, whether the CCL20/CCR6 axis has a role in the formation or migration of nTregs in the thymus is unknown. In this study, we addressed this by analyzing expression of CCR6/CCL20 within the thymus and assessing their role in thymocyte development using Ccr6(-/-) mice. CCL20 is predominately expressed in the thymic medulla and CCR6 expression is restricted to nTregs and a subset of early thymocyte progenitor double-negative 1 (DN1) cells (CD4(-)CD8(-)CD25(-)CD44(+)CD117(+)). Ex vivo chemotaxis assays indicated that these two subsets were apparently the sole subsets of thymocytes responsive to CCL20. The data indicate that nTreg frequencies and localization are unperturbed by deletion of Ccr6. However, in Ccr6(-/-) thymi, reduced frequencies of DN2 and DN3 cells, the thymocyte progenitor subsets that follow the DN1 stage, were apparent. Together, these data indicate that CCR6 has a supplementary role in coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for normal nTreg development.
    MeSH term(s) Animals ; Antigens, Differentiation/genetics ; Antigens, Differentiation/immunology ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Chemotaxis/genetics ; Chemotaxis/immunology ; Mice ; Mice, Knockout ; Receptors, CCR6/genetics ; Receptors, CCR6/immunology ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/immunology ; Thymocytes/cytology ; Thymocytes/immunology
    Chemical Substances Antigens, Differentiation ; CCR6 protein, mouse ; Receptors, CCR6
    Language English
    Publishing date 2014-03-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1038/icb.2014.14
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