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Article ; Online: Neurosurgery fellowships in Canada: expectations and practical considerations.

Karabatsou, Konstantina

2010 Volume 24, Issue 2, Page(s) 224–226

Abstract: The evolving face of neurosurgery with emphasis in subspecialisation along with the introduction of European Working Time Directives has led an increasing number of trainees to wish to pursue a fellowship either at home or abroad after they finish their ... ...

Abstract	The evolving face of neurosurgery with emphasis in subspecialisation along with the introduction of European Working Time Directives has led an increasing number of trainees to wish to pursue a fellowship either at home or abroad after they finish their training. Information about fellowship programs is not always widely available and fellowships can be highly competitive. This article aims to provide some useful tips on how to pursue an international neurosurgical fellowship in Canada.
MeSH term(s)	Canada ; Career Mobility ; Education, Medical, Graduate/methods ; Education, Medical, Graduate/standards ; Fellowships and Scholarships/standards ; Humans ; Neurosurgery/education
Language	English
Publishing date	2010-04
Publishing country	England
Document type	Journal Article
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.3109/02688690903536587
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Article ; Online: Do the indices of deprivation or smoking affect post-operative 1-year mortality in patients undergoing a craniotomy for a brain tumour in a public healthcare system?

Maye, Helen / Balogun, James / Waqar, Mueez / Heal, Calvin / McSorley, Nathan / D'Urso, Pietro / Coope, David / Bailey, Matthew / Karabatsou, Konstantina

Acta neurochirurgica

2023 Volume 165, Issue 7, Page(s) 1683–1693

Abstract: Objective: We sought to determine the 1-year survival following craniotomy for tumour resection in a public healthcare system and analyse the effect of indices of multiple deprivation (IMD) as well as smoking, alcohol, BMI, ASA grade and medical co- ... ...

Abstract	Objective: We sought to determine the 1-year survival following craniotomy for tumour resection in a public healthcare system and analyse the effect of indices of multiple deprivation (IMD) as well as smoking, alcohol, BMI, ASA grade and medical co-morbidities on post-operative morbidity and mortality. Methods: This is a retrospective, single-centre study in a high volume neurosurgical centre, over a 2-year period. All patients undergoing a craniotomy for a brain tumour were included. Data was collected from the neuro-oncology database and electronic patient records. Individual patient IMD data was obtained using their postcode from a national government database. Each English postcode being ranked from 1 to 32,844, with 1 being the most deprived and 32,844 the most affluent. Descriptive results are described along with further data analysis using multiple linear and logistic regression analyses. Results: 630 patients underwent an elective or urgent craniotomy for tumour. 10% of all patients underwent urgent surgery. 68% (95% CI: 64 to 71%) survived at least 1-year post-surgery. Our study found that social deprivation (IMD postcode rank) was not associated with mortality at 1 year after adjusting for potential confounding factors. Those from decile 1 had the lowest risk of death at 12 months for all tumour types (p = 0.0070). Previous smokers carried an increased risk of death at 12 months when compared with people who had never smoked RR 1.40 CI 1.10-1.78 (p = 0.006) but this risk was not evident in current smokers RR 0.92 CI 0.65-1.31 (p = 0.64). Increasing age and male gender were also found to be associated with higher mortality at 1 year (p = < 0.001). Conclusions: In the UK despite the discrepancy in the health of the general population between the north and south, social deprivation does not appear to be detrimental to neurooncological outcomes although smoking status, advancing age and male sex are.
MeSH term(s)	Humans ; Male ; Retrospective Studies ; Smoking/adverse effects ; Smoking/epidemiology ; Brain Neoplasms/surgery ; Delivery of Health Care ; Craniotomy/adverse effects ; Risk Factors
Language	English
Publishing date	2023-05-10
Publishing country	Austria
Document type	Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-023-05582-x
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Article ; Online: Awake craniotomy in the COVID-19 era - technical tips and feasibility.

Razak, Adam / Sloan, Geoff / Sebastian, Joseph / Ehsan, Sheeba / Karabatsou, Konstantina

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2020 Volume 82, Issue Pt A, Page(s) 49–51

Abstract: There has been a growing anxiety in carrying out awake craniotomy surgeries during the SARS-CoV-2 pandemic, not only due to airway management but also close proximity to the team in theatre. We set out to safely perform the first documented awake ... ...

Abstract	There has been a growing anxiety in carrying out awake craniotomy surgeries during the SARS-CoV-2 pandemic, not only due to airway management but also close proximity to the team in theatre. We set out to safely perform the first documented awake craniotomy in the UK since the beginning of lockdown. We performed a thorough workup of the patient with minimal hospital visits, using remote communication wherever possible. We modified our existing awake craniotomy protocol/technique guided by local/national policies. An asleep-awake-asleep craniotomy for tumour resection was performed successfully without compromising patient and staff safety with excellent post-operative outcome. With appropriate pre- and peri-operative modifications to established protocols, awake craniotomies with functional mapping can be safely carried out. By incorporating novel aspects to our technique, we believe that this service can safely resume in carefully selected patients.
MeSH term(s)	Adult ; Brain Neoplasms/surgery ; COVID-19/epidemiology ; Craniotomy/methods ; Feasibility Studies ; Female ; Glioma/surgery ; Humans ; Male ; Pandemics ; SARS-CoV-2/isolation & purification ; Wakefulness
Language	English
Publishing date	2020-10-27
Publishing country	Scotland
Document type	Case Reports ; Journal Article
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2020.10.048
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Article: Awake craniotomy in the COVID-19 era - technical tips and feasibility

Razak, Adam Sloan Geoff Sebastian Joseph Ehsan Sheeba Karabatsou Konstantina

Journal of Clinical Neuroscience

Abstract: There has been a growing anxiety in carrying out awake craniotomy surgeries during the SARS-CoV-2 pandemic, not only due to airway management but also close proximity to the team in theatre We set out to safely perform the first documented awake ... ...

Abstract	There has been a growing anxiety in carrying out awake craniotomy surgeries during the SARS-CoV-2 pandemic, not only due to airway management but also close proximity to the team in theatre We set out to safely perform the first documented awake craniotomy in the UK since the beginning of lockdown We performed a thorough workup of the patient with minimal hospital visits, using remote communication wherever possible We modified our existing awake craniotomy protocol/technique guided by local/national policies An asleep-awake-asleep craniotomy for tumour resection was performed successfully without compromising patient and staff safety with excellent post-operative outcome With appropriate pre- and peri-operative modifications to established protocols, awake craniotomies with functional mapping can be safely carried out By incorporating novel aspects to our technique, we believe that this service can safely resume in carefully selected patients
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #894057
Database	COVID19

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Article ; Online: Does the Use of Surgical Adjuncts Affect Postoperative Infection Rates in Neuro-oncology Surgery?

Maye, Helen / Colombo, Francesca / Bourama, Eva / Balogun, James / Karabatsou, Konstantina / Coope, David / Bailey, Matthew / Waqar, Mueez / D'Urso, Pietro I

World neurosurgery

2022 Volume 162, Page(s) e246–e250

Abstract: Background: Surgical site infection (SSI) is a significant cause of postoperative morbidity and mortality. As oncologic care advances, the use of surgical adjuncts such as intraoperative ultrasound (US), 5-aminolevulinic acid (5-ALA), and ... ...

Abstract	Background: Surgical site infection (SSI) is a significant cause of postoperative morbidity and mortality. As oncologic care advances, the use of surgical adjuncts such as intraoperative ultrasound (US), 5-aminolevulinic acid (5-ALA), and neurophysiologic monitoring has increased. This study set out to identify whether the use of surgical adjuncts in supratentorial tumor surgery lead to increased operative time or increased rates of SSI. Methods: This is a retrospective study at a large tertiary clinical neurosciences center in the UK. We included all patients who underwent an elective supratentorial craniotomy for a tumor over a 12 month period. We retrospectively assessed whether patients had had a postoperative infection at 30 days or 4 months using our electronic patient record system. Results: A total of 267 patients were included. The median age was 58 years (range: 17-87 years) with roughly equal numbers of men and women (men: 138 of 267, 52%). Most operations were carried out for gliomas (149 of 267, 56%) or metastases (61 of 267, 23%). The median length of surgery was 3 hours 6 minutes, with 24% lasting >4 hours. The overall infection rate was 4.5%. Intraoperative monitoring and 5-ALA was associated with longer operative times although not necessarily larger craniotomy sizes, whereas intraoperative US was associated with a shorter operative time and smaller craniotomy size. These adjuncts were not associated with an increased risk of infection. Conclusions: This study adds reassurance that although some surgical adjuncts lead to increased operative times, in our study there was no apparent increased risk of infection as a result of this.
MeSH term(s)	Craniotomy/adverse effects ; Elective Surgical Procedures/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Neurosurgical Procedures/adverse effects ; Retrospective Studies ; Risk Factors ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology
Language	English
Publishing date	2022-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2022.02.124
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Article: Perioperative Means to Prevent Surgical Site Infections following Elective Craniotomies: A Single-Center Experience.

Colombo, Francesca / Maye, Helen / Bourama, Eva / Waqar, Mueez / Karabatsou, Konstantina / Coope, David / Bailey, Matthew / Heal, Calvin / Patel, Hiren C / D'Urso, Pietro I

Asian journal of neurosurgery

2023 Volume 18, Issue 3, Page(s) 614–620

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2023-09-13
Publishing country	India
Document type	Journal Article
ZDB-ID	2621446-5
ISSN	2248-9614 ; 1793-5482
ISSN (online)	2248-9614
ISSN	1793-5482
DOI	10.1055/s-0043-1774720
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Article ; Online: Awake craniotomy in the COVID-19 era - technical tips and feasibility

Razak, Adam / Sloan, Geoff / Sebastian, Joseph / Ehsan, Sheeba / Karabatsou, Konstantina

Journal of Clinical Neuroscience

2020 Volume 82, Page(s) 49–51

Keywords	Physiology (medical) ; Neurology ; Clinical Neurology ; General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	1193674-5
ISSN	0967-5868
ISSN	0967-5868
DOI	10.1016/j.jocn.2020.10.048
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Venous thromboembolism chemical prophylaxis after endoscopic trans-sphenoidal pituitary surgery.

Waqar, Mueez / Chadwick, Annabel / Kersey, James / Horner, Daniel / Kearney, Tara / Karabatsou, Konstantina / Gnanalingham, Kanna K / Pathmanaban, Omar N

Pituitary

2021 Volume 25, Issue 2, Page(s) 267–274

Abstract: Purpose: There is no compelling outcome data or clear guidance surrounding postoperative venous thromboembolism (VTE) prophylaxis using low molecular weight heparin (chemoprophylaxis) in patients undergoing pituitary surgery. Here we describe our ... ...

Abstract	Purpose: There is no compelling outcome data or clear guidance surrounding postoperative venous thromboembolism (VTE) prophylaxis using low molecular weight heparin (chemoprophylaxis) in patients undergoing pituitary surgery. Here we describe our experience of early chemoprophylaxis (post-operative day 1) following trans-sphenoidal pituitary surgery. Methods: Single-centre review of a prospective surgical database and VTE records. Adults undergoing first time trans-sphenoidal pituitary surgery were included (2009-2018). VTE was defined as either deep vein thrombosis and/or pulmonary embolism within 3 months of surgery. Postoperative haematomas were those associated with a clinical deterioration together with radiological evidence. Results: 651 Patients included with a median age of 55 years (range 16-86 years). Most (99%) patients underwent trans-sphenoidal surgery using a standard endoscopic single nostril or bi-nostril trans-sphenoidal technique. More than three quarters had pituitary adenomas (n = 520, 80%). Postoperative chemoprophylaxis to prevent VTE was administered in 478 patients (73%). Chemoprophylaxis was initiated at a median of 1 day post-procedure (range 1-5 days postoperatively; 92% on postoperative day 1). Tinzaparin was used in 465/478 patients (97%) and enoxaparin was used in 14/478 (3%). There were no cases of VTE, even in 78 ACTH-dependent Cushing's disease patients. Six patients (1%) developed postoperative haematomas. Chemoprophylaxis was not associated with a significantly higher rate of postoperative haematoma formation (Fisher's Exact, p = 0.99) or epistaxis (Fisher's Exact, p > 0.99). Conclusions: Chemoprophylaxis after trans-sphenoidal pituitary surgery on post-operative day 1 is a safe strategy to reduce the risk of VTE without significantly increasing the risk of postoperative bleeding events.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anticoagulants/therapeutic use ; Humans ; Middle Aged ; Postoperative Complications/prevention & control ; Prospective Studies ; Pulmonary Embolism/drug therapy ; Pulmonary Embolism/prevention & control ; Risk Factors ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control ; Young Adult
Chemical Substances	Anticoagulants
Language	English
Publishing date	2021-11-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1385151-2
ISSN	1573-7403 ; 1386-341X
ISSN (online)	1573-7403
ISSN	1386-341X
DOI	10.1007/s11102-021-01195-8
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Article ; Online: Endoscopic transsphenoidal surgery for biochemically and clinically non-functioning adenohypophyseal tumours in the elderly: experience from a single UK centre.

Quah, Boon Leong / Edwards-Bailey, Andrew / Gnanalingham, Kanna / Pathmanaban, Omar / Vasilopoulos, Hariclea / Roncaroli, Federico / Kearney, Tara / Balogun, James / Karabatsou, Konstantina

Endocrine

2021 Volume 75, Issue 3, Page(s) 872–882

Abstract: Purpose: To assess and compare outcome of surgical management of non-functioning pituitary adenohypophyseal tumours in patients under 65-years, and 65-years and older at tertiary neurosurgical referral centre.: Methods: Data was retrospectively ... ...

Abstract	Purpose: To assess and compare outcome of surgical management of non-functioning pituitary adenohypophyseal tumours in patients under 65-years, and 65-years and older at tertiary neurosurgical referral centre. Methods: Data was retrospectively analysed from pituitary database. Forty-four patients aged 65 or older (Group 1) and 93 patients under 65 (Group 2) underwent endoscopic trans-sphenoidal surgery (ETSS) between January 2017 and July 2019. The surgical, endocrinological, ophthalmological and radiological outcomes were compared. Results: 6.8% of Group 1 patients had peri-operative surgical complications compared to 12.9% in Group 2 (p = 0.29). Improved visual fields and acuity were seen in 65.2% and 82.8% of Group 1 and Group 2 respectively (p = 0.124), although there were pre-existing ocular problems in 15.9% of Group 1. New hormone deficiencies were observed in 31.8% of Group 1 patients, and 24.7% of Group 2 (p = 0.555). Tumour regrowth/recurrence was seen in 2.3% of Group 1 (p = 0.553). The rate of repeat surgery was 6.8% in the Group 1 and 12.9% in Group 2 (p = 0.28). There was no significant relationship between extent of resection, complications or hormonal deficiency. The mean duration of follow-up was 10.5 ± 13.0 months for Group 1 patients and 13.0 ± 16.0 months for Group 2 patients (p = 0.526). Conclusions: ETSS for non-functioning pituitary adenohypophyseal tumours is safe and well tolerated in the patients aged 65 and older. Advanced age by itself should not be a contra-indication for ETSS. It is however highly recommended that the care of such patients to be offered at a high volume, dedicated pituitary surgical units.
MeSH term(s)	Adenoma/pathology ; Aged ; Humans ; Neoplasm Recurrence, Local/complications ; Pituitary Neoplasms/pathology ; Retrospective Studies ; Treatment Outcome ; United Kingdom
Language	English
Publishing date	2021-11-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-021-02910-y
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Article ; Online: Cerebral granulomatous condition mimicking optic pathway glioma.

Singh, Navneet / Palin, Martin / Karabatsou, Konstantina

British journal of neurosurgery

2016 Volume 32, Issue 4, Page(s) 448–449

Language	English
Publishing date	2016-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.1080/02688697.2016.1229754
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