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  1. Article: Mitochondrial DNA oxidation, methylation, and copy number alterations in major and bipolar depression.

    Ceylan, Deniz / Karacicek, Bilge / Tufekci, Kemal Ugur / Aksahin, Izel Cemre / Senol, Sevin Hun / Genc, Sermin

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1304660

    Abstract: Background: Mood disorders are common disabling psychiatric disorders caused by both genetic and environmental factors. Mitochondrial DNA (mtDNA) modifications and epigenetics are promising areas of research in depression since mitochondrial dysfunction ...

    Abstract Background: Mood disorders are common disabling psychiatric disorders caused by both genetic and environmental factors. Mitochondrial DNA (mtDNA) modifications and epigenetics are promising areas of research in depression since mitochondrial dysfunction has been associated with depression. In this study we aimed to investigate the mtDNA changes in depressive disorder (MDD) and bipolar disorder (BD).
    Methods: Displacement loop methylation (D-loop-met), relative mtDNA copy number (mtDNA-cn) and mtDNA oxidation (mtDNA-oxi) were investigated in DNA samples of individuals with MDD (
    Results: The study groups exhibited significant differences in D-loop-met (
    Conclusion: Our findings indicate significantly increased D-loop methylation in MDD compared to BD and HCs, suggesting distinct mtDNA modifications in these conditions. Moreover, the observed alterations in relative mtDNA-cn and D-loop-met during remission suggest a potential role of mtDNA alterations in the pathophysiology of MDD. Future studies may provide valuable insights into the dynamics of mtDNA modifications in both disorders and their response to treatment.
    Language English
    Publishing date 2023-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1304660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Implications of Possible HBV-Driven Regulation of Gene Expression in Stem Cell-like Subpopulation of Huh-7 Hepatocellular Carcinoma Cell Line.

    Demir, Ayse Banu / Benvenuto, Domenico / Karacicek, Bilge / Erac, Yasemin / Spoto, Silvia / Angeletti, Silvia / Ciccozzi, Massimo / Tosun, Metiner

    Journal of personalized medicine

    2022  Volume 12, Issue 12

    Abstract: Elevated levels of STIM1, an endoplasmic reticulum ... ...

    Abstract Elevated levels of STIM1, an endoplasmic reticulum Ca
    Language English
    Publishing date 2022-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12122065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Electrochemical detection of interaction between capsaicin and nucleic acids in comparison to agarose gel electrophoresis.

    Yilmaz, Nilay / Eksin, Ece / Karacicek, Bilge / Eraç, Yasemin / Erdem, Arzum

    Analytical biochemistry

    2017  Volume 535, Page(s) 56–62

    Abstract: In this study, the biomolecular interaction occurred between nucleic acids and Capsaicin (CPS), the active compound in chilli peppers, which has been reported to have anti-carcinogenic properties, was investigated for the first time herein using ... ...

    Abstract In this study, the biomolecular interaction occurred between nucleic acids and Capsaicin (CPS), the active compound in chilli peppers, which has been reported to have anti-carcinogenic properties, was investigated for the first time herein using disposable electrochemical biosensor. It is aimed to perform the surface-confined interaction between CPS and different types of nucleic acids and under this aim, the experimental conditions were optimized; such as, the concentration of CPS and DNA, DNA immobilization time and interaction time etc. The detection limit of DNA was estimated based on guanine oxidation signal in the linear concentration range of DNA from 1 to 5 μg/mL, and it was found to be 0.62 μg/mL. The effect of time-dependent manner from 1 min to 30 min on the interaction of CPS with nucleic acids was explored upon to the changes at guanine signal coming from double stranded DNA and cDNA as well as PCR samples. The interaction of CPS with double stranded DNA was also determined by agarose gel electrophoresis.
    MeSH term(s) Capsaicin/chemistry ; DNA/chemistry ; DNA/genetics ; Electrochemical Techniques ; Electrophoresis, Agar Gel ; Time Factors
    Chemical Substances DNA (9007-49-2) ; Capsaicin (S07O44R1ZM)
    Language English
    Publishing date 2017-10-15
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 1110-1
    ISSN 1096-0309 ; 0003-2697
    ISSN (online) 1096-0309
    ISSN 0003-2697
    DOI 10.1016/j.ab.2017.07.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 389: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  4. Article ; Online: A Novel Function for KLF4 in Modulating the De-differentiation of EpCAM

    Karagonlar, Zeynep Firtina / Akbari, Soheil / Karabicici, Mustafa / Sahin, Eren / Avci, Sanem Tercan / Ersoy, Nevin / Ates, Kıvılcım Eren / Balli, Tugsan / Karacicek, Bilge / Kaplan, Kubra Nur / Celiker, Canan / Atabey, Nese / Erdal, Esra

    Cells

    2020  Volume 9, Issue 5

    Abstract: The complex and heterogeneous nature of hepatocellular carcinoma (HCC) hampers the identification of effective therapeutic strategies. Cancer stem cells (CSCs) represent a fraction of cells within tumors with the ability to self-renew and differentiate, ... ...

    Abstract The complex and heterogeneous nature of hepatocellular carcinoma (HCC) hampers the identification of effective therapeutic strategies. Cancer stem cells (CSCs) represent a fraction of cells within tumors with the ability to self-renew and differentiate, and thus significantly contribute to the formation and maintenance of heterogeneous tumor mass. Increasing evidence indicates high plasticity in tumor cells, suggesting that non-CSCs could acquire stem cell properties through de-differentiation or reprogramming processes. In this paper, we reveal KLF4 as a transcription factor that can induce a CSC-like phenotype in non-CSCs through upregulating the EpCAM and E-CAD expression. Our studies indicated that KLF4 could directly bind to the promoter of
    MeSH term(s) AC133 Antigen/metabolism ; Animals ; Cadherins/metabolism ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Dedifferentiation ; Cell Line, Tumor ; Cell Membrane/metabolism ; Epithelial Cell Adhesion Molecule/genetics ; Epithelial Cell Adhesion Molecule/metabolism ; Humans ; Kruppel-Like Transcription Factors/metabolism ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Mice, Inbred NOD ; Mice, SCID ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Phenotype ; Transcription, Genetic ; beta Catenin/metabolism
    Chemical Substances AC133 Antigen ; Cadherins ; EPCAM protein, human ; Epithelial Cell Adhesion Molecule ; GKLF protein ; Kruppel-Like Transcription Factors ; beta Catenin
    Language English
    Publishing date 2020-05-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9051198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Introducing basic molecular biology to Turkish rural and urban primary school children via hands-on PCR and gel electrophoresis activities.

    Selli, Cigdem / Yıldırım, Gokce / Kaymak, Aysegul / Karacicek, Bilge / Ogut, Deniz / Gungor, Turkan / Erem, Erdem / Ege, Mehmet / Bümen, Nilay / Tosun, Metiner

    Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

    2014  Volume 42, Issue 2, Page(s) 114–120

    Abstract: This study includes the results of a 2-day education project titled "Molecular Biology Laboratory Summer School, MoBiLYO." The project was held at a University Research Center by scientists from Department of Pharmacology and graduate students. The ... ...

    Abstract This study includes the results of a 2-day education project titled "Molecular Biology Laboratory Summer School, MoBiLYO." The project was held at a University Research Center by scientists from Department of Pharmacology and graduate students. The project was composed of introductory lectures, model construction, DNA isolation, polymerase chain reaction (PCR), and gel electrophoresis. The participants were 13-year-old eighth-graders attending primary schools affiliated with Ministry of National Education in urban and rural areas of Izmir, Turkey. The purpose of this study was to introduce basic molecular biology concepts through individually performed experiments such as PCR and gel electrophoresis integrated with creative drama. The students were assessed at the beginning and the end of each project day via mini-tests, experimental and presentation skills evaluation forms. Data showed that students' knowledge about DNA structure and basic molecular biology techniques significantly increased. On the basis of experimental and presentational skills, there was no significant difference between kids from urban and rural schools or between public and boarding public schools, whereas the average score of girls was significantly higher than that of boys. In conclusion, individually performed experiments integrated with creative drama significantly increased students' perception of complex experimental procedures on basic molecular biology concepts. Data suggests that integration of these concepts into the science and technology curriculum of Turkish primary education may support the recruitment of future scientists who can handle rapidly developing genomic techniques that will affect our everyday life.
    MeSH term(s) Electrophoresis ; Female ; Humans ; Male ; Molecular Biology/education ; Polymerase Chain Reaction/methods ; Rural Population ; Schools ; Science ; Turkey ; Universities
    Language English
    Publishing date 2014-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1539-3429
    ISSN (online) 1539-3429
    DOI 10.1002/bmb.20758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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