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  1. Article ; Online: Role of simple inflammatory parameters in predicting the severity of coronary artery disease.

    Aydın, Cihan / Uyan, Umut / Karadeniz, Muhammed / Demirkıran, Aykut

    Revista da Associacao Medica Brasileira (1992)

    2023  Volume 69, Issue 11, Page(s) e20230518

    Abstract: Objective: In our study, we aimed to find simple, useful biomarkers in patients with non-ST elevation myocardial infarction to predict coronary artery severity.: Methods: Between May 2022 and December 2022, patients diagnosed with non-ST elevation ... ...

    Abstract Objective: In our study, we aimed to find simple, useful biomarkers in patients with non-ST elevation myocardial infarction to predict coronary artery severity.
    Methods: Between May 2022 and December 2022, patients diagnosed with non-ST elevation myocardial infarction according to the European cardiology guidelines were included in our study. The Synergy between PCI with Taxus and Cardiac Surgery score was calculated to determine the severity of coronary artery disease. These patients were classified into two groups according to Synergy between PCI with Taxus and Cardiac Surgery≥23 and Synergy between PCI with Taxus and Cardiac Surgery<23 scores. Biochemical markers such as platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio were studied in blood tests taken before coronary angiography in patients diagnosed with non-ST elevation myocardial infarction according to current guidelines. These two groups were compared in terms of the data obtained.
    Results: There were 281 patients in group 1 and 67 patients in group 2. There was no significant difference between the two groups in terms of demographic data such as age and gender. Platelet-to-lymphocyte ratio [group 1=125 (26-134) and group 2=156 (73-293); p=0.001] and neutrophil-to-lymphocyte ratio [group 1=2.71 (1.3-30.2) and group 2=3.2 (2.1-32.1); p=0.002] were higher in the group of patients with a Synergy between PCI with Taxus and Cardiac Surgery score of <23, while lymphocyte-to-monocyte ratio [group 1=3.6 (0.56-11) and group 2=3.4 (0.64-5.75); p=0.017] was lower in group 2.
    Conclusion: We observed that elevated platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios showed coronary artery severity. Multivessel disease and chronic total occlusion rates were observed to be higher in patients with high platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios.
    MeSH term(s) Humans ; Coronary Artery Disease/surgery ; Percutaneous Coronary Intervention ; Risk Factors ; Coronary Angiography ; Non-ST Elevated Myocardial Infarction
    Language English
    Publishing date 2023-10-09
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.20230518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Author's Reply to the Letter to the Editor "Hyperhomocysteinemia Predicts the Severity of Coronary Artery Disease as Determined by the SYNTAX Score in Patients with Acute Coronary Syndrome".

    Karadeniz, Muhammed / Celik, Ibrahim Etem

    Acta Cardiologica Sinica

    2020  Volume 36, Issue 4, Page(s) 397

    Language English
    Publishing date 2020-06-07
    Publishing country China (Republic : 1949- )
    Document type Journal Article ; Comment
    ZDB-ID 1051394-2
    ISSN 1011-6842
    ISSN 1011-6842
    DOI 10.6515/ACS.202007_36(4).20200518A
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The relationship between serum NT-proBNP levels and severity of coronary artery disease assessed by SYNTAX score in patients with acute myocardial infarction

    Sarak, Taner / Karadeniz, Muhammed

    Turkish journal of medical sciences

    2019  Volume 49, Issue 5, Page(s) 1366–1373

    Abstract: Background/aim: In the present study, we aimed to investigate the relationship between NT-proBNP and SYNTAX score, which is a measure of the complexity of coronary artery disease.: Materials and methods: We enrolled 405 consecutive patients ... ...

    Abstract Background/aim: In the present study, we aimed to investigate the relationship between NT-proBNP and SYNTAX score, which is a measure of the complexity of coronary artery disease.
    Materials and methods: We enrolled 405 consecutive patients with myocardial infarction who underwent coronary angiographic examination. Patients were divided into 3 groups according to their SYNTAX scores. Those with SYNTAX score ≤22 were included in the low SYNTAX score group (LSTX), those with a score of 23–32 were included in the intermediate SYNTAX score group (ISTX), and those with a score of ≥33 were included in the high SYNTAX score group (HSTX).
    Results: NT-proBNP levels were found to be significantly higher in the HSTX group compared to the other groups (P < 0.001) and in the ISTX group compared to the LSTX group (P < 0.001). The NT-proBNP levels demonstrated an increase from low SYNTAX score to high SYNTAX score tertiles.
    Conclusions: NT-ProBNP levels in patients with myocardial infarction on admission were independently associated with extent, severity, and complexity of coronary atherosclerosis as assessed by SYNTAX score.
    MeSH term(s) Aged ; Coronary Angiography ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/pathology ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/diagnosis ; Myocardial Infarction/pathology ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Retrospective Studies ; Severity of Illness Index
    Chemical Substances Peptide Fragments ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2019-10-24
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-1902-26
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prolonged P Wave Peak Time May Be a Sign of LV Diastolic Dysfunction in the Coronary Slow Flow Phenomenon.

    Aslan, Burhan / Işık, Ferhat / Akyüz, Abdurrahman / İnci, Ümit / Karadeniz, Muhammed

    International journal of clinical practice

    2022  Volume 2022, Page(s) 4626701

    Abstract: Background: The coronary slow flow phenomenon (CSFP) is an atherosclerotic process that causes ischemia at the microvascular level. The CSFP may affect P wave durations, especially P wave peak time (PWPT), by microvascular ischemia, left ventricular ... ...

    Abstract Background: The coronary slow flow phenomenon (CSFP) is an atherosclerotic process that causes ischemia at the microvascular level. The CSFP may affect P wave durations, especially P wave peak time (PWPT), by microvascular ischemia, left ventricular diastolic dysfunction, and changes in the left atrial dimension. Therefore, in the present study, we aimed to assess PWPT in the CSFP.
    Method: One hundred and ninety-five patients were included in this single-center, retrospective study. Ninety patients were enrolled in the CSFP group and 105 patients in the control group. PWPT was defined as the duration between the beginning and peak of the
    Results: The mean age of the study population was 48.5 ± 9.5, and 108 (55.3%) of the patients were female. We found PWPT was longer in the CSFP group than in the control group. Correlation analysis showed a positive correlation between PWPT in both leads (
    Conclusion: In the present study, we found prolonged PWPT in patients with the CSFP and found a relationship between PWPT and mean TFC.
    MeSH term(s) Coronary Angiography ; Female ; Heart Atria ; Humans ; Male ; No-Reflow Phenomenon/complications ; No-Reflow Phenomenon/diagnostic imaging ; Retrospective Studies ; Ventricular Dysfunction, Left/diagnostic imaging
    Language English
    Publishing date 2022-01-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1155/2022/4626701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Anterior myocardial infarction in a patient with isolated left ventricular non-compaction.

    Celik, Ibrahim Etem / Kilic, Alparslan / Karadeniz, Muhammed

    Cardiology in the young

    2019  Volume 29, Issue 5, Page(s) 708–710

    Abstract: We presented a 55-year-old male patient with isolated left ventricular non-compaction who was admitted to our emergency department for chest pain and exertional dyspnoea. He was hospitalised due to anterior myocardial infarction, and during his ... ...

    Abstract We presented a 55-year-old male patient with isolated left ventricular non-compaction who was admitted to our emergency department for chest pain and exertional dyspnoea. He was hospitalised due to anterior myocardial infarction, and during his assessment, isolated left ventricular non-compaction was diagnosed.
    MeSH term(s) Anterior Wall Myocardial Infarction/diagnosis ; Anterior Wall Myocardial Infarction/physiopathology ; Anterior Wall Myocardial Infarction/therapy ; Cardiomyopathy, Hypertrophic, Familial/complications ; Cardiomyopathy, Hypertrophic, Familial/diagnosis ; Chest Pain/etiology ; Coronary Angiography ; Dyspnea/etiology ; Echocardiography ; Electrocardiography ; Humans ; Incidental Findings ; Male ; Middle Aged
    Language English
    Publishing date 2019-05-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951119000283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The effect of body mass index on complications in cardiac implantable electronic device surgery.

    Güzel, Tuncay / Demir, Muhammed / Aktan, Adem / Kılıç, Raif / Arslan, Bayram / Günlü, Serhat / Altıntaş, Bernas / Karahan, Mehmet Zülküf / Özbek, Mehmet / Aslan, Burhan / Arpa, Abdulkadir / Coşkun, Mehmet Sait / Altunbaş, Mahsum / Tüzün, Rohat / Akgümüş, Alkame / Karadeniz, Muhammed / Aydın, Saadet / Güzel, Hamdullah / Aslan, Selen Filiz /
    Söner, Serdar / Taş, Ahmet / Ertaş, Faruk

    Pacing and clinical electrophysiology : PACE

    2023  Volume 47, Issue 2, Page(s) 292–299

    Abstract: Background: Cardiac implantable electronic device (CIED) procedures are prone to complications. In our study, we investigated the effect of body mass index (BMI) on CIED-related complications.: Methods: 1676 patients who had undergone CIED surgery ( ... ...

    Abstract Background: Cardiac implantable electronic device (CIED) procedures are prone to complications. In our study, we investigated the effect of body mass index (BMI) on CIED-related complications.
    Methods: 1676 patients who had undergone CIED surgery (de novo implantation, system upgrade, generator change, pocket revision or lead replacement) at two heart centers in Turkey and met the study criteria were included in our study. For analysis of primary and secondary endpoints, patients were classified as non-obese (BMI < 25 kg/m
    Results: The rate of cumulative events, defined as primary outcome, was higher in the obese patient group, and we found a significant difference between the groups (3.0%, 4.3%, 8.9%, p = .001). CSH and pneumothorax rates were significantly higher in the obese patient group (0.3%, 0.9%, 1.9%, p = .04; 1.0%, 1.4%, 3.3%, p = .04, respectively). According to our multivariate model analysis; gender (OR:1.882, 95%CI:1.156-3.064, p = .01), hypertension (OR:4.768, 95%CI:2.470-9.204, p < .001), BMI (OR:1.069, 95%CI:1.012-1.129, p = .01) were independent predictors of cumulative events rates.
    Conclusions: Periprocedural complications associated with CIED (especially hematoma and pneumothorax) are more common in the group with high BMI.
    MeSH term(s) Humans ; Defibrillators, Implantable/adverse effects ; Body Mass Index ; Pneumothorax/epidemiology ; Pneumothorax/etiology ; Obesity/complications ; Pericardial Effusion ; Hematoma/etiology ; Pacemaker, Artificial/adverse effects ; Retrospective Studies
    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 424437-0
    ISSN 1540-8159 ; 0147-8389
    ISSN (online) 1540-8159
    ISSN 0147-8389
    DOI 10.1111/pace.14903
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  7. Article ; Online: Serum pentraxin-3 levels and flow-mediated dilation in dipper and non-dipper hypertension.

    Alp, Çağlar / Dogru, Mehmet Tolga / Karadeniz, Muhammed / Sarak, Taner / Demir, Vahit / Çelik, Yunus / Kandemir, Hüseyin / Kısa, Üçler

    Journal of clinical laboratory analysis

    2018  Volume 33, Issue 3, Page(s) e22718

    Abstract: Background: Endothelial dysfunction is one of the main pathological processes of hypertension. The association of serum pentraxin-3 (PTX3) levels and endothelial dysfunction becomes a more interesting scientific research issue due to high potential of ... ...

    Abstract Background: Endothelial dysfunction is one of the main pathological processes of hypertension. The association of serum pentraxin-3 (PTX3) levels and endothelial dysfunction becomes a more interesting scientific research issue due to high potential of PTX3 as a diagnostic and prognostic biomarker. We aimed to investigate the relationship between serum PTX3 levels and flow-mediated dilation results in patients with dipper and non-dipper hypertension.
    Methods: This study included 90 hypertensive patients were divided into two groups based on 24 hours ambulatory blood pressure monitoring (ABPM): 38 patients with a dipper pattern and 52 patients with non-dipper pattern. Noninvasive evaluation of the endothelial functions was performed using flow-mediated dilation (FMD) method.
    Results: Serum pentraxin-3 levels were higher in patients with non-dipper HT compared to dipper hypertension (P = 0.028). In addition, we found negative correlation between serum PTX3 and FMD basal/FMD hyperemia ratio (r = -0.297, P = 0.05 for FMD basal/FMD hyperemia ratio, respectively).
    Conclusions: Serum PTX3 levels are closely related with the measures of indirect noninvasive evaluation methods (FMD) in both DH and NDH patients.
    MeSH term(s) Adult ; Aged ; Biomarkers/blood ; Blood Pressure Monitoring, Ambulatory ; C-Reactive Protein/analysis ; Cross-Sectional Studies ; Humans ; Hypertension/blood ; Hypertension/classification ; Hypertension/epidemiology ; Male ; Middle Aged ; Serum Amyloid P-Component/analysis ; Vascular Resistance ; Vasodilation
    Chemical Substances Biomarkers ; Serum Amyloid P-Component ; PTX3 protein (148591-49-5) ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2018-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645095-7
    ISSN 1098-2825 ; 0887-8013
    ISSN (online) 1098-2825
    ISSN 0887-8013
    DOI 10.1002/jcla.22718
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  8. Article: Hyperhomocysteinemia Predicts the Severity of Coronary Artery Disease as Determined by the SYNTAX Score in Patients with Acute Coronary Syndrome.

    Karadeniz, Muhammed / Sarak, Taner / Duran, Mustafa / Alp, Caglar / Kandemir, Huseyin / Etem Celik, İbrahim / Simsek, Vedat / Kılıc, Alparslan

    Acta Cardiologica Sinica

    2017  Volume 34, Issue 6, Page(s) 458–463

    Abstract: Background: Hyperhomocysteinemia is a known risk factor for acute coronary syndrome (ACS) and is related with the severity of coronary artery disease (CAD). Previous studies have used less quantifiable scoring systems for assessing the severity of CAD. ... ...

    Abstract Background: Hyperhomocysteinemia is a known risk factor for acute coronary syndrome (ACS) and is related with the severity of coronary artery disease (CAD). Previous studies have used less quantifiable scoring systems for assessing the severity of CAD. Therefore, we aimed to assess the relationship between homocysteine levels and SYNTAX score (SXscore), which is currently more widely used to grade the severity of CAD.
    Methods: A total of 503 patients with adiagnosis of ACS were examined angiographically with SXscore. The patients were divided into three groups according to SXscore; Group 1 a low SXscore (≤ 22), Group 2 a moderate SXscore (23-32), and Group 3 a high SXscore (≥ 33).
    Results: Plasma homocysteine levels were 16.3 ± 6.2 nmol/mL in Group 1, 18.1 ± 9.6 nmol/mL in Group 2, and 19.9 ± 9.5 nmol/mL in Group 3. Homocysteine levels were significantly higher in Group 2, and Group 3 compared to Group 1 (p = 0.023 and 0.007, respectively). In the correlation analysis, homocysteine levels were correlated with SXscore (r: 0.166, p < 0.01).
    Conclusions: Serum homocysteine levels on admission were associated with an increased severity of CAD in the patients with ACS.
    Language English
    Publishing date 2017-12-01
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 1051394-2
    ISSN 1011-6842
    ISSN 1011-6842
    DOI 10.6515/ACS.201811_34(6).20180528B
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  9. Article: An unusual etiology of Kounis syndrome; warble fly.

    Karadeniz, Muhammed / Akyel, Ahmet / Celik, Ibrahim Etem / Cankurt, Tayyar / Barış, Veysel Özgür / Murat, Sani Namık

    Indian heart journal

    2013  Volume 65, Issue 3, Page(s) 358–359

    MeSH term(s) Acute Coronary Syndrome/etiology ; Acute Coronary Syndrome/immunology ; Animals ; Coronary Angiography ; Diptera ; Humans ; Hypersensitivity/etiology ; Hypersensitivity/immunology ; Insect Bites and Stings/complications ; Insect Bites and Stings/immunology ; Male ; Middle Aged ; Syndrome
    Language English
    Publishing date 2013-04-09
    Publishing country India
    Document type Case Reports ; Letter
    ZDB-ID 604366-5
    ISSN 0019-4832
    ISSN 0019-4832
    DOI 10.1016/j.ihj.2013.04.015
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  10. Article ; Online: The association of red cell distribution width with in-stent restenosis in patients with stable coronary artery disease.

    Kurtul, Alparslan / Murat, Sani Namik / Yarlioglues, Mikail / Duran, Mustafa / Karadeniz, Muhammed / Ergun, Gokhan / Akyel, Ahmet / Mendi, Mehmet Ali / Oksuz, Fatih

    Platelets

    2015  Volume 26, Issue 1, Page(s) 48–52

    Abstract: Increased red cell distribution width (RDW) is closely related to the poor prognosis and adverse events of cardiovascular diseases. We aimed to investigate the association of serum RDW levels and in-stent restenosis (ISR) after coronary stenting with ... ...

    Abstract Increased red cell distribution width (RDW) is closely related to the poor prognosis and adverse events of cardiovascular diseases. We aimed to investigate the association of serum RDW levels and in-stent restenosis (ISR) after coronary stenting with bare-metal stent in patients with stable coronary artery disease. A total of 251 patients (age 62 ± 11 years, 69% male) with a history of coronary stenting who underwent control coronary angiography (128 with ISR and 123 without ISR) were enrolled into the study. Laboratory parameters were measured before angiography. ISR was defined as luminal stenosis ≥50% within the stent or within 5 mm of its edges by the quantitative coronary analysis. The patients were divided into the two groups: ISR group and no-ISR group. Baseline characteristics of the patients were similar. The ISR group had significantly higher RDW levels compared with patients in no-ISR group (14.47 ± 1.37 vs. 13.59 ± 0.88, p < 0.001). Furthermore, the ISR group had significantly longer stent length and lower stent diameter when compared to no-ISR group (p = 0.001 and p = 0.004, respectively). In a multivariate analysis, RDW levels >13.75%, high-sensitivity C-reactive protein levels, stent diameter and stent length were independently associated with ISR [odds ratio (OR) = 2.12, 95% confidence interval (CI) = 1.71-3.15, OR = 2.80, 95% CI = (1.34-4.61), OR = -2.60, 95% CI = -(1.19-4.51), OR = 2.02, 95% CI = 1.99-3.76, p = 0.001, respectively]. We concluded that increased serum RDW levels were independently associated with bare-metal ISR in patients with stable coronary artery disease.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Coronary Angiography ; Coronary Artery Disease/blood ; Coronary Artery Disease/pathology ; Coronary Artery Disease/surgery ; Coronary Restenosis/blood ; Erythrocyte Indices ; Female ; Humans ; Male ; Middle Aged ; Odds Ratio ; ROC Curve ; Risk Factors ; Stents/adverse effects
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.3109/09537104.2014.881990
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