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  1. Article ; Online: HPV16

    Konstantopoulos, Georgios / Leventakou, Danai / Saltiel, Despoina-Rozi / Zervoudi, Efthalia / Logotheti, Eirini / Pettas, Spyros / Karagianni, Korina / Daiou, Angeliki / Hatzistergos, Konstantinos E / Dafou, Dimitra / Arsenakis, Minas / Kottaridi, Christine

    Viruses

    2024  Volume 16, Issue 1

    Abstract: Human Papillomaviruses have been associated with the occurrence of cervical cancer, the fourth most common cancer that affects women globally, while 70% of cases are caused by infection with the high-risk types HPV16 and HPV18. The integration of these ... ...

    Abstract Human Papillomaviruses have been associated with the occurrence of cervical cancer, the fourth most common cancer that affects women globally, while 70% of cases are caused by infection with the high-risk types HPV16 and HPV18. The integration of these viruses' oncogenes
    MeSH term(s) Female ; Humans ; B7-H1 Antigen/genetics ; Human papillomavirus 16/genetics ; Immune Evasion ; MicroRNAs/genetics ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/virology ; Oncogene Proteins, Viral/genetics
    Chemical Substances B7-H1 Antigen ; MicroRNAs ; MIRN143 microRNA, human ; E6 protein, Human papillomavirus type 16 ; Oncogene Proteins, Viral ; HIF1A protein, human
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16010113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Αnti-prion effects of anthocyanins.

    Christoudia, Nikoletta / Bekas, Nikolaos / Kanata, Eirini / Chatziefsthathiou, Athanasia / Pettas, Spyros / Karagianni, Korina / Da Silva Correia, Susana Margarida / Schmitz, Matthias / Zerr, Inga / Tsamesidis, Ioannis / Xanthopoulos, Konstantinos / Dafou, Dimitra / Sklaviadis, Theodoros

    Redox biology

    2024  Volume 72, Page(s) 103133

    Abstract: Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), are protein-based neurodegenerative disorders (NDs) affecting humans and animals. They are characterized by the conformational conversion of the normal cellular prion protein, ...

    Abstract Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), are protein-based neurodegenerative disorders (NDs) affecting humans and animals. They are characterized by the conformational conversion of the normal cellular prion protein, PrP
    Language English
    Publishing date 2024-03-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2024.103133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Systematic Review of Common and Brain-Disease-Specific RNA Editing Alterations Providing Novel Insights into Neurological and Neurodegenerative Disease Manifestations.

    Karagianni, Korina / Pettas, Spyros / Christoforidou, Georgia / Kanata, Eirini / Bekas, Nikolaos / Xanthopoulos, Konstantinos / Dafou, Dimitra / Sklaviadis, Theodoros

    Biomolecules

    2022  Volume 12, Issue 3

    Abstract: RNA editing contributes to transcriptome diversification through RNA modifications in relation to genome-encoded information (RNA-DNA differences, RDDs). The deamination of Adenosine (A) to Inosine (I) or Cytidine (C) to Uridine (U) is the most common ... ...

    Abstract RNA editing contributes to transcriptome diversification through RNA modifications in relation to genome-encoded information (RNA-DNA differences, RDDs). The deamination of Adenosine (A) to Inosine (I) or Cytidine (C) to Uridine (U) is the most common type of mammalian RNA editing. It occurs as a nuclear co- and/or post-transcriptional event catalyzed by ADARs (Adenosine deaminases acting on RNA) and APOBECs (apolipoprotein B mRNA editing enzyme catalytic polypeptide-like genes). RNA editing may modify the structure, stability, and processing of a transcript. This review focuses on RNA editing in psychiatric, neurological, neurodegenerative (NDs), and autoimmune brain disorders in humans and rodent models. We discuss targeted studies that focus on RNA editing in specific neuron-enriched transcripts with well-established functions in neuronal activity, and transcriptome-wide studies, enabled by recent technological advances. We provide comparative editome analyses between human disease and corresponding animal models. Data suggest RNA editing to be an emerging mechanism in disease development, displaying common and disease-specific patterns. Commonly edited RNAs represent potential disease-associated targets for therapeutic and diagnostic values. Currently available data are primarily descriptive, calling for additional research to expand global editing profiles and to provide disease mechanistic insights. The potential use of RNA editing events as disease biomarkers and available tools for RNA editing identification, classification, ranking, and functional characterization that are being developed will enable comprehensive analyses for a better understanding of disease(s) pathogenesis and potential cures.
    MeSH term(s) Adenosine/genetics ; Adenosine/metabolism ; Adenosine Deaminase/genetics ; Adenosine Deaminase/metabolism ; Animals ; Brain/metabolism ; Brain Diseases ; Mammals/metabolism ; Neurodegenerative Diseases/genetics ; RNA ; RNA Editing/genetics
    Chemical Substances RNA (63231-63-0) ; Adenosine Deaminase (EC 3.5.4.4) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2022-03-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12030465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Profiling Microglia through Single-Cell RNA Sequencing over the Course of Development, Aging, and Disease.

    Pettas, Spyros / Karagianni, Korina / Kanata, Eirini / Chatziefstathiou, Athanasia / Christoudia, Nikoletta / Xanthopoulos, Konstantinos / Sklaviadis, Theodoros / Dafou, Dimitra

    Cells

    2022  Volume 11, Issue 15

    Abstract: Microglia are macrophages present in the brain that function as the primary and most important source of immune response in the central nervous system (CNS). Regardless of their multitasking role, our knowledge regarding their molecular heterogeneity is ... ...

    Abstract Microglia are macrophages present in the brain that function as the primary and most important source of immune response in the central nervous system (CNS). Regardless of their multitasking role, our knowledge regarding their molecular heterogeneity is limited; due to technical restrictions, it is only possible to measure gene expression in cell populations, not individual cells, with the results reflecting average mRNA levels. Therefore, recent scientific approaches have focused on single-cell techniques such as single-cell RNA sequencing (scRNAseq), a powerful technique that enables the delineation of transcriptomic cell-to-cell differences, revealing subpopulations with distinct molecular and functional characteristics. Here, we summarize recent studies that focused on transcriptomic microglial subpopulation clustering and classify them into three distinct groups based on age, spatial distribution, and disease. Additionally, we cross-compare populations from different studies to identify expressional and functional overlaps between them.
    MeSH term(s) Central Nervous System ; Microglia/metabolism ; Sequence Analysis, RNA ; Transcriptome/genetics
    Language English
    Publishing date 2022-08-02
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11152383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Recommendations for detection, validation, and evaluation of RNA editing events in cardiovascular and neurological/neurodegenerative diseases.

    Karagianni, Korina / Bibi, Alessia / Madé, Alisia / Acharya, Shubhra / Parkkonen, Mikko / Barbalata, Teodora / Srivastava, Prashant K / de Gonzalo-Calvo, David / Emanueli, Constanza / Martelli, Fabio / Devaux, Yvan / Dafou, Dimitra / Nossent, A Yaël

    Molecular therapy. Nucleic acids

    2023  Volume 35, Issue 1, Page(s) 102085

    Abstract: RNA editing, a common and potentially highly functional form of RNA modification, encompasses two different RNA modifications, namely adenosine to inosine (A-to-I) and cytidine to uridine (C-to-U) editing. As inosines are interpreted as guanosines by the ...

    Abstract RNA editing, a common and potentially highly functional form of RNA modification, encompasses two different RNA modifications, namely adenosine to inosine (A-to-I) and cytidine to uridine (C-to-U) editing. As inosines are interpreted as guanosines by the cellular machinery, both A-to-I and C-to-U editing change the nucleotide sequence of the RNA. Editing events in coding sequences have the potential to change the amino acid sequence of proteins, whereas editing events in noncoding RNAs can, for example, affect microRNA target binding. With advancing RNA sequencing technology, more RNA editing events are being discovered, studied, and reported. However, RNA editing events are still often overlooked or discarded as sequence read quality defects. With this position paper, we aim to provide guidelines and recommendations for the detection, validation, and follow-up experiments to study RNA editing, taking examples from the fields of cardiovascular and brain disease. We discuss all steps, from sample collection, storage, and preparation, to different strategies for RNA sequencing and editing-sensitive data analysis strategies, to validation and follow-up experiments, as well as potential pitfalls and gaps in the available technologies. This paper may be used as an experimental guideline for RNA editing studies in any disease context.
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2023.102085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Carnosic Acid and Carnosol Display Antioxidant and Anti-Prion Properties in In Vitro and Cell-Free Models of Prion Diseases.

    Karagianni, Korina / Pettas, Spyros / Kanata, Eirini / Lioulia, Elisavet / Thune, Katrin / Schmitz, Matthias / Tsamesidis, Ioannis / Lymperaki, Evgenia / Xanthopoulos, Konstantinos / Sklaviadis, Theodoros / Dafou, Dimitra

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 4

    Abstract: Prion diseases are transmissible encephalopathies associated with the conversion of the physiological form of the prion protein ( ... ...

    Abstract Prion diseases are transmissible encephalopathies associated with the conversion of the physiological form of the prion protein (PrP
    Language English
    Publishing date 2022-04-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11040726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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