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  1. AU="Karaji, Niloofar"
  2. AU="Tjempakasari, Artaria"
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  1. Article: Efferocytosis of Pathogen-Infected Cells.

    Karaji, Niloofar / Sattentau, Quentin J

    Frontiers in immunology

    2017  Volume 8, Page(s) 1863

    Abstract: The prompt and efficient clearance of unwanted and abnormal cells by phagocytes is termed efferocytosis and is crucial for organism development, maintenance of tissue homeostasis, and regulation of the immune system. Dying cells are recognized by ... ...

    Abstract The prompt and efficient clearance of unwanted and abnormal cells by phagocytes is termed efferocytosis and is crucial for organism development, maintenance of tissue homeostasis, and regulation of the immune system. Dying cells are recognized by phagocytes through pathways initiated
    Language English
    Publishing date 2017-12-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2017.01863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis.

    Drexhage, Linnea Z / Zhang, Shengpan / Dupont, Maeva / Ragaller, Franziska / Sjule, Ellen / Cabezas-Caballero, Jose / Deimel, Lachlan P / Robertson, Helen / Russell, Rebecca A / Dushek, Omer / Sezgin, Erdinc / Karaji, Niloofar / Sattentau, Quentin J

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 541

    Abstract: Efferocytic clearance of apoptotic cells in general, and T cells in particular, is required for tissue and immune homeostasis. Transmembrane mucins are extended glycoproteins highly expressed in the cell glycocalyx that function as a barrier to ... ...

    Abstract Efferocytic clearance of apoptotic cells in general, and T cells in particular, is required for tissue and immune homeostasis. Transmembrane mucins are extended glycoproteins highly expressed in the cell glycocalyx that function as a barrier to phagocytosis. Whether and how mucins may be regulated during cell death to facilitate efferocytic corpse clearance is not well understood. Here we show that normal and transformed human T cells express a subset of mucins which are rapidly and selectively removed from the cell surface during apoptosis. This process is mediated by the ADAM10 sheddase, the activity of which is associated with XKR8-catalyzed flipping of phosphatidylserine to the outer leaflet of the plasma membrane. Mucin clearance enhances uptake of apoptotic T cells by macrophages, confirming mucins as an enzymatically-modulatable barrier to efferocytosis. Together these findings demonstrate a glycocalyx regulatory pathway with implications for therapeutic intervention in the clearance of normal and transformed apoptotic T cells.
    MeSH term(s) Humans ; Efferocytosis ; Mucins ; T-Lymphocytes/metabolism ; Apoptosis ; Phagocytosis ; ADAM10 Protein/genetics ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Amyloid Precursor Protein Secretases
    Chemical Substances Mucins ; ADAM10 protein, human (EC 3.4.24.81) ; ADAM10 Protein (EC 3.4.24.81) ; Membrane Proteins ; Amyloid Precursor Protein Secretases (EC 3.4.-)
    Language English
    Publishing date 2024-01-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-44619-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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