Article: Macrophages - a perspective target for antineoplastic immunotherapy.
2019 Volume 41, Issue 4, Page(s) 282–290
Abstract: The review discusses the data on the functional/phenotypic M1/M2 types of macrophages and their chimeric forms, the molecular mechanisms of polarization of these cells, and their role in the development of malignant tumors. Information on the prognostic ... ...
Abstract | The review discusses the data on the functional/phenotypic M1/M2 types of macrophages and their chimeric forms, the molecular mechanisms of polarization of these cells, and their role in the development of malignant tumors. Information on the prognostic value of the presence (density and location) of M1/M2 cells in tumor tissue is analyzed. Our own results evidence on the necessity of determination of the functional/phenotypic state of M1/M2 macrophages from different biological niches in the dynamics of tumor growth, in particular in terms of NO level and arginase activity. |
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MeSH term(s) | Animals ; Arginase/analysis ; Arginase/immunology ; Humans ; Immunotherapy ; Macrophage Activation ; Macrophages/immunology ; Macrophages/pathology ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Nitric Oxide/analysis ; Nitric Oxide/immunology |
Chemical Substances | Nitric Oxide (31C4KY9ESH) ; Arginase (EC 3.5.3.1) |
Language | English |
Publishing date | 2019-12-23 |
Publishing country | Ukraine |
Document type | Journal Article ; Review |
ZDB-ID | 2176927-8 |
ISSN | 1812-9269 ; 0204-3564 |
ISSN | 1812-9269 ; 0204-3564 |
DOI | 10.32471/exp-oncology.2312-8852.vol-41-no-4.13698 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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