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  1. Article: Efficacy of Fosfomycin-Containing Regimens for Treatment of Bacteremia Due to Pan-Drug Resistant

    Assimakopoulos, Stelios F / Karamouzos, Vassilis / Eleftheriotis, Gerasimos / Lagadinou, Maria / Bartzavali, Christina / Kolonitsiou, Fevronia / Paliogianni, Fotini / Fligou, Fotini / Marangos, Markos

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: Acinetobacter ... ...

    Abstract Acinetobacter baumannii
    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12020286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Triple combination therapy with high-dose ampicillin/sulbactam, high-dose tigecycline and colistin in the treatment of ventilator-associated pneumonia caused by pan-drug resistant Acinetobacter baumannii: a case series study.

    Assimakopoulos, Stelios F / Karamouzos, Vassilis / Lefkaditi, Aikaterini / Sklavou, Christina / Kolonitsiou, Fevronia / Christofidou, Mirto / Fligou, Fotini / Gogos, Charalambos / Marangos, Markos

    Le infezioni in medicina

    2019  Volume 27, Issue 1, Page(s) 11–16

    Abstract: Acinetobacter baumannii has evolved in recent decades as a major problem in carbapenem-resistant gram-negative nosocomial infections, associated with high mortality rates especially in intensive care units (ICUs). Recent reports highlight the increasing ... ...

    Abstract Acinetobacter baumannii has evolved in recent decades as a major problem in carbapenem-resistant gram-negative nosocomial infections, associated with high mortality rates especially in intensive care units (ICUs). Recent reports highlight the increasing prevalence of resistance to colistin, a last resort therapeutic option for carbapenem-resistant A. baumannii. We retrospectively evaluated the potential efficacy, in terms of clinical and microbiological cure and mortality, of a combination of intravenous colistin and high-dose ampicillin/sulbactam and high-dose tigecycline, concurrently administered with inhaled colistin, in 10 ICU patients with ventilator-associated pneumonia (VAP) caused by carbapenem- and colistin-resistant A. baumannii strains, with high tigecycline MICs > 2μg/mL. Nine patients (90%) exhibited a successful clinical outcome, accompanied by microbiological eradication in seven of them. All clinically cured patients survived at 14 and 28 days. Acute kidney injury (AKI) was observed in one patient. In view of the increasing prevalence of pan-drug resistant A. baumannii infections in ICUs, its associated high rates of mortality and the lack of effective treatment options, we feel that there is an emerging need for our results to be further validated in larger prospective studies.
    MeSH term(s) Acinetobacter baumannii/drug effects ; Administration, Inhalation ; Adult ; Aged ; Aged, 80 and over ; Ampicillin/administration & dosage ; Anti-Bacterial Agents/administration & dosage ; Colistin/administration & dosage ; Combined Modality Therapy/methods ; Drug Resistance, Multiple, Bacterial ; Female ; Humans ; Injections, Intravenous ; Intensive Care Units ; Male ; Middle Aged ; Pneumonia, Ventilator-Associated/drug therapy ; Pneumonia, Ventilator-Associated/microbiology ; Retrospective Studies ; Sulbactam/administration & dosage ; Tigecycline/administration & dosage
    Chemical Substances Anti-Bacterial Agents ; Tigecycline (70JE2N95KR) ; Ampicillin (7C782967RD) ; Sulbactam (S4TF6I2330) ; Colistin (Z67X93HJG1)
    Language English
    Publishing date 2019-01-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2041081-5
    ISSN 1124-9390
    ISSN 1124-9390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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