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  1. Article ; Online: Evaluation of perinatal exposure of glyphosate and its mixture with 2,4-D and dicamba οn liver redox status in Wistar rats.

    Nechalioti, Paraskevi-Maria / Karampatzakis, Thomas / Mesnage, Robin / Antoniou, Michael N / Ibragim, Mariam / Tsatsakis, Aristidis / Docea, Anca Oana / Nepka, Charitini / Kouretas, Demetrios

    Environmental research

    2023  Volume 228, Page(s) 115906

    Abstract: Wide-scale emergence of glyphosate-resistant weeds has led to an increase in the simultaneous application of herbicide mixtures exacerbated by the introduction of crops tolerant to glyphosate plus dicamba or glyphosate plus 2,4-D. This raises serious ... ...

    Abstract Wide-scale emergence of glyphosate-resistant weeds has led to an increase in the simultaneous application of herbicide mixtures exacerbated by the introduction of crops tolerant to glyphosate plus dicamba or glyphosate plus 2,4-D. This raises serious concerns regarding the environmental and health risks resulting from increased exposure to a mixture of herbicide active ingredients. We evaluated hepatotoxic effects following perinatal exposure to glyphosate alone or in combination with 2,4-D and dicamba from gestational day-6 until adulthood in Wistar rats. Animals were administered with glyphosate at the European Union (EU) acceptable daily intake (ADI; 0.5 mg/kg bw/day) and no-observed-adverse-effect level (NOAEL; 50 mg/kg bw/day). A mixture of glyphosate with 2,4-D (0.3 mg/kg bw/day) and dicamba (0.02 mg/kg bw/day) with each at their EU ADI was evaluated. Redox status was determined by measuring levels of reduced glutathione, decomposition rate of Η
    MeSH term(s) Rats ; Animals ; Pregnancy ; Female ; Dicamba/chemistry ; Dicamba/toxicity ; Rats, Wistar ; Herbicides/toxicity ; Herbicides/chemistry ; Oxidation-Reduction ; 2,4-Dichlorophenoxyacetic Acid ; Liver ; Glyphosate
    Chemical Substances Dicamba (SJG3M6RY6H) ; Herbicides ; 2,4-Dichlorophenoxyacetic Acid (2577AQ9262)
    Language English
    Publishing date 2023-04-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2023.115906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Evaluation of perinatal exposure of glyphosate and its mixture with 2,4-D and dicamba οn liver redox status in Wistar rats

    Nechalioti, Paraskevi-Maria / Karampatzakis, Thomas / Mesnage, Robin / Antoniou, Michael N. / Ibragim, Mariam / Tsatsakis, Aristidis / Docea, Anca Oana / Nepka, Charitini / Kouretas, Demetrios

    Environmental Research. 2023 July, v. 228 p.115906-

    2023  

    Abstract: Wide-scale emergence of glyphosate-resistant weeds has led to an increase in the simultaneous application of herbicide mixtures exacerbated by the introduction of crops tolerant to glyphosate plus dicamba or glyphosate plus 2,4-D. This raises serious ... ...

    Abstract Wide-scale emergence of glyphosate-resistant weeds has led to an increase in the simultaneous application of herbicide mixtures exacerbated by the introduction of crops tolerant to glyphosate plus dicamba or glyphosate plus 2,4-D. This raises serious concerns regarding the environmental and health risks resulting from increased exposure to a mixture of herbicide active ingredients. We evaluated hepatotoxic effects following perinatal exposure to glyphosate alone or in combination with 2,4-D and dicamba from gestational day-6 until adulthood in Wistar rats. Animals were administered with glyphosate at the European Union (EU) acceptable daily intake (ADI; 0.5 mg/kg bw/day) and no-observed-adverse-effect level (NOAEL; 50 mg/kg bw/day). A mixture of glyphosate with 2,4-D (0.3 mg/kg bw/day) and dicamba (0.02 mg/kg bw/day) with each at their EU ADI was evaluated. Redox status was determined by measuring levels of reduced glutathione, decomposition rate of Η₂Ο₂, glutathione reductase, glutathione peroxidase, total antioxidant capacity, thiobarbituric reactive substances, and protein carbonyls. Gene expression analysis of Nr1d1, Nr1d2, Clec2g, Ier3, and Gadd45g associated with oxidative damage to DNA, was also performed. Analysis of liver samples showed that exposure to the mixture of the three herbicides induced a marked increase in the concentration of glutathione and malondialdehyde indicative of a disturbance in redox balance. Nevertheless, the effect of increased lipid peroxidation was not discernible following a 3-month recuperation period where animals were withdrawn from pesticide exposure post-weaning. Interestingly, toxic effects caused by prenatal exposure to the glyphosate NOAEL were present after the same 3-month recovery period. No statistically significant changes in the expression of genes linked with genotoxicity were observed. Our findings reinforce the importance of assessing the combined effects of chemical pollutants at doses that are asserted by regulatory agencies to be safe individually.
    Keywords 2,4-D ; DNA ; European Union ; acceptable daily intake ; adulthood ; antioxidant activity ; dicamba ; gene expression ; genotoxicity ; glutathione ; glutathione peroxidase ; glutathione-disulfide reductase ; glyphosate ; glyphosate resistance ; hepatotoxicity ; herbicide application ; lipid peroxidation ; liver ; malondialdehyde ; maternal exposure ; no observed adverse effect level ; research ; Pregnancy ; Pesticide mixtures ; Oxidative stress ; ADI ; ADHD ; AMPA ; ASD ; CARBs ; DPPH ; DNPH ; DTNB ; EFSA ; EPA ; FAO ; IARC ; GBHs ; GM ; GPx ; GR ; GSH ; GSSG ; MDA ; NADH ; NADPH ; NOAEL ; OD ; OECD ; PBS ; PCR ; RCV ; SEM ; TAC ; TBA ; TBARS ; t-BOOH ; TCA ; TNB
    Language English
    Dates of publication 2023-07
    Publishing place Elsevier Inc.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2023.115906
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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