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  1. Article: Combined Brucella melitensis and Staphylococcus aureus endocarditis in a patient with a prosthetic aortic valve with fatal outcome.

    Karahocagil, Mustafa / Karanfil, Aydin / Uyar, Mehtap Erkmen

    European journal of internal medicine

    2005  Volume 16, Issue 7, Page(s) 534

    Language English
    Publishing date 2005-11
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 0953-6205
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2005.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Association between adenoidal-nasopharyngeal ratio and right ventricular diastolic functions in children with adenoid hypertrophy causing upper airway obstruction.

    Tezer, Mesut S / Karanfil, Aydin / Aktaş, Davut

    International journal of pediatric otorhinolaryngology

    2005  Volume 69, Issue 9, Page(s) 1169–1173

    Abstract: Objective: Adenoid hypertrophy causing upper airway obstruction can cause cardiovascular complications, including pulmonary hypertension and right heart failure in children. Adenoidal-nasopharyngeal ratio (ANR) is a practical, non-invasive and reliable ... ...

    Abstract Objective: Adenoid hypertrophy causing upper airway obstruction can cause cardiovascular complications, including pulmonary hypertension and right heart failure in children. Adenoidal-nasopharyngeal ratio (ANR) is a practical, non-invasive and reliable method to evaluate adenoid enlargement. Our aim was to evaluate a possible association between ANR and echocardiographic parameters of right ventricle.
    Methods: Twenty-one children who were affected by upper respiratory obstruction symptoms due to adenoid hypertrophy were included in this study (male/female: 12/9; mean age was 6.0 +/- 1.5 years). ANRs were calculated as the ratio of adenoidal depths to the nasopharyngeal depths on lateral cephalometric radiographs. Pulmonary arterial pressures, right ventricular diastolic filling parameters (peak E, peak A, E/A ratio), right ventricular end-diastolic diameters, and left ventricular ejection fractions were measured using echocardiography both preoperatively and also 3 months after the operation.
    Results: Preoperative pulmonary arterial pressure, E/A ratio, right ventricular end-diastolic diameter, and left ventricular ejection fraction values were 23.10 +/-3.43 mmHg, 1.01 +/- 0.20, 1.95 +/- 0.16 cm, and 69.43 +/- 3.68%, respectively. Postoperative pulmonary arterial pressure, E/A ratio, right ventricular end-diastolic diameter, and left ventricular ejection fraction values were 16.94 +/- 1.45 mmHg, 1.24 +/- 0.14, 1.72 +/- 0.15 cm, and 69.77 +/- 2.17%, respectively. There were significant differences between preoperative and postoperative pulmonary arterial pressures, E/A ratios, and right ventricular end-diastolic diameters (p < 0.01 for each), while left ventricular ejection fraction values did not significantly change after the operation (p > 0.05). There was a negative correlation between E/A ratio and ANR-Ba (p < 0.05, r = -0.44).
    Conclusion: ANR can give information about the right ventricular functions in children with enlarged adenoids causing obstructive symptoms.
    MeSH term(s) Adenoidectomy ; Adenoids/diagnostic imaging ; Adenoids/pathology ; Adenoids/surgery ; Airway Obstruction/etiology ; Airway Obstruction/surgery ; Child ; Child, Preschool ; Echocardiography, Doppler, Pulsed ; Female ; Follow-Up Studies ; Heart Ventricles/diagnostic imaging ; Humans ; Hypertrophy/complications ; Hypertrophy/surgery ; Male ; Nasopharynx/diagnostic imaging ; Patient Selection ; Pulmonary Artery/physiology ; Pulmonary Wedge Pressure ; Radiography ; Treatment Outcome ; Ventricular Function, Right
    Language English
    Publishing date 2005-09
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 754501-0
    ISSN 1872-8464 ; 0165-5876
    ISSN (online) 1872-8464
    ISSN 0165-5876
    DOI 10.1016/j.ijporl.2005.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: T-wave depletion and bradycardia possibly secondary to acute pancreatitis: review of the literature.

    Türkay, Cansel / Aydoğan, Timuçin / Karanfil, Aydin / Uyar, Mehtap Erkmen / Selçoki, Yusuf / Kanbay, Mehmet

    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

    2010  Volume 20, Issue 4, Page(s) 295–297

    Abstract: Acute pancreatitis has frequently been reported to be associated with transient electrocardiography changes mimicking myocardial infarction despite normal epicardial coronary arteries. Although the origin of these findings is poorly understood, suggested ...

    Abstract Acute pancreatitis has frequently been reported to be associated with transient electrocardiography changes mimicking myocardial infarction despite normal epicardial coronary arteries. Although the origin of these findings is poorly understood, suggested mechanisms have included electrolyte abnormalities, a vagally mediated reflex, coronary vasospasm, and myonecrosis because of the release of pancreatic proteolytic enzymes. We report a case of acute pancreatitis with new-onset electrocardiography changes and bradycardia despite no evidence of coronary artery disease. After resolution of inflammation in the pancreas, T-wave depletions in V1-V6 derivations in electrocardiography disappeared and the rhythm was sinus with 70/min. 201-Tl myocardial perfusion scintigraphy revealed no evidence of significant coronary artery disease.
    MeSH term(s) Acute Disease ; Bradycardia/diagnosis ; Bradycardia/etiology ; Electrocardiography ; Female ; Humans ; Middle Aged ; Pancreatitis/complications
    Language English
    Publishing date 2010-01-15
    Publishing country Turkey
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1340275-4
    ISSN 2148-5607 ; 1300-4948
    ISSN (online) 2148-5607
    ISSN 1300-4948
    DOI 10.4318/tjg.2009.0031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Association between mitral annular calcification and stroke.

    Tunca, Ayşe / Karanfil, Aydin / Köktener, Asli / Kargili, Ayşe / Tekin, Oguz

    Japanese heart journal

    2004  Volume 45, Issue 6, Page(s) 999–1005

    Abstract: It remains controversial as to whether mitral annular calcification (MAC) is an independent predictor of stroke. The aim of this study was to investigate whether there is an association between the presence of MAC and stroke or whether MAC is one of the ... ...

    Abstract It remains controversial as to whether mitral annular calcification (MAC) is an independent predictor of stroke. The aim of this study was to investigate whether there is an association between the presence of MAC and stroke or whether MAC is one of the predictive factors of carotid atheroma and therefore is a secondary risk for stroke. Fifty-six patients who had MAC demonstrated by echocardiography underwent carotid artery duplex sonography and computed brain tomography with various causes were enrolled in the study. They were compared with 58 control patients without MAC. MAC was defined as a dense, localized, highly reflective area larger than 5 mm at the junction of the atrioventricular groove and posterior mitral valve leaflet. Carotid artery stenosis was defined as lumen diameter narrowing exceeding 60%. Cerebral ischemia was detected by spiral tomography and was classified as infarction and lacunae. A significant association was found between the presence of MAC and carotid atheroma (P = 0.011), MAC and hyperechogen plaque (P = 0.034), and MAC and stenosis (P = 0.008). There was an association between the presence of carotid atheroma and cerebral infarction (P = 0.007). Logistic regression analysis revealed hypertension and diabetes mellitus were independent risk factors (P = 0.030, P = 0.034, respectively) for developing carotid atheroma. MAC was an independent factor for carotid stenosis (P = 0.029). MAC may not be a significant causative factor for stroke, but may be a secondary risk factor. A significant association between the presence of MAC and carotid artery atherosclerotic disease may explain the high prevalence of stroke in patients with MAC.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Calcinosis/complications ; Calcinosis/diagnostic imaging ; Carotid Artery Diseases/complications ; Carotid Artery Diseases/diagnostic imaging ; Carotid Stenosis/complications ; Carotid Stenosis/diagnostic imaging ; Diabetes Complications ; Echocardiography ; Female ; Heart Valve Diseases/complications ; Heart Valve Diseases/diagnostic imaging ; Humans ; Hypertension/complications ; Logistic Models ; Male ; Middle Aged ; Mitral Valve ; Risk Factors ; Stroke/diagnostic imaging ; Stroke/etiology ; Tomography, Spiral Computed ; Ultrasonography, Doppler, Duplex
    Language English
    Publishing date 2004-11-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 214207-7
    ISSN 1348-673X ; 0021-4868
    ISSN (online) 1348-673X
    ISSN 0021-4868
    DOI 10.1536/jhj.45.999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The protective effect of erdosteine against cyclosporine A-induced cardiotoxicity in rats.

    Selcoki, Yusuf / Uz, Ebru / Bayrak, Reyhan / Sahin, Semsettin / Kaya, Arif / Uz, Burak / Karanfil, Aydin / Ozkara, Adem / Akcay, Ali

    Toxicology

    2007  Volume 239, Issue 1-2, Page(s) 53–59

    Abstract: Cyclosporine A (CsA) is a frequently used immunosuppressive agent in transplant medicine to prevent rejection and in the treatment of autoimmune diseases. However, CsA generates reactive oxygen species, which causes nephrotoxicity, hepatotoxicity and ... ...

    Abstract Cyclosporine A (CsA) is a frequently used immunosuppressive agent in transplant medicine to prevent rejection and in the treatment of autoimmune diseases. However, CsA generates reactive oxygen species, which causes nephrotoxicity, hepatotoxicity and cardiotoxicity. The use of antioxidants reduces the adverse effects of CsA. The aim of this study is to determine the protective effects of erdosteine on CsA-induced heart injury through tissue oxidant/antioxidant parameters and light microscopic evaluation in rats. CsA cardiotoxicity was induced by administrating an oral dose of 15mg/kg CsA daily for 21 days. The rats were divided into four groups: control group (n=4), CsA administrated group (15mg/kg, n=5), CsA+erdosteine administrated group (10mg/kg day orally erdosteine, n=4) and only erdosteine administrated group (10mg/kg day orally n=5). CsA treated rats showed increase in the number of infiltrated cells and disorganization of myocardial fibers with interstitial fibrosis. The number of infiltrated cells, disorganization of myocardial fibers and interstitial fibrosis was diminished in the hearts of CsA-treated rats given erdosteine. The malondialdehyde, the protein carbonyl content and nitric oxide levels were increased in the cyclosporine A group in comparison with the control and CsA plus erdosteine groups. The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) were higher in CsA plus erdosteine group than CsA group. However, the CAT, GSH-Px and SOD activities were significantly lower in CsA group than in control group and erdosteine group. These results suggest that erdosteine has protective effect against CsA-induced cardiotoxicity.
    MeSH term(s) Animals ; Catalase/metabolism ; Chemoprevention ; Cyclosporine/toxicity ; Disease Models, Animal ; Expectorants/therapeutic use ; Fibrosis/chemically induced ; Fibrosis/metabolism ; Fibrosis/pathology ; Glutathione Peroxidase/metabolism ; Heart/drug effects ; Heart Diseases/chemically induced ; Heart Diseases/pathology ; Heart Diseases/prevention & control ; Immunosuppressive Agents/toxicity ; Male ; Malondialdehyde/metabolism ; Myocardium/metabolism ; Myocardium/pathology ; Nitric Oxide/metabolism ; Oxidative Stress/drug effects ; Protein Carbonylation/drug effects ; Rats ; Rats, Wistar ; Superoxide Dismutase/metabolism ; Thioglycolates/therapeutic use ; Thiophenes/therapeutic use
    Chemical Substances Expectorants ; Immunosuppressive Agents ; Thioglycolates ; Thiophenes ; Nitric Oxide (31C4KY9ESH) ; Malondialdehyde (4Y8F71G49Q) ; erdosteine (76J0853EKA) ; Cyclosporine (83HN0GTJ6D) ; Catalase (EC 1.11.1.6) ; Glutathione Peroxidase (EC 1.11.1.9) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2007-09-24
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 184557-3
    ISSN 1879-3185 ; 0300-483X
    ISSN (online) 1879-3185
    ISSN 0300-483X
    DOI 10.1016/j.tox.2007.06.096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A forgotten but important risk factor for infective endocarditis in patients with prosthetic valve: pedicure.

    Turgut, Faruk / Kanbay, Mehmet / Uz, Burak / Carlioglu, Ayse / Selcoki, Yusuf / Karanfil, Aydin / Alici, Ozlem / Akcay, Ali

    Scandinavian journal of infectious diseases

    2007  Volume 39, Issue 3, Page(s) 274–276

    Abstract: We report a case of infective endocarditis developing after pedicure in a 36-y-old female. Methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis was diagnosed. Even aggressive therapy was ineffective. To our knowledge, we report the ...

    Abstract We report a case of infective endocarditis developing after pedicure in a 36-y-old female. Methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis was diagnosed. Even aggressive therapy was ineffective. To our knowledge, we report the first case of infective endocarditis secondary to pedicure in the literature.
    MeSH term(s) Adult ; Beauty Culture ; Cosmetic Techniques/adverse effects ; Endocarditis, Bacterial/drug therapy ; Endocarditis, Bacterial/etiology ; Endocarditis, Bacterial/microbiology ; Fatal Outcome ; Female ; Hallux/microbiology ; Heart Valve Prosthesis ; Humans ; Nails/microbiology ; Risk Factors ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/etiology ; Staphylococcal Infections/microbiology ; Staphylococcus aureus
    Language English
    Publishing date 2007
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 390956-6
    ISSN 1651-1980 ; 0036-5548
    ISSN (online) 1651-1980
    ISSN 0036-5548
    DOI 10.1080/00365540600904795
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  7. Article: Probrain natriuretic peptide for assessment of efficacy in heart failure treatment.

    Ozkara, Adem / Turgut, Faruk / Selcoki, Yusuf / Karanfil, Aydin / Metin, Melike Rusen / Kanbay, Mehmet / Tekin, Oguz / Akcay, Ali

    Advances in therapy

    2007  Volume 24, Issue 6, Page(s) 1233–1239

    Abstract: N-terminal probrain natriuretic peptide (NT-proBNP) is elevated in patients with heart failure. Numerous clinical trials have evaluated the efficacy of spironolactone in heart failure; however, no studies have directly examined the effects of ... ...

    Abstract N-terminal probrain natriuretic peptide (NT-proBNP) is elevated in patients with heart failure. Numerous clinical trials have evaluated the efficacy of spironolactone in heart failure; however, no studies have directly examined the effects of spironolactone treatment on NT-proBNP level. This study investigated whether NT-proBNP levels decrease with daily spironolactone treatment. The study consisted of 117 adult patients with heart failure. All participants were divided into 3 groups, class I, class II, and class III, according to the New York Heart Association classification system. Patients were randomly assigned to receive spironolactone or were treated with another drug, other than spironolactone, as placebo. NT-proBNP plasma samples were taken at baseline and after 6 mo of treatment. A total of 62 patients were treated with daily spironolactone; 55 patients were followed with available treatment without spironolactone. The baseline demographic and laboratory parameters were similar for patients in all groups. At the end of 6 mo, spironolactone-treated patients had significantly lower NT-proBNP levels and significantly better ejection fractions than did patients in all New York Heart Association classes who were not treated with spironolactone. Results suggest that spironolactone decreases plasma NT-proBNP concentrations, and that the measurement of plasma NT-proBNP levels may be helpful in assessing therapeutic efficacy in patients who are treated for heart failure.
    MeSH term(s) Aged ; Biomarkers/blood ; Female ; Heart Failure/blood ; Heart Failure/drug therapy ; Heart Failure/physiopathology ; Humans ; Male ; Mineralocorticoid Receptor Antagonists ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Prospective Studies ; Spironolactone/therapeutic use ; Stroke Volume
    Chemical Substances Biomarkers ; Mineralocorticoid Receptor Antagonists ; Peptide Fragments ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0) ; Spironolactone (27O7W4T232)
    Language English
    Publishing date 2007-12-25
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/bf02877769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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