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  1. Article ; Online: A Strict Patient Selection Protocol Could Be the Key to Success for Transanal Minimally Invasive Surgery (TAMIS).

    Theodoropoulos, George E / Frountzas, Maximos / Karathanasis, Panagiotis / Doulami, Georgia / Michalopoulou, Victoria / Kimpizi, Despina / Schizas, Dimitrios / Zografos, George C

    Southern medical journal

    2023  Volume 116, Issue 6, Page(s) 490–495

    Abstract: Objectives: In recent years, the local excision of benign rectal lesions or early-stage rectal cancers using minimally invasive surgical techniques has replaced radical interventions that caused impairment in patients' quality of life. The aim of the ... ...

    Abstract Objectives: In recent years, the local excision of benign rectal lesions or early-stage rectal cancers using minimally invasive surgical techniques has replaced radical interventions that caused impairment in patients' quality of life. The aim of the present study was to investigate the feasibility of transanal minimally invasive surgery (TAMIS), as well as its excision quality, its oncologic outcomes, and its impact on anorectal function.
    Methods: Patients who underwent TAMIS at a single colorectal unit of a tertiary university hospital from 2015 until 2020 for benign rectal lesions or early-stage malignant rectal lesions, along with unsuitable patients for radical interventions, were included in the present study.
    Results: Twenty-five patients underwent TAMIS for rectal lesions. Their median distance from the anal verge was 7 cm (range 4-12 cm) and their median size was 3.8 cm (range 2-6 cm). The median operative duration was 75 minutes (range 30-150 minutes) and the median hospitalization interval was 2 days (range 1-6 days). In addition, the negative resection rate was 100% and the recurrence rate was 4% during an average follow-up period of 30 months (range 3-36 months). Two patients (8%) presented short-term complications, and in 1 patient (4%) a hybrid technique was required. Seventeen patients (68%) reported moderate incontinence symptoms 6 weeks postoperatively that subsided in all patients 3 months postoperatively.
    Conclusions: TAMIS seemed to be a feasible technique with adequate oncologic outcomes and high excision quality, which preserved patients' quality of life. The impact of TAMIS on anorectal function after neoadjuvant chemoradiotherapy for rectal cancer should be further investigated, however.
    MeSH term(s) Humans ; Patient Selection ; Quality of Life ; Treatment Outcome ; Rectal Neoplasms/surgery ; Rectal Neoplasms/pathology ; Transanal Endoscopic Surgery/methods ; Anal Canal/surgery
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185329-6
    ISSN 1541-8243 ; 0038-4348
    ISSN (online) 1541-8243
    ISSN 0038-4348
    DOI 10.14423/SMJ.0000000000001570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Severe anaphylactic reaction after blue dye injection for sentinel lymph node biopsy in breast surgery: Report of two cases and literature review.

    Frountzas, Maximos / Theodoropoulos, Charalampos / Karathanasis, Panagiotis / Nikolaou, Christina / Zografos, Constantinos G / Larentzakis, Andreas / Zografos, George C / Michalopoulos, Nikolaos V

    Clinical case reports

    2021  Volume 9, Issue 7

    Abstract: Anaphylactic reactions, and especially the severe ones (types III and IV), should be kept in mind as considerable adverse effects while using blue dyes for SLNB. ...

    Abstract Anaphylactic reactions, and especially the severe ones (types III and IV), should be kept in mind as considerable adverse effects while using blue dyes for SLNB.
    Language English
    Publishing date 2021-05-07
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.3904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Kounis syndrome after patent blue dye injection for sentinel lymph node biopsy.

    Frountzas, Maximos / Karathanasis, Panagiotis / Vrakopoulou, Gavriella Zoi / Theodoropoulos, Charalampos / Zografos, Constantinos G / Schizas, Dimitrios / Zografos, George C / Michalopoulos, Nikolaos V

    Breast cancer (Tokyo, Japan)

    2020  Volume 27, Issue 6, Page(s) 1191–1197

    Abstract: Background: Kounis syndrome (KS) has been described as an acute coronary syndrome (ACS) associated with an anaphylactic reaction. Several triggers have been identified and the diagnostic and treatment process can be challenging.: Case: A 58-year-old, ...

    Abstract Background: Kounis syndrome (KS) has been described as an acute coronary syndrome (ACS) associated with an anaphylactic reaction. Several triggers have been identified and the diagnostic and treatment process can be challenging.
    Case: A 58-year-old, female patient diagnosed with breast cancer and no history of allergies had subcutaneous injection of patent blue V dye for sentinel lymph node biopsy (SLNB). Intraoperatively, she developed anaphylactic shock and was transferred to the intensive care unit (ICU). A few hours later, electrocardiographic alterations and elevation of blood troponin were observed. Emergency coronary angiography revealed no occlusive lesions in coronary vessels. Further investigation in the allergy department set the diagnosis of KS.
    Conclusion: There are just ten cases of perioperative KS in the literature so far and here we present the first one triggered by patent blue V dye for sentinel node biopsy.
    MeSH term(s) Anaphylaxis/diagnosis ; Anaphylaxis/drug therapy ; Anaphylaxis/etiology ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Ductal, Breast/surgery ; Coloring Agents/administration & dosage ; Coloring Agents/adverse effects ; Coronary Angiography ; Dual Anti-Platelet Therapy ; Electrocardiography ; Female ; Humans ; Injections, Subcutaneous ; Kounis Syndrome/diagnosis ; Kounis Syndrome/drug therapy ; Kounis Syndrome/etiology ; Lymphatic Metastasis/diagnosis ; Lymphatic Metastasis/pathology ; Mastectomy, Segmental ; Middle Aged ; Rosaniline Dyes/administration & dosage ; Rosaniline Dyes/adverse effects ; Sentinel Lymph Node/diagnostic imaging ; Sentinel Lymph Node/pathology ; Sentinel Lymph Node Biopsy/adverse effects ; Sentinel Lymph Node Biopsy/methods
    Chemical Substances Coloring Agents ; Rosaniline Dyes ; sulfan blue (FH1929ICIT)
    Language English
    Publishing date 2020-06-29
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2052429-8
    ISSN 1880-4233 ; 1340-6868
    ISSN (online) 1880-4233
    ISSN 1340-6868
    DOI 10.1007/s12282-020-01129-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Implant infections after breast reconstruction surgery following mastectomy: Experience from a Greek breast unit.

    Michalopoulos, Nikolaos V / Frountzas, Maximos / Karathanasis, Panagiotis / Theodoropoulos, Charalampos / Kolia, Aikaterini / Zografos, Constantinos G / Triantafyllou, Tania / Larentzakis, Andreas / Danias, Nikolaos / Zografos, George C

    Breast disease

    2021  Volume 41, Issue 1, Page(s) 37–44

    Abstract: Background: Despite the dominance of implant-based breast reconstruction after mastectomy, during recent years, it has been correlated to some complications. The aim of this study is to present the Greek experience about management of implant infections ...

    Abstract Background: Despite the dominance of implant-based breast reconstruction after mastectomy, during recent years, it has been correlated to some complications. The aim of this study is to present the Greek experience about management of implant infections after breast reconstructions and to investigate the relationship between possible risk factors and breast pocket fluid cultures.
    Methods: In total, 260 patients underwent implant-based breast reconstruction due to breast cancer in our center from 2016 until 2020. 46 patients, that underwent implant or expander replacement after breast reconstruction due to mastectomy were included in the present study.
    Results: 260 patients underwent breast reconstruction in our center and in 46 (18%) of them an implant replacement was required. 21 patients (8%) presented clinically with an implant infection, but 12 of them (5%) had positive cultures from the breast pocket fluid. On the contrary, 25 patients (10%) presented no clinical signs of implant infection, but 5 of them (2%) had a positive culture. In addition, we demonstrated a correlation between implant infection and positive cultures (p = 0.009), along with an association between chemotherapy before implant placements and negative cultures (p = 0.035). Finally, the most common pathogen was Staphylococcus epidermidis (29%), followed by Escherichia coli (24%) and Staphylococcus aureus (18%).
    Conclusion: Implant infection still remains a very serious complication after breast reconstruction surgery. The establishment of a therapeutic protocol, with specific antimicrobial and surgical targets seems as an effective strategy against implant infections.
    MeSH term(s) Adult ; Aged ; Bacteria/classification ; Bacteria/pathogenicity ; Bacterial Infections/etiology ; Breast Implantation/adverse effects ; Breast Implants/microbiology ; Breast Neoplasms/surgery ; Female ; Greece ; Humans ; Mammaplasty/adverse effects ; Mastectomy ; Middle Aged ; Postoperative Complications ; Reoperation/adverse effects ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2021-07-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639267-2
    ISSN 1558-1551 ; 0888-6008
    ISSN (online) 1558-1551
    ISSN 0888-6008
    DOI 10.3233/BD-201077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A novel way of hook wire placement for surgical resection of suspicious breast lesions using the stereotactic vacuum assisted breast biopsy table.

    Michalopoulos, Nikolaos V / Mitrousias, Apostolos / Karathanasis, Panagiotis V / Kalles, Vasileios / Frountzas, Maximos / Theodoropoulos, Charalampos / Alafaki, Maria / Zografos, Constantine G / Chronas, Angelos / Matiatou, Maria / Zografos, George C

    The breast journal

    2021  Volume 27, Issue 4, Page(s) 403–405

    Abstract: Preoperative hook localization is a necessary procedure for targeting impalpable breast lesions. The aim of the current study is to introduce an alternative technique of wire placement by using the stereotactic biopsy device instead of the conventionally ...

    Abstract Preoperative hook localization is a necessary procedure for targeting impalpable breast lesions. The aim of the current study is to introduce an alternative technique of wire placement by using the stereotactic biopsy device instead of the conventionally used mammography device. Fifty-one patients with impalpable mammographic lesions, graded BIRADS 4 or 5, were prospectively enrolled. Mean duration was 7 ± 1.5 minutes. Lesion-to-wire distance was <1 cm in 96% (51/53). Hook wire placement using the stereotactic biopsy device is considered as a safe, accurate, fast, and well-tolerable for the patient procedure.
    MeSH term(s) Biopsy ; Biopsy, Needle ; Breast/diagnostic imaging ; Breast/surgery ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/surgery ; Female ; Humans ; Mammography ; Stereotaxic Techniques
    Language English
    Publishing date 2021-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1289960-4
    ISSN 1524-4741 ; 1075-122X
    ISSN (online) 1524-4741
    ISSN 1075-122X
    DOI 10.1111/tbj.14164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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