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  1. Article: COVID-19 and Listeria Meningitis Treated by Ampicillin, Sulfamethoxazole/Trimethoprim and Meropenem.

    Seki, Masafumi / Karaushi, Haruka / Arai, Noriko / Hayashi, Takeshi / Mitsutake, Kotaro

    Infection and drug resistance

    2023  Volume 16, Page(s) 4289–4295

    Abstract: Background: Secondary bacterial infection was initially rare in SARS-CoV-2 infectious disease (COVID-19) patients, but COVID-19-associated bacterial infectious diseases have recently been increasing. Furthermore, it might be difficult to distinguish ... ...

    Abstract Background: Secondary bacterial infection was initially rare in SARS-CoV-2 infectious disease (COVID-19) patients, but COVID-19-associated bacterial infectious diseases have recently been increasing. Furthermore, it might be difficult to distinguish COVID-19 from bacterial meningitis by the symptoms, and one might be uncertain about antibiotic therapy for
    Case report: A 96-year-old woman who had been living alone was found to have SARS-CoV-2 infection in February 2023. She was admitted to our hospital with high fever and disturbance of consciousness and was started on treatment with remdesivir. Two days later, her consciousness was still disturbed, and she was found to have a stiff neck. In addition, increased white blood cell counts and C-reactive protein suggested bacterial infection. Therefore, a lumbar puncture was done, and
    Conclusion: COVID-19-associated secondary listeria infection was found in an elderly woman. She was treated with not only ampicillin, but also ST and meropenem. Meningitis caused by
    Language English
    Publishing date 2023-07-03
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S414879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Mycobacterium tuberculosis-Infected Patient Who Could Not Tolerate Oral Intake Successfully Treated Using an Intravenous Tedizolid-Containing Regimen.

    Karaushi, Haruka / Seki, Masafumi / Miyawaki, Yutaka / Watanabe, Noriyuki / Kamoshita, Fumitaka / Mitsutake, Kotaro

    The American journal of case reports

    2022  Volume 23, Page(s) e937485

    Abstract: BACKGROUND Mycobacterium tuberculosis (M. tuberculosis) is usually treated by oral antimycobacterial agents, including rifampicin, ethambutol, and pyrazinamide, but the treatment regimen with intravenous and/or intramuscular antimycobacterial agents for ... ...

    Abstract BACKGROUND Mycobacterium tuberculosis (M. tuberculosis) is usually treated by oral antimycobacterial agents, including rifampicin, ethambutol, and pyrazinamide, but the treatment regimen with intravenous and/or intramuscular antimycobacterial agents for patients who cannot take medications orally remains unclear. CASE REPORT A 77-year-old man with chronic renal failure had an esophageal-skin fistula after he had surgeries for removal of esophageal and gastric cancers and reconstruction using jejunum, and he showed a cavity, tree-in-bud formation, and pleural effusions in his left upper lung fields on his chest X-ray after treatment of cellulitis and bacteremia/candidemia by meropenem, teicoplanin, and micafungin. M. tuberculosis was isolated from his sputum and exudate fluid from the reconstructed esophageal-skin fistula. Although he could not take antimycobacterial agents orally, treatment was started with intravenous agents combining levofloxacin (LVFX) every other day, isoniazid (INH), and linezolid (LZD). However, his platelets were decreased 21 days after treatment started, and it was thought to be an adverse effect of LZD and/or INH. After changing LZD to tedizolid (TZD), in addition to changing from INH to intramuscular streptomycin twice per week, his platelet counts increased. Intravenous TZD could be continued, and it maintained his condition without exacerbations of thrombocytopenia and renal failure. The M. tuberculosis disappeared, and the abnormal chest X-ray shadows were improved 2 months after the start of treatment. CONCLUSIONS Administration of intravenous TZD, in addition to intravenous LVFX and intramuscular SM in combination, might be a candidate regimen for M. tuberculosis patients who cannot take oral medications.
    MeSH term(s) Aged ; Anti-Bacterial Agents/therapeutic use ; Antitubercular Agents/therapeutic use ; Cutaneous Fistula ; Ethambutol/pharmacology ; Humans ; Isoniazid ; Levofloxacin/therapeutic use ; Linezolid ; Male ; Meropenem/pharmacology ; Micafungin/pharmacology ; Mycobacterium tuberculosis ; Oxazolidinones ; Pyrazinamide ; Rifampin/therapeutic use ; Streptomycin/pharmacology ; Teicoplanin ; Tetrazoles ; Tuberculosis
    Chemical Substances Anti-Bacterial Agents ; Antitubercular Agents ; Oxazolidinones ; Tetrazoles ; Pyrazinamide (2KNI5N06TI) ; Teicoplanin (61036-62-2) ; Levofloxacin (6GNT3Y5LMF) ; Ethambutol (8G167061QZ) ; tedizolid (97HLQ82NGL) ; Meropenem (FV9J3JU8B1) ; Linezolid (ISQ9I6J12J) ; Micafungin (R10H71BSWG) ; Isoniazid (V83O1VOZ8L) ; Rifampin (VJT6J7R4TR) ; Streptomycin (Y45QSO73OB)
    Language English
    Publishing date 2022-10-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.937485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Effectiveness and Safety of Linezolid Versus Vancomycin, Teicoplanin, or Daptomycin against Methicillin-Resistant

    Kawasuji, Hitoshi / Nagaoka, Kentaro / Tsuji, Yasuhiro / Kimoto, Kou / Takegoshi, Yusuke / Kaneda, Makito / Murai, Yushi / Karaushi, Haruka / Mitsutake, Kotaro / Yamamoto, Yoshihiro

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: Vancomycin (VCM) and daptomycin (DAP) are standard therapies for methicillin- ... ...

    Abstract Vancomycin (VCM) and daptomycin (DAP) are standard therapies for methicillin-resistant
    Language English
    Publishing date 2023-04-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12040697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Multicenter Study of the Effectiveness of Antifungal Stewardship Team Intervention for Candidemia in Japan in 2008-2021.

    Tokano, Mieko / Tarumoto, Norihito / Sakai, Jun / Imai, Kazuo / Koizumi, Sakaru / Karaushi, Haruka / Hatanaka, Tamotsu / Kishi, Etsuko / Seki, Masafumi / Mitsutake, Koutaro / Maesaki, Shigefumi

    Infectious disease reports

    2024  Volume 16, Issue 2, Page(s) 356–366

    Abstract: Candidemia, linked to high mortality rates, requires prompt antifungal therapy for better outcomes. Treatment is structured as an action bundle, which is beneficial when followed closely. However, the Japanese action bundle lacks detailed guidance on ... ...

    Abstract Candidemia, linked to high mortality rates, requires prompt antifungal therapy for better outcomes. Treatment is structured as an action bundle, which is beneficial when followed closely. However, the Japanese action bundle lacks detailed guidance on severe complications like endocarditis or ocular issues. To address this, we adjusted the action bundle and assessed outcomes with and without AFT intervention. We strengthened protocols for blood cultures and organ assessments, and the AFT contacted the primary physician when yeast-like fungi were detected in the patient's blood culture bottles. Analyzing 204 candidemia cases from 2008-2021, we observed increased adherence and reduced mortality post-AFT intervention. Ophthalmology consultations rose significantly, but many patients had only one visit, suggesting inadequate follow-up. If endophthalmitis is diagnosed, a change in the treatment approach may be necessary. There is a possibility that abnormal ocular findings will be detected during subsequent visits, which highlights the need for improvement in ophthalmology follow-up rates as a future challenge for our AFT activities.
    Language English
    Publishing date 2024-04-15
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr16020027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Thoracic aortic mycotic aneurysm due to Staphylococcus argenteus: A case report.

    Mitsutake, Kotaro / Watanabe, Noriyuki / Karaushi, Haruka / Tarumoto, Norihito / Koyama, Sachie / Ebihara, Yasuhiro / Yoshitake, Akihiro / Nakajima, Hiroyuki

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2020  Volume 26, Issue 11, Page(s) 1213–1215

    Abstract: Staphylococcus argenteus was subdivided as a novel species from Staphylococcus aureus in 2014. We herein report a case of mycotic aneurysm caused by S. argenteus. A 59-year-old woman with diabetes and schizophrenia visited at the emergency room because ... ...

    Abstract Staphylococcus argenteus was subdivided as a novel species from Staphylococcus aureus in 2014. We herein report a case of mycotic aneurysm caused by S. argenteus. A 59-year-old woman with diabetes and schizophrenia visited at the emergency room because of falling. Chest computed tomography revealed a left humerus fracture and a thoracic aortic aneurysm. With her elevated WBC count and CRP level, she was suspected to have a mycotic aneurysm. After being transferred to our hospital, vascular graft replacement surgery was performed. Isolates of blood cultures and surgical specimens were identified as S. argenteus by Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MAS MALDI Biotyper Ver. 8.0). Although S. argenteus lacks staphyloxanthin, a carotenoid pigment, it is coagulase positive. In addition to traditional and automated biochemical identification systems, even MALDI-TOF MAS may misidentify the organism as S. aureus depending on its version. S. argenteus should be considered when coagulase-negative Staphylococcus like colonies are obtained from samples of S. aureus infection. To our knowledge, this is the first case of aortic mycotic aneurysm caused by S. argenteus in Japan. Although S. argenteus is considered less virulent than Staphylococcus aureus, we should closely monitor the prevalence and the clinical impact of this pathogen on community-acquired infections and health care-associated infections.
    MeSH term(s) Aneurysm, Infected/diagnostic imaging ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Female ; Humans ; Japan ; Middle Aged ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Staphylococcal Infections/diagnosis ; Staphylococcus ; Staphylococcus aureus
    Language English
    Publishing date 2020-08-21
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2020.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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