Article ; Online: Nebulization with alkaline hipertonic ibuprofen induces a rapid increase in platelets circulating in COVID-19 patients but not in healthy subjects.
2021 Volume 33, Issue 3, Page(s) 471–478
Abstract: We analyze changes in circulating platelets in COVID-19 positive patients who received conventional treatment Dexamethasone and Enoxaparin (Dexa-Enoxa) compared to patients treated with conventional therapy plus nebulization with alkaline hypertonic ... ...
| Abstract | We analyze changes in circulating platelets in COVID-19 positive patients who received conventional treatment Dexamethasone and Enoxaparin (Dexa-Enoxa) compared to patients treated with conventional therapy plus nebulization with alkaline hypertonic ibuprofenate (AHI). Results show that after 24 h of nebulization with AHI, circulating platelets shows an increase about 40% at 24 h and reach 65% at 96 h. In patients with platelets content below 200,000 by microliter the increase was 49% and 79% at 24 and 96 h respectively. In patients with platelets above 200,000 by microliter the increase was 24% and 31% at 24 and 96 h, respectively. The increase of platelets via AHI was similar in both, men and women.To evaluate whether this action of AHI was related to platelets from COVID-19 positive patients or also for healthy people, two controls were included: one of them with 10 healthy volunteers and another one with COVID-19 positive patients hospitalized and treated only with Dexa-Enoxa. Results show that, in healthy volunteers, the number of circulating platelets remains unchanged even after 7 days of treatment with AHI. In COVID-19 positive patients treated only with Dexa-Enoxa for 4 days, platelets increased only 16%. |
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| MeSH term(s) | Adult ; Blood Platelets/metabolism ; COVID-19/blood ; COVID-19/drug therapy ; Enoxaparin/administration & dosage ; Female ; Humans ; Ibuprofen/administration & dosage ; Male ; Middle Aged ; Nebulizers and Vaporizers ; Platelet Count ; SARS-CoV-2/metabolism | |||||
| Chemical Substances | Enoxaparin ; Ibuprofen (WK2XYI10QM) | |||||
| Language | English | |||||
| Publishing date | 2021-08-22 | |||||
| Publishing country | England | |||||
| Document type | Clinical Trial ; Comparative Study ; Journal Article | |||||
| ZDB-ID | 1034283-7 | |||||
| ISSN | 1369-1635 ; 0953-7104 | |||||
| ISSN (online) | 1369-1635 | |||||
| ISSN | 0953-7104 | |||||
| DOI | 10.1080/09537104.2021.1967918 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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