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  1. Article: Assessment of omeprazole and famotidine effects on the pharmacokinetics of tacrolimus in patients following kidney transplant-randomized controlled trial.

    Miedziaszczyk, Miłosz / Karczewski, Marek / Grabowski, Tomasz / Wolc, Anna / Idasiak-Piechocka, Ilona

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1352323

    Abstract: Tacrolimus is metabolized in the liver with the participation of the CYP3A4 and CYP3A5 enzymes. Proton pump inhibitors are used in kidney transplant patients to prevent duodenal and gastric ulcer disease due to glucocorticoids. Omeprazole, unlike ... ...

    Abstract Tacrolimus is metabolized in the liver with the participation of the CYP3A4 and CYP3A5 enzymes. Proton pump inhibitors are used in kidney transplant patients to prevent duodenal and gastric ulcer disease due to glucocorticoids. Omeprazole, unlike famotidine, is a substrate and inhibitor of the enzymes CYP2C19, CYP3A4, CYP3A5. The aim of this study was to compare the impact of omeprazole and famotidine on the pharmacokinetics of tacrolimus. A randomized, non-blinded study involving 22 stabilized adult kidney transplant patients was conducted. Patients received the standard triple immunosuppression regimen and omeprazole 20 mg (n = 10) or famotidine 20 mg (n = 12). The study material consisted of blood samples in which tacrolimus concentrations were determined using the Chemiluminescent Microparticle Immuno Assay method. A single administration of omeprazole increased tacrolimus concentrations at 2 h (day 2) = 11.90 ± 1.59 ng/mL vs. 2 h (day 1 - no omeprazole administration) = 9.40 ± 0.79 ng/mL (
    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1352323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A Rare Case of Dedifferentiated Liposarcoma with Osteosarcomatous Differentiation-Diagnostic and Therapeutic Challenges.

    Sosnowska-Sienkiewicz, Patrycja / Mańkowski, Przemysław / Stadnik, Honorata / Dłubak, Agata / Czekała, Anna / Karczewski, Marek

    Diseases (Basel, Switzerland)

    2023  Volume 12, Issue 1

    Abstract: Introduction: Liposarcomas are the most common of all sarcomas. A well-differentiated liposarcoma can transform into a dedifferentiated liposarcoma with myogenic, osteo- or chondrosarcomatous heterologous differentiation. Genomic amplification of : ... ...

    Abstract Introduction: Liposarcomas are the most common of all sarcomas. A well-differentiated liposarcoma can transform into a dedifferentiated liposarcoma with myogenic, osteo- or chondrosarcomatous heterologous differentiation. Genomic amplification of
    Case report: A 60-year-old patient was admitted to the hospital for surgical treatment of a left renal mass. The true location of the tumor was discovered only intraoperatively. The lesion was completely removed laparoscopically with preservation of the capsule. Genomic amplification of
    Conclusion: Dedifferentiated liposarcoma with osteosarcomatous differentiation is a sporadic case and may occur in various locations of the retroperitoneal space, also mimicking a renal tumor. The laparoscopic technique is a safe surgical treatment for tumors of unclear origin. Removal of dedifferentiated liposarcoma with osteosarcomatous differentiation tumor with preservation of the lesion capsule without maintaining a margin of healthy tissue also allows for long-term cure. Precise immunohistochemical and molecular studies may have an impact on the effectiveness of further treatment and the prognosis of the patient. A patient after surgical treatment of liposarcoma requires constant outpatient follow-up for the reason of the high risk of local and distant recurrence.
    Language English
    Publishing date 2023-12-25
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2720869-2
    ISSN 2079-9721
    ISSN 2079-9721
    DOI 10.3390/diseases12010006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effects of Isoflavonoid and Vitamin D Synergism on Bone Mineral Density-A Systematic and Critical Review.

    Miedziaszczyk, Miłosz / Maciejewski, Adam / Idasiak-Piechocka, Ilona / Karczewski, Marek / Lacka, Katarzyna

    Nutrients

    2023  Volume 15, Issue 24

    Abstract: Phytoestrogens are non-steroidal plant compounds, which bind to α and β estrogen receptors, thereby causing specific effects. The best-known group of phytoestrogens are flavonoids, including isoflavonoids-genistein and daidzein. They play a role in the ... ...

    Abstract Phytoestrogens are non-steroidal plant compounds, which bind to α and β estrogen receptors, thereby causing specific effects. The best-known group of phytoestrogens are flavonoids, including isoflavonoids-genistein and daidzein. They play a role in the metabolism of bone tissue, improving its density and preventing bone loss, which contributes to reducing the risk of fractures. Vitamin D is found in the form of cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) and is traditionally recognized as a regulator of bone metabolism. The aim of this review was to evaluate the synergistic effect of isoflavonoids and vitamin D on bone mineral density (BMD). The MEDLINE (PubMed), Scopus and Cochrane databases were searched independently by two authors. The search strategy included controlled vocabulary and keywords. Reference publications did not provide consistent data regarding the synergistic effect of isoflavonoids on BMD. Some studies demonstrated a positive synergistic effect of these compounds, whereas in others, the authors did not observe any significant differences. Therefore, further research on the synergism of isoflavonoids and vitamin D may contribute to a significant progress in the prevention and treatment of osteoporosis.
    MeSH term(s) Vitamin D/pharmacology ; Bone Density ; Phytoestrogens/pharmacology ; Vitamins/pharmacology ; Cholecalciferol/pharmacology
    Chemical Substances Vitamin D (1406-16-2) ; Phytoestrogens ; Vitamins ; Cholecalciferol (1C6V77QF41)
    Language English
    Publishing date 2023-12-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15245014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impaired Expression of Humanin during Adrenocortical Carcinoma.

    Blatkiewicz, Małgorzata / Szyszka, Marta / Olechnowicz, Anna / Kamiński, Kacper / Jopek, Karol / Komarowska, Hanna / Tyczewska, Marianna / Klimont, Anna / Wierzbicki, Tomasz / Karczewski, Marek / Ruchała, Marek / Rucinski, Marcin

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: The discovery of mitochondria-derived peptides (MDPs) has provided a new perspective on mitochondrial function. MDPs encoded by mitochondrial DNA (mtDNA) can act as hormone-like peptides, influencing cell survival and proliferation. Among these peptides, ...

    Abstract The discovery of mitochondria-derived peptides (MDPs) has provided a new perspective on mitochondrial function. MDPs encoded by mitochondrial DNA (mtDNA) can act as hormone-like peptides, influencing cell survival and proliferation. Among these peptides, humanin has been identified as a crucial factor for maintaining cell survival and preventing cell death under various conditions. Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy that results from adrenal hormone dysfunction. This study aimed to investigate humanin expression in the adrenal tissue and serum of patients with ACC. For the first time, our study revealed significant reduction in the mRNA expression of humanin in patients with ACC compared to healthy controls. However, no significant changes were observed in the serum humanin levels. Interestingly, we identified a positive correlation between patient age and serum humanin levels and a negative correlation between tumor size and LDL levels. While the impaired expression of humanin in patients with ACC may be attributed to mitochondrial dysfunction, an alternative explanation could be related to diminished mitochondrial copy number. Further investigations are warranted to elucidate the intricate relationship among humanin, mitochondrial function, and ACC pathology.
    MeSH term(s) Humans ; Adrenocortical Carcinoma/genetics ; Intracellular Signaling Peptides and Proteins ; DNA, Mitochondrial/genetics ; Adrenal Cortex Neoplasms/genetics ; Hormones
    Chemical Substances humanin ; Intracellular Signaling Peptides and Proteins ; DNA, Mitochondrial ; Hormones
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The role of genetic risk factors, diet, and gut microbiota in type 1 diabetes mellitus, pancreas and pancreatic islet transplantation.

    Zawada, Agnieszka / Skrzypczak-Zielińska, Marzena / Gondek, Sarah / Witkowski, Piotr / Rychter, Anna M / Ratajczak-Pawłowska, Alicja E / Karczewski, Marek / Dobrowolska, Agnieszka / Krela-Kaźmierczak, Iwona

    Endokrynologia Polska

    2024  Volume 75, Issue 2, Page(s) 140–147

    Abstract: Despite advances in insulin delivery and glucose monitoring technology, prevention of the progression of secondary complications in patients with type 1 diabetes (T1DM) remains a challenge. Beta cell replacement therapy in the form of islet or pancreas ... ...

    Abstract Despite advances in insulin delivery and glucose monitoring technology, prevention of the progression of secondary complications in patients with type 1 diabetes (T1DM) remains a challenge. Beta cell replacement therapy in the form of islet or pancreas transplantation can restore long-term normoglycaemia with sustained periods of insulin independence among T1DM patients. However, the same genetic, behavioural, or gut microbiota-related factors that promoted autoimmunity and primary islet destruction may also affect the function of transplanted islets and the ultimate results of transplant procedures. In such cases, identifying genetic risk factors and modifying behavioural factors and those related to gut microbiota may be beneficial for the outcomes of transplant procedures. Herein, we review related literature to the identified current gap in knowledge to be addressed in future clinical trials.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 1 ; Islets of Langerhans Transplantation ; Gastrointestinal Microbiome ; Risk Factors ; Pancreas Transplantation ; Diet
    Language English
    Publishing date 2024-04-22
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 419270-9
    ISSN 2299-8306 ; 0423-104X
    ISSN (online) 2299-8306
    ISSN 0423-104X
    DOI 10.5603/ep.98903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 204: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Scaffolds from surgically removed kidneys as a potential source of organ transplantation.

    Karczewski, Marek / Malkiewicz, Tomasz

    BioMed research international

    2015  Volume 2015, Page(s) 325029

    Abstract: End stage renal disease (ESRD) is a common disease, which relates to nearly 600 million people in the total population. What is more, it seems to be a crucial problem from the epidemiological point of view. These facts lead to a further necessity of ... ...

    Abstract End stage renal disease (ESRD) is a common disease, which relates to nearly 600 million people in the total population. What is more, it seems to be a crucial problem from the epidemiological point of view. These facts lead to a further necessity of renal replacement therapy development connected with rising expenditures for the health care system. The aim of kidney tissue engineering is to develop and innovate methods of obtaining renal extracellular matrix (ECM) scaffolds derived from kidney decellularization. Recently, progress has been made towards developing a functional kidney graft in vitro on demand. In fact, decellularized tissues constitute ideal natural scaffolds, due to the preservation of native ECM architecture, as well as of cell-ECM binding domains critical in promoting cell attachment, migration, and proliferation. One of the potential sources of the natural scaffolds is the kidney, which cannot be transplanted immediately after excision.
    MeSH term(s) Cell Movement/physiology ; Cell Proliferation/physiology ; Extracellular Matrix/physiology ; Humans ; Kidney/cytology ; Kidney/physiology ; Kidney/surgery ; Kidney Transplantation ; Tissue Engineering ; Tissue Scaffolds
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2015/325029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Enhanced Expression of ZWILCH Predicts Poor Survival of Adrenocortical Carcinoma Patients.

    Blatkiewicz, Małgorzata / Kamiński, Kacper / Szyszka, Marta / Al-Shakarchi, Zaid / Olechnowicz, Anna / Stelcer, Ewelina / Komarowska, Hanna / Tyczewska, Marianna / Klimont, Anna / Karczewski, Marek / Wierzbicki, Tomasz / Mikołajczyk-Stecyna, Joanna / Ruchała, Marek / Malendowicz, Ludwik K / Ruciński, Marcin

    Biomedicines

    2023  Volume 11, Issue 4

    Abstract: Zwilch kinetochore protein (ZWILCH) plays a key role in proper cell proliferation. The upregulation of ... ...

    Abstract Zwilch kinetochore protein (ZWILCH) plays a key role in proper cell proliferation. The upregulation of the
    Language English
    Publishing date 2023-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11041233
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  8. Article ; Online: Biological response of adrenal carcinoma and melanoma cells to mitotane treatment.

    Stelcer, Ewelina / Komarowska, Hanna / Jopek, Karol / Żok, Agnieszka / Iżycki, Dariusz / Malińska, Agnieszka / Szczepaniak, Beata / Komekbai, Zhanat / Karczewski, Marek / Wierzbicki, Tomasz / Suchorska, Wiktoria Maria / Ruchała, Marek / Ruciński, Marcin

    Oncology letters

    2022  Volume 23, Issue 4, Page(s) 120

    Abstract: A previous case report described an adrenal incidentaloma initially misdiagnosed as adrenocortical carcinoma (ACC), which was treated with mitotane. The final diagnosis was metastatic melanoma of unknown primary origin. However, the patient developed ... ...

    Abstract A previous case report described an adrenal incidentaloma initially misdiagnosed as adrenocortical carcinoma (ACC), which was treated with mitotane. The final diagnosis was metastatic melanoma of unknown primary origin. However, the patient developed rapid disease progression after mitotane withdrawal, suggesting a protective role for mitotane in a non-adrenal-derived tumor. The aim of the present study was to determine the biological response of primary melanoma cells obtained from that patient, and that of other established melanoma and ACC cell lines, to mitotane treatment using a proliferation assay, flow cytometry, quantitative PCR and microarrays. Although mitotane inhibited the proliferation of both ACC and melanoma cells, its role in melanoma treatment appears to be limited. Flow cytometry analysis and transcriptomic studies indicated that the ACC cell line was highly responsive to mitotane treatment, while the primary melanoma cells showed a moderate response
    Language English
    Publishing date 2022-02-10
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2022.13240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Abnormal Nailfold Capillaries in Patients after Hand Transplantation.

    Sikorska, Dorota / Samborski, Włodzimierz / Kamińska, Dorota / Kusztal, Mariusz / Jabłecki, Jerzy / Nijakowski, Kacper / Oko, Andrzej / Karczewski, Marek / Korybalska, Katarzyna / Witowski, Janusz

    Journal of clinical medicine

    2020  Volume 9, Issue 11

    Abstract: Background: The development of graft vasculopathy may play a role in the long-term deterioration of hand grafts. The aim of study was to examine the patterns of the nailfold capillaries in hand transplant recipients.: Methods: the study was performed ...

    Abstract Background: The development of graft vasculopathy may play a role in the long-term deterioration of hand grafts. The aim of study was to examine the patterns of the nailfold capillaries in hand transplant recipients.
    Methods: the study was performed on six patients who received hand transplantation. To normalize for the effect of immunosuppression an age- and sex-matched group of 12 patients with active kidney transplant was selected. As an additional control group, 12 healthy volunteers were recruited. Nailfold videocapillaroscopy was performed in all participants. Additionally, serum concentrations of vascular endothelial growth factor (VEGF) were measured.
    Results: Videocapillaroscopic examination of the hand allografts revealed significant abnormalities: including capillary disorganization and microhaemorrhages. The number of capillaries was reduced, the vessels were enlarged and branched. Surprisingly, similar, albeit slightly less pronounced, changes were seen in the nailfolds of healthy hands of the limb transplant recipients. In kidney transplant recipients the capillaroscopic pattern was general normal and comparable to healthy individuals. Moreover, serum concentrations of VEGF in all participants correlated with average capillary diameter in capillaroscopy.
    Conclusions: in hand transplant recipients advanced microvascular abnormalities are found in nailfold capillaroscopic pattern in both transplanted and own extremities connected with elevated levels of VEGF.
    Language English
    Publishing date 2020-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9113422
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  10. Article ; Online: Immunoregulatory defect in patients with active Crohn's disease.

    Karczewski, Jacek / Karczewski, Marek

    Inflammatory bowel diseases

    2011  Volume 19, Issue 1, Page(s) E2–4

    MeSH term(s) Adult ; Case-Control Studies ; Crohn Disease/immunology ; Crohn Disease/metabolism ; Cytokines/blood ; Female ; Flow Cytometry ; Humans ; Male ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Th1 Cells/immunology ; Th1 Cells/metabolism ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Th2 Cells/immunology ; Th2 Cells/metabolism
    Chemical Substances Cytokines
    Language English
    Publishing date 2011-11-13
    Publishing country England
    Document type Comparative Study ; Letter
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1002/ibd.21934
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4530: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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