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  1. Article ; Online: The relationship between metabolic syndrome criteria and pentraxin-3 levels in children.

    Somuncu, Eda / Ornek, Zuhal / Kardes, Hakan / Guven, Berrak / Somuncu, Mustafa Umut

    Journal of pediatric endocrinology & metabolism : JPEM

    2023  Volume 36, Issue 9, Page(s) 865–872

    Abstract: Objectives: While the positive correlation was shown in a few studies which investigated the relationship between obesity and pentraxin-3 (PTX-3) levels, different findings were obtained in other studies. We aimed to determine PTX-3 levels in obese and ... ...

    Abstract Objectives: While the positive correlation was shown in a few studies which investigated the relationship between obesity and pentraxin-3 (PTX-3) levels, different findings were obtained in other studies. We aimed to determine PTX-3 levels in obese and healthy children, and their relationship with Metabolic Syndrome (MetS) criteria.
    Methods: 105 children and adolescents were considered as the study population. Participants were divided into three groups; obese and MetS (OM+), obese and non-MetS (OM-) and the control group. Fasting glucose, blood lipids and PTX-3 levels were measured. Ultrasonography was performed to detect hepatic steatosis. MetS and hepatic steatosis were investigated by dividing the patients into two groups according to PTX-3 levels.
    Results: The study population consisted of 37 patients with OM+; 35 patients with OM- and 33 healthy children. OM+ patients had higher fasting insulin (p<0.001), homeostatic model assessment for insulin resistance (p<0.001), triglyceride (p<0.001) and lower high-density lipoprotein (p=0.001). The PTX-3 level was higher in the OM+ group compared to both OM- group and the control group (p=0.002). When two groups were generated according to PTX-3 level, a higher frequency of MetS was detected in the high PTX 3 group than in all three major MetS diagnostic criteria groups. Moreover, there was more hepatic steatosis in the high PTX-3 group independent from obesity and MetS.
    Conclusions: Higher PTX-3 levels were present in children and adolescent obese patients with MetS.
    MeSH term(s) Adolescent ; Humans ; Child ; Metabolic Syndrome/epidemiology ; Obesity ; Insulin Resistance ; Fatty Liver ; Fasting
    Language English
    Publishing date 2023-08-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1231070-0
    ISSN 2191-0251 ; 0334-018X
    ISSN (online) 2191-0251
    ISSN 0334-018X
    DOI 10.1515/jpem-2023-0082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2258: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article ; Online: COVID-19 Pandemisine Pediatrik Yaklaşım ; Pediatric Approach to COVID-19 Pandemic

    KARDEŞ, Hakan / ÖRNEK, Zühal

    Volume: 4, Issue: 2 170-176 ; 2587-0335 ; 2587-0572 ; Türkiye Diyabet ve Obezite Dergisi

    2020  

    Abstract: Yeni koronavirüs hastalığı (2019-nCoV, COVID-19) ilk kez Çin’de 2019 yılı sonlarında bildirilmiştir. Kısa sürede tüm dünyayı etkilemiş ve pandemi olarak kabul edilmiştir. Çocuklarda kliniği erişkinlere göre hafif seyretmektedir ve çocuklarda prognoz ... ...

    Abstract Yeni koronavirüs hastalığı (2019-nCoV, COVID-19) ilk kez Çin’de 2019 yılı sonlarında bildirilmiştir. Kısa sürede tüm dünyayı etkilemiş ve pandemi olarak kabul edilmiştir. Çocuklarda kliniği erişkinlere göre hafif seyretmektedir ve çocuklarda prognoz iyidir.Tanısı gerçek zamanlı polimeraz zincir reaksiyonu testi ile konulur. Çocuklarda spesifik laboratuvar testi yoktur. Bağışıklığı baskılanmışve altta yatan hastalığı olan çocuklarda hastalık daha ağır seyreder. Şu an için çocuklarda COVID-19 enfeksiyonuna yönelik tedavi için yeterli ve kesinleşmiş veriler bulunmamaktadır. Bu derlemede güncel literatür bilgileri ışığında COVID-19 hastalığının çocuklarda epidemiyolojisi, kliniği, tanısı, tedavi yaklaşımları ve olası sık görülen temas durumlarına karşı korunma önlemlerinin sunulması amaçlanmıştır.

    The novel coronavirus disease (2019-nCoV, COVID-19) was first reported in China in late 2019. It has impacted the world in a shorttime and characterized as a pandemic. The clinical picture in children is milder than adults and prognosis are good in children. The diagnosis is made by a real-time polymerase chain reaction test. There is no specific laboratory test for COVID-19 infection in children. The disease progresses more severely in children with an underlying condition and immunocompromised children. There are currently no sufficient and conclusive data on treatment for COVID-19 infection in children. This review aims to present the epidemiology, clinical picture, diagnosis, treatment approaches, and possible preventive measures of COVID-19 disease in children in light of thecurrent literature.
    Keywords Koronavirüs,COVID-19,Çocuk,Pediatri ; Coronavirus,COVID-19,Child,Pediatrics ; covid19
    Language Turkish
    Publishing date 2020-08-30T00:00:00Z
    Publisher Bülent Ecevit Üniversitesi
    Publishing country tr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Clinical evaluation of a cohort of patients with rheumatoid arthritis treated with anti-TNF-alpha in the community.

    Genta, Marcia S / Kardes, Hakan / Gabay, Cem

    Joint bone spine

    2005  Volume 73, Issue 1, Page(s) 51–56

    Abstract: Objectives: TNF-alpha inhibitors have been effective in randomized controlled studies for the treatment of RA. The purpose of this study was to evaluate the clinical, laboratory, and radiological responses in a cohort of unselected patients with RA ... ...

    Abstract Objectives: TNF-alpha inhibitors have been effective in randomized controlled studies for the treatment of RA. The purpose of this study was to evaluate the clinical, laboratory, and radiological responses in a cohort of unselected patients with RA treated with TNF-alpha inhibitors in the community.
    Methods: Using the Swiss Clinical Quality Management in Rheumatoid Arthritis, a centralized system of data gathering for RA patients, we obtained the following information regarding patients treated with a TNF-alpha inhibitor in the Geneva Canton before 02/2003: demographics; clinical data (disease activity, functional status, treatments received and type of TNF-alpha inhibitor used); laboratory and radiographic data.
    Results: A total of 66 patients (mean age = 60.5 years) with long-standing disease (mean duration = 12.5 years) were analyzed. Sixteen patients (24%) discontinued anti-TNF-alpha, half within the first 6 months of the study. Mean DAS score decreased from 4.8+ /- 0.4 to 3.8 +/- 0.4 (P < 0.01); HAQ scores (mean = 1.35) remained unchanged; pain, evaluated on a 10-point scale, decreased from 5.0 at baseline to 3.3 (P < 0.001). CRP values decreased steadily from 17.9 at baseline to 5.6 at 20 months or later. The progression of radiographic damage decelerated in 30 patients, accelerated in 12, and remained unchanged in one.
    Conclusions: The responses of this community-based group of patients with severe, long-standing RA to TNF-alpha inhibitors revealed a reassuring similarity to those of patients enrolled in controlled clinical trials.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal/therapeutic use ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/diagnostic imaging ; Arthritis, Rheumatoid/drug therapy ; Etanercept ; Female ; Follow-Up Studies ; Humans ; Immunoglobulin G/therapeutic use ; Infliximab ; Male ; Middle Aged ; Pain Measurement ; Radiography ; Receptors, Tumor Necrosis Factor/therapeutic use ; Recombinant Fusion Proteins/therapeutic use ; Retrospective Studies ; Surveys and Questionnaires ; Treatment Outcome ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Antibodies, Monoclonal ; Antirheumatic Agents ; Immunoglobulin G ; Receptors, Tumor Necrosis Factor ; Recombinant Fusion Proteins ; Tumor Necrosis Factor-alpha ; Infliximab (B72HH48FLU) ; Etanercept (OP401G7OJC)
    Language English
    Publishing date 2005-12-05
    Publishing country France
    Document type Comparative Study ; Journal Article
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2005.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4590: Show issues Location:
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  4. Article ; Online: COVID-19 Disease in Presenting to the Pediatric Emergency Department: A Multicenter Study of 8886 Cases.

    Duman, Murat / Şık, Nihan / Tekşam, Özlem / Akça, Halise / Kurt, Funda / Çağlar, Ayla Akca / Yıldız, Leman Akcan / Taşar, Medine Ayşin / Fidancı, İlknur / Yayla, Burcu Ceylan Cura / Yılmaz, Durgül / Güngör, Emre / Demir, Şule / Çokuğraş, Haluk / Cebeci, Sinem Oral / Önal, Pınar / Saz, Eylem Ulaş / Yurtseven, Ali / Uysalol, Metin /
    Yıldız, Raif / Gümüş, Süheyla / Bal, Alkan / Bayturan, Semra Şen / Zengin, Neslihan / Atik, Sinem / Çiftdoğan, Dilek Yılmaz / Berksoy, Emel / Çiçek, Alper / Şahin, Sabiha / Kızıl, Mahmut Can / Kara, Yalçın / Apa, Hurşit / Ulusoy, Emel / Kara, Aybüke Akaslan / Yesil, Edanur / Erdem, Meltem / Turan, Caner / Arslanoglu, Sertac / Duyu, Muhterem / Besli, Gulser Esen / Arslan, Gazi / Oflu, Ayşe Tolunay / Çeleğen, Mehmet / Buldu, Ebru / Pişkin, İbrahim Etem / Kardeş, Hakan / Yılmaz, Hayri Levent / Yıldızdaş, Dinçer / Gökulu, Gamze / Çay, Pınar / Özer, Utku / Güleryüz, Okşan Derinöz / Çolak, Özlem / Güneysu, Songül Tomar

    The American journal of emergency medicine

    2022  Volume 59, Page(s) 133–140

    Abstract: Background: The aim was to evaluate the epidemiological, clinical, laboratory, and radiologic data of children with SARS-CoV-2 positivity by polymerase chain reaction (PCR) together with treatment strategies and clinical outcomes and to evaluate cases ... ...

    Abstract Background: The aim was to evaluate the epidemiological, clinical, laboratory, and radiologic data of children with SARS-CoV-2 positivity by polymerase chain reaction (PCR) together with treatment strategies and clinical outcomes and to evaluate cases of multisystem inflammatory syndrome in children (MIS-C) in this population.
    Methods: This was a multicenter retrospective observational cohort study performed in the pediatric emergency departments of 19 tertiary hospitals. From March 11, 2020, to May 31, 2021, children who were diagnosed with confirmed nasopharyngeal/tracheal specimen SARS-CoV-2 PCR positivity or positivity for serum-specific antibodies against SARS-CoV-2 were included. Demographics, presence of chronic illness, symptoms, history of contact with SARS-CoV-2 PCR-positive individuals, laboratory and radiologic investigations, clinical severity, hospital admissions, and prognosis were recorded.
    Results: A total of 8886 cases were included. While 8799 (99.0%) cases resulted in a diagnosis of SARS-CoV-2 with PCR positivity, 87 (1.0%) patients were diagnosed with MIS-C. Among SARS-CoV-2 PCR-positive patients, 51.0% were male and 8.5% had chronic illnesses. The median age was 11.6 years (IQR: 5.0-15.4) and 737 (8.4%) patients were aged <1 year. Of the patients, 15.5% were asymptomatic. The most common symptoms were fever (48.5%) and cough (30.7%) for all age groups. There was a decrease in the rate of fever as age increased (p < 0.001); the most common age group for this symptom was <1 year with the rate of 69.6%. There was known contact with a SARS-CoV-2 PCR-positive individual in 67.3% of the cases, with household contacts in 71.3% of those cases. In terms of clinical severity, 83 (0.9%) patients were in the severe-critical group. There was hospital admission in 1269 (14.4%) cases, with 106 (1.2%) of those patients being admitted to the pediatric intensive care unit (PICU). Among patients with MIS-C, 60.9% were male and the median age was 6.4 years (IQR: 3.9-10.4). Twelve (13.7%) patients presented with shock. There was hospital admission in 89.7% of these cases, with 29.9% of the patients with MIS-C being admitted to the PICU.
    Conclusion: Most SARS-CoV-2 PCR-positive patients presented with a mild clinical course. Although rare, MIS-C emerges as a serious consequence with frequent PICU admission. Further understanding of the characteristics of COVID-19 disease could provide insights and guide the development of therapeutic strategies for target groups.
    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; Child ; Emergency Service, Hospital ; Female ; Fever/etiology ; Humans ; Male ; Retrospective Studies ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
    Language English
    Publishing date 2022-06-09
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2022.06.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2005: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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