LIVIVO - Search results -

Search results

Result 1 - 10 of total 39

Search options

Article ; Online: Metabolic sinkholes: Histones as methyl repositories.

Karimian, Ansar / Vogelauer, Maria / Kurdistani, Siavash K

2023 Volume 21, Issue 10, Page(s) e3002371

Abstract: Perez and Sarkies uncover histones as methyl group repositories in normal and cancer human cells, shedding light on an intriguing function of histone methylation in optimizing the cellular methylation potential independently of gene regulation. ...

Abstract	Perez and Sarkies uncover histones as methyl group repositories in normal and cancer human cells, shedding light on an intriguing function of histone methylation in optimizing the cellular methylation potential independently of gene regulation.
MeSH term(s)	Humans ; Histones/metabolism ; Methylation ; Gene Expression Regulation ; Neoplasms/genetics ; Histone Methyltransferases/metabolism
Chemical Substances	Histones ; Histone Methyltransferases (EC 2.1.1.-)
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.3002371
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6193: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Zinc is Essential for the Copper Reductase Activity of Yeast Nucleosomes.

Vogelauer, Maria / Cheng, Chen / Karimian, Ansar / Iranpour, Hooman Golshan / Kurdistani, Siavash K

bioRxiv : the preprint server for biology

2023

Abstract: The histone H3-H4 tetramer is a copper reductase enzyme, facilitating the production of cuprous ( ... ...

Abstract	The histone H3-H4 tetramer is a copper reductase enzyme, facilitating the production of cuprous (Cu
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.09.14.557765
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: The role of histone H3 leucine 126 in fine-tuning the copper reductase activity of nucleosomes.

Tod, Nataliya P / Vogelauer, Maria / Cheng, Chen / Karimian, Ansar / Schmollinger, Stefan / Camacho, Dimitrios / Kurdistani, Siavash K

The Journal of biological chemistry

2024 , Page(s) 107314

Abstract: The copper reductase activity of histone H3 suggests undiscovered characteristics within the protein. Here, we investigated the function of leucine 126 (H3L126), which occupies an axial position relative to copper binding. Typically found as a methionine ...

Abstract	The copper reductase activity of histone H3 suggests undiscovered characteristics within the protein. Here, we investigated the function of leucine 126 (H3L126), which occupies an axial position relative to copper binding. Typically found as a methionine or leucine in copper binding proteins, the axial ligand influences the reduction potential of the bound ion, modulating its tendency to accept or yield electrons. We found that mutation of H3L126 to methionine (H3L126M) enhanced the enzymatic activity of native yeast nucleosomes in vitro and increased intracellular levels of Cu
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2024.107314
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.108: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The effects of statins with a high hepatoselectivity rank on the extra-hepatic tissues; New functions for statins.

Ahmadi, Yasin / Mahmoudi, Neda / Yousefi, Bahman / Karimian, Ansar

Pharmacological research

2019 Volume 152, Page(s) 104621

Abstract: Statins, as the most common treatment for hyperlipidemia, exert effects beyond their lipid-lowering role which are known as pleiotropic effects. These effects are mainly due to the inhibition of isoprenoids synthesis and consequently blocking prenylation ...

Abstract	Statins, as the most common treatment for hyperlipidemia, exert effects beyond their lipid-lowering role which are known as pleiotropic effects. These effects are mainly due to the inhibition of isoprenoids synthesis and consequently blocking prenylation of proteins involved in the cellular signaling pathways regulating cell development, growth, and apoptosis. Statins target cholesterol synthesis in the liver as the major source of cholesterol in the body and so reduce whole-body cholesterol. The reduced level of cholesterol forces other organs to an adaptive homeostatic reaction to increase their cholesterol synthesis capacity, however, this only occurs when statins have unremarkable access to the extra-hepatic tissues. In order to reduce the adverse effects of statin on the skeletal muscle, most recent efforts have been towards formulating new statins with the highest level of hepatoselectivity rank and the least level of access to the extra-hepatic tissues; however, the inaccessibility of statins for the extra-hepatic tissues may induce several biological reactions. In this review, we aim to evaluate the effects of statins on the extra-hepatic tissues when statins have unremarkable access to these tissues.
MeSH term(s)	Animals ; Cholesterol/metabolism ; Homeostasis/drug effects ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Liver/metabolism ; Mevalonic Acid/metabolism
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Cholesterol (97C5T2UQ7J) ; Mevalonic Acid (S5UOB36OCZ)
Language	English
Publishing date	2019-12-28
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2019.104621
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 721: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Synthesis of biocompatible nanocrystalline cellulose against folate receptors as a novel carrier for targeted delivery of doxorubicin.

Karimian, Ansar / Yousefi, Bahman / Sadeghi, Farzin / Feizi, Farideh / Najafzadehvarzi, Hossein / Parsian, Hadi

Chemico-biological interactions

2021 Volume 351, Page(s) 109731

Abstract: We designed amine-functionalized nanocrystalline cellulose grafted folic acid/magnetic nanoparticles (AF-NCC/ ... ...

Abstract	We designed amine-functionalized nanocrystalline cellulose grafted folic acid/magnetic nanoparticles (AF-NCC/Fe
MeSH term(s)	Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cellulose/chemistry ; Cellulose/metabolism ; Cellulose/toxicity ; Doxorubicin/chemistry ; Doxorubicin/pharmacology ; Drug Carriers/chemical synthesis ; Drug Carriers/chemistry ; Drug Carriers/metabolism ; Drug Carriers/toxicity ; Drug Liberation ; Female ; Folate Receptors, GPI-Anchored/metabolism ; Folic Acid/analogs & derivatives ; Folic Acid/metabolism ; Folic Acid/toxicity ; Humans ; Magnetite Nanoparticles/chemistry ; Magnetite Nanoparticles/toxicity ; Mice, Inbred BALB C ; Mice
Chemical Substances	Antineoplastic Agents ; Drug Carriers ; Folate Receptors, GPI-Anchored ; Magnetite Nanoparticles ; Doxorubicin (80168379AG) ; Cellulose (9004-34-6) ; Folic Acid (935E97BOY8)
Language	English
Publishing date	2021-10-30
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2021.109731
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 686: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: The modulatory effects of two bioflavonoids, quercetin and thymoquinone on the expression levels of DNA damage and repair genes in human breast, lung and prostate cancer cell lines.

Karimian, Ansar / Majidinia, Maryam / Moliani, Afshin / Alemi, Forough / Asemi, Zatollah / Yousefi, Bahman / Fazlollahpour Naghibi, Andarz

Pathology, research and practice

2022 Volume 240, Page(s) 154143

Abstract: Background: The recent decade has witnessed the increasing potential of various flavonoids such as quercetin and thymoquinone in inhibiting cancer cells proliferation and growth and their therapeutic effects in various cancers. Therefore, in the current ...

Abstract	Background: The recent decade has witnessed the increasing potential of various flavonoids such as quercetin and thymoquinone in inhibiting cancer cells proliferation and growth and their therapeutic effects in various cancers. Therefore, in the current study, we aim to evaluate the expression levels of key factors of DNA damage response in human breast, lung and prostate cancer cell lines in response to treatment with quercetin and thymoquinone. Methods: MTT assay was applied to assess the effects of quercetin and thymoquinone on the viability of MCF-7, A549, and PC3 cancer cells. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to evaluate the expression levels of p53, RAD51, Ku70, XRCC1, and H2AX in treated cells. In addition, the expression rate of 8-hydroxy-deoxyguanosine (8-OH-dG) was assessed by ELISA kit. Results: The quercetin and thymoquinone induce cytotoxicity in breast, lung, and prostate cancer cells effectively; MCF-7 cells were the most sensitive cells to quercetin with an IC50 value of 50 μM and PC3 cells were more sensitive to thymoquinone with an IC50 value of 20 μM. The expression levels of DNA damage markers, H2AX, and 8-OH-dG were significantly increased in all cancer cells treated with quercetin and thymoquinone (p < 0.05). Moreover, both flavonoids significantly decreased the expression levels of DNA repair mediators, RAD51, Ku70, XRCC1, in cell lines. P53 was also increased in MCF-7 and A549 cells. Conclusion: We concluded that quercetin and thymoquinone may exert their effects through modulation of DNA damage response, increasing DNA damage, and suppressing DNA repair genes.
MeSH term(s)	Male ; Humans ; Quercetin/pharmacology ; Flavonoids/pharmacology ; Tumor Suppressor Protein p53/metabolism ; 8-Hydroxy-2'-Deoxyguanosine ; DNA Damage ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; MCF-7 Cells ; Lung/metabolism ; Cell Line, Tumor ; Apoptosis ; X-ray Repair Cross Complementing Protein 1/genetics
Chemical Substances	Quercetin (9IKM0I5T1E) ; thymoquinone (O60IE26NUF) ; Flavonoids ; Tumor Suppressor Protein p53 ; 8-Hydroxy-2'-Deoxyguanosine (88847-89-6) ; XRCC1 protein, human ; X-ray Repair Cross Complementing Protein 1
Language	English
Publishing date	2022-09-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2022.154143
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ud III Zs.20: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Targeting miRNAs by polyphenols: Novel therapeutic strategy for aging.

Majidinia, Maryam / Karimian, Ansar / Alemi, Forough / Yousefi, Bahman / Safa, Amin

Biochemical pharmacology

2019 Volume 173, Page(s) 113688

Abstract: Regarding the importance of genetic and epigenetic factors in regulation of aging process, different expression pattern of non-coding RNAs in aging could be investigated. Accordingly, micro RNAs (miRNAs) with a wide range of physiological functions as ... ...

Abstract	Regarding the importance of genetic and epigenetic factors in regulation of aging process, different expression pattern of non-coding RNAs in aging could be investigated. Accordingly, micro RNAs (miRNAs) with a wide range of physiological functions as well as a significant footprint in many diseases have been demonstrated to be down or upregulated during the aging process. Therefore, age-associated microRNAs and their targets have potentially detected the accelerated aging and predicted the risks for age-related diseases. Polyphenols as important antioxidants in human dietary observed in fruits and some beverages have beneficial effects on longevity and aging. Considering miRNAs as an interesting mediator in modulating polyphenols' biological effects, targeting miRNAs which is using polyphenols could be a novel strategy for aging.
MeSH term(s)	Aging/genetics ; Cardiovascular Diseases/genetics ; Catechin/analogs & derivatives ; Catechin/therapeutic use ; Gene Expression Regulation/drug effects ; Humans ; Longevity/genetics ; MicroRNAs/genetics ; Neoplasms/genetics ; Nervous System Diseases/genetics ; Polyphenols/metabolism ; Polyphenols/therapeutic use
Chemical Substances	MicroRNAs ; Polyphenols ; Catechin (8R1V1STN48) ; epigallocatechin gallate (BQM438CTEL)
Language	English
Publishing date	2019-11-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2019.113688
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 19: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Red Cell Distribution Width as a Novel Prognostic Marker in Multiple Clinical Studies.

Yousefi, Bahman / Sanaie, Sarvin / Ghamari, Ali A / Soleimanpour, Hassan / Karimian, Ansar / Mahmoodpoor, Ata

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

2020 Volume 24, Issue 1, Page(s) 49–54

Abstract: Red cell distribution width (RDW), which is a quantitative method applied for the measurement of anisocytosis, is the most reliable and inexpensive method for differentiation of iron deficiency anemia and thalassemia trait. An increase in its rate ... ...

Abstract	Red cell distribution width (RDW), which is a quantitative method applied for the measurement of anisocytosis, is the most reliable and inexpensive method for differentiation of iron deficiency anemia and thalassemia trait. An increase in its rate reflects a great heterogeneity in the size of red blood cells (RBCs). Recent studies have shown a significant relationship between RDW and the risk of morbidity and mortality in patients with multiple diseases. A strong association is established between changes in RDW and the risk of adverse outcome in patients with heart failure in multiple studies. In this review, we try to focus on the association and correlation between the increase in RDW and different outcomes of common diseases that may be related to RDW and based on the results of various studies, we are trying to introduce RDW as a diagnostic indicator for these diseases. How to cite this article: Yousefi B, Sanaie S, Ghamari AA, Soleimanpour H, Karimian A, Mahmoodpoor A. Red Cell Distribution Width as a Novel Prognostic Marker in Multiple Clinical Studies. Indian J Crit Care Med 2020;24(1):49-54.
Language	English
Publishing date	2020-01-30
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2121263-6
ISSN	1998-359X ; 0972-5229
ISSN (online)	1998-359X
ISSN	0972-5229
DOI	10.5005/jp-journals-10071-23328
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Natural products and the balancing act of autophagy-dependent/independent ferroptosis in cancer therapy.

Rahimipour Anaraki, Shiva / Farzami, Payam / Hosseini Nasab, Seyed Soheil / Kousari, Ali / Fazlollahpour Naghibi, Andarz / Shariat Zadeh, Mahdieh / Barati, Reza / Taha, Seyed Reza / Karimian, Ansar / Nabi-Afjadi, Mohsen / Yousefi, Bahman

Naunyn-Schmiedeberg's archives of pharmacology

2023 Volume 397, Issue 5, Page(s) 2531–2549

Abstract: The control of biological cell death is essential for the body's appropriate growth. The resistance of cells to the apoptotic process presents a new difficulty in the treatment of cancer. To combat cancer cells, researchers are working to find new ... ...

Abstract	The control of biological cell death is essential for the body's appropriate growth. The resistance of cells to the apoptotic process presents a new difficulty in the treatment of cancer. To combat cancer cells, researchers are working to find new apoptotic pathways and components to activate. One of the processes of regulated cell death (RCD) is referred to as ferroptosis marked by a decline in the activity of lipid glutathione peroxidase 4 (GPX4) after the buildup of reactive oxygen species (ROS). Since lipid peroxidation is a crucial component of ferroptosis and is required for its start, numerous medicines have been studied, particularly for the treatment of cancer. In this context, autophagy is an additional form of RCD that can govern ferroptosis through shared signaling pathways/factors involved in both mechanisms. In this review, we will explore the molecular mechanisms underlying ferroptosis and its association with autophagy, to gain fresh insights into their interplay in cancer advancement, and the potential of natural products for its treatment.
MeSH term(s)	Ferroptosis/drug effects ; Ferroptosis/physiology ; Humans ; Neoplasms/drug therapy ; Neoplasms/pathology ; Neoplasms/metabolism ; Autophagy/drug effects ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Animals ; Reactive Oxygen Species/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Signal Transduction/drug effects
Chemical Substances	Biological Products ; Reactive Oxygen Species ; Antineoplastic Agents
Language	English
Publishing date	2023-10-25
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-023-02782-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ud II Zs.5: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: MicroRNA-26a-5p as a potential predictive factor for determining the effectiveness of trastuzumab therapy in HER-2 positive breast cancer patients.

Tehrani, Sadra Samavarchi / Zaboli, Ehsan / Sadeghi, Farzin / Khafri, Soraya / Karimian, Ansar / Rafie, Mahnoosh / Parsian, Hadi

BioMedicine

2021 Volume 11, Issue 2, Page(s) 30–39

Abstract: Background: Breast cancer (BC) is known as the most prevalent type of cancer among women. Trastuzumab, as an anticancer drug, has been used broadly in human epidermal growth factor receptor 2 (HER-2) positive (+) BC patients. Moreover, accumulating ... ...

Abstract	Background: Breast cancer (BC) is known as the most prevalent type of cancer among women. Trastuzumab, as an anticancer drug, has been used broadly in human epidermal growth factor receptor 2 (HER-2) positive (+) BC patients. Moreover, accumulating evidence has demonstrated that microRNAs is involved in the pathogenesis BC. Hence, we aimed to investigate the effect of trastuzumab on the expression levels of microRNA-26a in HER-2 positive BC patients. Methods: This study was conducted among HER-2 + and HER-2 Negative (-) BC patients. Serum expression of microRNA-26a was detected by real-time PCR. Then, we assessed the correlations of microRNA-26a levels with multiple clinico-pathological characteristics of BC. Results: In HER-2 + patients, the microRNA-26a expression significantly increased after treatment with Docetaxel/Trastuzumab in comparison to before the treatment levels (p.value = 0.01). However, this overexpression in HER-2-patients after treatment with Docetaxel was not significant compared to the levels before the treatment (p.value = 0.14). In addition, the expression of microRNA -26a has significantly increased in HER-2 + patients who were ≤48 years old and premenopausal after the treatment with Docetaxel/Trastuzumab when compared to the levels before the treatment (p.value = 0.039 vs. 0.031, respectively). Furthermore, there was a significant correlation between the expression of microRNA -26a and the tumor size, stage, estrogen receptor (ER) and progesterone receptor (PR) status in the HER-2 + group before and after the treatment (p.value = 0.043, 0.042, 0.049 and 0.034 respectively). Conclusions: Trastuzumab led to overexpression of microRNA-26a in HER-2 + BC patients. It seems that the detecting microRNA -26a expression levels, during or after the trastuzumab therapy could be a useful biomarker for monitoring the therapeutic response in HER-2 + BC patients. However, further studies on large populations of women with HER-2+ BC are needed to explore this possible novel biomarker, in more detail, within various clinical contexts.
Language	English
Publishing date	2021-06-01
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	2648006-2
ISSN	2211-8039 ; 2211-8020
ISSN (online)	2211-8039
ISSN	2211-8020
DOI	10.37796/2211-8039.1150
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito