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  1. Article ; Online: Coccidioidomycosis presenting years after returning from travel

    Koos Korsten / Josje Altenburg / Marieke Gittelbauer / Peter van Hengel / Rogier Jansen / Karin van Dijk

    Medical Mycology Case Reports, Vol 43, Iss , Pp 100623- (2024)

    2024  

    Abstract: After having traveled to California in 2017, a 26-year old Dutch man presented in 2020 with persisting cough and shortness of breath. Radiology showed cystic bronchiectasis with peri-bronchial consolidation in his right upper lobe. Laboratory studies in ... ...

    Abstract After having traveled to California in 2017, a 26-year old Dutch man presented in 2020 with persisting cough and shortness of breath. Radiology showed cystic bronchiectasis with peri-bronchial consolidation in his right upper lobe. Laboratory studies in August 2021 showed an increased total IgE, specific Aspergillus IgE, eosinophilia and positive BAL culture for Coccidioides immitis/posadasii. After 6 weeks of itraconazole treatment for suspected allergic bronchopulmonary aspergillosis, symptoms persisted and respiratory cultures remained positive. The infection was cleared after a 6-month course of fluconazole. (max 75 words)
    Keywords Coccidioidomycosis ; Pulmonary ; Mycology ; Microbiology ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2024-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Nakaseomyces glabrata endocarditis

    Kin Ki Jim / Joelle J.N. Daems / S. Matthijs Boekholdt / Karin van Dijk

    Medical Mycology Case Reports, Vol 40, Iss , Pp 54-

    A therapeutic dilemma

    2023  Volume 57

    Abstract: Candida infective endocarditis is a rare but serious entity that often requires aggressive treatment. However, treatment can be challenging in patients infected with drug-resistant fungi and/or with substantial comorbidity. Moreover, recommendations in ... ...

    Abstract Candida infective endocarditis is a rare but serious entity that often requires aggressive treatment. However, treatment can be challenging in patients infected with drug-resistant fungi and/or with substantial comorbidity. Moreover, recommendations in treatment guidelines for these patients are based on limited clinical data due to their rarity. Here we report a case of Nakaseomyces glabrata (Candida glabrata) prosthetic valve endocarditis in a patient with congenital heart disease. This case illustrates a therapeutic dilemma for Nakaseomyces glabrata prosthetic valve endocarditis and the need for novel antifungal drugs and further clinical studies.
    Keywords Nakaseomyces glabrata ; Candida glabrata ; Endocarditis ; Invasive candidiasis ; Anti-fungal therapy ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Olecranon bursitis caused by Scedosporium apiospermum in a patient treated with CAR-T cells

    Willem J.J. Falkenburg / Marit Jalink / Marie José Kersten / Jochem B. Buil / Karin van Dijk

    Medical Mycology Case Reports, Vol 38, Iss , Pp 33-

    2022  Volume 35

    Abstract: Chimeric antigen receptor (CAR-) T cell therapy is a relatively new form of immunotherapy for hematological malignancies. Although patients are at increased risk of infection following CAR-T cell therapy, reports of fungal infections are scarce. We ... ...

    Abstract Chimeric antigen receptor (CAR-) T cell therapy is a relatively new form of immunotherapy for hematological malignancies. Although patients are at increased risk of infection following CAR-T cell therapy, reports of fungal infections are scarce. We report a case of Scedosporium apiospermum infection causing bursitis of the elbow in a lymphoma patient after treatment with CAR-T cells. The fungal bursitis relapsed under posaconazole treatment, but was cured after surgical extirpation of the bursa.
    Keywords CAR-T cell therapy ; Scedosporium apiospermum ; Bursitis ; Voriconazole ; Posaconazole ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A glass bead semi-hydroponic system for intact maize root exudate analysis and phenotyping

    Martha G. Lopez-Guerrero / Peng Wang / Felicia Phares / Daniel P. Schachtman / Sophie Alvarez / Karin van Dijk

    Plant Methods, Vol 18, Iss 1, Pp 1-

    2022  Volume 21

    Abstract: Abstract Background Although there have been numerous studies describing plant growth systems for root exudate collection, a common limitation is that these systems require disruption of the plant root system to facilitate exudate collection. Here, we ... ...

    Abstract Abstract Background Although there have been numerous studies describing plant growth systems for root exudate collection, a common limitation is that these systems require disruption of the plant root system to facilitate exudate collection. Here, we present a newly designed semi-hydroponic system that uses glass beads as solid support to simulate soil impedance, which combined with drip irrigation, facilitates growth of healthy maize plants, collection and analysis of root exudates, and phenotyping of the roots with minimal growth disturbance or root damage. Results This system was used to collect root exudates from seven maize genotypes using water or 1 mM CaCl2, and to measure root phenotype data using standard methods and the Digital imaging of root traits (DIRT) software. LC–MS/MS (Liquid Chromatography—Tandem Mass Spectrometry) and GC–MS (Gas Chromatography—Mass Spectrometry) targeted metabolomics platforms were used to detect and quantify metabolites in the root exudates. Phytohormones, some of which are reported in maize root exudates for the first time, the benzoxazinoid DIMBOA (2,4-Dihydroxy-7-methoxy-1,4-benzoxazin-3-one), amino acids, and sugars were detected and quantified. After validating the methodology using known concentrations of standards for the targeted compounds, we found that the choice of the exudate collection solution affected the exudation and analysis of a subset of analyzed metabolites. No differences between collection in water or CaCl2 were found for phytohormones and sugars. In contrast, the amino acids were more concentrated when water was used as the exudate collection solution. The collection in CaCl2 required a clean-up step before MS analysis which was found to interfere with the detection of a subset of the amino acids. Finally, using the phenotypic measurements and the metabolite data, significant differences between genotypes were found and correlations between metabolites and phenotypic traits were identified. Conclusions A new plant growth system combining glass beads ...
    Keywords Maize ; Corn ; Zea mays ; Root exudates ; Hydroponics ; Glass beads ; Plant culture ; SB1-1110 ; Biology (General) ; QH301-705.5
    Subject code 580
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Low vision

    Karin van Dijk

    Community Eye Health Journal, Vol 25, Iss 77, p

    the patient's perspective

    2012  Volume 3

    Abstract: For this issue on low vision, the Community Eye Health Journal contacted low vision practitioners in India, Tanzania, Nepal, and Peru to help gather the views of eighteen people attending their low vision clinics. The people varied in age from 14 to 81, ... ...

    Abstract For this issue on low vision, the Community Eye Health Journal contacted low vision practitioners in India, Tanzania, Nepal, and Peru to help gather the views of eighteen people attending their low vision clinics. The people varied in age from 14 to 81, and suffered from a range of vision problems including nystagmus, retinitis pigmentosa, diabetic retinopathy, and bilateral aphakia.
    Keywords Low Vision ; Patients ; Ophthalmology ; RE1-994 ; Medicine ; R ; DOAJ:Ophthalmology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher The International Centre for Eye Health (ICEH), London
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Low vision care

    Karin van Dijk

    Community Eye Health Journal, Vol 25, Iss 77, Pp 14-

    who can help?

    2012  Volume 15

    Abstract: We know that, in many low- and middle-income countries, low vision services are limited to tertiary or teaching hospitals, which means that most people are not able to access them.If this is the case, who can those with low vision turn to for help? ...

    Abstract We know that, in many low- and middle-income countries, low vision services are limited to tertiary or teaching hospitals, which means that most people are not able to access them.If this is the case, who can those with low vision turn to for help?
    Keywords Low Vision ; Delivery of Health Care ; Community Outreach ; Ophthalmology ; RE1-994 ; Medicine ; R ; DOAJ:Ophthalmology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher The International Centre for Eye Health (ICEH), London
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: A role for heritable transcriptomic variation in maize adaptation to temperate environments

    Guangchao Sun / Huihui Yu / Peng Wang / Martha Lopez-Guerrero / Ravi V. Mural / Olivier N. Mizero / Marcin Grzybowski / Baoxing Song / Karin van Dijk / Daniel P. Schachtman / Chi Zhang / James C. Schnable

    Genome Biology, Vol 24, Iss 1, Pp 1-

    2023  Volume 27

    Abstract: Abstract Background Transcription bridges genetic information and phenotypes. Here, we evaluated how changes in transcriptional regulation enable maize (Zea mays), a crop originally domesticated in the tropics, to adapt to temperate environments. Result ... ...

    Abstract Abstract Background Transcription bridges genetic information and phenotypes. Here, we evaluated how changes in transcriptional regulation enable maize (Zea mays), a crop originally domesticated in the tropics, to adapt to temperate environments. Result We generated 572 unique RNA-seq datasets from the roots of 340 maize genotypes. Genes involved in core processes such as cell division, chromosome organization and cytoskeleton organization showed lower heritability of gene expression, while genes involved in anti-oxidation activity exhibited higher expression heritability. An expression genome-wide association study (eGWAS) identified 19,602 expression quantitative trait loci (eQTLs) associated with the expression of 11,444 genes. A GWAS for alternative splicing identified 49,897 splicing QTLs (sQTLs) for 7614 genes. Genes harboring both cis-eQTLs and cis-sQTLs in linkage disequilibrium were disproportionately likely to encode transcription factors or were annotated as responding to one or more stresses. Independent component analysis of gene expression data identified loci regulating co-expression modules involved in oxidation reduction, response to water deprivation, plastid biogenesis, protein biogenesis, and plant-pathogen interaction. Several genes involved in cell proliferation, flower development, DNA replication, and gene silencing showed lower gene expression variation explained by genetic factors between temperate and tropical maize lines. A GWAS of 27 previously published phenotypes identified several candidate genes overlapping with genomic intervals showing signatures of selection during adaptation to temperate environments. Conclusion Our results illustrate how maize transcriptional regulatory networks enable changes in transcriptional regulation to adapt to temperate regions.
    Keywords Expression quantitative loci ; Maize transcriptional regulatory network ; Temperate adaptation ; Biology (General) ; QH301-705.5 ; Genetics ; QH426-470
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Proven Fatal Invasive Aspergillosis in a Patient With COVID-19 and Staphylococcus aureus Pneumonia

    Frank van Someren Gréve / Romy du Long / Raju Talwar / Charlotte J.P. Beurskens / Huibertus J. Voerman / Karin van Dijk

    Journal of Fungi, Vol 7, Iss 230, p

    2021  Volume 230

    Abstract: There is increasing attention for opportunistic pathogens such as Aspergillus fumigatus complicating SARS-CoV-2 infections in the critically ill. For invasive fungal disease, establishing a clear diagnosis can be challenging due to the invasiveness of ... ...

    Abstract There is increasing attention for opportunistic pathogens such as Aspergillus fumigatus complicating SARS-CoV-2 infections in the critically ill. For invasive fungal disease, establishing a clear diagnosis can be challenging due to the invasiveness of diagnostic procedures required for a proven case. Here we present one of the first proven cases of COVID-19-associated pulmonary aspergillosis by positive culture of post-mortem lung biopsy.
    Keywords COVID-19 ; SARS-CoV-2 ; Invasive Aspergillosis ; Aspergillus fumigatus ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: When someone has low vision

    Clare Gilbert / Karin van Dijk

    Community Eye Health Journal, Vol 25, Iss 77, Pp 4-

    2012  Volume 11

    Abstract: As clinicians, being faced with a patient whose vision we cannot improve any further can make us feel like a failure. However, there are many ways to help such a person with low vision. ...

    Abstract As clinicians, being faced with a patient whose vision we cannot improve any further can make us feel like a failure. However, there are many ways to help such a person with low vision.
    Keywords Low Vision ; Treatment ; Refraction ; Visual Acuity ; Vision Tests ; Sensory Aids ; Ophthalmology ; RE1-994 ; Medicine ; R ; DOAJ:Ophthalmology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher The International Centre for Eye Health (ICEH), London
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Providing care for children with low vision

    Karin van Dijk

    Community Eye Health Journal, Vol 20, Iss 62, Pp 24-

    2007  Volume 25

    Abstract: The importance of providing care for children with low vision is recognised by many initiatives, such as VISION 2020, the 2004 Oslo Workshop on Low Vision,1 and the United Nation's global campaign, Education for All. ...

    Abstract The importance of providing care for children with low vision is recognised by many initiatives, such as VISION 2020, the 2004 Oslo Workshop on Low Vision,1 and the United Nation's global campaign, Education for All.
    Keywords Child Care ; Child ; Vision ; Low ; Education ; Refractive Errors ; Ophthalmology ; RE1-994 ; Medicine ; R ; DOAJ:Ophthalmology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2007-06-01T00:00:00Z
    Publisher The International Centre for Eye Health (ICEH), London
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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