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  1. Article ; Online: Remembering Laura Corrigan

    Karis Baker / Fiona Bracken / Rich Corrigan / Simon Creer / Andy Foote / Heather Fotherby / Howard Gray / Martyn Lucas / Stefano Mariani / Colin McKenzie / Boyd McKew

    Environmental DNA, Vol 3, Iss 2, Pp 321-

    2021  Volume 322

    Keywords Environmental sciences ; GE1-350 ; Microbial ecology ; QR100-130
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Variation in the prion protein gene (PRNP) sequence of wild deer in Great Britain and mainland Europe

    Amy L. Robinson / Helen Williamson / Mariella E. Güere / Helene Tharaldsen / Karis Baker / Stephanie L. Smith / Sílvia Pérez-Espona / Jarmila Krojerová-Prokešová / Josephine M. Pemberton / Wilfred Goldmann / Fiona Houston

    Veterinary Research, Vol 50, Iss 1, Pp 1-

    2019  Volume 10

    Abstract: Abstract Susceptibility to prion diseases is largely determined by the sequence of the prion protein gene (PRNP), which encodes the prion protein (PrP). The recent emergence of chronic wasting disease (CWD) in Europe has highlighted the need to ... ...

    Abstract Abstract Susceptibility to prion diseases is largely determined by the sequence of the prion protein gene (PRNP), which encodes the prion protein (PrP). The recent emergence of chronic wasting disease (CWD) in Europe has highlighted the need to investigate PRNP gene diversity in European deer species, to better predict their susceptibility to CWD. Here we report a large genetic survey of six British deer species, including red (Cervus elaphus), sika (Cervus nippon), roe (Capreolus capreolus), fallow (Dama dama), muntjac (Muntiacus reevesii), and Chinese water deer (Hydropotes inermis), which establishes PRNP haplotype and genotype frequencies. Two smaller data sets from red deer in Norway and the Czech Republic are also included for comparison. Overall red deer show the most PRNP variation, with non-synonymous/coding polymorphisms at codons 98, 168, 226 and 247, which vary markedly in frequency between different regions. Polymorphisms P168S and I247L were only found in Scottish and Czech populations, respectively. T98A was found in all populations except Norway and the south of England. Significant regional differences in genotype frequencies were observed within both British and European red deer populations. Other deer species showed less variation, particularly roe and fallow deer, in which identical PRNP gene sequences were found in all individuals analysed. Based on comparison with PRNP sequences of North American cervids affected by CWD and limited experimental challenge data, these results suggest that a high proportion of wild deer in Great Britain may be susceptible to CWD.
    Keywords Veterinary medicine ; SF600-1100
    Subject code 590
    Language English
    Publishing date 2019-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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