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  1. AU="Karkoszka, Henryk"
  2. AU="Burton, Jeffrey H"
  3. AU="Frederique Pitel"
  4. AU="Pierce, Aimee"
  5. AU="Luque-Ballesteros, Laura"
  6. AU="Dondi, Francesco"
  7. AU="McLachlan, Alex"
  8. AU="Krizova, Ludmila"
  9. AU="Balog, Attila"
  10. AU="Faerber, Karin"
  11. AU="Prettner, Klaus"
  12. AU="Ambrožová, I."
  13. AU="William, Doreen"
  14. AU="Gutiérrez-Sánchez, A M"
  15. AU="Bohan, Dana"
  16. AU="Spracklen, D."
  17. AU="Lobo, Brian C"
  18. AU=Zhuang Jianjian AU=Zhuang Jianjian
  19. AU=Pathanki Adithya M
  20. AU="Armando Vilchis-Ordoñez"
  21. AU="Zhongfu Lu"
  22. AU="Lo, Hong-Yip"
  23. AU="Ziman Xiong"
  24. AU="Oakes, Allison H"
  25. AU="Ma, Shaotong"
  26. AU="Zang, Lili"
  27. AU="Adams Brian D"
  28. AU="Maria Papaioannou"
  29. AU="Kollia, Georgia"
  30. AU="Auxiette, Catherine"
  31. AU="Guzmán, Luis"
  32. AU="Alipour, Elnaz"
  33. AU="Queiroz, Dayanna Joyce Marques"
  34. AU="Ramamurthy, Santosh"
  35. AU="Xueying Huang"
  36. AU="Cromwell, Howard C"
  37. AU="Spence, John C H"
  38. AU="Chapinal, Libertad"
  39. AU=Rohaim Mohammed A AU=Rohaim Mohammed A
  40. AU=Hempel Cornelius

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  1. Artikel: Successful chemotherapy with liposomal doxorubicin for metastatic Kaposi's sarcoma without skin involvement in the kidney transplant recipient.

    Kozak, Sylwia / Gładyś, Aleksandra / Karkoszka, Henryk / Pająk, Jacek / Wdowiak, Kamil / Chudek, Jerzy

    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

    2022  Band 32, Heft 2, Seite(n) 548–553

    Abstract: Kaposi's sarcoma (KS), one of the most typical malignancies after kidney transplantation, is strongly associated with human herpes virus 8 infection. More than 90% of patients had primary skin changes, which make the diagnosis easier and faster. The lack ...

    Abstract Kaposi's sarcoma (KS), one of the most typical malignancies after kidney transplantation, is strongly associated with human herpes virus 8 infection. More than 90% of patients had primary skin changes, which make the diagnosis easier and faster. The lack of skin lesions is considered rare, especially in the iatrogenic type of sarcoma, including patients on immunosuppression and may cause a diagnostic challenge due to the variety of organ involvement, imitating other diseases. The aim of this case presentation is to raise attention to the atypical clinical manifestation of this malignancy. Currently, several different therapeutic options are available for patients with KS, including reduction of immunosuppression, conversion of immunosuppression to mTOR inhibitors, or chemotherapy. Here, we present an unusual case of advanced KS human immunodeficiency virus-negative patient after kidney transplantation without primary skin involvement.
    Mesh-Begriff(e) Adult ; Antibiotics, Antineoplastic/therapeutic use ; Doxorubicin/analogs & derivatives ; Doxorubicin/therapeutic use ; Female ; Humans ; Immunocompromised Host ; Kidney Transplantation/adverse effects ; MTOR Inhibitors ; Polyethylene Glycols/therapeutic use ; Sarcoma, Kaposi/diagnosis ; Sarcoma, Kaposi/drug therapy ; Transplant Recipients
    Chemische Substanzen Antibiotics, Antineoplastic ; MTOR Inhibitors ; liposomal doxorubicin ; Polyethylene Glycols (3WJQ0SDW1A) ; Doxorubicin (80168379AG)
    Sprache Englisch
    Erscheinungsdatum 2022-01-12
    Erscheinungsland Saudi Arabia
    Dokumenttyp Case Reports
    ZDB-ID 1379955-1
    ISSN 1319-2442
    ISSN 1319-2442
    DOI 10.4103/1319-2442.335469
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Association between Kidney Donor Risk Index, kidney graft function and histological changes in early post-transplant graft biopsy.

    Słabiak-Błaż, Natalia / Kujawa-Szewieczek, Agata / Kolonko, Aureliusz / Ziółkowska, Joanna / Karkoszka, Henryk / Więcek, Andrzej / Piecha, Grzegorz

    Clinical kidney journal

    2023  Band 16, Heft 11, Seite(n) 2226–2234

    Abstract: Background: Proper assessment of donor organ quality is crucial for optimal kidney allocation and best long-term outcomes. The aim of this study was to analyze the association between the Kidney Donor Risk Index (KDRI) and histological parameters in ... ...

    Abstract Background: Proper assessment of donor organ quality is crucial for optimal kidney allocation and best long-term outcomes. The aim of this study was to analyze the association between the Kidney Donor Risk Index (KDRI) and histological parameters in early post-transplant graft biopsy in a Polish cohort of kidney transplant recipients.
    Methods: In 418 consecutive kidney transplant recipients, a histological evaluation of very early [at median 11 (9-13) post-transplant day] protocol core needle biopsy was performed and analyzed according to the Banff classification. Subjects were divided into quartiles of the KDRI value. Kidney graft function, patient and graft survival were also analyzed over a median follow-up period of 44 (26-56) months.
    Results: There was a significant trend toward greater intensity of chronic histology changes along the KDRI quartiles (χ
    Conclusion: The KDRI values correlate with chronic histological changes found in early post-implantation kidney biopsies and can also be helpful in the prediction of graft outcome.
    Sprache Englisch
    Erscheinungsdatum 2023-06-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfad124
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  3. Artikel ; Online: Lipid disorders before and after successful liver transplantation.

    Gojowy, Damian / Urbaniec-Stompór, Joanna / Adamusik, Joanna / Wójcik, Gabriela / Karkoszka, Henryk / Król, Robert / Więcek, Andrzej / Adamczak, Marcin

    Acta biochimica Polonica

    2023  Band 70, Heft 4, Seite(n) 823–828

    Abstract: Introduction: Liver transplantation (LTx) is the only successful treatment for end-stage liver disease. The results of liver transplantation depend not only on graft survival but may be also affected by superimposed cardiovascular morbidities. The aim ... ...

    Abstract Introduction: Liver transplantation (LTx) is the only successful treatment for end-stage liver disease. The results of liver transplantation depend not only on graft survival but may be also affected by superimposed cardiovascular morbidities. The aim of this retrospective study was to assess the prevalence of lipid disorders as one of the important cardiovascular risk factors in patients before and after successful LTx.
    Material and methods: One hundred eleven patients who underwent liver transplantation because of liver cirrhosis and survived at least 2 years with functioning graft between November 2005 and May 2014 were included in this retrospective analysis. The mean age of the patients at the time of liver transplantation was 49.7±12.2 years. The prevalence of dyslipidemia was assessed before and two years after liver transplantation. This was analyzed in relation to the etiology of liver disease, including alcohol toxicity, viral or autoimmune diseases.
    Results: The prevalence of hypertriglyceridemia before and after LTx was 13.5% and 40.5%, respectively (P<0.001). Similarly, hypercholesterolemia was noted in 17.1% and 51.4% respectively (P<0.001). The annual incidence of hypertriglyceridemia and hypercholesterolemia during the first two years after LTx was 16.2% and 20.7%, respectively. The prevalence of hypertriglyceridemia (18.5% vs 66.7%, P<0.001) and hypercholesterolemia (29.6% vs 70.0%, P=0.002) was significantly lower in patients with the autoimmune cause of liver cirrhosis in comparison to patients with the alcoholic liver disease.
    Conclusions: The prevalence of dyslipidemia is increased after liver transplantation. The prevalence of dyslipidemia may be related to the cause of liver injury before LTx.
    Mesh-Begriff(e) Humans ; Adult ; Middle Aged ; Liver Transplantation/adverse effects ; Retrospective Studies ; Hypercholesterolemia/etiology ; Liver Cirrhosis/epidemiology ; Liver Cirrhosis/surgery ; Hypertriglyceridemia/etiology ; Lipids
    Chemische Substanzen Lipids
    Sprache Englisch
    Erscheinungsdatum 2023-11-28
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ZDB-ID 595762-x
    ISSN 1734-154X ; 0001-527X
    ISSN (online) 1734-154X
    ISSN 0001-527X
    DOI 10.18388/abp.2020_6629
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Transplanted kidney loss during colorectal cancer chemotherapy: A case report.

    Pośpiech, Marta / Kolonko, Aureliusz / Nieszporek, Teresa / Kozak, Sylwia / Kozaczka, Anna / Karkoszka, Henryk / Winder, Mateusz / Chudek, Jerzy

    World journal of clinical cases

    2022  Band 10, Heft 19, Seite(n) 6647–6655

    Abstract: Background: The overall risk of : Case summary: A 36-year-old woman with a medical history of kidney transplantation (2005) because of end-stage kidney disease, secondary to chronic glomerular nephritis, and long-term immunosuppression was diagnosed ... ...

    Abstract Background: The overall risk of
    Case summary: A 36-year-old woman with a medical history of kidney transplantation (2005) because of end-stage kidney disease, secondary to chronic glomerular nephritis, and long-term immunosuppression was diagnosed with locally advanced pT
    Conclusion: Initiation of adjuvant chemotherapy for colon cancer increases the risk of rapid kidney graft loss driven also by under-immunosuppression.
    Sprache Englisch
    Erscheinungsdatum 2022-07-28
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v10.i19.6647
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  5. Artikel ; Online: Cardiovascular Risk Factors in Patients Before and After Successful Liver Transplantation.

    Gojowy, Damian / Urbaniec-Stompór, Joanna / Adamusik, Joanna / Wójcik, Gabriela / Karkoszka, Henryk / Więcek, Andrzej / Adamczak, Marcin

    Annals of transplantation

    2022  Band 27, Seite(n) e935656

    Abstract: BACKGROUND Liver transplantation (LTx) is useful in the treatment of end-stage liver disease. Outcomes of transplantation are dependent upon graft survival and can also be affected by superimposed cardiovascular morbidities. The present retrospective ... ...

    Abstract BACKGROUND Liver transplantation (LTx) is useful in the treatment of end-stage liver disease. Outcomes of transplantation are dependent upon graft survival and can also be affected by superimposed cardiovascular morbidities. The present retrospective study was performed to assess the prevalence of cardiovascular risk factors before and after LTx. MATERIAL AND METHODS A retrospective review of 130 patients undergoing liver transplantation between October 2005 and April 2014 was completed. The mean age of the patients was 49.3±11.9 years. The prevalence of cardiovascular risk factors was assessed before and 2 years after transplantation. The prevalence of cardiovascular risk factors was assessed using a comparison based upon the etiologies of liver disease resulting in transplantation including alcohol, viral, and autoimmune processes using a chi-square analysis. RESULTS The prevalence of diabetes mellitus before and 2 years after liver transplantation (LTx) were 18% and 48% (P<0.001). Hypertension was documented in 24% of patients at baseline and 70% after 2 years of follow-up (P<0.001). The prevalence rates of diabetes mellitus before and 2 years after LTx were 18% and 48% (P<0.001). The prevalence of hypertriglyceridemia before and after LTx was 15% and 38%, respectively (P<0.001). Hypercholesterolemia was noted in 16% and 46%, respectively (P<0.001). Thirteen percent of patients before LTx and 18% after were obese (body mass index higher than 30 kg/m²). The annual incidence of diabetes mellitus, hypertension, hypertriglyceridemia, hypercholesterolemia, and obesity during the first 2 years after LTx was 15%, 23.5%, 15%, 18.5%, and 6%, respectively. Twenty-four percent of patients before and 10% after LTx admitted to tobacco use (P<0.001). The prevalence of diabetes (38% vs 67%, P=0.02), hypertriglyceridemia (19% vs 63%, P<0.001), hypercholesterolemia (28% vs 67%, P=0.002), and obesity (9% vs 33%, P=0.02) was lower in patients with an autoimmune cause of liver cirrhosis in comparison to patients with alcoholic disease. CONCLUSIONS The prevalence of hypertension and glucose and lipid metabolism abnormalities may increase in patients after liver transplantation. The prevalence of cardiovascular risk factors in patients after LTx may be related to the cause of liver injury before LTx.
    Mesh-Begriff(e) Adult ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/etiology ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/etiology ; Glucose ; Heart Disease Risk Factors ; Humans ; Hyperlipidemias/etiology ; Hypertension/complications ; Hypertriglyceridemia/complications ; Liver Transplantation/methods ; Middle Aged ; Obesity/complications ; Retrospective Studies ; Risk Factors
    Chemische Substanzen Glucose (IY9XDZ35W2)
    Sprache Englisch
    Erscheinungsdatum 2022-10-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1484710-3
    ISSN 2329-0358 ; 1425-9524
    ISSN (online) 2329-0358
    ISSN 1425-9524
    DOI 10.12659/AOT.935656
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: The Preliminary Results of Bortezomib Used as A Primary Treatment for An Early Acute Antibody-Mediated Rejection after Kidney Transplantation-A Single-Center Case Series.

    Kolonko, Aureliusz / Słabiak-Błaż, Natalia / Karkoszka, Henryk / Więcek, Andrzej / Piecha, Grzegorz

    Journal of clinical medicine

    2020  Band 9, Heft 2

    Abstract: Proteasome inhibitor bortezomib has been used in the treatment of refractory cases of acute and chronic antibody-mediated rejection (AMR) in kidney transplant recipients. However, its efficacy and safety as a primary treatment for early AMR has been ... ...

    Abstract Proteasome inhibitor bortezomib has been used in the treatment of refractory cases of acute and chronic antibody-mediated rejection (AMR) in kidney transplant recipients. However, its efficacy and safety as a primary treatment for early AMR has been scarcely investigated. We herein present our preliminary experience with bortezomib- and plasmapheresis-based primary treatment for early AMR. Thirteen patients transplanted between October 2015 and September 2019 were treated (starting at median 19th post-transplant day) with bortezomib/plasmapheresis protocol for early biopsy-proven AMR. Twelve out of thirteen patients received 4 doses and one patient recieved 3 doses of bortezomib (1.3 mg/m
    Sprache Englisch
    Erscheinungsdatum 2020-02-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9020529
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  7. Artikel ; Online: Chronic Kidney Disease in Patients After Liver Transplantation: A Long-Term Retrospective Analysis From 1 Transplantation Center.

    Gojowy, Damian / Kubis, Piotr / Gorecka, Magdalena / Karkoszka, Henryk / Wiecek, Andrzej / Adamczak, Marcin

    Transplantation proceedings

    2020  Band 52, Heft 8, Seite(n) 2492–2496

    Abstract: Objective: Liver transplantation (LTx) is the only effective method of treating end-stage insufficiency of the liver. Coexisting chronic kidney disease (CKD) in these patients may worsen the long-term prognosis. The aim of this retrospective, a 1-center, ...

    Abstract Objective: Liver transplantation (LTx) is the only effective method of treating end-stage insufficiency of the liver. Coexisting chronic kidney disease (CKD) in these patients may worsen the long-term prognosis. The aim of this retrospective, a 1-center, observational study, was to determine the prevalence and predisposing factors of CKD in patients in the long run after LTx.
    Patients and method: Medical records were obtained, and the 130 patients after LTx (with a mean age of 49.3 ± 11.9 years) who completed the 24-month follow-up period were enrolled in the study. CKD was diagnosed in patients with an estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m
    Results: CKD was found in 17% of the patients before liver transplantation and in 32% and 39% 12 and 24 months after LTx, respectively. The eGFR values before, 12 months after, and 24 months after LTx were 98.6 ± 48.3, 79.1 ± 29.6, and 76.9 ± 21.3 mL/kg/1.73 m
    Conclusions: The prevalence of CKD in patients after liver transplantation seems to be higher than in the general population. Patients with autoimmune etiology of the liver disease have better renal function than patients with viral or ethanol abuse liver cirrhosis etiology. Treatment with calcineurin inhibitors adversely influences renal function in patients after liver transplantations.
    Mesh-Begriff(e) Adult ; Calcineurin Inhibitors/adverse effects ; Female ; Glomerular Filtration Rate/drug effects ; Humans ; Liver Transplantation/adverse effects ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Prevalence ; Renal Insufficiency, Chronic/epidemiology ; Retrospective Studies
    Chemische Substanzen Calcineurin Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2020-04-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2020.02.081
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  8. Artikel: The Relationship between Initial Tacrolimus Metabolism Rate and Recipients Body Composition in Kidney Transplantation.

    Kolonko, Aureliusz / Pokora, Patrycja / Słabiak-Błaż, Natalia / Czerwieńska, Beata / Karkoszka, Henryk / Kuczera, Piotr / Piecha, Grzegorz / Więcek, Andrzej

    Journal of clinical medicine

    2021  Band 10, Heft 24

    Abstract: There are several premises that the body composition of kidney transplant recipients may play a role in tacrolimus metabolism early after transplantation. The present study aimed at analyzing the relationship between the body composition parameters ... ...

    Abstract There are several premises that the body composition of kidney transplant recipients may play a role in tacrolimus metabolism early after transplantation. The present study aimed at analyzing the relationship between the body composition parameters assessed by bioimpedance analysis (BIA) and initial tacrolimus metabolism. Immediately prior to transplantation, BIA using InBody 770 device was performed in 122 subjects. Tacrolimus concentration-to-dose (C/D) ratio was calculated based on the first blood trough level measurement. There was no difference in phase angle, visceral fat area, lean body mass index (LBMI) and the proportion of lean mass as a percentage of total body mass between the subgroups of slow and fast metabolizers. However, subjects with LBMI ≥ median value of 18.7 kg/m
    Sprache Englisch
    Erscheinungsdatum 2021-12-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10245793
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  9. Artikel ; Online: Renal amyloidosis in a patient with systemic lupus erythematosus.

    Semik-Grabarczyk, Elżbieta / Pietrukaniec, Marta / Karkoszka, Henryk / Wichary, Hanna / Chudek, Jerzy / Holecki, Michał

    Polish archives of internal medicine

    2019  Band 129, Heft 11, Seite(n) 817–818

    Mesh-Begriff(e) Adult ; Amyloidosis/diagnosis ; Amyloidosis/etiology ; Amyloidosis/physiopathology ; Amyloidosis/therapy ; Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/physiopathology ; Lupus Erythematosus, Systemic/therapy ; Male
    Sprache Englisch
    Erscheinungsdatum 2019-09-13
    Erscheinungsland Poland
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.14971
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  10. Artikel: Eosinophilia in patient with acute cellular rejection after liver transplantation--case presentation and literature overview.

    Musialik, Joanna / Karkoszka, Henryk / Wiecek, Andrzej

    Przeglad lekarski

    2015  Band 72, Heft 6, Seite(n) 321–324

    Abstract: Acute cellular rejection (ACR) is still an important problem affecting patients after liver transplantation. Early diagnosis is necessary for initiate treatment, but there are not simple, noninvasive methods to confirm the diagnosis, and up to now, the ... ...

    Abstract Acute cellular rejection (ACR) is still an important problem affecting patients after liver transplantation. Early diagnosis is necessary for initiate treatment, but there are not simple, noninvasive methods to confirm the diagnosis, and up to now, the gold standard in the evaluation of ACR is liver biopsy. The blood eosinophilia seems to be a promising tool supporting the diagnosis and monitoring the effectiveness of ACR treatment in patients after liver transplantation. In this paper a young patient transplanted due to primary sclerosing cholagitis with blood and graft eosinophilia is presented. Based on this interesting case, the literature overview is presented. We conclude that blood eosinophilia, especially with concomitant increase of gamma-glutamyl transpeptidase activity and bilirubin concentration could be an effective tool to predict ACR and may help to choose the.
    Mesh-Begriff(e) Adult ; Bilirubin/blood ; Eosinophilia/diagnosis ; Graft Rejection/diagnosis ; Graft Rejection/etiology ; Humans ; Liver Transplantation/adverse effects ; gamma-Glutamyltransferase/blood
    Chemische Substanzen gamma-Glutamyltransferase (EC 2.3.2.2) ; Bilirubin (RFM9X3LJ49)
    Sprache Englisch
    Erscheinungsdatum 2015
    Erscheinungsland Poland
    Dokumenttyp Case Reports ; Journal Article ; Review
    ZDB-ID 414053-9
    ISSN 0033-2240 ; 0860-0422
    ISSN 0033-2240 ; 0860-0422
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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