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  1. Article ; Online: Differentiating PC12 cells to evaluate neurite densities through live-cell imaging.

    Karliner, Jordyn / Merry, Diane E

    STAR protocols

    2023  Volume 4, Issue 1, Page(s) 101993

    Abstract: Although PC12 cells are a valuable tool in neuroscience research, previously published PC12 cell differentiation techniques fail to consider the variability in differentiation rates between different PC12 cell strains and clonal variants. Here, we ... ...

    Abstract Although PC12 cells are a valuable tool in neuroscience research, previously published PC12 cell differentiation techniques fail to consider the variability in differentiation rates between different PC12 cell strains and clonal variants. Here, we present a comprehensive protocol to differentiate PC12 cells into equivalent neurite densities through live-cell imaging for morphological, immunocytochemical, and biochemical analyses. We detail steps on optimized substrate coating, plating techniques, culture media, validation steps, and quantification techniques.
    MeSH term(s) Animals ; Rats ; Neurites ; PC12 Cells ; Cell Differentiation ; Diagnostic Imaging ; Culture Media
    Chemical Substances Culture Media
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101993
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  2. Article ; Online: Establishing the Necessary Conditions for Achieving Language Access and Equitable, Quality Care for Populations with Limited English Proficiency.

    Karliner, Leah

    Joint Commission journal on quality and patient safety

    2019  Volume 45, Issue 6, Page(s) 395–396

    MeSH term(s) Communication Barriers ; Hospitals ; Language ; Limited English Proficiency ; Quality of Health Care
    Language English
    Publishing date 2019-05-21
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 1189890-2
    ISSN 1938-131X ; 1549-425X ; 1553-7250 ; 1070-3241 ; 1549-3741
    ISSN (online) 1938-131X ; 1549-425X
    ISSN 1553-7250 ; 1070-3241 ; 1549-3741
    DOI 10.1016/j.jcjq.2019.04.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2055: Show issues Location:
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  3. Article ; Online: Protocols can lead to equitable emergency cardiac care for patients with language barriers, but quality communication remains important for access, outcomes, and prevention.

    Karliner, Leah S

    European heart journal. Quality of care & clinical outcomes

    2020  Volume 6, Issue 4, Page(s) 229–230

    MeSH term(s) Communication ; Communication Barriers ; Emergency Service, Hospital ; Humans ; Limited English Proficiency ; Percutaneous Coronary Intervention
    Language English
    Publishing date 2020-01-29
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2823451-0
    ISSN 2058-1742 ; 2058-5225
    ISSN (online) 2058-1742
    ISSN 2058-5225
    DOI 10.1093/ehjqcco/qcaa008
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  4. Article ; Online: Cornucopia of Antineutrons and Hyperons from a Super J/ψ Factory for Next-Generation Nuclear and Particle Physics High-Precision Experiments.

    Yuan, Chang-Zheng / Karliner, Marek

    Physical review letters

    2021  Volume 127, Issue 1, Page(s) 12003

    Abstract: In order to study the interactions and structure of various types of matter, one typically needs to carry out scattering experiments utilizing many different particles as projectiles. Whereas beams of e^{±}, μ^{±}, π^{±}, K^{±}, protons, antiprotons, and ...

    Abstract In order to study the interactions and structure of various types of matter, one typically needs to carry out scattering experiments utilizing many different particles as projectiles. Whereas beams of e^{±}, μ^{±}, π^{±}, K^{±}, protons, antiprotons, and various heavy ions have been produced and have enabled many scientific breakthroughs, beams of antineutrons, hyperons (Λ, Σ, and Ξ) and their antiparticles are typically not easy to obtain. Here we point out and investigate a new high-quality source of these particles: a super-J/ψ factory with the capability of accumulating trillions of J/ψ decays each year. In the relevant J/ψ decays, the desired particle is produced together with other final-state particles that can be tagged. This allows accurate determination of the flux and momentum of the projectile, enabling unprecedented precision in the study of the corresponding interactions with a broad range of targets. These novel high-statistics sources of baryons and antibaryons with precisely known kinematics open fresh opportunities for applications in particle and nuclear physics, including antinucleon-nucleon interaction, a nonvalence ss[over ¯] component of the nucleon, (anti)hyperon-nucleon interaction, OZI violation, (multistrange) hypernuclei, exotic light hadron spectroscopy, and many others, as well as calibration of Monte Carlo simulation for hadronic and medical physics.
    Language English
    Publishing date 2021-07-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.127.012003
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  5. Article ; Online: Comments on new heavy exotic Z

    Karliner, Marek / Rosner, Jonathan L

    Science bulletin

    2021  Volume 66, Issue 20, Page(s) 2045–2046

    Language English
    Publishing date 2021-07-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2021.07.006
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  6. Article ; Online: Low Health Literacy and Transitional Care Needs: Beyond Screening.

    Karliner, Leah

    Journal of hospital medicine

    2016  Volume 12, Issue 11, Page(s) 941–942

    MeSH term(s) Health Literacy ; Humans ; Mass Screening ; Patients ; Transitional Care
    Language English
    Publishing date 2016-11-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2233783-0
    ISSN 1553-5606 ; 1553-5592
    ISSN (online) 1553-5606
    ISSN 1553-5592
    DOI 10.12788/jhm.2881
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6276: Show issues Location:
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  7. Article ; Online: The most important global public health agreement of the century.

    Karliner, Josh

    BMJ (Clinical research ed.)

    2015  Volume 351, Page(s) h6878

    MeSH term(s) Climate Change ; Global Health/legislation & jurisprudence ; Humans ; Politics ; Public Health/legislation & jurisprudence ; United Nations
    Language English
    Publishing date 2015-12-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.h6878
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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: Language Access Systems Improvement initiative: impact on professional interpreter utilisation, a natural experiment.

    Karliner, Leah S / Gregorich, Steven E / Mutha, Sunita / Kaplan, Celia / Livaudais-Toman, Jennifer / Pathak, Sarita / Garcia, Maria E / Diamond, Lisa

    BMJ open

    2024  Volume 14, Issue 1, Page(s) e073486

    Abstract: Objectives: This study aims to evaluate the Language Access Systems Improvement (LASI) initiative's impact on professional interpreter utilisation in primary care and to explore patient and clinician perspectives on professional interpreter use.: ... ...

    Abstract Objectives: This study aims to evaluate the Language Access Systems Improvement (LASI) initiative's impact on professional interpreter utilisation in primary care and to explore patient and clinician perspectives on professional interpreter use.
    Design: Multi methods: Quantitative natural experiment pre-LASI and post-LASI, qualitative semistructured interviews with clinicians and focus groups with patients post-LASI.
    Setting: Large, academic primary care practice.
    Participants: Cantonese, Mandarin, Spanish, English-speaking adult patients and their clinicians.
    Intervention: LASI initiative: Implementation of a clinician language proficiency test and simultaneous provision of on-demand access to professional interpreters via video medical interpretation.
    Main outcome measures: Quantitative: Proportion of language discordant primary care visits which were professionally interpreted. Qualitative: Salient themes related to professional interpreter use and non-use.
    Results: The researchers categorised language concordance for 1475 visits with 152 unique clinicians; 698 were not fully language concordant (202 pre-LASI and 496 post-LASI). Professional interpreter utilisation increased (pre-LASI 57% vs post-LASI 66%; p=0.01); the visits with the lowest percentage of profssional interpreter use post-LASI were those in which clinicians and patients had partial language concordance. In inverse probability weighted analysis, restricting to 499 visits with strict estimated propensity score overlap (100% common support), post-LASI visits had higher odds of using a professional interpreter compared with pre-LASI visits (OR 2.39; 95% CI 1.04 to 5.48). Qualitative results demonstrate video interpretation was convenient and well liked by both clinicians and patients. Some partially bilingual clinicians reported frustration with patient refusal of interpreter services; others reported using the video interpreters as a backup during visits. Views of the care-partner role differed for clinicians and patients. Clinicians reported sometimes having family interpret out of convenience or habit, whereas patients reported wanting family members present for support and advocacy, not interpretation.
    Conclusions: LASI increased utilisation of professional interpreters; however, this was least prominent for partially language concordant visits. Health systems wishing to implement LASI or similar interventions will need to support clinicians and patients with partial bilingual skills in their efforts to use professional interpreters.
    Trial registration number: HSRP20153367.
    MeSH term(s) Adult ; Humans ; Communication Barriers ; Physician-Patient Relations ; Translating ; Language ; Focus Groups
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-073486
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  9. Article ; Online: Caring for Patients with Functional Impairment in Middle Age: Perspectives from Primary Care Providers and Geriatricians.

    Schmucker, Abigail M / Reyes-Farias, David / Nicosia, Francesca M / Xu, Edison / B Potter, Michael / Karliner, Leah S / Brown, Rebecca T

    Journal of general internal medicine

    2024  

    Abstract: Background: The prevalence of functional impairment is increasing among middle-aged adults and is associated with adverse health outcomes. Primary care providers (PCPs) and geriatricians may have important insights about optimal approaches to caring for ...

    Abstract Background: The prevalence of functional impairment is increasing among middle-aged adults and is associated with adverse health outcomes. Primary care providers (PCPs) and geriatricians may have important insights about optimal approaches to caring for these patients, but little is known about their perspectives.
    Objective: To examine PCPs' and geriatricians' perspectives on clinical needs and optimal approaches to care for middle-aged patients with functional impairment.
    Design: Qualitative study using semi-structured interviews.
    Participants: PCPs and geriatricians from outpatient practices in the San Francisco Bay area.
    Approach: Interviews focused on characteristics and care needs of middle-aged patients with functional impairment and models of care to address these needs. We analyzed interviews using hybrid deductive-inductive qualitative thematic analysis.
    Key results: Clinicians (14 PCPs, 15 geriatricians) described distinct characteristics of functional impairment in middle-aged versus older adults, such as different rates of onset, but similar clinical needs. Despite these similar needs, clinicians identified age-specific barriers to delivering optimal care to middle-aged patients. These included system-level challenges such as limited access to insurance and social services; practice- and clinician-level barriers including inadequate clinician training; and patient-level factors including less access to family caregivers and perceptions of stigma. To overcome these challenges, clinicians suggested clinical approaches including addressing health-related social needs within healthcare systems; implementing practice-based models that are multi-disciplinary, team-based, and coordinated; training clinicians to effectively manage functional impairment; and expanding community-based services and supports to help patients navigate the medical system. Identified needs, challenges, and solutions were generally similar across geriatricians and PCPs.
    Conclusions: Clinicians face challenges in delivering optimal care to middle-aged patients who have functional impairments similar to their older counterparts but lack access to services and supports available to older people. These findings suggest the importance of increasing access to care models that address functional impairment regardless of age.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-024-08701-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2205: Show issues Location:
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  10. Article ; Online: Telemedicine and Depression Screening After the Start of the COVID-19 Pandemic.

    Garcia, Maria E / Neuhaus, John / Livaudais-Toman, Jennifer / Feldman, Mitchell D / Ochoa-Frongia, Lisa / Khoong, Elaine / Karliner, Leah S

    JAMA network open

    2024  Volume 7, Issue 2, Page(s) e2355830

    MeSH term(s) Humans ; COVID-19 ; Depression/diagnosis ; Depression/epidemiology ; Pandemics ; Telemedicine
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.55830
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