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  1. Article ; Online: Endoscopic pilonidal sinus treatment: tutorial with tips and tricks - a video vignette.

    Kršul, Dorian / Karlović, Damir / Jerković, Ante / Zelić, Marko

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2024  Volume 26, Issue 4, Page(s) 824–825

    MeSH term(s) Humans ; Pilonidal Sinus/surgery ; Male
    Language English
    Publishing date 2024-02-25
    Publishing country England
    Document type Video-Audio Media ; Letter ; Case Reports
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.16919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Video-assisted anal fistula treatment in combination with ligation of the intersphincteric fistula tract in the treatment of complex transsphincteric fistulas - a video vignette.

    Karlović, D / Kršul, D / Bačić, Đ / Zelić, M

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2020  Volume 22, Issue 9, Page(s) 1204–1205

    MeSH term(s) Anal Canal/surgery ; Humans ; Ligation ; Rectal Fistula/etiology ; Rectal Fistula/surgery ; Treatment Outcome
    Language English
    Publishing date 2020-04-06
    Publishing country England
    Document type Letter ; Video-Audio Media
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.15050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Schyzotipy: from Personality Organization to Transition to Schizophrenia.

    Aukst Margetić, Branka / Karlović, Dalibor

    Psychiatria Danubina

    2021  Volume 33, Issue Suppl 4, Page(s) 529–534

    Abstract: The traditional medical model of schizophrenia assumes a categorical view of the syndrome. On the contrary, the dimensional approach to schizophrenia infers that schizophrenia is not a discrete illness entity, but that psychotic symptoms differ in ... ...

    Abstract The traditional medical model of schizophrenia assumes a categorical view of the syndrome. On the contrary, the dimensional approach to schizophrenia infers that schizophrenia is not a discrete illness entity, but that psychotic symptoms differ in quantitative ways from normal experiences and behaviours. Schizotypy comprise a set of inherited traits reflected in personality organization, which presents as qualitatively similar to schizophrenia. Schizotipy is in line with continuum hypothesis of schizophrenia where different combinations of genes and environmental risk factors result in a range of different phenotypic expressions lying on a continuum from normal through to clinical psychosis. We discuss evidences for the continuity of psychotic symptoms to normal experiences and theoretical and future research implications of such a continuum.
    MeSH term(s) Humans ; Personality ; Phenotype ; Psychotic Disorders ; Schizophrenia/genetics ; Schizotypal Personality Disorder/diagnosis ; Schizotypal Personality Disorder/genetics
    Language English
    Publishing date 2021-10-31
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 1067580-2
    ISSN 0353-5053
    ISSN 0353-5053
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  4. Article ; Online: Flavonols in Action: Targeting Oxidative Stress and Neuroinflammation in Major Depressive Disorder.

    Jazvinšćak Jembrek, Maja / Oršolić, Nada / Karlović, Dalibor / Peitl, Vjekoslav

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: Major depressive disorder is one of the most common mental illnesses that highly impairs quality of life. Pharmacological interventions are mainly focused on altered monoamine neurotransmission, which is considered the primary event underlying the ... ...

    Abstract Major depressive disorder is one of the most common mental illnesses that highly impairs quality of life. Pharmacological interventions are mainly focused on altered monoamine neurotransmission, which is considered the primary event underlying the disease's etiology. However, many other neuropathological mechanisms that contribute to the disease's progression and clinical symptoms have been identified. These include oxidative stress, neuroinflammation, hippocampal atrophy, reduced synaptic plasticity and neurogenesis, the depletion of neurotrophic factors, and the dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis. Current therapeutic options are often unsatisfactory and associated with adverse effects. This review highlights the most relevant findings concerning the role of flavonols, a ubiquitous class of flavonoids in the human diet, as potential antidepressant agents. In general, flavonols are considered to be both an effective and safe therapeutic option in the management of depression, which is largely based on their prominent antioxidative and anti-inflammatory effects. Moreover, preclinical studies have provided evidence that they are capable of restoring the neuroendocrine control of the HPA axis, promoting neurogenesis, and alleviating depressive-like behavior. Although these findings are promising, they are still far from being implemented in clinical practice. Hence, further studies are needed to more comprehensively evaluate the potential of flavonols with respect to the improvement of clinical signs of depression.
    MeSH term(s) Humans ; Depressive Disorder, Major/drug therapy ; Depression/drug therapy ; Hypothalamo-Hypophyseal System ; Neuroinflammatory Diseases ; Flavonols/therapeutic use ; Flavonols/pharmacology ; Quality of Life ; Pituitary-Adrenal System ; Oxidative Stress ; Stress, Psychological
    Chemical Substances Flavonols
    Language English
    Publishing date 2023-04-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24086888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Video-Assisted Anal Fistula Treatment for Treatment of Complex Cryptoglandular Anal Fistulas with 2 Years Follow-Up Period: Our Experience.

    Zelić, M / Karlović, D / Kršul, D / Bačić, Đ / Warusavitarne, J

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2020  Volume 30, Issue 12, Page(s) 1329–1333

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Adolescent ; Adult ; Aged ; Female ; Follow-Up Studies ; Humans ; Ligation ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Prospective Studies ; Rectal Fistula/diagnosis ; Rectal Fistula/surgery ; Recurrence ; Reoperation ; Surgical Flaps ; Time Factors ; Treatment Outcome ; Video-Assisted Surgery/methods ; Young Adult
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2020.0231
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  6. Article: The Impact of Long-acting Paliperidone in Reducing Hospitalizations and Clinical Severity in Recent Onset Schizophrenia: A Mirror-image Study in Real-world Clinical Setting.

    Peitl, Vjekoslav / Margetić, Branka Aukst / Vidrih, Branka / Karlović, Dalibor

    Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

    2022  Volume 20, Issue 1, Page(s) 118–125

    Abstract: Objective: Schizophrenia is a debilitating disease that disrupts the lives of many affected individuals and exerts a toll on the health system. Only few studies assessed once-monthly injectable formulation of paliperidone palmitate (PP-1M) and other ... ...

    Abstract Objective: Schizophrenia is a debilitating disease that disrupts the lives of many affected individuals and exerts a toll on the health system. Only few studies assessed once-monthly injectable formulation of paliperidone palmitate (PP-1M) and other long-acting antipsychotics in recent onset schizophrenia (ROS). To evaluate whether PP-1M is efficacious in reducing frequency and length of hospitalizations and psychosis symptom severity in patients with ROS.
    Methods: This mirror-image study included 112 patients, suffering from ROS admitted in a psychiatric ward and successively treated with PP-1M for 1-year. Other psychotic disorders were excluded. We collected socio-demographic data of all subjects included, number and days of hospitalization, as well as Clinical Global Impression-Severity scale (CGI-S) and Clinician-Rated Dimensions of Psychosis Symptom Severity (CRDPSS) scores at the initiation and after 1-year of PP treatment.
    Results: After 1-year PP-1M treatment, mean scores of both CGI and CRDPSS significantly decreased (
    Conclusion: Our results suggest that PP-1M can be considered as an important therapeutic option in patients with ROS. Its use led to a meaningful reduction in the patient's use of hospital services, as well as a significant clinical improvement of psychotic symptoms in our sample.
    Language English
    Publishing date 2022-01-25
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2211550-X
    ISSN 1738-1088
    ISSN 1738-1088
    DOI 10.9758/cpn.2022.20.1.118
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  7. Article: Clozapine in Treatment-Resistant Schizophrenia and Its Augmentation with Electroconvulsive Therapy in Ultra-Treatment-Resistant Schizophrenia.

    Peitl, Vjekoslav / Puljić, Antonia / Škrobo, Mislav / Nadalin, Sergej / Fumić Dunkić, Lidija / Karlović, Dalibor

    Biomedicines

    2023  Volume 11, Issue 4

    Abstract: Clozapine is considered the gold standard for patients with treatment-resistant schizophrenia (TRS) who have previously tried other antipsychotics at adequate doses (two or more, with at least one being atypical). However, despite optimal treatment, a ... ...

    Abstract Clozapine is considered the gold standard for patients with treatment-resistant schizophrenia (TRS) who have previously tried other antipsychotics at adequate doses (two or more, with at least one being atypical). However, despite optimal treatment, a subgroup of TRS patients with what is known as ultra-treatment-resistant schizophrenia (UTRS) fails to respond to clozapine, which occurs in 40-70% of cases. The most common approach to manage UTRS involves augmenting clozapine with pharmacological or non-pharmacological interventions, with a growing body of evidence that supports the use of electroconvulsive therapy (ECT) as an augmenter. This prospective non-randomized 8-week study, which followed the TRIPP Working Group guidelines and is one of few that separate TRS from UTRS, aimed to evaluate the effectiveness of clozapine in TRS patients and the efficacy of ECT augmentation of clozapine in UTRS patients. Patients with TRS were assigned to receive clozapine alone (clozapine group), whereas UTRS patients received bilateral ECT in addition to their current medication regimen (ECT plus clozapine group). The severity of symptoms was evaluated using the Clinical Global Impression Scale (CGI) and Positive and Negative Syndrome Scale (PANSS) at baseline and at the end of the 8-week trial. Both treatment approaches resulted in improved CGI and PANSS scores. The results suggest that both clozapine and ECT are effective treatment options for patients with TRS and UTRS, respectively, and that adherence to guidelines should provide a better frame for future clinical studies.
    Language English
    Publishing date 2023-04-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11041072
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  8. Article: ERG and OCT as an Effective Screening and Staging Tools for Schizophrenia?

    Silić, Ante / Ostojić, Draženka / Karlović, Dalibor

    Psychiatria Danubina

    2020  Volume 32, Issue 1, Page(s) 74–75

    MeSH term(s) Electroretinography ; Humans ; Mass Screening/methods ; Schizophrenia/diagnosis ; Tomography, Optical Coherence ; Visual Acuity
    Language English
    Publishing date 2020-04-08
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 1067580-2
    ISSN 0353-5053
    ISSN 0353-5053
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  9. Article: Platelet Serotonin Concentration Is Associated with Illness Duration in Schizophrenia and Chronological Age in Depression.

    Peitl, Vjekoslav / Getaldić-Švarc, Biserka / Karlović, Dalibor

    Psychiatry investigation

    2020  Volume 17, Issue 6, Page(s) 579–586

    Abstract: Objective: Impaired serotonergic neurotransmission has been implicated in the pathogenesis of depression and schizophrenia. Blood platelets have been used for years as a peripheral model of neuronal serotonin dynamics. The objective was to investigate ... ...

    Abstract Objective: Impaired serotonergic neurotransmission has been implicated in the pathogenesis of depression and schizophrenia. Blood platelets have been used for years as a peripheral model of neuronal serotonin dynamics. The objective was to investigate platelet count and serotonin concentration in patients with depression and schizophrenia, in an attempt to ascertain their clinical usefulness.
    Methods: 953 participants were included in the study, 329 patients with depression, 339 patients with schizophrenia and 285 healthy controls. ELISA was used to assess platelet serotonin concentrations.
    Results: There were no statistically significant differences among groups regarding age, total platelet count and serotonin concentration. Linear regression analyses revealed inverse correlations between platelet serotonin concentration and age of patients with depression and healthy individuals, as well as between platelet serotonin concentration and illness duration in patients with schizophrenia. In other words, longer illness duration in patients with schizophrenia, and higher age in patients with depression and healthy individuals was associated with lower platelet serotonin concentrations.
    Conclusion: Platelet count and serotonin concentration did not prove to be of diagnostic value in differentiating patients and healthy individuals. However, illness duration in patients with schizophrenia may be associated with reduced concentrations of platelet serotonin.
    Language English
    Publishing date 2020-06-03
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2414364-9
    ISSN 1976-3026 ; 1738-3684
    ISSN (online) 1976-3026
    ISSN 1738-3684
    DOI 10.30773/pi.2020.0033
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  10. Article ; Online: Effects of aripiprazole long-acting injectable antipsychotic on hospitalization in recent-onset schizophrenia.

    Karlović, Dalibor / Silić, Ante / Crnković, Danijel / Peitl, Vjekoslav

    Human psychopharmacology

    2020  Volume 36, Issue 2, Page(s) e2763

    Abstract: Objective: Recent-onset schizophrenia (ROS) represents a critical period that can greatly influence the clinical course of schizophrenia. The use of long-acting injectable antipsychotics (LAIs) in this period is increasingly being considered as a first- ... ...

    Abstract Objective: Recent-onset schizophrenia (ROS) represents a critical period that can greatly influence the clinical course of schizophrenia. The use of long-acting injectable antipsychotics (LAIs) in this period is increasingly being considered as a first-line treatment option. Aripiprazole LAI (ALAI) is the newest of all LAI's available on the market, with limited data on its effects on hospitalization rates after first episode of schizophrenia. It was our goal to evaluate whether ALAI has an effect on hospitalization rates, number of bed days and clinical improvement in patients with ROS.
    Methods: This mirror-image study included 138 inpatients suffering from schizophrenia. We collected sociodemographic data on all individuals, number of hospitalization days, hospitalization rates as well as Clinical Global Impression Scale-severity of illness (CGI-S) and Clinician-Rated Dimensions of Psychosis Symptom Severity (CRDPSS) scores at the initiation of ALAI and at the end of a 1 year follow up.
    Results: Mean number of hospitalizations and hospitalization days in the year after starting ALAI significantly decreased compared to the year before (p = 0.005 and p < 0.001). Mean scores on both CGI and CRDPSS also significantly decreased after initiating ALAI (p < 0.001).
    Conclusion: Results suggest that ALAI is an important therapeutic option in patients with ROS. It leads to reduced usage of hospital services, potentially reducing the socio-economic healthcare burden.
    MeSH term(s) Antipsychotic Agents/therapeutic use ; Aripiprazole/therapeutic use ; Delayed-Action Preparations/therapeutic use ; Hospitalization ; Humans ; Injections ; Schizophrenia/drug therapy ; Schizophrenia/epidemiology
    Chemical Substances Antipsychotic Agents ; Delayed-Action Preparations ; Aripiprazole (82VFR53I78)
    Language English
    Publishing date 2020-10-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 632931-7
    ISSN 1099-1077 ; 0885-6222
    ISSN (online) 1099-1077
    ISSN 0885-6222
    DOI 10.1002/hup.2763
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