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Article ; Online: Metody stosowane do wykrywania i identyfikacji toksyn botulinowych w próbkach klinicznych i żywności*

Karolina Rudnicka / Karolina Durka / Paweł Chwaluk / Magdalena Chmiela

Postępy Higieny i Medycyny Doświadczalnej, Vol 74, Pp 116-

2020 Volume 130

Abstract: Botulism is a severe neuroparalytic illness, which affects the nervous system. It is caused by botulinum neurotoxins (BoNTs), produced by anaerobic gram-positive bacteria Clostridium botulinum. There are 7 serotypes of BoNT A-G, but BoNT A/B/D/E plays a ... ...

Abstract	Botulism is a severe neuroparalytic illness, which affects the nervous system. It is caused by botulinum neurotoxins (BoNTs), produced by anaerobic gram-positive bacteria Clostridium botulinum. There are 7 serotypes of BoNT A-G, but BoNT A/B/D/E plays a major role in botulism affecting humans. Foodborne botulism (classic botulism) is the most frequent clinical manifestation occurring after consumption of food containing botulinum neurotoxins. The diagnosis of botulism is based on clinical symptoms; however, recommended and alternative laboratory methods are used to confirm the etiology of symptoms and the identification of BoNT toxin type. The aim of this work was to present the epidemiology of foodborne botulism in Poland and to gather and analyze the available diagnostic methods that allow us to detect BoNT in clinical samples. Using the epidemiological reports of National Institute of Hygiene in Poland and findings presented in the Przegląd Epidemiologiczny, the incidence of classical botulism in Poland has been presented over a period of recent 18 years. Searching for the optimal diagnostic method for BoNT identification in various samples, we have confronted the sensitivity and specificity of recently available alternative methods with classical biological assay.
Keywords	botulinum toxin ; Clostridium botulinum ; intoxication ; foodborn botulism ; microbiological diagnostics ; Medicine ; R
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Helicobacter pylori outer membrane vesicles involvement in the infection development and Helicobacter pylori-related diseases

Magdalena Chmiela / Natalia Walczak / Karolina Rudnicka

Journal of Biomedical Science, Vol 25, Iss 1, Pp 1-

2018 Volume 11

Abstract: Abstract Helicobacter pylori - (H. pylori) play a role in the pathogenesis of gastritis, gastric and duodenal ulcers as well as gastric cancer. A possible involvement of outer membrane vesicles (OMVs) produced by H. pylori in the distribution of ... ...

Abstract	Abstract Helicobacter pylori - (H. pylori) play a role in the pathogenesis of gastritis, gastric and duodenal ulcers as well as gastric cancer. A possible involvement of outer membrane vesicles (OMVs) produced by H. pylori in the distribution of bacterial antigens through the gastric epithelial barrier and their role in the development of local and systemic host inflammatory and immune responses has been suggested. OMVs contain various biologically active compounds, which internalize into host cells affecting signaling pathways and promoting apoptosis of gastric epithelial and immunocompetent cells. OMVs-associated H. pylori virulence factors may strengthen or downregulate the immune responses leading to disease development. This review describes the biological importance of H. pylori OMVs and their role in the course of H. pylori infections, as well as H. pylori related local and systemic effects.
Keywords	Helicobacter pylori ; outer membrane vesicles ; virulence factor ; inflammation ; gastritis ; Medicine ; R
Subject code	570
Language	English
Publishing date	2018-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Controlling the Spatiotemporal Release of Nerve Growth Factor by Chitosan/Polycaprolactone Conduits for Use in Peripheral Nerve Regeneration

Katarzyna Nawrotek / Monika Kubicka / Justyna Gatkowska / Marek Wieczorek / Sylwia Michlewska / Adrian Bekier / Radosław Wach / Karolina Rudnicka

International Journal of Molecular Sciences, Vol 23, Iss 2852, p

2022 Volume 2852

Abstract: Tubular polymeric structures have been recognized in the treatment of peripheral nerves as comparable to autologous grafting. The best therapeutic outcomes are obtained with conduits releasing therapeutic molecules. In this study, a new approach for the ... ...

Abstract	Tubular polymeric structures have been recognized in the treatment of peripheral nerves as comparable to autologous grafting. The best therapeutic outcomes are obtained with conduits releasing therapeutic molecules. In this study, a new approach for the incorporation of biologically active agent-loaded microspheres into the structure of chitosan/polycaprolactone conduits was developed. The support of a polycaprolactone helix formed by 3D melt extrusion was coated with dopamine in order to adsorb nerve growth factor-loaded microspheres. The complex analysis of the influence of process factors on the coverage efficiency of polycaprolactone helix by nerve grow factor-loaded microspheres was analyzed. Thus, the PCL helix characterized with the highest adsorption of microspheres was subjected to nerve growth factor release studies, and finally incorporated into chitosan hydrogel deposit through the process of electrophoretic deposition. It was demonstrated by chemical and physical tests that the chitosan/polycaprolactone conduit meets the requirements imposed on peripheral nerve implants, particularly mimicking mechanical properties of surrounding soft tissue. Moreover, the conduit may support regrowing nerves for a prolonged period, as its structure and integrity persist upon incubation in lysozyme-contained PBS solution up to 28 days at body temperature. In vitro cytocompatibility toward mHippoE-18 embryonic hippocampal cells of the chitosan/polycaprolactone conduit was proven. Most importantly, the developed conduits stimulate axonal growth and support monocyte activation, the latter is advantageous especially at early stages of nerve regeneration. It was demonstrated that, through the described approach for controlling spatiotemporal release of nerve growth factors, these biocompatible structures adjusted to the specific peripheral nerve injury case can be manufactured.
Keywords	electrodeposition ; 3D printing ; chitosan ; conduit ; peripheral nerve regeneration ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effects of Yeast (1,3)-(1,6)-Beta-Glucan on Severity of Upper Respiratory Tract Infections: A Double-Blind, Randomized, Placebo-Controlled Study in Healthy Subjects

Dharsono, Tanita / Christiane Schoen / Karolina Rudnicka / Manfred Wilhelm

Journal of the American College of Nutrition. 2019 Jan. 2, v. 38, no. 1

2019

Abstract: Objectives: Each year, adults suffer about two to four upper respiratory tract infections (URTIs), mostly in winter. The aim of the study was to evaluate the effects of brewers’ yeast (1,3)-(1,6)-beta-glucan on incidence and severity of upper respiratory ...

Abstract	Objectives: Each year, adults suffer about two to four upper respiratory tract infections (URTIs), mostly in winter. The aim of the study was to evaluate the effects of brewers’ yeast (1,3)-(1,6)-beta-glucan on incidence and severity of upper respiratory tract infections (URTIs). Methods: Generally healthy men and women (n = 299) reporting at least three URTIs during the previous year were randomized to receive either a placebo or 900 mg of yeast beta-glucan daily for 16 weeks during winter. In cases of acute URTI, the severity of URTI symptoms was assessed via the WURSS-21 questionnaire and the Jackson scale, and a clinical confirmation was implemented by the investigator. Results: Overall, 70 subjects under placebo and 71 subjects under yeast beta-glucan experienced at least one clinically confirmed URTI episode. The global severity using WURSS-21 had been quite similar between the study groups (p = 0.5267), whereas during the first days of URTIs the severity was less pronounced in the yeast beta-glucan group. On the episode level, the severity of physical symptoms was significantly lower for all investigated time intervals up to 7 days under yeast beta-glucan (WURSS (Q2-11) (days 1–2: p = 0.0465, days 1–3: p = 0.0323, days 1–4: p = 0.0248, days 1–7: p = 0.0278), also confirmed for the Jackson scale). The reduction of severity was accompanied by a significant increase in the joy subscore of the Perceived Stress Questionnaire (PSQ20) (p = 0.0148). In addition, there was a reduction of systolic (p = 0.0458) and diastolic (p = 0.1439) blood pressure. Conclusion: Subjects supplementing with yeast beta-glucan benefit by a reduced severity of physical URTI symptoms during the first week of an episode, even though the incidence and global severity of common colds could not be altered in comparison to placebo. Furthermore, accompanying benefits in terms of blood pressure and mood were identified. Altogether, yeast beta-glucan supports the immune function.
Keywords	adults ; beta-glucans ; blood pressure ; common cold ; emotions ; immune response ; men ; placebos ; questionnaires ; winter ; women ; yeasts ; covid19
Language	English
Dates of publication	2019-0102
Size	p. 40-50.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	603204-7
ISSN	1541-1087 ; 0731-5724
ISSN (online)	1541-1087
ISSN	0731-5724
DOI	10.1080/07315724.2018.1478339
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly( l -Lactide)- and Poly( l -Lactide-co-Glycolide)-Based Composites

Małgorzata Gazińska / Anna Krokos / Magdalena Kobielarz / Marcin Włodarczyk / Paulina Skibińska / Bogusz Stępak / Arkadiusz Antończak / Milena Morawiak / Przemysław Płociński / Karolina Rudnicka

International Journal of Molecular Sciences, Vol 21, Iss 6711, p

2020 Volume 6711

Abstract: Novel biocomposites of poly(L-lactide) (PLLA) and poly( l- lactide-co-glycolide) (PLLGA) with 10 wt.% of surface-modified hydroxyapatite particles, designed for applications in bone tissue engineering, are presented in this paper. The surface of ... ...

Abstract	Novel biocomposites of poly(L-lactide) (PLLA) and poly( l- lactide-co-glycolide) (PLLGA) with 10 wt.% of surface-modified hydroxyapatite particles, designed for applications in bone tissue engineering, are presented in this paper. The surface of hydroxyapatite (HAP) was modified with polyethylene glycol by using l- lysine as a linker molecule. The modification strategy fulfilled two important goals: improvement of the adhesion between the HAP surface and PLLA and PLLGA matrices, and enhancement of the osteological bioactivity of the composites. The surface modifications of HAP were confirmed by attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), TGA, and elemental composition analysis. The influence of hydroxyapatite surface functionalization on the thermal and in vitro biological properties of PLLA- and PLLGA-based composites was investigated. Due to HAP modification with polyethylene glycol, the glass transition temperature of PLLA was reduced by about 24.5 °C, and melt and cold crystallization abilities were significantly improved. These achievements were scored based on respective shifting of onset of melt and cold crystallization temperatures and 1.6 times higher melt crystallization enthalpy compared with neat PLLA. The results showed that the surface-modified HAP particles were multifunctional and can act as nucleating agents, plasticizers, and bioactive moieties. Moreover, due to the presented surface modification of HAP, the crystallinity degree of PLLA and PLLGA and the polymorphic form of PLLA, the most important factors affecting mechanical properties and degradation behaviors, can be controlled.
Keywords	biocomposites ; hydroxyapatite surface biofunctionalization ; l -lysine ; biosafety ; monocytes ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	620
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Helicobacter pylori morphological forms and their potential role in the transmission of infection

Karolina Rudnicka, / Maciej Graczykowski / Michał Tenderenda / Magdalena Chmiela

Postępy Higieny i Medycyny Doświadczalnej, Vol 68, Pp 219-

2014 Volume 229

Abstract: More than 50% of the world’s population is infected with Helicobacter pylori (H. pylori) – a Gram negative bacterium, which persists in the human stomach and duodenum, causing gastric or duodenal ulcers and gastric cancer. The majority of H. pylori cells ...

Abstract	More than 50% of the world’s population is infected with Helicobacter pylori (H. pylori) – a Gram negative bacterium, which persists in the human stomach and duodenum, causing gastric or duodenal ulcers and gastric cancer. The majority of H. pylori cells demonstrate rod-shape morphology occurring in two subtypes: spiral and S-shaped. Both are isolated from mucus layer biopsy specimens of the stomach or from short-term cultures. However, results obtained from electron microscopy revealed that H. pylori long-term cultures not only consist of classic, spiral shaped bacteria, but also contain alternative forms of coccoid cells. Further investigations showed that coccoid forms of H. pylori may be divided into two types: viable but non-culturable coccus (VBnC) and a degenerative form, coccoid stage which is probably the effect of bacterial cell death. Transformation from spiral to coccoid form is induced under stress conditions, such as the presence of antibiotics. But still there is no evidence for reversion from the coccoid state to the viable and infectious spiral form. Besides the planktonic form, H. pylori also forms homo-, and heterogenic biofilms, which may constitute a potential environmental reservoir of this bacterium. The antigenic repertoire and the immunomodulatory and infectious properties of different H. pylori forms differ greatly. The variation in those properties suggests that morphological forms of H. pylori are potentially involved in the transmission of the infection. This review presents recent findings on the variability, antigenicity and infectious properties of H. pylori morphological forms and their potential role in the transmission of the infection.
Keywords	H. pylori ; morphological forms ; rod ; Coccoid form ; Medicine ; R
Language	English
Publishing date	2014-03-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Helicobacter pylori morphological forms and their potential role in the transmission of infection

Karolina Rudnicka, / Maciej Graczykowski / Michał Tenderenda / Magdalena Chmiela

Postępy Higieny i Medycyny Doświadczalnej, Vol 68, Iss 871113, Pp 219-

2014 Volume 229

Abstract	More than 50% of the world’s population is infected with Helicobacter pylori (H. pylori) – a Gram negative bacterium, which persists in the human stomach and duodenum, causing gastric or duodenal ulcers and gastric cancer. The majority of H. pylori cells demonstrate rod-shape morphology occurring in two subtypes: spiral and S-shaped. Both are isolated from mucus layer biopsy specimens of the stomach or from short-term cultures. However, results obtained from electron microscopy revealed that H. pylori long-term cultures not only consist of classic, spiral shaped bacteria, but also contain alternative forms of coccoid cells. Further investigations showed that coccoid forms of H. pylori may be divided into two types: viable but non-culturable coccus (VBnC) and a degenerative form, coccoid stage which is probably the effect of bacterial cell death. Transformation from spiral to coccoid form is induced under stress conditions, such as the presence of antibiotics. But still there is no evidence for reversion from the coccoid state to the viable and infectious spiral form. Besides the planktonic form, H. pylori also forms homo-, and heterogenic biofilms, which may constitute a potential environmental reservoir of this bacterium. The antigenic repertoire and the immunomodulatory and infectious properties of different H. pylori forms differ greatly. The variation in those properties suggests that morphological forms of H. pylori are potentially involved in the transmission of the infection. This review presents recent findings on the variability, antigenicity and infectious properties of H. pylori morphological forms and their potential role in the transmission of the infection.
Keywords	H. pylori;morphological forms;rod;Coccoid form ; Medicine ; R
Language	English
Publishing date	2014-03-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Effect of Pore Size Distribution and L-Lysine Modified Apatite Whiskers (HAP) on Osteoblasts Response in PLLA/HAP foam Scaffolds Obtained in the Thermally Induced Phase Separation Process

Konrad Szustakiewicz / Marcin Włodarczyk / Małgorzata Gazińska / Karolina Rudnicka / Przemysław Płociński / Patrycja Szymczyk-Ziółkowska / Grzegorz Ziółkowski / Monika Biernat / Katarzyna Sieja / Michał Grzymajło / Piotr Jóźwiak / Sylwia Michlewska / Andrzej W. Trochimczuk

International Journal of Molecular Sciences, Vol 22, Iss 3607, p

2021 Volume 3607

Abstract: In this research, we prepared foam scaffolds based on poly(L-lactide) (PLLA) and apatite whiskers (HAP) using thermally induced phase separation technique supported by the salt leaching process (TIPS-SL). Using sodium chloride having a size of a) 150–315 ...

Abstract	In this research, we prepared foam scaffolds based on poly(L-lactide) (PLLA) and apatite whiskers (HAP) using thermally induced phase separation technique supported by the salt leaching process (TIPS-SL). Using sodium chloride having a size of a) 150–315 μm, b) 315–400 μm, and c) 500–600 μm, three types of foams with different pore sizes have been obtained. Internal structure of the obtained materials has been investigated using SEM as well as μCT. The materials have been studied by means of porosity, density, and compression tests. As the most promising, the composite prepared with salt size of 500–600 μm was prepared also with the L-lysine modified apatite. The osteoblast hFOB 1.19 cell response for the scaffolds was also investigated by means of cell viability, proliferation, adhesion/penetration, and biomineralization. Direct contact cytotoxicity assay showed the cytocompatibility of the scaffolds. All types of foam scaffolds containing HAP whiskers, regardless the pore size or L-lysine modification induced significant stimulatory effect on the cal-cium deposits formation in osteoblasts. The PLLA/HAP scaffolds modified with L-lysine stimulated hFOB 1.19 osteoblasts proliferation. Compared to the scaffolds with smaller pores (150–315 µm and 315–400 µm), the PLLA/HAP foams with large pores (500–600 µm) promoted more effective ad-hesion of osteoblasts to the surface of the biomaterial.
Keywords	polymers ; foam scaffolds ; PLLA ; hydroxyapatite ; cell adhesion ; TIPS ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	600
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: PGS/HAp Microporous Composite Scaffold Obtained in the TIPS-TCL-SL Method

Paweł Piszko / Marcin Włodarczyk / Sonia Zielińska / Małgorzata Gazińska / Przemysław Płociński / Karolina Rudnicka / Aleksandra Szwed / Agnieszka Krupa / Michał Grzymajło / Agnieszka Sobczak-Kupiec / Dagmara Słota / Magdalena Kobielarz / Magdalena Wojtków / Konrad Szustakiewicz

International Journal of Molecular Sciences, Vol 22, Iss 8587, p

An Innovation for Bone Tissue Engineering

2021 Volume 8587

Abstract: In this research, we synthesize and characterize poly(glycerol sebacate) pre-polymer (pPGS) ( 1 H NMR, FTiR, GPC, and TGA). Nano-hydroxyapatite (HAp) is synthesized using the wet precipitation method. Next, the materials are used to prepare a PGS-based ... ...

Abstract	In this research, we synthesize and characterize poly(glycerol sebacate) pre-polymer (pPGS) ( 1 H NMR, FTiR, GPC, and TGA). Nano-hydroxyapatite (HAp) is synthesized using the wet precipitation method. Next, the materials are used to prepare a PGS-based composite with a 25 wt.% addition of HAp. Microporous composites are formed by means of thermally induced phase separation (TIPS) followed by thermal cross-linking (TCL) and salt leaching (SL). The manufactured microporous materials (PGS and PGS/HAp) are then subjected to imaging by means of SEM and µCT for the porous structure characterization. DSC, TGA, and water contact angle measurements are used for further evaluation of the materials. To assess the cytocompatibility and biological potential of PGS-based composites, preosteoblasts and differentiated hFOB 1.19 osteoblasts are employed as in vitro models. Apart from the cytocompatibility, the scaffolds supported cell adhesion and were readily populated by the hFOB1.19 preosteoblasts. HAp-facilitated scaffolds displayed osteoconductive properties, supporting the terminal differentiation of osteoblasts as indicated by the production of alkaline phosphatase, osteocalcin and osteopontin. Notably, the PGS/HAp scaffolds induced the production of significant amounts of osteoclastogenic cytokines: IL-1β, IL-6 and TNF-α, which induced scaffold remodeling and promoted the reconstruction of bone tissue. Initial biocompatibility tests showed no signs of adverse effects of PGS-based scaffolds toward adult BALB/c mice.
Keywords	poly(glycerol sebacate) ; thermal induced phase separation ; osteoblasts ; osteoconductive ; osteoclastogenic cytokines ; in vivo biocompatibility ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	660
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Three Component Composite Scaffolds Based on PCL, Hydroxyapatite, and L-Lysine Obtained in TIPS-SL

Aleksandra Korbut / Marcin Włodarczyk / Karolina Rudnicka / Aleksandra Szwed / Przemysław Płociński / Monika Biernat / Paulina Tymowicz-Grzyb / Martyna Michalska / Natalia Karska / Sylwia Rodziewicz-Motowidło / Konrad Szustakiewicz

International Journal of Molecular Sciences, Vol 22, Iss 13589, p

Bioactive Material for Bone Tissue Engineering

2021 Volume 13589

Abstract: In this research, we describe the properties of three-component composite foam scaffolds based on poly(ε-caprolactone) (PCL) as a matrix and hydroxyapatite whiskers (HAP) and L-Lysine as fillers (PCL/HAP/Lys with wt% ratio 50/48/2). The scaffolds were ... ...

Abstract	In this research, we describe the properties of three-component composite foam scaffolds based on poly(ε-caprolactone) (PCL) as a matrix and hydroxyapatite whiskers (HAP) and L-Lysine as fillers (PCL/HAP/Lys with wt% ratio 50/48/2). The scaffolds were prepared using a thermally induced phase separation technique supported by salt leaching (TIPS-SL). All materials were precisely characterized: porosity, density, water uptake, wettability, DSC, and TGA measurements and compression tests were carried out. The microstructure of the obtained scaffolds was analyzed via SEM. It was found that the PCL/HAP/Lys scaffold has a 45% higher Young’s modulus and better wettability compared to the PCL/HAP system. At the same time, the porosity of the system was ~90%. The osteoblast hFOB 1.19 cell response was also investigated in osteogenic conditions (39 °C) and the cytokine release profile of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α was determined. Modification of PCL scaffolds with HAP and L-Lysine significantly improved the proliferation of pre-osteoblasts cultured on such materials.
Keywords	polymers ; foam scaffolds ; PCL ; cell adhesion ; L-Lysine ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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