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  1. Article ; Online: Proceedings of the WFNS Neuro-Oncology Committee Workshop Rome 2015

    Karolyn Au / Zvi Ram / Gelareh Zadeh

    Surgical Neurology International, Vol 7, Iss 41, Pp 963-

    2016  Volume 975

    Keywords Gliomas ; imaging ; international neuro-oncology ; meningiomas ; tumors ; Medicine ; R ; Surgery ; RD1-811 ; Internal medicine ; RC31-1245 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Neurology. Diseases of the nervous system ; RC346-429
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Investigation of the in vitro therapeutic efficacy of nilotinib in immortalized human NF2-null vestibular schwannoma cells.

    Nesrin Sabha / Karolyn Au / Sameer Agnihotri / Sanjay Singh / Rupinder Mangat / Abhijit Guha / Gelareh Zadeh

    PLoS ONE, Vol 7, Iss 6, p e

    2012  Volume 39412

    Abstract: Vestibular schwannomas (VS) are a common posterior fossa brain tumor, and though benign can cause significant morbidity, particularly loss of hearing, tinnitus, vertigo and facial paralysis. The current treatment options for VS include microsurgical ... ...

    Abstract Vestibular schwannomas (VS) are a common posterior fossa brain tumor, and though benign can cause significant morbidity, particularly loss of hearing, tinnitus, vertigo and facial paralysis. The current treatment options for VS include microsurgical resection, stereotactic radiosurgery or close surveillance monitoring, with each treatment option carrying associated complications and morbidities. Most importantly, none of these options can definitively reverse hearing loss or tinnitus. Identification of a novel medical therapy, through the use of targeted molecular inhibition, is therefore a highly desirable treatment strategy that may minimize complications arising from both tumor and treatment and more importantly be suitable for patients whose options are limited with respect to surgical or radiosurgical interventions. In this study we chose to examine the effect of Nilotinib on VS. Nilotinib (Tasigna®) is a second-generation receptor tyrosine kinase (RTK) inhibitor with a target profile similar to that of imatinib (Gleevec®), but increased potency, decreased toxicity and greater cellular and tissue penetration. Nilotinib targets not only the BCR-ABL oncoprotein, but also platelet-derived growth factor (PDGF) receptor signalling. In this preclinical study, the human NF2-null schwannoma cell line HEI-193 subjected to nilotinib inhibition demonstrated decreased viability, proliferation and anchorage-independent growth, and increased apoptosis. A daily dose of nilotinib for 5 days inhibited HEI-I93 proliferation at a clinically-relevant concentration in a dose-dependent manner (IC(50) 3-5 µmol/L) in PDGF-stimulated cells. These anti-tumorigenic effects of nilotinib were correlated to inhibited activation of PDGFR-α and PDGFR-β and major downstream signalling pathways. These experiments support a therapeutic potential for Nilotinib in VS.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

    Sameer Agnihotri / Suganth Suppiah / Peter D. Tonge / Shahrzad Jalali / Arnavaz Danesh / Jeffery P. Bruce / Yasin Mamatjan / George Klironomos / Lior Gonen / Karolyn Au / Sheila Mansouri / Sharin Karimi / Felix Sahm / Andreas von Deimling / Michael D. Taylor / Normand J. Laperriere / Trevor J. Pugh / Kenneth D. Aldape / Gelareh Zadeh

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Volume 7

    Abstract: Radiation-induced meningiomas are often more aggressive than sporadic ones. In this study, the authors perform an exome, methylation and RNA-seq analysis of 31 cases of radiation-induced meningioma and show NF2 rearrangement, an observation previously ... ...

    Abstract Radiation-induced meningiomas are often more aggressive than sporadic ones. In this study, the authors perform an exome, methylation and RNA-seq analysis of 31 cases of radiation-induced meningioma and show NF2 rearrangement, an observation previously unreported in the sporadic tumors.
    Keywords Science ; Q
    Language English
    Publishing date 2017-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: External validation and recalibration of an incidental meningioma prognostic model – IMPACT

    Julie Woodfield / Boris Krischek / Giles Critchley / Damian Holliman / Angelos Kolias / Thomas Santarius / Ola Rominiyi / Michael McDermott / Michael D Jenkinson / Jörg-Christian Tonn / Mohsen Javadpour / Andrea Saladino / Tiit Illimar Mathiesen / Rory Piper / Michael Vogelbaum / Chaya Brodie / Sara Venturini / Daniel M Fountain / Roland Goldbrunner /
    Elliot Tilling / Felix Sahm / Priscilla Brastianos / Rory J Piper / Antonio Santoro / Sylvia Kurz / Pierfrancesco Lapolla / Andrea Mingoli / Jennifer Brown / Debraj Mukherjee / Simon Walling / Andrew Morokoff / Patrick Wen / Ghazaleh Tabatabai / Jill Barnholtz-Sloan / Ryan K Mathew / Alexander Smedley / Helen Shih / William Taylor / Minh Nguyen / Bryony Ford / Samantha J Mills / Tamara Ali / Ruwanthi Kolamunnage-Dona / Josephine Jung / Muhammed Elhadi / Erminia Albanese / Aswin Chari / David Rowland / Melissa Gough / Michael Cearns / Simon Lammy / Yasir Chowdhury / Christian Mawrin / Mahmoud Saleh / Jens Schittenhelm / Farshad Nassiri / Raymond Huang / Pietro Familiari / Manfred Westphal / Warren Selman / Daniel Brown / Nathan McSorley / Oliver Hanemann / Richard Pullicino / Francesco Gaillard / Mirjam Renovanz / Chris Barrett / Christine Jungk / Aaron Cohen-Gadol / Javier Martín-Alonso / Gelareh Zadeh / Hytham Hamid / Abdurrahman I Islim / Christopher P Millward / Shaveta Mehta / Usama Ali / Shelli Diane Koszdin / Theo Georgious / Andrew R Brodbelt / Mohamed Abdelsadg / Suhaib Abualsaud / Amro Abuleil / Kevin Agyemang / Hanan Akbari / Likhith Alakandy / Clarissa Alfonso / Arousa Ali / Michael Amoo / Mohamed A. R. Arbab / Mutiu Asha / Kareem Austin / Khaled Badran / Jarnail Bal / Parameswaran Bhattathiri / Paul M. Brennan / Andrew R. Brodbelt / Ferran Brugada-Bellsolà / Placido Bruzzaniti / Annabel Butcher / Rory S. Cairns / Michael Canty / Sachiv Chakravarti / Rebecca Chave-Cox / Anna Craig-McQuade / Peter Crossley / Elizabeth Culpin / Alessia D'Amico / Bassam Dabbous / Pedro David Delgado-López / Mohamed Draz / Katharine J. Drummond / Rusiru T. Ekanayaka / Ibrahim Elmaadawi / Omar Elmandouh / Mazin Elsharif / Daisy Evans / Andreas Fahlström / Fleur L. Fisher / Daniel M. Fountain / Keiko Fox / Chloé Gelder / Shamayitri Ghosh / Aimee Goel / Athanasios Grivas / Andrew Gvozdanovic / Allan Hall / Liv Hartrick / Samih Hassan / Jack Henry / Abdurrahman I. Islim / Asgeir S. Jakola / Michael D. Jenkinson / Sanjeeva Jeyaretna / Adrian Jimenez / Andranik Kahramanian / Neeraj Kalra / David O. Kamson / Oliver Kennion / Adham M. Khalafallah / Sarah Kingdon / Howra Ktayen / Aditaya Kumar / Jun Yi Lau / Jing Xian Lee / Ryan Leyden / Patricia Littlechild / Sophie Liu / Darmanin Lora-Kay / Vivia Lung / Stephen T. Magill / Hani J. Marcus / Fawaz E. Marhoom / Ryan K. Mathew / Calan Mathieson / Tobias Mederer / Torstien R. Meling / Samantha J. Mills / Christopher P. Millward / Mujtaba Mohammad / Amir H. Zamanipoor Najafabadi / Olivia Näslund / Imran Noorani / Gildas Patet / Omar N. Pathmanaban / Andrea Perera / Amit Persad / See Yung Phang / Rory J. Piper / Jonathan Pollock / Benjamin Price / Martin Proescholdt / James Robins / Bobby Sachdev / Fozia Saeed / Ieva Sataite / Antony Kevin Scafa / Verena Schadewaldt / Syed Wajahat Shah / Mustafa El Sheikh / Zenab Sher / Bente Sandvei Skeie / Agbolahan Sofela / Jerome St George / Torbjørn Strømsnes / Nigel Suttner / Philip Theodosopoulos / Manjul Tripathi / Ismail Ughratdar / James Ulrich / Adithya Varma / Anil Varma / Maria Velicu / Esther Wu / Jacob Young / Giuseppa Zancana / Catherine Zhang / Karolyn Au / Felix Behling / Linda Bi / Nicholas Butowski / Ana Castro / Marta Couce / Francesco Dimeco / Katherine J. Drummond / Ian Dunn / Craig Erker / Michelle Felicella / Eva Galanis / Norbert Galldiks / Caterina Giannini / Christel Herold-Mende / Luke Hnenny / Craig Horbinski / Gerhard Jungwirth / Timothy Kaufmann / Daniel Lachance / Christian Lafougere / Katrin Lamszus / Serge Makarenko / Tathiana Malta / Jennifer Moliterno-Gunel / HK Ng / Houtan Noushmehr / Arie Perry / Laila Poisson / Bianco Pollo / Aditya Ragunathan / David Raleigh / Franz Ricklefs / Antonio Santacroce / Christian Schichor / Nils Schimdt / Andrew Sloan / Matija Snuderl / Jim Snyder / Erik Sulman / Suganth Suppiah / Marcos Tatagiba / Marco Timmer / Andreas Von Deimling / Tobias Walbert / Justin Z. Wang / Stephen Yip / Gabriel Zada / Viktor Zherebitskiy / Michael T.C. Poon

    BMJ Open, Vol 12, Iss

    protocol for an international multicentre retrospective cohort study

    2022  Volume 1

    Keywords Medicine ; R
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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