LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 91

Search options

  1. Article ; Online: Palladium-Catalyzed Regiodivergent C-H Olefination of Imidazo[1,2a]pyridine Carboxamide and Unactivated Alkenes.

    Mohite, Sachin Balaso / Mane, Manoj V / Bera, Milan / Karpoormath, Rajshekhar

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 70, Page(s) e202302759

    Abstract: Despite remarkable successes in linear and branched vinyl (hetero) arene synthesis, regiodivergent C-H olefination with a single catalytic system has remained underdeveloped. Overcoming this limitation, a Pd/MPAA-catalyzed regiodivergent C-H olefination ... ...

    Abstract Despite remarkable successes in linear and branched vinyl (hetero) arene synthesis, regiodivergent C-H olefination with a single catalytic system has remained underdeveloped. Overcoming this limitation, a Pd/MPAA-catalyzed regiodivergent C-H olefination of imidazo[1,2a] pyridine carboxamides with unactivated terminal alkenes to generate branched and linear olefinated products depending upon the electronic nature of alkenes is reported herein. Moreover, this protocol can be applied for C-H deuteriation of the corresponding heteroarenes with D
    Language English
    Publishing date 2023-10-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202302759
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: An Overview on Synthetic and Medicinal Perspectives of [1,2,4]Triazolo[1,5-a]pyrimidine Scaffold.

    Merugu, Srinivas Reddy / Cherukupalli, Srinivasulu / Karpoormath, Rajshekhar

    Chemistry & biodiversity

    2022  Volume 19, Issue 9, Page(s) e202200291

    Abstract: 1,2,4]Triazolo[1,5-a]pyrimidine is an important heterocyclic scaffold known to have a wide range of pharmacological activities such as anticancer, antimicrobial, anti-tubercular, ... ...

    Abstract [1,2,4]Triazolo[1,5-a]pyrimidine is an important heterocyclic scaffold known to have a wide range of pharmacological activities such as anticancer, antimicrobial, anti-tubercular, CB
    MeSH term(s) Adenosine ; Anti-Infective Agents/pharmacology ; Cannabinoid Receptor Agonists/pharmacology ; Pyrimidines/pharmacology ; Structure-Activity Relationship ; Trapidil
    Chemical Substances Anti-Infective Agents ; Cannabinoid Receptor Agonists ; Pyrimidines ; Trapidil (EYG5Y6355E) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2022-08-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202200291
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Repurposing antiviral phytochemicals from the leaf extracts of Spondias mombin (Linn) towards the identification of potential SARSCOV-2 inhibitors.

    Boadu, Akwasi / Agoni, Clement / Karpoormath, Rajshekhar / Soliman, Mahmoud / Nlooto, Manimbulu

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 10896

    Abstract: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a pneumonia-like disease with a pattern of acute respiratory symptoms, currently remains a significant public health concern causing tremendous human suffering. Although several approved ... ...

    Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a pneumonia-like disease with a pattern of acute respiratory symptoms, currently remains a significant public health concern causing tremendous human suffering. Although several approved vaccines exist, vaccine hesitancy, limited vaccine availability, high rate of viral mutation, and the absence of approved drugs account for the persistence of SARS-CoV-2 infections. The investigation of possibly repurposing of phytochemical compounds as therapeutic alternatives has gained momentum due to their reported affordability and minimal toxicity. This study investigated anti-viral phytochemical compounds from ethanolic leaf extracts of Spondias mombin L as potential inhibitor candidates against SARS-CoV-2. We identified Geraniin and 2-O-Caffeoyl-(+)-allohydroxycitric acid as potential SARS-CoV-2 inhibitor candidates targeting the SARS-CoV-2 RNA-dependent polymerase receptor-binding domain (RBD) of SARS-CoV-2 viral S-protein and the 3C-like main protease (3CL
    MeSH term(s) Anacardiaceae ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Coronavirus 3C Proteases ; Cysteine Endopeptidases/chemistry ; Drug Repositioning ; Humans ; Phytochemicals/pharmacology ; RNA, Viral ; SARS-CoV-2 ; Viral Proteins/chemistry ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; Phytochemicals ; RNA, Viral ; Viral Proteins ; Cysteine Endopeptidases (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28)
    Language English
    Publishing date 2022-06-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-14558-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Recent progress in electrochemical sensors for detection and quantification of malaria.

    Nate, Zondi / Gill, Atal A S / Chauhan, Ruchika / Karpoormath, Rajshekhar

    Analytical biochemistry

    2022  Volume 643, Page(s) 114592

    Abstract: Malaria is still a major disease in sub-Saharan Africa and South-East Asia. This is despite different interventions by the World Health Organization (WHO), such as insecticide-treated mosquito net, antimalarial drugs, indoor residual spraying, and rapid ... ...

    Abstract Malaria is still a major disease in sub-Saharan Africa and South-East Asia. This is despite different interventions by the World Health Organization (WHO), such as insecticide-treated mosquito net, antimalarial drugs, indoor residual spraying, and rapid diagnostic tools. In 2018, the mortality rate due to malaria was estimated to be 405 000, with children under five years accounting for 67% of all malaria deaths. Malaria can be prevented and treated using different strategies as recommended by WHO. However, the lack of rapid diagnostic tools with good selectivity and sensitivity is still a challenge. Therefore there is a need to develop rapid, low-cost, and portable analytical methods for quantifying malaria. This review focuses on the role of malaria biomarkers (Plasmodium falciparum Lactate Dehydrogenase (PfLDH), Plasmodium aldolase, Plasmodium falciparum Histidine-Rich Protein 2 (PfHRP2), Plasmodium falciparum Glutamate dehydrogenase (PfGDH), and Hemozoin) in diagnosis. Recent developments in nanomaterial-based electrochemical and colorimetric biosensors for malaria diagnosis are discussed. Finally, the review concludes with closing remarks and future perspectives of electrochemical biosensors.
    MeSH term(s) Biomarkers/analysis ; Biosensing Techniques ; Electrochemical Techniques ; Humans ; Malaria/diagnosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-02-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1110-1
    ISSN 1096-0309 ; 0003-2697
    ISSN (online) 1096-0309
    ISSN 0003-2697
    DOI 10.1016/j.ab.2022.114592
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 389: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Rapid and label-free A2 peptide epitope decorated CoFe

    Adu, Darko Kwabena / Nate, Zondi / Alake, John / Ike, Blessing Wisdom / Mahlalela, Mavela Cleopus / Mohite, Sachin Balaso / Mokoena, Sithabile / Chauhan, Ruchika / Karpoormath, Rajshekhar

    Bioelectrochemistry (Amsterdam, Netherlands)

    2024  Volume 157, Page(s) 108662

    Abstract: Diagnosis of Visceral Leishmaniasis is challenging due to the shared clinical features with malaria, typhoid, and tuberculosis. A ... ...

    Abstract Diagnosis of Visceral Leishmaniasis is challenging due to the shared clinical features with malaria, typhoid, and tuberculosis. A CoFe
    MeSH term(s) Humans ; Epitopes ; Biosensing Techniques/methods ; Leishmaniasis, Visceral/diagnosis ; Reproducibility of Results ; Immunoassay/methods ; Nanocomposites/chemistry ; Peptides ; Antibodies ; Electrochemical Techniques/methods ; Limit of Detection ; Metal Nanoparticles/chemistry
    Chemical Substances Epitopes ; Peptides ; Antibodies
    Language English
    Publishing date 2024-02-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2010650-6
    ISSN 1878-562X ; 0302-4598 ; 1567-5394
    ISSN (online) 1878-562X
    ISSN 0302-4598 ; 1567-5394
    DOI 10.1016/j.bioelechem.2024.108662
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1178: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Electrochemical immunosensing of tumor markers.

    Palakollu, Venkata Narayana / Veera Manohara Reddy, Y / Shekh, Mehdihasan I / Vattikuti, S V Prabhakar / Shim, Jaesool / Karpoormath, Rajshekhar

    Clinica chimica acta; international journal of clinical chemistry

    2024  Volume 557, Page(s) 117882

    Abstract: The rising incidence and mortality rates of cancer have led to a growing need for precise and prompt early diagnostic approaches to effectively combat this disease. However, traditional methods employed for detecting tumor cells, such as ... ...

    Abstract The rising incidence and mortality rates of cancer have led to a growing need for precise and prompt early diagnostic approaches to effectively combat this disease. However, traditional methods employed for detecting tumor cells, such as histopathological and immunological techniques, are often associated with complex procedures, high analytical expenses, elevated false positive rates, and a dependence on experienced personnel. Tracking tumor markers is recognized as one of the most effective approaches for early detection and prognosis of cancer. While onco-biomarkers can also be produced in normal circumstances, their concentration is significantly elevated when tumors are present. By monitoring the levels of these markers, healthcare professionals can obtain valuable insights into the presence, progression, and response to treatment of cancer, aiding in timely diagnosis and effective management. This review aims to provide researchers with a comprehensive overview of the recent advancements in tumor markers using electrochemical immunosensors. By highlighting the latest developments in this field, researchers can gain a general understanding of the progress made in the utilization of electrochemical immunosensors for detecting tumor markers. Furthermore, this review also discusses the current limitations associated with electrochemical immunosensors and offers insights into paving the way for further improvements and advancements in this area of research.
    MeSH term(s) Humans ; Biomarkers, Tumor ; Biosensing Techniques ; Electrochemical Techniques ; Immunoassay/methods ; Neoplasms/diagnosis
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2024-03-21
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2024.117882
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.173: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Palladium-Catalyzed C-H Olefination of Imidazo[1,2a] pyridine Carboxamide in Aqueous Ethanol under Oxygen.

    Balaso Mohite, Sachin / Kousin Mirza, Yafia / Kumar, Vishal / Partap, Sangh / Baji Baba, Shaik / Alake, John / Bera, Milan / Karpoormath, Rajshekhar

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  Volume 30, Issue 23, Page(s) e202304239

    Abstract: The advancement of sustainable chemistry and changes in the economy are strongly intertwined. Reaction time, cost savings, moderate temperatures, and generation of the fewest byproducts are frequently achieved by using catalytic processes. Herein, we ... ...

    Abstract The advancement of sustainable chemistry and changes in the economy are strongly intertwined. Reaction time, cost savings, moderate temperatures, and generation of the fewest byproducts are frequently achieved by using catalytic processes. Herein, we report the C-H olefination of imidazo[1,2a] pyridine carboxamides with various acrylates in the presence of Pd (OAc)
    Language English
    Publishing date 2024-03-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202304239
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Recent progress in electrochemical sensors for detection and quantification of malaria

    Nate, Zondi / Gill, Atal A.S. / Chauhan, Ruchika / Karpoormath, Rajshekhar

    Analytical biochemistry. 2022 Apr. 15, v. 643

    2022  

    Abstract: Malaria is still a major disease in sub-Saharan Africa and South-East Asia. This is despite different interventions by the World Health Organization (WHO), such as insecticide-treated mosquito net, antimalarial drugs, indoor residual spraying, and rapid ... ...

    Abstract Malaria is still a major disease in sub-Saharan Africa and South-East Asia. This is despite different interventions by the World Health Organization (WHO), such as insecticide-treated mosquito net, antimalarial drugs, indoor residual spraying, and rapid diagnostic tools. In 2018, the mortality rate due to malaria was estimated to be 405 000, with children under five years accounting for 67% of all malaria deaths. Malaria can be prevented and treated using different strategies as recommended by WHO. However, the lack of rapid diagnostic tools with good selectivity and sensitivity is still a challenge. Therefore there is a need to develop rapid, low-cost, and portable analytical methods for quantifying malaria. This review focuses on the role of malaria biomarkers (Plasmodium falciparum Lactate Dehydrogenase (PfLDH), Plasmodium aldolase, Plasmodium falciparum Histidine-Rich Protein 2 (PfHRP2), Plasmodium falciparum Glutamate dehydrogenase (PfGDH), and Hemozoin) in diagnosis. Recent developments in nanomaterial-based electrochemical and colorimetric biosensors for malaria diagnosis are discussed. Finally, the review concludes with closing remarks and future perspectives of electrochemical biosensors.
    Keywords Plasmodium falciparum ; World Health Organization ; antimalarials ; biomarkers ; biosensors ; colorimetry ; electrochemistry ; fructose-bisphosphate aldolase ; glutamate dehydrogenase ; insecticide application ; lactate dehydrogenase ; malaria ; mortality ; mosquito nets ; South East Asia ; Sub-Saharan Africa
    Language English
    Dates of publication 2022-0415
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1110-1
    ISSN 1096-0309 ; 0003-2697
    ISSN (online) 1096-0309
    ISSN 0003-2697
    DOI 10.1016/j.ab.2022.114592
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 70/124: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Metal-free direct annulation of 2-aminophenols and 2-aminothiophenols with unactivated amides through transamidation: Access to polysubstituted benzoxazole and benzothiazole derivatives

    Kumar, Vishal / Dhawan, Sanjeev / Bala, Renu / Girase, Pankaj Sanjay / Singh, Parvesh / Karpoormath, Rajshekhar

    Tetrahedron. 2022 June 04, v. 115

    2022  

    Abstract: We herein report a simple yet novel oxidant, metal and solvent-free green protocol for synthesising differently 2-substituted 1,3-benzoxazoles and benzothiazoles from 2-aminophenol hydrochloride salt unactivated amide as in situ carbon source. Further, ... ...

    Abstract We herein report a simple yet novel oxidant, metal and solvent-free green protocol for synthesising differently 2-substituted 1,3-benzoxazoles and benzothiazoles from 2-aminophenol hydrochloride salt unactivated amide as in situ carbon source. Further, the hydrogen ion of hydrochloride played a crucial role in amide activation followed nucleophilic attack that through eliminations of amine as a side product, and de-hydrolysis step leads to final annulation. This versatile strategy is applicable to a wide variety of differently substituted o-aminophenols, unactivated aliphatic and aromatic amides, yielding the corresponding product in good to excellent yields in a single step.
    Keywords Lewis bases ; amides ; aminophenols ; carbon ; hydrogen ; oxidants
    Language English
    Dates of publication 2022-0604
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204285-x
    ISSN 1464-5416 ; 0040-4020 ; 0563-2064
    ISSN (online) 1464-5416
    ISSN 0040-4020 ; 0563-2064
    DOI 10.1016/j.tet.2022.132794
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1076: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Exploring MDR-TB Inhibitory Potential of 4-Aminoquinazolines as Mycobacterium tuberculosis N-Acetylglucosamine-1-Phosphate Uridyltransferase (GlmU

    Patel, Harun M / Palkar, Mahesh / Karpoormath, Rajshekhar

    Chemistry & biodiversity

    2020  Volume 17, Issue 8, Page(s) e2000237

    Abstract: Drug resistance tuberculosis is one of the challenging tasks that dictates the desperate need for the development of new antitubercular agents which operate via novel modes of action. Here, we are reporting on 4-aminoquinazolines as M. tuberculosis N- ... ...

    Abstract Drug resistance tuberculosis is one of the challenging tasks that dictates the desperate need for the development of new antitubercular agents which operate via novel modes of action. Here, we are reporting on 4-aminoquinazolines as M. tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU
    MeSH term(s) Antitubercular Agents/pharmacology ; Enzyme Inhibitors/pharmacology ; Mycobacterium tuberculosis/drug effects ; Nucleotidyltransferases/antagonists & inhibitors ; Quinazolines/pharmacology ; Spectrum Analysis/methods ; Tuberculosis, Multidrug-Resistant/microbiology
    Chemical Substances 4-aminoquinazoline ; Antitubercular Agents ; Enzyme Inhibitors ; Quinazolines ; Nucleotidyltransferases (EC 2.7.7.-) ; UDPacetylglucosamine pyrophosphorylase (EC 2.7.7.23)
    Language English
    Publishing date 2020-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202000237
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top