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  1. Article: IgD

    Kasahara, Taissa de M / Gupta, Sudhir

    Pathogens (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: Common variable immunodeficiency (CVID) is the most frequent form of primary hypogammaglobulinemia in adults. In addition to recurrent infections and respiratory manifestations, CVID patients may present several non-infection complications such as ... ...

    Abstract Common variable immunodeficiency (CVID) is the most frequent form of primary hypogammaglobulinemia in adults. In addition to recurrent infections and respiratory manifestations, CVID patients may present several non-infection complications such as autoimmune diseases. The mechanisms that lead to immune dysregulation in CVID are not completely understood. Given the role of IgD on naïve B cells in the maintenance of tolerance and secreted IgD in the respiratory mucosa, we evaluated the frequency of IgD
    Language English
    Publishing date 2024-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens13020136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Phenotypic analysis of T follicular helper and T follicular regulatory cells in primary selective IgM deficiency.

    Kasahara, Taissa de M / Bento, Cleonice Alves de Melo / Gupta, Sudhir

    Human immunology

    2020  Volume 81, Issue 10-11, Page(s) 625–633

    Abstract: Selective IgM deficiency (SIgMD) is a rare immunodeficiency characterized by serum IgM below two standard of mean, and normal IgG and IgA levels. Both in human and mice with selective IgM deficiency, germinal centers cells are decreased. The development ... ...

    Abstract Selective IgM deficiency (SIgMD) is a rare immunodeficiency characterized by serum IgM below two standard of mean, and normal IgG and IgA levels. Both in human and mice with selective IgM deficiency, germinal centers cells are decreased. The development of germinal center and humoral immunity are regulated in part by follicular helper T (T
    MeSH term(s) Aged ; Antibody Formation/drug effects ; Antigens, Bacterial/immunology ; Antigens, Bacterial/pharmacology ; Cells, Cultured ; Female ; Germinal Center/immunology ; Humans ; Immunity, Humoral ; Immunoglobulin M/blood ; Immunoglobulin M/deficiency ; Immunologic Deficiency Syndromes/blood ; Immunologic Deficiency Syndromes/immunology ; Male ; Middle Aged ; Phenotype ; Polysaccharides/immunology ; Polysaccharides/pharmacology ; T Follicular Helper Cells/immunology ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances Antigens, Bacterial ; Immunoglobulin M ; Polysaccharides
    Language English
    Publishing date 2020-08-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 801524-7
    ISSN 1879-1166 ; 0198-8859
    ISSN (online) 1879-1166
    ISSN 0198-8859
    DOI 10.1016/j.humimm.2020.07.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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