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  1. Article ; Online: Application of Partial Hydrogenation for the Generation of Minor Tocochromanol Homologs and Functional Evaluation of Hydrogenated Tocotrienol-rich Vitamin E Oil in Diabetic Obese Mice.

    Beppu, Fumiaki / Sakuma, Aimi / Kasatani, Satoshi / Aoki, Yoshinori / Gotoh, Naohiro

    Journal of oleo science

    2021  Volume 70, Issue 1, Page(s) 103–112

    Abstract: Recent research has identified minor homologs of vitamin E with one or two double bonds in the side-chain, namely tocomonoenol (T1) and tocodienol (T2), in natural products. We first explored the effectiveness of partial hydrogenation for generating ... ...

    Abstract Recent research has identified minor homologs of vitamin E with one or two double bonds in the side-chain, namely tocomonoenol (T1) and tocodienol (T2), in natural products. We first explored the effectiveness of partial hydrogenation for generating minor tocochromanols from tocotrienol (T3). During hydrogenation with pure α-T3 as a substrate, the side-chain was partially saturated in a time-dependent manner, and a large amount of α-T1 and α-T2 was obtained. To investigate the beneficial effects of the hydrogenated product, we fed diabetic obese KK-A
    MeSH term(s) Animals ; Cholesterol, HDL/blood ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/metabolism ; Glucose/metabolism ; Hydrogenation ; Hyperglycemia/drug therapy ; Hyperglycemia/metabolism ; Lipid Metabolism/drug effects ; Male ; Mice, Inbred Strains ; Obesity/drug therapy ; Obesity/metabolism ; Structure-Activity Relationship ; Time Factors ; Tocotrienols/administration & dosage ; Tocotrienols/chemistry ; Tocotrienols/pharmacology ; Vitamin E/administration & dosage ; Vitamin E/chemistry ; Vitamin E/pharmacology ; Mice
    Chemical Substances Cholesterol, HDL ; Tocotrienols ; Vitamin E (1406-18-4) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-01-11
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2218264-0
    ISSN 1347-3352 ; 1345-8957
    ISSN (online) 1347-3352
    ISSN 1345-8957
    DOI 10.5650/jos.ess20233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: LC-MS/MS analysis of milk triacylglycerol hydroperoxide isomers which are generated corresponding to the photo- and thermal-oxidation.

    Saito, Hirotada / Kato, Shunji / Shimizu, Naoki / Takahashi, Takumi / Jutanom, Mirinthorn / Ito, Junya / Kasatani, Satoshi / Nakagawa, Kiyotaka

    Food research international (Ottawa, Ont.)

    2023  Volume 178, Page(s) 113913

    Abstract: Milk is a rich source of essential nutrients such as lipids. However, lipid oxidation can be considered a crucial factor in determining the initial stage of milk deterioration. Therefore, it is essential to identify the mechanisms of lipid oxidation, ... ...

    Abstract Milk is a rich source of essential nutrients such as lipids. However, lipid oxidation can be considered a crucial factor in determining the initial stage of milk deterioration. Therefore, it is essential to identify the mechanisms of lipid oxidation, such as photo-oxidation or thermal oxidation, to efficiently prevent it by selecting proper antioxidants. In this study, the oxidation mechanisms of long-life (LL) milk were investigated, and triacylglycerol hydroperoxide isomers generated corresponding to the oxidation mechanisms were analyzed by LC-MS/MS. This study first prepared the standard of TG 4:0_16:0_18:1;OOH isomers, which are the appropriate target for evaluating LL milk's oxidation mechanism. The authentic standards provided the robust analysis of TG 4:0_16:0_18:1;OOH isomers and suggested that LL milk was susceptible to photo-oxidation rather than thermal-oxidation. Furthermore, it was discovered that radicals play a role in the oxidation of LL milk during photo-oxidation. This information could be valuable in effectively preventing photo-oxidation in LL milk. It is important to note that milk is contained in a variety of food products. Hence, these findings would be applicable not only to milk but also to various milk-containing food products.
    MeSH term(s) Animals ; Milk ; Chromatography, Liquid ; Liquid Chromatography-Mass Spectrometry ; Hydrogen Peroxide ; Triglycerides ; Tandem Mass Spectrometry
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; Triglycerides
    Language English
    Publishing date 2023-12-22
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2023.113913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Quantitative Analysis of the Accumulation of Marine-derived Tocopherol in the Tissue of Mice Fed with Salmon Roe Oil Using HPLC-fluorescence.

    Beppu, Fumiaki / Kondo, Hitomi / Kasatani, Satoshi / Aoki, Yoshinori / Gotoh, Naohiro

    Journal of oleo science

    2018  Volume 67, Issue 3, Page(s) 283–288

    Abstract: In this study, we measured the quantity of marine-derived tocopherol (MDT), a monounsaturated vitamin E (VE), stored in the body tissue of mice fed with a diet containing a VE-rich fraction extracted from salmon roe. We first prepared the calibration ... ...

    Abstract In this study, we measured the quantity of marine-derived tocopherol (MDT), a monounsaturated vitamin E (VE), stored in the body tissue of mice fed with a diet containing a VE-rich fraction extracted from salmon roe. We first prepared the calibration curves for the MDT concentration using an HPLC-fluorescence system. Ranging from 0.016 to 50 μg/mL, the slope was expressed as first-order equations, with R
    MeSH term(s) Adipose Tissue/metabolism ; Animals ; Chromatography, High Pressure Liquid/methods ; Fish Oils/administration & dosage ; Fish Oils/chemistry ; Fluorescence ; Kidney/metabolism ; Liver/metabolism ; Male ; Mice, Inbred Strains ; Tissue Distribution ; Tocopherols/administration & dosage ; Tocopherols/analysis ; Tocopherols/metabolism
    Chemical Substances Fish Oils ; salmon oil (68991-43-5) ; Tocopherols (R0ZB2556P8)
    Language English
    Publishing date 2018-03-01
    Publishing country Japan
    Document type Journal Article
    ISSN 1347-3352
    ISSN (online) 1347-3352
    DOI 10.5650/jos.ess17218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Trans-octadecenoic Acid Positional Isomers Have Different Accumulation and Catabolism Properties in Mice.

    Beppu, Fumiaki / Asanuma, Masaharu / Kawamura, Yoshinori / Nagai, Toshiharu / Yoshinaga, Kazuaki / Mizobe, Hoyo / Kojima, Koichi / Kasatani, Satoshi / Nagao, Koji / Kubo, Atsushi / Kanda, Jota / Gotoh, Naohiro

    Journal of oleo science

    2015  Volume 64, Issue 11, Page(s) 1159–1167

    Abstract: Trans fatty acids (TFA) are considered risk factors for cardiovascular disease (CVD), while the details of distribution and metabolism of the individual isomers are not clear. Here we investigated the accumulation and catabolic rate of TFA positional ... ...

    Abstract Trans fatty acids (TFA) are considered risk factors for cardiovascular disease (CVD), while the details of distribution and metabolism of the individual isomers are not clear. Here we investigated the accumulation and catabolic rate of TFA positional isomers of octadecenoic acid (18:1) in mice. ICR mice were fed deuterium- and [1-(13)C] stable isotope-labeled trans-9-18:1 (9t-18:1*), trans-10-18:1 (10t-18:1*), or trans-11-18:1 (11t-18:1*) for 2 or 4 weeks, or a TFA mixture (9t-18:1*, 10t-18:1*, and 11t-18:1*) for 3 weeks. Analysis of whole-body tissues by gas chromatography-chemical ionization mass spectrometry revealed the highest 9t-18:1* levels in the heart. Significant differences in the accumulation of the respective trans-18:1 were observed in the heart and erythrocytes, where 9t- > 11t- > 10t-18:1*, but no significant difference was observed in the liver or white adipose tissue (WAT). Mice fed on 11t-18:1 demonstrated accumulation of endogenously synthesized conjugated linoleic acid in the liver, WAT, and heart, but any other metabolites were not found in other groups. Furthermore, we analyzed catabolic rates of single-dose-administered trans-18:1* isomers into [(13)C]-labeled CO2 using isotope-ratio mass spectrometry, and the 10t-18:1*catabolic rate was significantly higher than those of 9t- and 11t-18:1*. We found that the accumulation and catabolism of trans-18:1 positional isomers varied in these mice. Differential accumulation in tissues suggests that individual TFA positional isomers may play different roles in human health.
    MeSH term(s) Adipose Tissue/metabolism ; Animals ; Erythrocytes/metabolism ; Gas Chromatography-Mass Spectrometry/methods ; Isomerism ; Liver/metabolism ; Male ; Mice, Inbred ICR ; Myocardium/metabolism ; Stearic Acids/metabolism ; Tissue Distribution ; Trans Fatty Acids/metabolism
    Chemical Substances 5-octadecenoic acid ; Stearic Acids ; Trans Fatty Acids
    Language English
    Publishing date 2015
    Publishing country Japan
    Document type Journal Article
    ISSN 1347-3352
    ISSN (online) 1347-3352
    DOI 10.5650/jos.ess15139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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