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Article ; Online: Antimicrobial efficacy of Lactobacillus plantarum strain against the B. cereus, B. subtilis, S. aureus and E.coli strains

Samreen Akhtar / Syed Kashif Nawaz

Bioscience Journal, Vol 39, Pp e39061-e

2023 Volume 39061

Abstract: The current study aimed to detect the antimicrobial effect of cell free supernatant (CFS) of Lactobacillus plantarum strain against Gram +ve and Gram –ve bacterial strains. The strain of Lactobacillus plantarum was isolated using selective media MRS agar. ...

Abstract	The current study aimed to detect the antimicrobial effect of cell free supernatant (CFS) of Lactobacillus plantarum strain against Gram +ve and Gram –ve bacterial strains. The strain of Lactobacillus plantarum was isolated using selective media MRS agar. The strain was characterized on the basis of the gram staining, colony morphology, the biochemical tests and the DNA sequencing based method of 16S ribotyping. A total of four test strains (The three already isolated and reported strains (E.coli, S. aureus and B. subtilis) and the one recently identified novel strain (B. cereus) were used for the analysis of antagonistic activity of bacteriocin produced by L. plantarum strain. The CFS of L. plantarum showed zone of inhibition against all the test strains (Gram +ve and Gram –ve bacteria). The conditions favoring the growth of bacteria were associated with the antimicrobial efficacy of CFS. Bacteriocin activity of CFS remained effective after exposure to temperature stress. Wide range of antagonistic potential of CFS of L. plantarum provides an alternative for antibiotics in pharmaceutical industry. Heat resistant feature of bacteriocin suggests its application in food industry.
Keywords	antimicrobial activity ; bacteriocin ; bacillus cereus ; lactobacillus plantarum ; molecular identification ; Agriculture ; S ; Biology (General) ; QH301-705.5
Subject code	630
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Universidade Federal de Uberlândia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Histone modifications and DNA methylation act cooperatively in regulating symbiosis genes in the sea anemone Aiptasia

Kashif Nawaz / Maha J. Cziesielski / Kiruthiga G. Mariappan / Guoxin Cui / Manuel Aranda

BMC Biology, Vol 20, Iss 1, Pp 1-

2022 Volume 17

Abstract: Abstract Background The symbiotic relationship between cnidarians and dinoflagellates is one of the most widespread endosymbiosis in our oceans and provides the ecological basis of coral reef ecosystems. Although many studies have been undertaken to ... ...

Abstract	Abstract Background The symbiotic relationship between cnidarians and dinoflagellates is one of the most widespread endosymbiosis in our oceans and provides the ecological basis of coral reef ecosystems. Although many studies have been undertaken to unravel the molecular mechanisms underlying these symbioses, we still know little about the epigenetic mechanisms that control the transcriptional responses to symbiosis. Results Here, we used the model organism Exaiptasia diaphana to study the genome-wide patterns and putative functions of the histone modifications H3K27ac, H3K4me3, H3K9ac, H3K36me3, and H3K27me3 in symbiosis. While we find that their functions are generally conserved, we observed that colocalization of more than one modification and or DNA methylation correlated with significantly higher gene expression, suggesting a cooperative action of histone modifications and DNA methylation in promoting gene expression. Analysis of symbiosis genes revealed that activating histone modifications predominantly associated with symbiosis-induced genes involved in glucose metabolism, nitrogen transport, amino acid biosynthesis, and organism growth while symbiosis-suppressed genes were involved in catabolic processes. Conclusions Our results provide new insights into the mechanisms of prominent histone modifications and their interaction with DNA methylation in regulating symbiosis in cnidarians.
Keywords	Symbiosis ; Corals ; Climate Change ; Epigenetics ; Histone modifications ; Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Rivaroxaban in Stroke Prevention in Patient with Atrial Fibrillation due to Valvular Heart Disease

Waqar shamim / Muhammad Rizwan / Rizwan Rasul Khan / Masood Javed / Nasir Mahmood / Kashif Nawaz

Journal of Aziz Fatimah Medical and Dental College, Vol 4, Iss

2022 Volume 1

Abstract: Objective: To observe the effect of rivaroxaban in patients with atrial fibrillation due to valvular heart diseases for proper anticoagulation to avoid stroke. Methodology: An observational follow up study was carried out in Cardiology Department of Aziz ...

Abstract	Objective: To observe the effect of rivaroxaban in patients with atrial fibrillation due to valvular heart diseases for proper anticoagulation to avoid stroke. Methodology: An observational follow up study was carried out in Cardiology Department of Aziz Fatimah Hospital, Faisalabad from February to August 2021. The study included 36 patients of valvular heart disease with atrial fibrillation on warfarin, whose INR was not tested during the last 4 months due to lack of facility nearby. All patients with non valvular atrial fibrillation were excluded .All patients were given rivaroxaban to replace warfarin. These patients were followed up for 6 months in the OPD of the same hospital to observe the end points including stroke and bleeding episodes and ischemic changes on ECG. Results: Total of 36 patients of mean age and SD of 56±7.00 years were followed up. Out of which 20 were male and 16 were female subjects.Not a single incident of stroke or bleeding episode or bruises was observed during the 6 month follow up. On echocardiographic examination, none of the patients showed clot in the left atrium. Left atrium size and LV ejection fraction remained the same, during next visit. LA size 44±5 and 44±6 on 1st and second visit respectively (p value =0.059) No other ischemic changes found in the ECG of any patient. International normalization ratio (INR) mean and SD was 2.1± 0.9, 2.2± 0.8, on 1st and 2nd visit of follow up respectively and no significant difference was noted between INR values. Conclusion: Rivaroxaban can be given safely to the patients with valvular heart disease with atrial fibrillation, particularly in patients who cannot get the INR checked on regular basis.
Keywords	Atrial fibrillation ; Rivaroxaban ; Valvular Heart Disease ; Dentistry ; RK1-715 ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Aziz Fatimah Medical and Dental College
Document type	Article ; Online
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Article ; Online: Determination of pyrethroids in water samples by dispersive solid‐phase extraction coupled with high‐performance liquid chromatography

Zhang, Jie / Wang, Ya / Yu, Jun / Wang, Qingying / Khattak, Kashif Nawaz / Yang, Xiupei

Water Environment Research. 2022 Nov., v. 94, no. 11 p.e10813-

2022

Abstract: A metal–organic framework UiO‐66 was prepared and used as a sorbent for dispersive solid‐phase extraction combined with high‐performance liquid chromatography (DSPE‐HPLC) for extracting and determining four pyrethroids in water samples for the first time. ...

Abstract	A metal–organic framework UiO‐66 was prepared and used as a sorbent for dispersive solid‐phase extraction combined with high‐performance liquid chromatography (DSPE‐HPLC) for extracting and determining four pyrethroids in water samples for the first time. The as‐synthesized material was confirmed by Fourier transform infrared spectroscopy (FT‐IR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), X‐ray diffraction (XRD), thermogravimetric analysis (TGA), and N₂ adsorption–desorption analysis. In addition, several important parameters affecting DSPE efficiency, including sorbent dosage, extraction time, salt concentration, pH, elution solvent, elution volume, and elution time, were optimized. Under the optimum conditions, the UiO‐66 based on the DSPE‐HPLC method displayed a wide linear range (10–1000 ng/ml), low limits of detection (2.8–3.5 ng/ml), and good precision (relative standard deviations [RSDs] < 3%) for the four pyrethroids. The recoveries at different spiked levels ranged from 89.3% to 107.7%. In addition, UiO‐66 featured good reusability and reproducibility. The results demonstrated that π–π stacking interactions, hydrophobic interactions, and van der Waals forces between UiO‐66 and the four pyrethroids played a crucial role in the adsorption process. Meanwhile, the maximum extraction capability could be obtained within 5 min. Thus, the DSPE coupled with the UiO‐66 sorbent can be successfully used in the analysis of four pyrethroids in environmental water samples. PRACTITIONER POINTS: Simultaneous determination of four pyrethroids using the developed UiO‐66‐based DSPE‐HPLC method in water samples. The developed method had a short enrichment time, broad linear ranges, a low detection limit, and high enrichment factor. It is showed that π–π stacking interaction, hydrophobic interaction, and van der Waals forces were the main mechanism.
Keywords	Fourier transform infrared spectroscopy ; X-ray diffraction ; adsorption ; coordination polymers ; detection limit ; environment ; high performance liquid chromatography ; hydrophobic bonding ; hydrophobicity ; pH ; pyrethrins ; research ; salt concentration ; solid phase extraction ; solvents ; sorbents ; thermogravimetry ; transmission electron microscopy ; van der Waals forces ; water
Language	English
Dates of publication	2022-11
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1098976-6
ISSN	1554-7531 ; 1047-7624 ; 1061-4303
ISSN (online)	1554-7531
ISSN	1047-7624 ; 1061-4303
DOI	10.1002/wer.10813
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Determination of pyrethroids in water samples by dispersive solid-phase extraction coupled with high-performance liquid chromatography.

Zhang, Jie / Wang, Ya / Yu, Jun / Wang, Qingying / Khattak, Kashif Nawaz / Yang, Xiupei

Water environment research : a research publication of the Water Environment Federation

2022 Volume 94, Issue 11, Page(s) e10813

Abstract: A metal-organic framework UiO-66 was prepared and used as a sorbent for dispersive solid-phase extraction combined with high-performance liquid chromatography (DSPE-HPLC) for extracting and determining four pyrethroids in water samples for the first time. ...

Abstract	A metal-organic framework UiO-66 was prepared and used as a sorbent for dispersive solid-phase extraction combined with high-performance liquid chromatography (DSPE-HPLC) for extracting and determining four pyrethroids in water samples for the first time. The as-synthesized material was confirmed by Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and N
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Pyrethrins ; Spectroscopy, Fourier Transform Infrared ; Reproducibility of Results ; Solid Phase Extraction/methods ; Water
Chemical Substances	UiO-66 ; Pyrethrins ; Water (059QF0KO0R)
Language	English
Publishing date	2022-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1098976-6
ISSN	1554-7531 ; 1047-7624 ; 1061-4303
ISSN (online)	1554-7531
ISSN	1047-7624 ; 1061-4303
DOI	10.1002/wer.10813
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Article ; Online: Evaluation of the anti-inflammatory, analgesic, anti-pyretic and anti-ulcerogenic potentials of synthetic indole derivatives

Saira Siddique / Khawaja Raees Ahmad / Syed Kashif Nawaz / Syeda Nadia Ahmad / Rabiyah Ali / Iram Inayat / Sadia Suleman / Muhammad Ali Kanwal / Muhammad Usman

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 12

Abstract: Abstract A large number of new synthetic compounds are synthesized in the field of heterocyclic chemistry having a variety of biological potentials. In the present study, some synthetic indole derivatives are used to check anti-inflammatory, analgesic, ... ...

Abstract	Abstract A large number of new synthetic compounds are synthesized in the field of heterocyclic chemistry having a variety of biological potentials. In the present study, some synthetic indole derivatives are used to check anti-inflammatory, analgesic, antipyretic and gastroprotective activity in albino mice. Albino mice of either sex of reproductive age were used for each study (n = 5). In anti-inflammatory activity, the negative control (NC) and positive control group animals were treated with normal saline and 10 mg/kg of indomethacin respectively. The treated groups received the twenty four different synthetic chemicals, after 30 min of sub cutaneous injection of carrageenan. In analgesic activity, hot-plate method is used and for each group the latency period was recorded at zero moment of the provision of required dose and after 30, 60, 90, 120 and 180 min. In anti-pyretic activity, Pyrexia was induced by using Brewer's yeast method. Before any treatment and then after duration of 18 h, the rectal temperatures were recorded. Among all the chemicals, only those chemicals which show any potential related to above mentioned activities were selected for gastroprotective activity. The gastroprotective activity was performed to check the gastric ulcers by using 300 mg/kg of single oral dose of indomethacin to animals of all groups except NC group. This study helped to screen out the most potent indole derivatives 3a-II and 4a-II from the 24 synthetic indole derivatives which demonstrated the best biological potential (anti-inflammatory, analgesic, antipyretic, and gastroprotection) as compared to the remaining ones. The micrometric and biochemical results also support the histological findings. Out of the twenty-four novel indole amines tested, 3a-II and 4a-II have shown the effective pharmacological capacity and additionally have not shown any overt and systemic toxicity. Thus these two indole amines need further in-depth pharmacokinetic and pharmacodynamics studies before they are recommended for any ...
Keywords	Medicine ; R ; Science ; Q
Subject code	540
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Role of rs4986790 Polymorphism of TLR4 Gene in Susceptibility towards Malaria Infection in the Pakistani Population

Asima RANI / Syed Kashif NAWAZ / Muhammad ARSHAD / Shazia IRFAN

Iranian Journal of Public Health, Vol 47, Iss

2018 Volume 5

Abstract: Background: Toll-like receptors (TLRs) of the human immune mechanism play important role in the detection of invading pathogens. TLRs specifically recognize the pathogen-associated molecular patterns (PAMPs) from pathogens and start the effective ... ...

Abstract	Background: Toll-like receptors (TLRs) of the human immune mechanism play important role in the detection of invading pathogens. TLRs specifically recognize the pathogen-associated molecular patterns (PAMPs) from pathogens and start the effective response. Single nucleotide polymorphisms (SNPs) in the TLRs can mediate their functions. Present study evaluated the importance of rs4986790 polymorphism of TLR4 gene in susceptibility towards malaria, clinical outcomes of the disease and responsible species of malaria. Methods: Blood samples of 228 malaria patients and 226 healthy volunteers were selected for the study. Sample collection was completed during Sep 2013 to Sep 2015 from different hospitals of Punjab, Pakistan. Patient's samples were divided into P. vivax group and P. falciparum group on the basis of causative species of Plasmodium. Malaria samples were also divided into mild and severe malaria group based on clinical outcomes of the disease according to WHO criteria. Healthy individuals were placed in the control group. Whole blood was used for the isolation of DNA. Genomic DNA was isolated and amplification of targeted SNP was performed using allele-specific PCR. Results: Results indicate the protective role of AA genotype against the susceptibility of P. vivax infection, OR: 0.5, 95%CI: 0.285- 0.876, P=0.038. Conclusion: rs4986790 polymorphism of TLR4 gene modulates the susceptibility towards P. vivax infection. AA genotype is found to be protective against the development of P. vivax infection in the local population of Pakistan.
Keywords	TLR4 ; rs4986790 ; Malaria ; Plasmodium ; Pakistani population ; Public aspects of medicine ; RA1-1270
Subject code	616
Language	English
Publishing date	2018-05-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
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Article: Comparative Evaluation of Heavy Metals in Patients with Rheumatoid Arthritis and Healthy Control in Pakistani Population.

Irfan, Shazia / Rani, Asima / Riaz, Naila / Arshad, Muhammad / Kashif Nawaz, Syed

Iranian journal of public health

2017 Volume 46, Issue 5, Page(s) 626–633

Abstract: Background: Exposure to heavy metals in development of many diseases has been investigated previously, specially created by oxidative stress. The etiology of Rheumatoid arthritis (RA) is still not fully understood but oxidative stress created by heavy ... ...

Abstract	Background: Exposure to heavy metals in development of many diseases has been investigated previously, specially created by oxidative stress. The etiology of Rheumatoid arthritis (RA) is still not fully understood but oxidative stress created by heavy metals may have role in development of RA. The aim of present study was to compare serum level of heavy metals in RA and healthy control individuals. Methods: Blood samples of 100 RA patients were collected from different hospitals in district Sargodha, Punjab, Pakistan and 100 control individuals from Dec 2013 to May 2014.The serum samples were analyzed for determination of Pb, Cd, Cr and Ni through Atomic absorption spectrophotometer (AA 6600 Shimadzu). Results: Statistically highly significant difference was observed between RA patients and healthy control individuals for Pb, Cd, Cr, and Ni level ( Conclusion: Concentration of heavy metals in serum samples of RA patients and healthy control individuals differ significantly, which shows that heavy metals may contributes towards development of RA.
Language	English
Publishing date	2017-05
Publishing country	Iran
Document type	Journal Article
ISSN	2251-6085
ISSN	2251-6085
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Structural, Thermal, and Mechanical Characterization of a Thermally Conductive Polymer Composite for Heat Exchanger Applications

Jamieson Brechtl / Yuzhan Li / Kai Li / Logan Kearney / Kashif Nawaz / Alexis Flores-Betancourt / Michael Thompson / Orlando Rios / Ayyoub M. Momen

Polymers, Vol 13, Iss 1970, p

2021 Volume 1970

Abstract: Polymer composites are being considered for numerous thermal applications because of their inherent benefits, such as light weight, corrosion resistance, and reduced cost. In this work, the microstructural, thermal, and mechanical properties of a 3D ... ...

Abstract	Polymer composites are being considered for numerous thermal applications because of their inherent benefits, such as light weight, corrosion resistance, and reduced cost. In this work, the microstructural, thermal, and mechanical properties of a 3D printed polymer composite with high thermal conductivity are examined using multiple characterization techniques. Infrared spectroscopy and X-ray diffraction reveal that the composite contains a polyphenylene sulfide matrix with graphitic fillers, which is responsible for the high thermal conductivity. Furthermore, differential scanning calorimetry determines that the glass transition and melting point of the composite are 87.6 °C and 285.6 °C, respectively. Thermogravimetric analysis reveals that the composite is thermally stable up to ~400 °C. Creep tests are performed at different isotherms to evaluate the long-term performance of the composite. The creep result indicates that the composite can maintain mechanical integrity when used below its glass transition temperature. Nanoindentation tests reveal that modulus and hardness of the composite is not significantly influenced by heating or creep conditions. These findings indicate that the composite is potentially suitable for heat exchanger applications.
Keywords	polymer composites ; microstructure analysis ; thermal analysis ; creep modeling ; mechanical properties ; Organic chemistry ; QD241-441
Subject code	621
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of noise exposure on catalase activity of growing lymphocytes

Syed Kashif Nawaz / Shahida Hasnain

Bosnian Journal of Basic Medical Sciences, Vol 11, Iss

2012 Volume 4

Abstract: Oxidative stress due to noise was estimated at cell level using model of growing lymphocytes. Lymphocytes were isolated and cultured using conventional methodology. Cell culture of each group was exposed to sound of frequency 1 KHz during incubation. ... ...

Abstract	Oxidative stress due to noise was estimated at cell level using model of growing lymphocytes. Lymphocytes were isolated and cultured using conventional methodology. Cell culture of each group was exposed to sound of frequency 1 KHz during incubation. Three groups were defined on the basis of exposure of sound with specific range of intensity and duration of exposure. Group A and Group B were exposed to sound with intensity 110 dBA for four hours per day and for eight hours per day respectively. Control group was exposed to sound less than 85 dBA. Viable cell count was performed using trypan blue. Catalase activity of each group was estimated using ELISA kit. Viable cell count of Group A and Group B was almost same but significantly less than that of control group. Catalase activity of lymphocytes in Group B was significantly low as compared to Group A and controls (p=0.003,p< 0.05). There was no significant difference between catalase activity of Group A and control group. Exposure of sound with frequency 1 KHz and intensity 110 dBA for 4 hours and eight hours per day may induce oxidative stress in growing lymphocytes causing the difference in viable cell count. However the catalase activity depends on duration of exposure. In case of noise exposure of 8 hours per day, it declines significantly as compared to noise exposure of 4 hours per day.
Keywords	Oxidative stress ; catalase activity ; noise exposure ; oxidative damage in lymphocytes ; noise induced oxidative damage ; Medicine (General) ; R5-920
Subject code	571
Language	English
Publishing date	2012-11-01T00:00:00Z
Publisher	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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