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  1. Article ; Online: New Daily Persistent Headache (NDPH): Unraveling the Complexities of Diagnosis, Pathophysiology, and Treatment.

    Sadeghpour, Majid / Abdolizadeh, Ali / Yousefi, Pourya / Rastegar-Kashkouli, Ali / Chitsaz, Ahmad

    Current pain and headache reports

    2023  Volume 27, Issue 10, Page(s) 551–559

    Abstract: Purpose of review: The current article aims to provide an overview of new daily persistent headache (NDPH), with a particular emphasis on its pathophysiology, evaluation, and current treatment options.: Recent findings: NDPH is an uncommon and ... ...

    Abstract Purpose of review: The current article aims to provide an overview of new daily persistent headache (NDPH), with a particular emphasis on its pathophysiology, evaluation, and current treatment options.
    Recent findings: NDPH is an uncommon and heterogeneous condition associated with various comorbidities and is of great significance due to its prolonged duration and high severity. Variable causes and clinical aspects of NDPH may reflect differences in its underlying pathophysiological mechanisms, including genetics, environmental triggers, neuroinflammation, and brain changes. When assessing a patient with NDPH, potential triggers, past medical history, and differential diagnosis should be carefully considered. Non-pharmacological interventions aimed to improve diet, sleep patterns, and reduce consumption of caffeine and alcohol are recommended for all patients. Nerve blockade and nerve stimulation seem to be more efficacious in children than adults. Antiviral medications and neuroinflammation-targeting treatments may be helpful, particularly, when an infectious disease or severe inflammation is suspected. NDPH patients with concurrent affective disorders may benefit from treatment with serotonin reuptake inhibitors, serotonin/norepinephrine reuptake inhibitors, or benzodiazepines. Cerebrospinal-fluid-lowering medications may be useful for headaches started with a thunderclap or a Valsalva maneuver. Possible treatments for refractory NDPH include intravenous ketamine or lidocaine, onabotulinumtoxinA, and calcitonin gene-related peptide antibodies. Considering the variety of NDPH, it is critical to properly screen patients for correct diagnosis. Proper identification of potential mimics may enable precise therapy opportunities, yet there is no gold standard treatment for NDPH. Further well-designed studies are needed to elucidate the underlying mechanisms and develop effective treatment strategies for NDPH.
    MeSH term(s) Adult ; Child ; Humans ; Neuroinflammatory Diseases ; Headache Disorders/diagnosis ; Headache Disorders/therapy ; Headache/diagnosis ; Treatment Outcome ; Diagnosis, Differential
    Language English
    Publishing date 2023-08-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055062-5
    ISSN 1534-3081 ; 1531-3433
    ISSN (online) 1534-3081
    ISSN 1531-3433
    DOI 10.1007/s11916-023-01161-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5477: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article ; Online: Renal hemodynamic effects of glucagon-like peptide-1 agonist are mediated by nitric oxide but not prostaglandin.

    Thomson, Scott C / Kashkouli, Ali / Liu, Zhi Zhao / Singh, Prabhleen

    American journal of physiology. Renal physiology

    2017  Volume 313, Issue 4, Page(s) F854–F858

    Abstract: The incretin hormone, glucagon-like peptide-1 (GLP-1), is known for responding to dietary fat and carbohydrate. It elicits effects on pancreas, gut, and brain to stabilize blood glucose levels. We have previously reported that the GLP-1 agonist, ... ...

    Abstract The incretin hormone, glucagon-like peptide-1 (GLP-1), is known for responding to dietary fat and carbohydrate. It elicits effects on pancreas, gut, and brain to stabilize blood glucose levels. We have previously reported that the GLP-1 agonist, exenatide, vasodilates the kidney and suppresses proximal reabsorption. The present study was undertaken to determine whether the renal effects of exenatide are mediated by nitric oxide (NO) and/or prostaglandins. Inulin clearance (glomerular filtration rate, GFR) and urine flow rate (UV) were measured in anesthetized rats before and during exenatide infusion (1 nmol/h iv). Animals were pretreated with cyclooxygenase (COX) inhibitor (meclofenamate), NO synthase (NOS) inhibitor (
    MeSH term(s) Animals ; Exenatide ; Glucagon-Like Peptide 1/agonists ; Male ; Nitric Oxide/metabolism ; Peptides/pharmacology ; Prostaglandins/metabolism ; Rats, Wistar ; Renal Circulation/drug effects ; Venoms/pharmacology
    Chemical Substances Peptides ; Prostaglandins ; Venoms ; Nitric Oxide (31C4KY9ESH) ; Glucagon-Like Peptide 1 (89750-14-1) ; Exenatide (9P1872D4OL)
    Language English
    Publishing date 2017-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00258.2017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Glucagon-like peptide-1 receptor stimulation increases GFR and suppresses proximal reabsorption in the rat.

    Thomson, Scott C / Kashkouli, Ali / Singh, Prabhleen

    American journal of physiology. Renal physiology

    2012  Volume 304, Issue 2, Page(s) F137–44

    Abstract: The incretin hormone glucagon-like peptide-1 (GLP-1) is released from the gut in response to fat or carbohydrate and contributes to negative feedback control of blood glucose by stimulating insulin secretion, inhibiting glucagon, and slowing gastric ... ...

    Abstract The incretin hormone glucagon-like peptide-1 (GLP-1) is released from the gut in response to fat or carbohydrate and contributes to negative feedback control of blood glucose by stimulating insulin secretion, inhibiting glucagon, and slowing gastric emptying. GLP-1 receptors (GLP-1R) are also expressed in the proximal tubule, and possibly elsewhere in the kidney. Presently, we examined the effect of a GLP-1R agonist on single-nephron glomerular filtration rate (GFR; SNGFR), proximal reabsorption (Jprox), tubuloglomerular feedback (TGF) responses, and urine flow rate in hydropenic male Wistar and Wistar-Froemter rats. Micropuncture and whole-kidney data were obtained before and during infusion of the GLP-1 agonist exenatide (1 nmol/h iv). SNGFR and Jprox were measured by late proximal collection at both extremes of TGF activation, which was achieved by perfusing Henle's loop at 0 or 50 nl/min. Primary changes in Jprox were revealed by analysis of covariance for Jprox with SNGFR as a covariate. Effects on TGF activation were determined in a separate set of experiments by comparing early distal and late proximal collections. Exenatide increased SNGFR by 33-50%, suppressed proximal tubular reabsorption by 20-40%, doubled early distal flow rate, and increased urine flow rate sixfold without altering the efficiency of glomerulotubular balance, TGF responsiveness, or the tonic influence of TGF. This implies that exenatide is both a proximal diuretic and a renal vasodilator. Since the natural agonist for the GLP-1R is regulated by intake of fat and carbohydrate, but not by salt or fluid, the control of salt excretion by the GLP-1R system departs from the usual negative-feedback paradigm for regulating salt balance.
    MeSH term(s) Animals ; Exenatide ; Glomerular Filtration Rate/physiology ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents/pharmacology ; Kidney Tubules, Proximal/physiology ; Male ; Peptides/pharmacology ; Rats ; Rats, Wistar ; Receptors, Glucagon/agonists ; Receptors, Glucagon/genetics ; Receptors, Glucagon/metabolism ; Sodium Chloride/metabolism ; Venoms/pharmacology ; Water-Electrolyte Balance
    Chemical Substances Glp1r protein, rat ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; Peptides ; Receptors, Glucagon ; Venoms ; Sodium Chloride (451W47IQ8X) ; Exenatide (9P1872D4OL)
    Language English
    Publishing date 2012-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00064.2012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pathological characteristics of light chain crystalline podocytopathy.

    Nasr, Samih H / Kudose, Satoru / Javaugue, Vincent / Harel, Stéphanie / Said, Samar M / Pascal, Virginie / Stokes, M Barry / Vrana, Julie A / Dasari, Surendra / Theis, Jason D / Osuchukwu, George A / Sathick, Insara Jaffer / Das, Arjun / Kashkouli, Ali / Suchin, Elliot J / Liss, Yaakov / Suldan, Zalman / Verine, Jerome / Arnulf, Bertrand /
    Talbot, Alexis / Sethi, Sanjeev / Zaidan, Mohamad / Goujon, Jean-Michel / Valeri, Anthony M / Mcphail, Ellen D / Sirac, Christophe / Leung, Nelson / Bridoux, Frank / D'Agati, Vivette D

    Kidney international

    2022  Volume 103, Issue 3, Page(s) 616–626

    Abstract: Monoclonal immunoglobulin light chain (LC) crystalline inclusions within podocytes are rare, poorly characterized entities. To provide more insight, we now present the first clinicopathologic series of LC crystalline podocytopathy (LCCP) encompassing 25 ... ...

    Abstract Monoclonal immunoglobulin light chain (LC) crystalline inclusions within podocytes are rare, poorly characterized entities. To provide more insight, we now present the first clinicopathologic series of LC crystalline podocytopathy (LCCP) encompassing 25 patients (68% male, median age 56 years). Most (80%) patients presented with proteinuria and chronic kidney disease, with nephrotic syndrome in 28%. Crystalline keratopathy and Fanconi syndrome were present in 22% and 10%, respectively. The hematologic condition was monoclonal gammopathy of renal significance (MGRS) in 55% and multiple myeloma in 45%. The serum monoclonal immunoglobulin was IgG κappa in 86%. Histologically, 60% exhibited focal segmental glomerulosclerosis (FSGS), often collapsing. Ultrastructurally, podocyte LC crystals were numerous with variable effacement of foot processes. Crystals were also present in proximal tubular cells as light chain proximal tubulopathy (LCPT) in 80% and in interstitial histiocytes in 36%. Significantly, frozen-section immunofluorescence failed to reveal the LC composition of crystals in 88%, requiring paraffin-immunofluorescence or immunohistochemistry, with identification of kappa LC in 87%. The LC variable region gene segment, determined by mass spectrometry of glomeruli or bone marrow plasma cell sequencing, was IGKV1-33 in four and IGKV3-20 in one. Among 21 patients who received anti-plasma cell-directed chemotherapy, 50% achieved a kidney response, which depended on a deep hematologic response. After a median follow-up of 36 months, 26% progressed to kidney failure and 17% died. The mean kidney failure-free survival was 57.6 months and was worse in those with FSGS. In sum, LCCP is rare, mostly associates with IgG κappa MGRS, and frequently has concurrent LCPT, although Fanconi syndrome is uncommon. Paraffin-immunofluorescence and electron microscopy are essential to prevent misdiagnosis as primary FSGS since kidney survival depends on early diagnosis and subsequent clone-directed therapy.
    MeSH term(s) Humans ; Male ; Middle Aged ; Female ; Glomerulosclerosis, Focal Segmental/pathology ; Fanconi Syndrome/pathology ; Paraffin ; Kidney/pathology ; Kidney Diseases/pathology ; Renal Insufficiency/pathology ; Immunoglobulin G
    Chemical Substances Paraffin (8002-74-2) ; Immunoglobulin G
    Language English
    Publishing date 2022-12-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.11.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
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  5. Article ; Online: Beyond a broken heart: circulatory dysfunction in the failing Fontan.

    Mori, Makoto / Aguirre, Alfredo J / Elder, Robert W / Kashkouli, Ali / Farris, Alton Brad / Ford, Ryan M / Book, Wendy M

    Pediatric cardiology

    2014  Volume 35, Issue 4, Page(s) 569–579

    Abstract: The role of ventricular dysfunction in late morbidity and mortality of univentricular hearts has been described previously. However, a significant proportion of adult Fontan patients who die or require heart transplantation do so with preserved ... ...

    Abstract The role of ventricular dysfunction in late morbidity and mortality of univentricular hearts has been described previously. However, a significant proportion of adult Fontan patients who die or require heart transplantation do so with preserved ventricular function. The clinical deterioration in patients who have undergone Fontan palliation requires a broader view of circulatory dysfunction, one that takes into account the complex interaction of regulatory systems affecting hepatic, renal, and pulmonary blood flow, in addition to cardiac function. This review focuses primarily on the pathophysiology of multiple organ involvement in this circulatory dysfunction, with particular focus on the consequences of hepatic dysfunction and portal hypertension. The authors discuss hepatic perfusion, both in health and disease, and review the current understanding of liver histopathology and liver disease in adult Fontan patients and similar clinicopathologic states. They compare and contrast features of postsinusoidal portal hypertension with more typical adult cirrhotic disease. Finally, they delineate the related effects of portal hypertensive physiology on the systemic and pulmonary vasculature, the kidney, and the heart itself and discuss how these changes affect the care of the adult Fontan patient.
    MeSH term(s) Adult ; Fontan Procedure/adverse effects ; Global Health ; Heart Defects, Congenital/physiopathology ; Heart Defects, Congenital/surgery ; Heart Ventricles/abnormalities ; Heart Ventricles/physiopathology ; Heart Ventricles/surgery ; Hemodynamics/physiology ; Humans ; Hypertension, Portal/epidemiology ; Hypertension, Portal/etiology ; Hypertension, Portal/physiopathology ; Incidence ; Survival Rate/trends ; Treatment Failure
    Language English
    Publishing date 2014-02-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-014-0881-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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